| Champions Path | ||||
|---|---|---|---|---|
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
| FK Sarajevo | Bye | N/A | N/A | N/A |
| Tre Penne | 0-10 | FK Sūduva | 0-5 Giedrius Matulevicius, Mihret Topcagic, Andro Svrljuga, Josip Tadic, Tosaint Ricketts | 0-5 Josip Tadic, Semir Kerla, Mihret Topcagic (2), Sandro Gotal |
| Piast Gliwice | 4-4 | Riga FC | 3-2 Jakub Czerwinski, Jorge Felix (2) / Uros Korun (og), Roman Debelko | 1-2 Jorge Felix, Armands Petersons / Kamil Bilinski |
| Partizani | 1-2 | Sheriff Tiraspol | 0-1 Robert Tambe | 1-1 Jasir Asani / Ousmane N'Diaye |
| Ararat-Armenia | 4-1 | Lincoln Red Imps | 2-0 Anton Kobyalko, Kodjo Alphonse | 2-1 Ogana (2) / Anthony Hernandez |
| Valur | 1-5 | Ludogorets Razgrad | 1-1 Lasse Petry / Anicet | 0-4 Dan Biton, Jordan Ikoko, Jakub Swierczok (2) |
| Slovan Bratislava | 4-1 | Feronikeli | 2-1 Nono, Andraz Sporar / Mendurim Hoti | 2-0 Vernon De Marco, David Holman |
| FC Santa Coloma | 1-4 | Astana | 0-0 | 1-4 Enric Pi / Runar Mar Sigurjonsson, Marin Tomasov (3) |
| HB Tórshavn | 2-3 | Linfield | 2-2 Adrian Justinussen, Paetur Petersen / Andrew Waterworth (2) | 0-1 Andrew Waterworth |
| Shkëndija | 2-3 | F91 Dudelange | 1-2 Ibraimi / Adel Bettaieb, Danel Sinani | 1-1 Besart Ibraimi/ Ricardo Delgado |
| Main Path | ||||
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
| IFK Norrköping | 3-0 | Liepāja | 2-0 Simon Thern, Sead Haksabanovic | 1-0 Sead Haksabanovic |
| Haugesund | 1-4 | Sturm Graz | 2-0 Kevin Martin Krygard, Niklas Sandberg | 1-2 Kevin Martin Krygard / Niklas Sandberg (og), Ivan Ljubic |
| Lechia Gdańsk | 3-5 | Brøndby | 2-1 Flavio Paixao, Patryk Lipski, Simon Hedlund | 1-4 Flavio Paixao / Jesper Lindstrom (2), Paulus Arajuuri, Kamil Wilczek |
| Domžale | 4-5 | Malmö FF | 2-2 Shamar Nicholson, Adam Gnezda / Rasmus Bengtsson, Marcus Antonsson | 2-3 Shamar Nicholson, Sven Karic / Oscar Lewicki, Markus Rosenberg, Rasmus Bengtsson |
| CSKA Sofia | 1-1 (3-2 pen.) | NK Osijek | 1-0 Evandro | 0-1 Ante Majstorovic |
| Hapoel Be'er Sheva | 3-1 | Kairat | 2-0 Safuri Ramzi, Eden Shamir | 1-1 Rade Dugalic (og) / Rade Dugalic |
| AEK Larnaca | 7-0 | Levski Sofia | 3-0 Apostolos Giannou, Raul Ruiz, Hector Hevel | 4-0 Ivan Trickovski (4) |
| Fehérvár | 1-2 | Vaduz | 1-0 Stopira | 0-2 Milan Gajic, Mohamed Coulibaly |
| Molde | 3-1 | Čukarički | 0-0 | 3-1 Asmir Kajevic / Ohi Omoijuanfo, Magnus Eikrem, Erling Knudtzon |
| Torino | 7-1 | Debrecen | 3-0 Andrea Belotti, Cristian Ansaldi, Simone Zaza | 4-1 Simone Zaza, Armando Izzo, Andrea Belotti, Vincenzo Millico / Haruna Garba |
| Arsenal Tula | 0-4 | Neftçi Baku | 0-1 Junior Dario | 0-3 Rauf Aliyev, Junior Dario, Mamadou Pape Mbodj |
| Legia Warsaw | 1-0 | KuPS | 1-0 Mateusz Wieteska | 0-0 |
| Gabala | 0-5 | Dinamo Tbilisi | 0-2 Levan Kutalia, Arfang Daffe | 0-3 Levan Shengelia (2), Kwame Karikari |
| Chikhura Sachkhere | 1-6 | Aberdeen | 1-1 Giorgi Koripadze / Sam Cosgrove | 0-5 Greg Leigh, Scott Wright, Sam Cosgrove (3) |
| Luzern | 2-0 | KÍ Klaksvík | 1-0 Christian Schneuwly | 1-0 Idriz Voca |
| Espanyol | 7-1 | Stjarnan | 4-0 Facundo Ferreyra (2), Borja Iglesias (2) | 3-1 Giner Adria, Borja Iglesias, Facundo Ferreyra / Baldur Sigurdsson |
| FC Utrecht | 2-3 | Zrinjski Mostar | 1-1 Gyrano Kerk / Miljan Govedarica | 1-2 Simon Gustafson / Irfan Hadzic, Ivan Lendric |
| Yeni Malatyaspor | 3-2 | Olimpija Ljubljana | 2-2 Arturo Mina, Adis Jahovic / Stefan Savic, Ante Vukusic | 1-0 Adis Jahovic |
| KAA Gent | 7-5 | Viitorul Constanța | 6-3 Nana Asare, Brecht Dejaegere, Yuya Kubo (2), Roman Yaremchuk (2) / Sebastian Mladen, Bogdan Tiru (2) | 1-2 Roman Yaremchuk / Gabriel Iancu (2) |
| Rangers | 2-0 | Progrès Niederkorn | 2-0 Joe Aribo, Sheyi Ojo | 0-0 |
| DAC Dunajská Streda | 3-5 | Atromitos | 1-2 Kristopher Vida / Georgios Manousos, Javier Umbides | 2-3 Eric Ramirez, Zsolt Kalmar / Spyros Risvanis, Alexandros Katranis, Georgios Manousos |
| Pyunik | 2-1 | Jablonec | 2-1 Artur Miranyan (2) / Martin Dolezal | 0-0 |
| Flora | 2-4 | Eintracht Frankfurt | 1-2 Mihkel Ainsalu / Dejan Joveljic, Lucas Torro | 1-2 Vlasiy Sinyavskiy / Goncalo Paciencia (2) |
| Budućnost Podgorica | 1-4 | Zorya Luhansk | 1-3 Mihailo Perovic / Artem Gromov (2), Levan Arveladze | 0-1 Artem Gromov |
| Ventspils | 6-2 | Gżira United | 4-0 Kaspars Svarups, Helio, Ingars Stuglis, Tosin Aiyegun | 2-2 Jevgenijs Kazacoks, Mykhailo Serhiichuk / Mateus De Assis, Jefferson |
| Strasbourg | 4-3 | Maccabi Haifa | 3-1 Ludovic Ajorque, Adrien Thomasson, Jonas Martin / Maxim Plakushchenko | 1-2 Ludovic Ajorque / Yarden Shua, Nikita Rukavytsya |
| Wolverhampton Wanderers | 6-1 | Crusaders | 2-0 Diogo Jota, Ruben Vinagre | 4-1 Ryan Bennett, Raul Jimenez (2), Jordan Forsythe (og) / Ryan Bennett (og) |
| Mladá Boleslav | 4-3 | Ordabasy | 1-1 Nikolay Komlichenko / Mirzad Mehanovi | 3-2 Marek Matejovsky, Nikolay Komlichenko, Pavel Bucha / Aleksey Shchetkin, Abdoulaye Diakhate |
| Aris | 1-0 | AEL Limassol | 0-0 | 1-0 Nicolas Diguiny |
| Shamrock Rovers | 3-4 | Apollon Limassol | 2-1 Lee Grace, Roberto Lopes / Fotis Papoulis | 1-3 Aaron Greene / Emilio Zelaya, Attila Szalai, Aaron Greene, Adrian Sardinero |
| Jeunesse Esch | 0-5 | Vitória de Guimarães | 0-1 Joseph Amoah | 0-4 Edmond Tapsoba (2), Alexandre Guedes, Joao Carlos Teixeira |
| AZ | 3-0 | BK Häcken | 0-0 | 3-0 Myron Boadu, Calvin Stengs, Guus Til |
| Honvéd | 0-0 (3-1 pen.) | Universitatea Craiova | 0-0 | 0-0 (3-1 pen.) |
| Alashkert | 3-5 | FCSB | 0-3 Florin Tanase, Lucian Cristea, Florinel Coman | 3-2 Gustavo Marmentini (2), Thiago Galvao / Florinel Coman, Florin Tanase |
| Shakhtyor Soligorsk | 2-0 | Esbjerg | 2-0 Elis Bakaj, Pavel Rybak | 0-0 |
| Lokomotiv Plovdiv | 3-3 | Spartak Trnava | 2-0 Dimitar Iliev (2) | 1-3 Alen Ozbolt / Filip Dangubic, Bogdan Mitrea, Rafael Tavares |
| Connah's Quay Nomads | 0-4 | Partizan | 0-1 Aleksandar Scekic | 0-3 Zoran Tosic, Ognjen Ozegovic, Filip Stevanovic |
