| ROUND 1 | |||
|---|---|---|---|
| 09.01.21 03:30 | Puebla | 1-1 Santiago Ormeno / Miguel Ponce | Guadalajara Chivas |
| 09.01.21 05:06 | Club Tijuana | 0-0 | U.N.A.M. - Pumas |
| 09.01.21 05:30 | Mazatlan FC | 3-2 Fernando Aristeguieta, Carlos Vargas, Camilo Sanvezzo / Juan Delgado, Alex Zendejas | Necaxa |
| 10.01.21 01:00 | Atlas | 0-2 Ramiro Funes Mori (2) | Monterrey |
| 10.01.21 03:00 | Tigres UANL | 2-0 Andre-Pierre Gignac, Carlos Gonzalez Espinola | Leon |
| 10.01.21 05:00 | Club America | 2-1 Mauro Alberto Lainez Leyva, Sebastian Cordova / Nicolas Ibanez | Atletico San Luis |
| 10.01.21 20:00 | Toluca | 3-1 Kevin Castaneda, Alexis Canelo, Michael Steveen Estrada / Angel Baltazar Sepulveda | Club Queretaro |
| 11.01.21 03:06 | Santos Laguna | 1-0 Diego Alfonso Valdes | Cruz Azul |
| 12.01.21 05:00 | Pachuca | 1-1 Mauro Quiroga / Victor Gustavo Velazquez | FC Juarez |
| ROUND 2 | |||
| 16.01.21 03:30 | Necaxa | 1-0 Ian Gonzalez | Atletico San Luis |
| 16.01.21 05:30 | FC Juarez | 0-0 | Club Tijuana |
| 17.01.21 01:00 | Guadalajara Chivas | 1-1 Jesus Molina / Kevin Castaneda | Toluca |
| 17.01.21 03:00 | Cruz Azul | 0-1 Christian Tabo | Puebla |
| 17.01.21 05:06 | Monterrey | 1-0 Ramiro Funes Mori | Club America |
| 17.01.21 20:00 | U.N.A.M. - Pumas | 3-0 Facundo Waller , Carlos Gutierrez, Emanuel Montejano | Mazatlan FC |
| 18.01.21 03:00 | Santos Laguna | 2-0 Juan Otero, Eduardo Aguirre | Tigres UANL |
| 18.01.21 05:00 | Club Queretaro | 1-0 Francisco Da Costa | Atlas |
| 19.01.21 05:00 | Leon | 0-0 | Pachuca |
| ROUND 3 | |||
| 22.01.21 05:00 | Atletico San Luis | 3-1 Ramiro Gonzalez, Nicolas Ibanez (2) / Jose Macias | Guadalajara Chivas |
| 23.01.21 03:30 | Puebla | 0-1 Fidel Martinez | Club Tijuana |
| 23.01.21 05:30 | Mazatlan FC | 0-0 | Santos Laguna |
| 24.01.21 03:00 | Atlas | 0-2 Julian Quinones, Carlos Gonzalez Espinola | Tigres UANL |
| 24.01.21 20:00 | Toluca | 2-0 Michael Estrada, Joao Plata | Necaxa |
| 25.01.21 03:00 | Club Queretaro | 2-0 Jose Gurrola, Angel Sepulveda | U.N.A.M. - Pumas |
| 26.01.21 05:00 | Pachuca | 0-1 Juan Escobar | Cruz Azul |
| 27-01-2021 | Club America | 2-0 Emanuel Aguilera, Roger Martinez | FC Juarez |
| 11-03-221 | Monterrey | 1-1 Ramiro Funes Mori / Victor Davila | Leon |
| ROUND 4 | |||
| 29.01.21 05:00 | Tigres UANL | 1-1 Carlos Salcedo / Martin Barragan | Necaxa |
| 30.01.21 05:30 | Mazatlan FC | 1-0 Fernando Aristeguieta | Pachuca |
| 31.01.21 03:00 | Guadalajara Chivas | 1-2 Jose Macias / Dario Lezcano, Matias Garcia | FC Juarez |
| 31.01.21 05:00 | Cruz Azul | 4-1 Adrian Aldrete, Orbelin Pineda, Jonathan Rodriguez, Elias Hernandez / Angel Sepulveda | Club Queretaro |
| 31.01.21 05:06 | Club Tijuana | 3-2 Mauro Manotas, Fidel Martinez, Miguel Sansores / Pedro Canelo, Miguel Barbieri | Toluca |
| 31.01.21 20:00 | U.N.A.M. - Pumas | 0-0 | Atlas |
| 01.02.21 03:06 | Santos Laguna | 1-1 Santiago Munoz / Henry Martin | Club America |
| 02.02.21 05:00 | Leon | 3-1 Victor Davila (2), Jean Meneses / German Berterame | Atletico San Luis |
| 03-02-21 05:00 | Puebla | 0-0 | Monterrey |
| ROUND 5 | |||
| 05.02.21 03:00 | Atletico San Luis | 2-2 Juan Castro, Luis Gallegos / Fidel Martinez (2) | Club Tijuana |
| 05.02.21 05:00 | Club Queretaro | 3-1 Fernando Madrigal, Antonio Valencia, Ramirez Kevin / Hugo Magallanes (k.k.) | Pachuca |
| 06.02.21 05:30 | Necaxa | 0-2 Juan Escobar, Luis Francisco Romo | Cruz Azul |
| 07.02.21 01:00 | Atlas | 1-1 Jonathan Herrera / Omar Chagoya | Santos Laguna |
| 07.02.21 03:00 | Club America | 1-0 Roger Martinez | Puebla |
| 07.02.21 05:06 | Monterrey | 1-0 Ake Arnaud Loba | U.N.A.M. - Pumas |
| 07.02.21 20:00 | Toluca | 4-1 Alexis Canelo (3), Rubens Sambueza / Camilo Da Silva | Mazatlan FC |
| 09.02.21 05:00 | Leon | 1-3 Antonio Briseno (og) / Jesus Sanchez, Jose Macias, Alejandro Mayorga | Guadalajara Chivas |
| 14.04.21 04:00 | FC Juarez | 2-3 William Mendieta, Gustavo Velazquez / Diego Reyes, Nicolas Lopez (2) | Tigres UANL |
| ROUND 6 | |||
| 13.02.21 03:30 | Puebla | 4-0 Santiago Ormeno (3), Christian Tabo | FC Juarez |
| 13.02.21 05:06 | Club Tijuana | 2-0 Mauro Manotas, Fabian Castillo | Leon |
| 13.02.21 05:30 | Mazatlan FC | 0-3 Nicolas Ibanez (2), German Berterame | Atletico San Luis |
| 14.02.21 03:00 | Guadalajara Chivas | 0-0 | Necaxa |
| 14.02.21 05:00 | Club America | 2-1 Santiago Naveda, Henry Josue Martin / Angel Baltazar Sepulveda | Club Queretaro |
| 14.02.21 20:00 | Toluca | 1-0 Alexis Canelo | U.N.A.M. - Pumas |
| 15.02.21 03:06 | Santos Laguna | 1-0 Doria | Monterrey |
| 16.02.21 05:00 | Pachuca | 0-1 Victor Malcorra | Atlas |
| 18.02.21 05:00 | Tigres UANL | 0-2 Luis Romo, Guillermo Fernandez | Cruz Azul |
| ROUND 7 | |||
| 19.02.21 05:00 | Atletico San Luis | 1-0 Nicolas Ibanez | Santos Laguna |
| 20.02.21 03:30 | Necaxa | 1-1 Martin Barragan / Maximiliano Meza | Monterrey |
| 20.02.21 05:30 | FC Juarez | 1-0 Dario Lezcano | Mazatlan FC |
| 21.02.21 03:00 | Cruz Azul | 3-2 Jonathan Rodriguez, Roberto Alvarado, Guillermo Fernandez / Miguel Barbieri, Alexis Canelo | Toluca |
| 21.02.21 05:00 | Atlas | 0-2 Henry Martin, Richard Sanchez | Club America |
| 21.02.21 20:00 | U.N.A.M. - Pumas | 0-1 Angel Mena | Leon |
| 22.02.21 01:00 | Club Queretaro | 1-1 Joe Gallardo / Daniel Alvarez | Puebla |
| 22.02.21 03:00 | Tigres UANL | 3-2 Luis Quinones, Nicolas Lopez (2) / David Barbona, Edgar Lopez | Club Tijuana |
| 23.02.21 05:00 | Pachuca | 1-1 Gustavo Cabral / Jesus Molina | Guadalajara Chivas |
| ROUND 8 | |||
| 26.02.21 05:00 | Atletico San Luis | 2-2 Juan Castro, Nicolas Ibanez / Nicolas Lopez (2) | Tigres UANL |
| 27.02.21 03:30 | Puebla | 1-0 Emanuel Gularte | Necaxa |
| 27.02.21 05:30 | Mazatlan FC | 3-0 Fernando Aristeguieta, Camilo Da Silva, Nicolas Diaz | Club Queretaro |
| 28.02.21 01:00 | Toluca | 0-0 | Atlas |
| 28.02.21 03:00 | Club America | 2-0 Richard Sanchez, Pedro Aquino | Pachuca |
| 28.02.21 05:00 | Leon | 0-1 Bryan Angulo | Cruz Azul |
| 01.03.21 01:00 | Monterrey | 1-1 Maximiliano Meza / Mauro Manotas | Club Tijuana |
| 01.03.21 03:00 | Santos Laguna | 3-2 Pol Garcia (og), Santiago Munoz, Doria / Luis Alberto Pavez, Dario Lezcano | FC Juarez |
| 01.03.21 05:00 | Guadalajara Chivas | 2-1 Jose Macias, Alejandro Mayorga / Gabriel Torres | U.N.A.M. - Pumas |
| ROUND 9 | |||
| 03.03.21 01:00 | Atlas | 3-1 Aldo Rocha, Jairo Torres, Angel Marquez / German Berterame | Atletico San Luis |
| 03.03.21 03:00 | Tigres UANL | 0-1 Alexis Canelo | Toluca |
| 03.03.21 05:00 | Leon | 1-2 Angel Mena / Santiago Ormeno, Daniel Alvarez | Puebla |
| 04.03.21 03:00 | Club Queretaro | 2-2 Hugo Silveira, Kevin Ramirez / Jose Macias, Miguel Ponce | Guadalajara Chivas |
| 04.03.21 03:00 | FC Juarez | 1-6 Dario Lezcano / Vincent Janssen (2), Arturo Gonzalez, Ramiro Funes Mori (2), Jose Alvarado | Monterrey |
| 04.03.21 05:00 | Cruz Azul | 1-0 Roberto Alvarado | Mazatlan FC |
| 04.03.21 05:06 | Club Tijuana | 0-2 Pedro Aquino, Henry Martin | Club America |
| 05.03.21 03:00 | Necaxa | 2-2 Alex Zendejas, Maximiliano Salas / Roberto Nurse, Mauro Quiroga | Pachuca |
| 05.03.21 05:00 | U.N.A.M. - Pumas | 1-0 Juan Dinenno | Santos Laguna |
| ROUND 10 | |||
| 06.03.21 03:30 | Atletico San Luis | 0-0 | Toluca |
| 06.03.21 05:30 | Puebla | 1-1 Santiago Ormeno / Andre-Pierre Gignac | Tigres UANL |
| 07.03.21 01:00 | Atlas | 2-0 Jairo Torres, Renato Ibarra | FC Juarez |
| 07.03.21 03:00 | Club America | 2-1 Henry Martin, Emanuel Aguilera / Victor Davila | Leon |
| 07.03.21 03:00 | Monterrey | 2-1 Ramiro Funes Mori (2) / Angel Sepulveda | Club Queretaro |
| 07.03.21 05:00 | Mazatlan FC | 1-1 Nicolas Diaz / Jesus Molina | Guadalajara Chivas |
| 08.03.21 03:00 | Santos Laguna | 3-1 Santiago Munoz, Juan Otero, Fernando Gorriaran / Daniel Lopez | Necaxa |
| 08.03.21 05:00 | U.N.A.M. - Pumas | 0-1 Jonathan Rodriguez | Cruz Azul |
| 09.03.21 05:00 | Pachuca | 2-1 Victor Sosa, Kevin Alvarez / Fabian Castillo | Club Tijuana |
| ROUND 11 | |||
| 13.03.21 03:30 | Puebla | 0-1 Aldo Rocha | Atlas |
| 13.03.21 05:30 | FC Juarez | 1-1 Matias Garcia / Juan Dinenno | U.N.A.M. - Pumas |
| 14.03.21 03:00 | Tigres UANL | 1-2 Carlos Gonzalez / Michael Rangel, Giovanni Augusto | Mazatlan FC |
| 14.03.21 05:00 | Club Tijuana | 0-1 Felix Torres | Santos Laguna |
| 14.03.21 05:00 | Cruz Azul | 1-0 Roberto Alvarado | Monterrey |
| 14.03.21 20:00 | Toluca | 0-2 Roberto De La Rosa, Luis Chavez | Pachuca |
| 15.03.21 03:00 | Club Queretaro | 2-1 Angel Baltazar Sepulveda, Hugo Silveira / Nicolas Ibanez | Atletico San Luis |
| 15.03.21 05:00 | Guadalajara Chivas | 0-3 Henry Josue Martin (2), Sebastian Cordova | Club America |
| 16.03.21 05:00 | Leon | 3-1 Joel Campbell, Santiago Colombatto, Angel Mena / Maximiliano Salas | Necaxa |
| ROUND 12 | |||
| 19.03.21 04:00 | Pachuca | 1-0 Roberto De La Rosa | Tigres UANL |
| 20-03-2021 | Necaxa | 1-0 Ian Gonzalez | FC Juarez |
| 20-03-2021 | Mazatlan FC | 0-1 Jose Ortiz (og) | Club America |
| 21-03-2021 | Atletico San Luis | 0-1 Juan Dinenno | U.N.A.M. - Pumas |
| 21-03-2021 | Cruz Azul | 3-2 Bryan Angulo, Jonathan Rodriguez (2) / Anderson Santamaria, Milton Caraglio | Atlas |
| 21-03-2021 | Club Tijuana | 3-1 Fidel Martinez (2), Mauro Manotas / Victor Guzman (og) | Club Queretaro |
| 21-03-2021 | Toluca | 4-4 Michael Estrada (2), Alexis Canelo, Diego Rigonato / Santiago Ormeno, Juan Segovia, Daniel Aguilar, Daniel Alvarez | Puebla |
| 22-03-2021 | Santos Laguna | 1-2 Fernando Gorriaran / Angel Mena, Fernando Navarro | Leon |
| 22-04-2021 | Monterrey | 1-2 Vincent Janssen / Isaac Brizuela, Alexis Vega | Guadalajara Chivas |
| ROUND 13 | |||
| 03-04-2021 | Puebla | 3-1 Santiago Ormeno, Salvador Reyes, Maximiliano Araujo / Giovanni Augusto | Mazatlan FC |
| 03-04-2021 | FC Juarez | 0-1 Jonathan Rodriguez | Cruz Azul |
| 04-04-2021 | Atlas | 1-0 Renato Ibarra | Club Tijuana |
| 04-04-2021 | Club America | 2-1 Richard Sanchez, Giovani dos Santos / Martin Barragan | Necaxa |
| 04-04-2021 | Monterrey | 2-0 Maximiliano Meza, Ramiro Funes Mori | Atletico San Luis |
| 04-04-2021 | U.N.A.M. - Pumas | 2-2 Sebastian Saucedo, Juan Dinenno / Victor Sosa, Erick Aguirre | Pachuca |
| 05-04-2021 | Guadalajara Chivas | 1-1 Jesus Angulo / Jesus Ocejo | Santos Laguna |
| 05-04-2021 | Club Queretaro | 0-1 Diego Reyes | Tigres UANL |
| 05-04-2021 | Leon | 2-1 Stiven Barreiro, Angel Mena / Michael Estrada | Toluca |
| ROUND 14 | |||
| 10-04-2021 | Necaxa | 0-1 Juan Pablo Vigon Cham | U.N.A.M. - Pumas |
| 10-04-2021 | FC Juarez | 2-1 Dario Lezcano, Francisco Contreras / Nicolas Ibanez | Atletico San Luis |
| 11-04-2021 | Atlas | 1-3 Edgar Zaldivar / Emanuel Gigliotti (2), Osvaldo Rodriguez | Leon |
| 11-04-2021 | Cruz Azul | 1-0 Jonathan Rodriguez | Guadalajara Chivas |
| 11-04-2021 | Tigres UANL | 1-3 Diego Reyes / Roger Martinez (2), Pedro Aquino | Club America |
| 11-04-2021 | Toluca | 1-2 Jorge Torres / Sebastian Vegas, Maximiliano Meza | Monterrey |
| 12-04-2021 | Club Queretaro | 1-0 Gonzalo Montes | Santos Laguna |
| 12-04-2021 | Club Tijuana | 2-3 Mauro Manotas, Fidel Martinez / Camilo Da Silva (2), Michael Rangel | Mazatlan FC |
| 12-04-2021 | Pachuca | 1-3 Erick Sanchez / Maximiliano Araujo, Maximiliano Perg, Salvador Reyes | Puebla |
| ROUND 15 | |||
| 17-04-2021 | Necaxa | 0-0 | Club Queretaro |
| 17-04-2021 | Mazatlan FC | 0-0 | Atlas |
| 18-04-2021 | Atletico San Luis | 1-4 Felipe Gallegos / Santiago Ormeno, Christian Tabo, Daniel Alvarez, Guillermo Martinez | Puebla |
| 18-04-2021 | Guadalajara Chivas | 2-0 Alexis Vega, Jesus Angulo | Club Tijuana |
| 18-04-2021 | Club America | 1-1 Emanuel Aguilera / Jonathan Rodriguez | Cruz Azul |
| 18-04-2021 | U.N.A.M. - Pumas | 0-0 | Tigres UANL |
| 19-04-2021 | Santos Laguna | 3-1 Eduardo Aguirre (2), Juan Otero / Alexis Canelo | Toluca |
| 19-04-2021 | Monterrey | 0-1 Erick Aguirre | Pachuca |
| 19-04-2021 | Leon | 2-0 Jean Meneses, Victor Davila | FC Juarez |
| ROUND 16 | |||
| 24-04-2021 | Puebla | 0-0 | U.N.A.M. - Pumas |
| 24-04-2021 | Club Tijuana | 1-0 Fidel Martinez | Necaxa |
| 24-04-2021 | Mazatlan FC | 4-3 Michael Rangel (2), Giovanni Augusto (2) / Luis Montes, Victor Davila, Angel Israel Mena Delgado | Leon |
| 25-04-2021 | Cruz Azul | 3-2 Elias Hernandez, Jonathan Rodriguez, Pablo Aguilar / Nicolas Ibanez, Julio Dominguez (k.k.) | Atletico San Luis |
| 25-04-2021 | Atlas | 0-1 Angel Zaldivar Caviedes | Guadalajara Chivas |
| 25-04-2021 | Tigres UANL | 2-1 Carlos Gonzalez Espinola, Andre-Pierre Gignac / Arturo Gonzalez | Monterrey |
| 26-04-2021 | Toluca | 3-1 Michael Estrada, Raul Lopez, Alexis Canelo / Emanuel Aguilera | Club America |
| 26-04-2021 | Club Queretaro | 1-0 Hugo Silveira | FC Juarez |
| 27-04-2021 | Pachuca | 1-0 Victor Sosa | Santos Laguna |
| ROUND 17 | |||
| 30-04-2021 | Atletico San Luis | 1-5 Ramiro Gonzalez / Roberto De La Rosa (2), Erick Sanchez (2), Romario Ibarra | Pachuca |
| 01-05-2021 | Necaxa | 1-5 Juan Delgado / Jonathan Herrera (2), Jairo Torres, Aldo Rocha, Julio Furch | Atlas |
| 01-05-2021 | FC Juarez | 1-0 Martin Galvan | Toluca |
| 02-05-2021 | Guadalajara Chivas | 0-0 | Tigres UANL |
| 02-05-2021 | Cruz Azul | 1-1 Orbelin Pineda / Edgar Ivan Lopez Rodriguez | Club Tijuana |
| 02-05-2021 | Monterrey | 1-0 Vincent Janssen | Mazatlan FC |
| 02-05-2021 | Leon | 2-1 Angel Israel Mena Delgado (2) / Jose Doldan | Club Queretaro |
| 03-05-2021 | Santos Laguna | 0-0 | Puebla |
| 03-05-2021 | U.N.A.M. - Pumas | 0-1 Henry Martin | Club America |
