| Champions Path | ||||
|---|---|---|---|---|
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
| Sūduva | 2-4 | Ferencváros | 0-0 | 2-4 Ovidijus Verbickas, Mihret Topcagic / Roland Varga, Franck Boli, Tokmac Nguen, Nikolai Signevich |
| Copenhagen | 3-2 | Riga | 3-1 Viktor Fischer, Pieros Sotiriou, Mohammed Daramy / Vladimir Kamess | 0-1 Felipe Brisola |
| Celtic | 6-1 | AIK | 2-0 James Forrest, Odsonne Edouard | 4-1 James Forrest, Michael Johnston, Christopher Jullien, Lewis Morgan / Sebastian Larsson |
| Ararat-Armenia | 3-3 (4-5 pen.) | F91 Dudelange | 2-1 Mailson Lima, Ilja Antonov / Danel Sinani | 1-2 Mailson Lima / Danel Sinani (2) (4-5 pen.) |
| Ludogorets Razgrad | 2-2 | Maribor | 0-0 | 2-2 Marcos Tavares, Rudi Pozeg Vancas / Marcelinho, Claudiu Keseru |
| Linfield | 4-4 | Qarabağ | 3-2 Mark Stafford, Shayne Lavery (2) / Faycal Rherras, Magaye Gueye | 1-2 Shayne Lavery / Jaime Romero, Abdellah Zoubir |
| Slovan Bratislava | 3-3 | PAOK | 1-0 Myenty Abena | 2-3 Jurij Medvedev, Vernon / Dimitris Limnios, Karol Swiderski, Dimitris Giannoulis |
| Astana | 3-2 | BATE Borisov | 3-0 Marin Tomasov, Yuri Logvinenko, Runar Mar Sigurjonsson | 0-2 Maksim Skavysh, Evgeni Yablonski |
| Main Path | ||||
| Torino | 3-5 | Wolverhampton Wanderers | 2-3 Lorenzo De Silvestri, Andrea Belotti / Kasper Bremer (og), Diogo Jota, Raul Jimenez | 1-2 Andrea Belotti / Raul Jimenez, Leander Dendoncke |
| Legia Warsaw | 0-1 | Rangers | 0-0 | 0-1 Alfredo Morelos |
| FCSB | 0-1 | Vitória de Guimarães | 0-0 | 0-1 Edmond Tapsoba |
| PSV Eindhoven | 7-0 | Apollon Limassol | 3-0 Mohammed Ihattaren, Cody Gakpo, Denzel Dumfries | 4-0 Mohammed Ihattaren, Konstantinos Mitroglou, Donyell Malen (2) |
| AEK Athens | 3-3 | Trabzonspor | 1-3 Marko Livaja / Caleb Ekuban (3) | 2-0 Marko Livaja, Petros Mantalos |
| Feyenoord | 6-0 | Hapoel Be'er Sheva | 6-0 Sam Larsson, Leroy Fer (2) | 6-0 Orkun Kocku, Steven Berghuis, Wouter Burger |
| KAA Gent | 3-2 | Rijeka | 2-1 Laurent Depoitre (2) / Tibor Halilovic | 1-1 Igor Plastun / Jakov Puljic |
| Espanyol | 5-3 | Zorya Luhansk | 3-1 Facundo Ferreyra, Javi Lopez, Matias Vargas / Vladyslav Kochergin | 2-2 Facundo Ferreyra, Matias Vargas / Bogdan Lednev, Nazariy Rusyn |
| Partizan | 3-2 | Molde | 2-1 Seydouba Soumah, Zoran Tosic / Mathis Bolly | 1-1 Nemanja Miletic / Leke James |
| Braga | 3-1 | Spartak Moscow | 1-0 Ricardo Horta | 2-1 Ricardo Horta (2) / Zelimkhan Bakaev |
| Malmö FF | 4-0 | Bnei Yehuda | 3-0 Markus Rosenberg, Rasmus Bengtsson, Oscar Lewicki | 1-0 Guillermo Molins |
| Strasbourg | 1-3 | Eintracht Frankfurt | 1-0 Kevin Zohi | 0-3 Stefan Mitrovic, Filip Kostic, Danny da Costa |
| AZ | 5-2 | Antwerp | 1-1 Myron Boadu / Dylan Batubinsika | 4-1 Calvin Stengs, Ferdy Druijf, Teun Koopmeiners, Albert Gudmundsson / Didier Lamkel Ze |
