| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Malmö FF | 11-0 | Ballymena United | 7-0 Markus Rosenberg (3), Erdal Rakip (2), Franz Brorsson, Guillermo Molins | 4-0 Behrang Safari, Guillermo Molins, Erdal Rakip, Romain Gall |
| Connah's Quay Nomads | 3-2 | Kilmarnock | 1-2 Greg Taylor (og) / Eamonn Brophy, Stuart Findlay | 2-0 Callum Morris (2) |
| KuPS | 3-1 | Vitebsk | 2-0 Luis Carlos Murillo, Lucas Rangel | 1-1 Babacar Diallo / Artem Starhorodskyi |
| Breiðablik | 1-2 | Vaduz | 0-0 | 1-2 Hoskuldur Gunnlaugsson / Mohamed Coulibaly, Dominik Schwizer |
| Brann | 3-4 | Shamrock Rovers | 2-2 Taijo Teniste, Veton Berisha / Amer Ordagiç (og), Lopes | 1-2 Daouda Karamoko Bamba / Jack Byrne, Gary O'Neill |
| Ordabasy | 3-0 | Torpedo Kutaisi | 1-0 Temirlan Erlanov | 2-0 Mirzad Mehanovic, Ziguy Badibanga |
| Europa F.C. | 0-3 | Legia Warsaw | 0-0 | 0-3 Carlos Lopez (2), Sandro Kulenovic |
| CSKA Sofia | 4-0 | Titograd | 4-0 Evandro Da Silva, Tiago Rodrigues, Geferson, Kristiyan Malinov | 0-0 |
| Gżira United | 3-3 | Hajduk Split | 0-2 Adam Gyurcso, Ivan Dolcek | 3-1 Mateus De Assis, Hamed Kone (2) / Bassel Jradi |
| Flora | 4-2 | Radnički Niš | 2-0 Lepik, Konstantin Vassiljev | 2-2 Henrik Purg, Mark Lepig / Stefan Mihajlovic, Nikola Cumic |
| Maccabi Haifa | 4-3 | Mura | 2-0 Yuval Ashkenazi, Mohammed Awaed | 2-3 Luka Bobicanec, Jon Sporn / Muhamad Awad, Yuval Ashkenazi (2) |
| Debrecen | 4-1 | Kukësi | 3-0 Haruna Garba, Kevin Varga (2) | 1-1 Csaba Szatmari / Valon Ethemi |
| Čukarički | 8-0 | Banants | 3-0 Slobodan Tediç (2), Kovac | 5-0 Luka Stojanoviç (2), Slobodan Tediç, Luka Lukoviç, Veljko Birmancevic |
| Jeunesse Esch | 1-1 | Tobol | 0-0 | 1-1 Halim Meddour (og) / Mehmet Arslan |
| FCSB | 4-1 | Milsami Orhei | 2-0 Florin Tanase (2) | 2-1 Cristian Dumitru, Razvan Oaida / Vadim Bolohan |
| Crusaders | 5-2 | B36 Tórshavn | 2-0 Hegarty, Philip Lowry | 3-2 Jordan Forsythe, Paul Heatley (2) / Hugin Samuelsen, Lukasz Cieslewicz |
| Brøndby | 4-3 | Inter Turku | 4-1 Kamil Wilczek (2), Simon Tibbling, Kasper Fisker / Timo Furuholm | 0-2 Niko Markkula, Filip Valencic |
| Molde | 7-1 | KR | 7-1 Leke James (3), Fredrik Aursnes, Vegard Forren, Etzaz Hussain, Ohi Omoijuanfo / Tobias Thomsen | 0-0 |
| St Joseph's | 0-10 | Rangers | 0-4 Ryan Jack, Sheyi Ojo, Connor Goldson, Alfredo Morelos | 0-6 Joe Aribo, Alfredo Morelos (3), Jermain Defoe (2) |
| Cork City | 2-3 | Progrès Niederkorn | 0-2 Muratoviç, Mayron De Almeida | 2-1 Garry Buckley, Conor McCarthy / Issa Bah |
| Ružomberok | 0-4 | Levski Sofia | 0-2 Davide Mariani, Paulo Victor De Menezes | 0-2 Davide Mariani, Deni Alar |
| Akademija Pandev | 0-6 | Zrinjski Mostar | 0-3 İrfan Hadzic, Stanisa Mandic, Miljan Govedarica | 0-6 Stanisa Mandic, Miljan Govedarica, Renato Gojkovic |
| Speranța Nisporeni | 0-9 | Neftçi Baku | 0-3 Emin Mahmudov, Steeven Joseph-Monrose, Rahman Hajiyev | 0-6 Vangelis Platellas (2), Emin Makhmudov, Junior Dari, Joseph-Monrose Steven, Ismayil Zulfugarli |
| Zeta | 1-5 | Fehérvár | 1-5 Goranoviç / Loic Nego (3), Rolanf Juhasz, Szabolcs Huszti | 0-0 |
| Shakhtyor Soligorsk | 2-0 | Hibernians | 1-0 Valeriy Gromyko | 1-0 Mykyta Tatarkov |
| Olimpija Ljubljana | 4-3 | RFS | 2-3 Boakye, Luka Menalo / Darko Lemajiç, Glebs Kluskins, Vukmaniç | 2-0 Endri Cekici, Luka Menalo |
| Honvéd | 4-2 | Žalgiris | 3-1 Bence Bano-Szabo, David N'Gog, Daniel Gazdag / Uzela | 1-1 Djordje Kamber / Liviu Antal |
| Alashkert | 6-1 | Makedonija GP | 3-1 Nikkita Tankov, Danilo Sekuliç, Bianor (og) / Jasharoski | 3-0 Uros Nenadovic, Thiago Galvao, Taron Voskanyan |
| Radnik Bijeljina | 2-2 (2-3 pen.) | Spartak Trnava | 2-0 Mekiç, Velibor Duriç | 0-2 Alex Sobczyk, Kristian Mihalek (2-3 pen.) |
| Fola Esch | 2-4 | Chikhura Sachkhere | 1-2 Sinani / Sardalishvili, Koripadze, | 1-2 Sinani / Ardazishvili, Sardalishvili |
| Dinamo Tbilisi | 7-0 | Engordany | 6-0 Ninua, Kukhinaidze (2), Nodar Kavtaradze, Kutalia, Zaria | 1-0 Abdel Jalil |
| Široki Brijeg | 2-4 | Kairat | 1-2 Ivan Yenini / Aderinsola Habib Eseola (2) | 1-2 Drazen Bagaric / Islambek Kuat, Ramazan Orazov |
| DAC Dunajská Streda | 3-3 | Cracovia | 1-1 Marko Divkoviç / Dominik Kruzliak | 2-2 Ronan Connor, Eric Ramirez / Rafael Lopes, Filip Piszczek |
| Kauno Žalgiris | 0-6 | Apollon Limassol | 0-2 Ioannis Pittas, Emilio Zelaya | 0-4 Emilio Zelaya (3), Attila Szalai |
| Ventspils | 3-1 | Teuta | 3-0 Mykhaylo Serhiychuk, Daniils Ulimbasevs, Aiyegun | 0-1 Sherif Kallaku |
| Stjarnan | 3-4 | FCI Levadia | 1-1 Ragnarsson / Nikita Andreyev | 2-3 Brynjar Gudjonsson, Thorsteinn Ragnarsson / Evgeni Osipov (2), Dmitri Kruglov |
| Cliftonville | 1-6 | Haugesund | 0-1 Christian Grindheim | 1-5 Conor McMenamin / Kristoffer Velde (2), Martin Samuelsen, Ibrahima Kone, Bruno Leite |
| Riteriai | 1-1 | KÍ Klaksvík | 1-1 Valdemar Borovskji / Andreasen | 0-0 |
| Liepāja | 3-2 | Dinamo Minsk | 1-1 Janis Ikaunieks / Nikita Kaplenko | 2-1 Danu Spataru, Dodo / Valentins Ralkevics (og) |
| St Patrick's Athletic | 1-4 | IFK Norrköping | 0-2 Simon Thern, Lee Desmond | 1-2 Conor Clifford / Karl Holmberg, Jordan Larsson |
| Aberdeen | 4-2 | RoPS | 2-1 Niall McGinn, Sam Cosgrove / Jantti | 2-1 Sam Cosgrove, Lewis Ferguson / Tarik Kada |
| Balzan | 3-5 | Domžale | 3-4 Correa, Ljubomirac, Alfred Effiong / Senijad Ibricic, Slobodan Vuk, Gregor Sikosek, Matej Podlogar | 0-1 Slobodan Vuk |
| Laçi | 1-2 | Hapoel Be'er Sheva | 1-1 Kyrian Nwabueze / Gal Levi | 0-1 Naor Sabag |
| Narva Trans | 1-6 | Budućnost Podgorica | 0-2 Igor Ivanoviç, Miloş Mijic | 1-4 Eduard Golovljov / Milos Vucic, Dusan Bakic, Mihailo Perovic, Dejan Zarubica |
| Sabail | 4-6 | Universitatea Craiova | 2-3 Aghabala Ramazanov (2) / Alexandru Mateiu, Nicoşur Bancu, Mihai Roman | 2-3 Agabala Ramazanov, Dylan Duventru / Alexandru Cicaldau, Bogdan Vatajelu, Carlos Fortes |
| Pyunik | 5-4 | Shkupi | 3-3 Erik Vardanyan, Maksim Zhestokov, Edgar Manucharyan / Muharem Bajrami (2), Ilieski | 2-1 Artak Yedigaryan, Artur Miranyan / Marin Jurina |
| AEK Larnaca | 2-0 | Petrocub Hîncești | 1-0 Hector Hevel | 1-0 Jean Luc Assoubre |
