Champions Path
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Sutjeska Nikšić | 3-5 | Linfield | 1-2 Damir Kojasevic / Kirk Millar (2) | 2-3 Bojan Bozovic (2) / Mark Stafford, Shayne Lavery, Matthew Clarke |
| Maccabi Tel Aviv | 2-4 | Sūduva | 1-2 Chico Ofoedu / Semir Kerla, Eligijus Jankauskas | 1-2 Nick Blackman / Mihret Topcagic, Andro Svrljuga |
| Ararat-Armenia | 3-2 | Saburtalo Tbilisi | 1-2 Anton Kobyalko / Sandro Altunashvili, Levan Kenia | 2-0 Anton Kobyalko, Petros Avetisyan |
| Ludogorets Razgrad | 9-0 | The New Saints | 5-0 Ryan Harrington (og), Mavis Tchibota, Jody Lukoki, Claudiu Keseru, Cosmin Moti | 4-0 Jody Lukoki, Jakub Swierczok (2), Dan Biton |
| Riga | 3-3 | HJK Helsinki | 1-1 Kamil Bilinski / Tim Vayrynen | 2-2 Roman Debelko (2) / Petteri Forsell, Tim Vayrynen |
| Sarajevo | 1-2 | BATE Borisov | 1-2 Haris Handzic / Dmitri Baga, Hervaine Moukam | 0-0 |
| F91 Dudelange | 4-1 | Nõmme Kalju | 3-1 Dominik Stolz (3) / Sander Puri | 1-0 Danel Sinani |
| Astana | 9-1 | Valletta | 5-1 Runar Mar Sigurjonsson (2), Yuri Logvinenko, Marin Tomasov, Rangelo Janga / Mario Fontanella | 4-0 Roman Murtazaev (2), Marin Tomasov (2) |
| Sheriff Tiraspol | 2-3 | AIK | 1-2 Yuri Kendysh / Andrej Lukic (og), Kolbeinn Sigthorsson | 1-1 Gabrijel Boban / Nabil Bahoui |
| Slovan Bratislava | 4-1 | Dundalk | 1-0 David Holman | 3-1 Rafael Ratao, Aleksandar Cavric, Erik Daniel / Michael Duffy |
Main Path
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| IFK Norrköping | 2-4 | Hapoel Be'er Sheva | 1-1 Maic Sema / Eden Shamir | 1-3 Rasmus Lauritsen / Niv Zrihen (2), Nigel Hasselbaink |
| Torino | 6-1 | Shakhtyor Soligorsk | 5-0 Andrea Belotti (2), Armando Izzo, Lorenzo De Silvestri, Kevin Bonifazi | 1-1 Simone Zaza / Nikolai Yanush |
| Antwerp | 2-2 | Viktoria Plzeň | 1-0 Ivo Rodrigues | 1-2 Dieumerci Mbokani / Michael Krmencik (2) |
| Austria Wien | 2-5 | Apollon Limassol | 1-2 Florian Klein / Sasa Markovic, Serge Gakpe | 1-3 Maudo / Serge Gakpe, Johannes Handl (og), Giannis Gianniotas |
| Feyenoord | 5-1 | Dinamo Tbilisi | 4-0 Luis Sinisterra , Davit Kobouri (og), Steven Berghuis, Luciano Narsingh | 1-1 Eric Botteghin / Levan Shengelia |
| Brøndby | 3-7 | Braga | 2-4 Dominik Kaiser (2) / Paulinho, Andre Horta, Ricardo Horta, Hjortur Hermannsson (og) | 1-3 Peter Bjur / Joao Palhinha (2), Andre Horta |
| Molde | 4-3 | Aris | 3-0 Magnus Eikrem, Eirik Hestad, Martin Ellingsen | 1-3 Mathis Bolly / Javier Matilla, Georgios Delizisis, Nicolas Diguiny |
| Lokomotiv Plovdiv | 0-2 | Strasbourg | 0-1 Stefan Mitrovic | 0-1 Lucien Kevin Zohi |
| Thun | 3-5 | Spartak Moscow | 2-3 Nias Hefti, Simone Rapp / Ezequiel Ponce, Zelimkhan Bakaev (2) | 1-2 Stefan Glarner / Ezequiel Ponce, Andre Schurrle |
| FCSB | 1-0 | Mladá Boleslav | 0-0 | 1-0 Ionut Pantiru |
| Pyunik | 0-8 | Wolverhampton Wanderers | 0-4 Matthew Doherty, Raul Jimenez (2), Patrick Cutrone | 0-4 Pedro Neto, Morgan Gibbs-White, Ruben Vinagre, Diogo Jota |
| Midtjylland | 3-7 | Rangers | 2-4 Ogochukwu Onyeka, Sory Kaba / Alfredo Morelos, Joe Aribo, Nikola Katic, Scott Arfield | 1-3 Evander / Alfredo Morelos (2), Sheyi Ojo |
| Mariupol | 0-4 | AZ Alkmaar | 0-0 | 0-4 Calvin Stengs, Thomas Ouwejan, Stijn Wuytens, Serhiy Yavorskyy (og) |
| AEK Larnaca | 1-4 | Gent | 1-1 Ivan Trickovski / Roman Yaremchuk | 0-3 Laurent Depoitre, Jonathan David (2) |
| Legia Warsaw | 2-0 | Atromitos | 0-0 | 2-0 Pawel Stolarski, Vako Gvilia |
| Haugesund | 0-1 | PSV Eindhoven | 0-1 Steven Bergwijn | 0-0 |
| Rijeka | 4-0 | Aberdeen | 2-0 Antonio Colak, Robert Muric | 2-0 Stjepan Loncar, Antonio Colak |
| Ventspils | 0-9 | Vitória de Guimarães | 0-3 Davidson, Pepe, Joseph Amoah | 0-6 Davidson, Rochinha (2), Joao Carlos Teixeira, Pedro Joao, Pepe |
| Vaduz | 0-6 | Eintracht Frankfurt | 0-5 Filip Kostic (2), Dominik Kohr, Goncalo Paciencia, Mijat Gacinovic | 0-1 Jonathan de Guzman |
| Partizan | 3-2 | Yeni Malatyaspor | 3-1 Umar Sadiq, Takuma Asano, Seydouba Soumah / Issam Chebake | 0-1 Adis Jahovic |
| Malmö FF | 3-1 | Zrinjski Mostar | 3-0 Rasmus Bengtsson, Anders Christiansen, Soren Rieks | 0-1 Damir Sovsic |
| CSKA Sofi | 1-2 | Zorya Luhansk | 1-1 Evandro / Vladlen Yurchenko | 0-1 Nazariy Rusyn |
| Neftçi Baku | 3-4 | Bnei Yehuda | 2-2 Joseph-Monrose Steven, Namik Alaskarov / Sagas Tambi, Mohammad Ghadir | 1-2 Emin Makhmudov / Dor Jan, Sagas Tambi |
| Luzern | 0-6 | Espanyol | 0-3 Facundo Ferreyra, Didac Vila, Matias Vargas | 0-3 Wu Lei, Victor Campuzano (2) |
| Sparta Prague | 3-4 | Trabzonspor | 2-2 Costa Nhamoinesu, Guelor Kanga / Caleb Ekuban, Alexander Sorloth | 1-2 Adam Hlozek / Alexander Sorloth, Filip Novak |
| Universitatea Craiova | 1-3 | AEK Athens | 0-2 Petros Mantalos, Marko Livaja | 1-1 Antoni Ivanov / Petros Mantalos |