| APERTURA - ROUND 1 | |||
|---|---|---|---|
| 15-05-2021 | Villa Espanola | 0-0 | CA Progreso |
| 15-05-2021 | Montevideo Wanderers FC | 1-0 Hernan Rivero | Boston River |
| 15-05-2021 | Montevideo City Torque | 0-1 Pablo Olivera | SUD America |
| 16-05-2021 | Rentistas | 0-3 Luciano Nequecaur (2), Kaique | CA Fenix |
| 16-05-2021 | Deportivo Maldonado | 2-4 Federico Ramos, Facundo Agustin Batista / Ignacio Ramirez (3), Federico Martinez | Liverpool FC |
| 17-05-2021 | CS Cerrito | 3-1 Maximiliano Joaquin Silvera, Matias Ferreira, Maximiliano Daniel Perez / Facundo Bonifazi | CA River Plate |
| 03-06-2021 | Club Nacional | 1-2 Guillermo May / Leandro Otormin, Emanuel Beltran | Cerro Largo |
| 03-06-2021 | CA Penarol | 0-0 | Plaza Colonia |
| APERTURA - ROUND 2 | |||
| 22-05-2021 | Boston River | 1-2 Ruben Bentancourt / Joaquin Sosa, Emiliano Villar | Rentistas |
| 22-05-2021 | CA Fenix | 0-0 | CA Penarol |
| 22-05-2021 | Cerro Largo | 3-1 Leandro Otormin (2), Angel Cayetano / Cristian Daniel Cruz | CS Cerrito |
| 23-05-2021 | Plaza Colonia | 1-0 Diogo de Oliveira Barbosa | Montevideo City Torque |
| 23-05-2021 | CA Progreso | 1-3 Fabricio Fernandez Pertusso / Gonzalo Bergessio, Leandro Fernandez, Alfonso Trezza | Club Nacional |
| 23-05-2021 | Montevideo Wanderers FC | 0-0 | Deportivo Maldonado |
| 24-05-2021 | CA River Plate | 3-2 Luciano Boggio, Nicolas Rodriguez, Thiago Nicolas Borbas Silva / Ignacio Ramirez (2) | Liverpool FC |
| 25-05-2021 | SUD America | 2-1 Pablo Olivera, Tomas Andrade / Nicolas Digiano | Villa Espanola |
| APERTURA - ROUND 3 | |||
| 29-05-2021 | Liverpool FC | 3-0 Emiliano Garcia, Federico Martinez, Alan Medina | Cerro Largo |
| 29-05-2021 | Villa Espanola | 1-3 Dennis Olivera / Alvaro Fernandez, Diogo (2) | Plaza Colonia |
| 29-05-2021 | CS Cerrito | 0-0 | CA Progreso |
| 30-05-2021 | Deportivo Maldonado | 0-0 | CA River Plate |
| 31-05-2021 | CA Penarol | 5-2 Agustin Alvarez Martinez (2), Facundo Torres, Pablo Ceppelini, Jesus Trindade / Agustin Nadruz, Ruben Bentancourt | Boston River |
| 31-05-2021 | Club Nacional | 1-0 Gonzalo Bergessio | SUD America |
| 31-05-2021 | Rentistas | 0-1 Renzo Lopez | Montevideo Wanderers FC |
| 31-05-2021 | Montevideo City Torque | 2-0 Franco Catarozzi, Lucas Rodriguez | CA Fenix |
| APERTURA - ROUND 4 | |||
| 04-06-2021 | CA Progreso | 1-3 Jonathan Barboza / Federico Martinez, Martin Marta (k.k.), Emiliano Garcia | Liverpool FC |
| 05-06-2021 | Plaza Colonia | 1-2 Nicolas Ecequiel Dibble / Alfonso Trezza, Gonzalo Bergessio | Club Nacional |
| 05-06-2021 | SUD America | 0-0 | CS Cerrito |
| 06-06-2021 | Boston River | 1-2 Jose Alberti / Marcelo Ivan Allende, Gustavo Del Prete | Montevideo City Torque |
| 06-06-2021 | Rentistas | 0-2 Eduardo Darias, Tomas Conechny | Deportivo Maldonado |
| 06-06-2021 | Cerro Largo | 2-4 Leandro Otormin, Angel Cayetano / Thiago Nicolas Borbas Silva, Matias Arezo (3) | CA River Plate |
| 07-06-2021 | Montevideo Wanderers FC | 0-0 | CA Penarol |
| 07-06-2021 | CA Fenix | 1-0 Maureen Franco | Villa Espanola |
| APERTURA - ROUND 5 | |||
| 11-06-2021 | Liverpool FC | 5-0 Federico Martinez (2), Ignacio Ramirez (3) | SUD America |
| 11-06-2021 | Montevideo City Torque | 2-1 Gustavo Del Prete (2) / Nicolas Quagliata | Montevideo Wanderers FC |
| 12-06-2021 | CA River Plate | 4-0 Horacio Salaberry, Thiago Borbas, Facundo Bonifazi, Gonzalo Castro | CA Progreso |
| 12-06-2021 | CS Cerrito | 1-2 Maximiliano Silvera / Mario Risso, Cristian Rodriguez | Plaza Colonia |
| 13-06-2021 | CA Penarol | 1-1 Agustin Canobbio / Franco Perez | Rentistas |
| 13-06-2021 | Deportivo Maldonado | 2-1 Ignacio Vazquez (og), Facundo Batista / Ignacio Vazquez | Cerro Largo |
| 13-06-2021 | Club Nacional | 3-1 Gonzalo Bergessio (3) / Armando Mendez (og) | CA Fenix |
| 14-06-2021 | Villa Espanola | 2-2 Pablo Silva, Dennis Olivera / Enzo Larrosa, Ruben Bentancourt | Boston River |
| APERTURA - ROUND 6 | |||
| 17-06-2021 | Plaza Colonia | 2-1 Alvaro Fernandez, Mario Risso / Sebastian Fernandez | Liverpool FC |
| 18-06-2021 | Rentistas | 0-2 Lucas Rodriguez Trezza, Diego Arismendi | Montevideo City Torque |
| 18-06-2021 | CA Fenix | 1-3 Juan Alvez / Maximiliano Joaquin Silvera (3) | CS Cerrito |
| 19-06-2021 | CA Progreso | 0-0 | Cerro Largo |
| 19-06-2021 | Boston River | 1-1 Facundo Rodriguez / Gonzalo Bergessio | Club Nacional |
| 19-06-2021 | SUD America | 1-2 Bruno Rodrigo Gimenez Miglionico / Matias Arezo (2) | CA River Plate |
| 20-06-2021 | Montevideo Wanderers FC | 3-0 Nicolas Quagliata, Mathias Abero, Renzo Lopez | Villa Espanola |
| 20-06-2021 | CA Penarol | 4-0 Walter Gargano, Agustin Alvarez Martinez (2), Joaquin Varela (og) | Deportivo Maldonado |
| APERTURA - ROUND 7 | |||
| 22-06-2021 | Liverpool FC | 5-2 Ignacio Ramirez (2), Fabricio Diaz, Federico Martinez, Sebastian Fernandez / Andres Schetino, Rodrigo Amaral | CA Fenix |
| 22-06-2021 | CA River Plate | 0-1 Cristian Rodriguez | Plaza Colonia |
| 22-06-2021 | Cerro Largo | 2-1 Agustin Heredia, Mauro Brasil / Marcos Camarda | SUD America |
| 23-06-2021 | CS Cerrito | 1-0 Maximiliano Perez | Boston River |
| 23-06-2021 | Villa Espanola | 0-1 Emiliano Albin (og) | Rentistas |
| 23-06-2021 | Montevideo City Torque | 0-1 Ariel Nahuelpan | CA Penarol |
| 24-06-2021 | Deportivo Maldonado | 1-1 Mariano Bogliacino / Gustavo Alles | CA Progreso |
| 24-06-2021 | Club Nacional | 3-0 Gonzalo Bergessio (3) | Montevideo Wanderers FC |
| APERTURA - ROUND 8 | |||
| 26-06-2021 | CA Fenix | 3-4 Luciano Nequecaur, Ignacio Pereira, Maureen Franco / Matias Arezo (2), Luciano Boggio, Facundo Bone | CA River Plate |
| 26-06-2021 | CA Penarol | 1-1 Agustin Alvarez / Facundo Silva | Villa Espanola |
| 27-06-2021 | Boston River | 1-1 Enzo Larrosa / Mauricio Loffreda | Liverpool FC |
| 27-06-2021 | Rentistas | 1-1 Emiliano Villar / Gonzalo Vega | Club Nacional |
| 28-06-2021 | Plaza Colonia | 1-1 Leonai / Briant D'Altoe | Cerro Largo |
| 28-06-2021 | Montevideo City Torque | 2-3 Gustavo Del Prete, Andrew Teuten / Hernan Toledo, Matias Aguirregaray (2) | Deportivo Maldonado |
| 29-06-2021 | SUD America | 2-4 Pablo Olivera, Marcos Camarda / Gustavo Alles (2), Lucas Morales, Ricardo Roldan | CA Progreso |
| 29-06-2021 | Montevideo Wanderers FC | 1-0 Renzo Lopez | CS Cerrito |
| APERTURA - ROUND 9 | |||
| 03-07-2021 | Villa Espanola | 2-3 Jonathan Rios, Pablo Silva / Alvaro Brun, Andrew Teuten, Franco Pizzichillo | Montevideo City Torque |
| 03-07-2021 | CA River Plate | 1-1 Douglas Arezo / Ruben Bentancourt | Boston River |
| 03-07-2021 | Cerro Largo | 1-2 Leandro Onetto / Maureen Franco, Fernando Alfaro | CA Fenix |
| 04-07-2021 | Deportivo Maldonado | 1-3 Lucas Fernandez / Tomas Andrade, Pablo Mouche, Marcos Camarda | SUD America |
| 04-07-2021 | Club Nacional | 2-0 Brian Ocampo, Camilo Candido | CA Penarol |
| 05-07-2021 | CA Progreso | 1-2 Martin Marta / Danilo Asconeguy (og), Juan Cruz Mascia | Plaza Colonia |
| 05-07-2021 | CS Cerrito | 0-1 Mateo Barcia | Rentistas |
| 06-07-2021 | Liverpool FC | 2-1 Rodrigo Viega, Hernan Figueredo / Diego Riolfo | Montevideo Wanderers FC |
| APERTURA - ROUND 10 | |||
| 10-07-2021 | Villa Espanola | 2-0 Facundo Tancredi (2) | Deportivo Maldonado |
| 10-07-2021 | Plaza Colonia | 1-0 Leandro Suhr | SUD America |
| 10-07-2021 | Montevideo Wanderers FC | 1-2 Nicolas Quagliata / Thiago Nicolas Borbas Silva, Matias Arezo | CA River Plate |
| 11-07-2021 | Boston River | 1-0 Alan Jesus Rodriguez | Cerro Largo |
| 11-07-2021 | CA Fenix | 2-1 Edward Andres Barboza, Fabian Estoyanoff / Gustavo Alles | CA Progreso |
| 12-07-2021 | Montevideo City Torque | 3-0 Lucas Rodriguez Trezza, Juan Cejas,Franco Nicolas Pizzichillo | Club Nacional |
| 12-07-2021 | CA Penarol | 2-0 Ariel Nahuelpan, Gary Kagelmacher | CS Cerrito |
| 12-07-2021 | Rentistas | 2-1 Joaquin Sosa, Juninho da Rocha Junior / Ignacio Ramirez | Liverpool FC |
| APERTURA - ROUND 11 | |||
| 16-07-2021 | CA Progreso | 1-0 Lucas Morales | Boston River |
| 17-07-2021 | CA River Plate | 0-0 | Rentistas |
| 17-07-2021 | Deportivo Maldonado | 0-1 Gonzalo Camargo | Plaza Colonia |
| 17-07-2021 | Cerro Largo | 2-0 Angel Cayetano, Santiago Paiva | Montevideo Wanderers FC |
| 24-07-2021 | SUD America | 1-1 Santiago Etchebarne / Ignacio Pereira | CA Fenix |
| 25-07-2021 | Montevideo City Torque | 0-2 Maximiliano Silvera (2) | CS Cerrito |
| 25-07-2021 | Liverpool FC | 3-3 Federico Martinez, Sebastian Fernandez, Alan Medina / Pablo Ceppelini (2), Agustin Alvarez Martinez | CA Penarol |
| 26-07-2021 | Club Nacional | 3-0 Gonzalo Bergessio, Brian Ocampo, Andres D'Alessandro | Villa Espanola |
| APERTURA - ROUND 12 | |||
| 30-07-2021 | Rentistas | 1-3 Andres Rodales / Leandro Otormin (2), Santiago Paiva | Cerro Largo |
| 31-07-2021 | Boston River | 2-0 Facundo Labandeira, Bruno Gabriel Barja Sampedro | SUD America |
| 31-07-2021 | Montevideo Wanderers FC | 2-0 Renzo Lopez, Rodrigo Rivero | CA Progreso |
| 01-08-2021 | Montevideo City Torque | 0-3 Sebastian Fernandez, Gaston Martirena, Thomas Chacon | Liverpool FC |
| 01-08-2021 | CA Fenix | 0-1 Diogo | Plaza Colonia |
| 02-08-2021 | CA Penarol | 2-0 Agustin Alvarez Martinez, Facundo Torres | CA River Plate |
| 02-08-2021 | Club Nacional | 2-0 Gonzalo Bergessio, Leandro Fernandez | Deportivo Maldonado |
| 02-08-2021 | Villa Espanola | 1-1 Mathias Riquero / Maximiliano Joaquin Silvera | CS Cerrito |
| APERTURA - ROUND 13 | |||
| 06-08-2021 | CA Progreso | 2-2 Luciano Rodriguez, Lucas Morales / Franco Perez (k.k.), Emiliano Villar | Rentistas |
| 07-08-2021 | Cerro Largo | 0-1 Pablo Cepellini | CA Penarol |
| 07-08-2021 | CA River Plate | 3-3 Thiago Borbas, Marcos Montiel, Adrian Leites / Gabriel Chocobar, Sebastian Guerrero, Agustin Pena | Montevideo City Torque |
| 08-08-2021 | Liverpool FC | 2-2 Sebastian Fernandez, Thomas Chacon / Robert Flores, Mathias Riquero | Villa Espanola |
| 09-08-2021 | CS Cerrito | 2-0 Maximiliano Silvera (2) | Club Nacional |
| 09-08-2021 | SUD America | 1-0 Tomas Andrade | Montevideo Wanderers FC |
| 09-08-2021 | Plaza Colonia | 0-0 | Boston River |
| 10-08-2021 | Deportivo Maldonado | 0-0 | CA Fenix |
| APERTURA - ROUND 14 | |||
| 14-08-2021 | Rentistas | 1-2 Nahuel Acosta / Tomas Andrade, Agustin Cayetano | SUD America |
| 15-08-2021 | CA Penarol | 1-0 Agustin Alvarez | CA Progreso |
| 15-08-2021 | Villa Espanola | 1-1 Pablo Silva / Douglas Arezo | CA River Plate |
| 15-08-2021 | Montevideo City Torque | 3-0 Sebastian Guerrero (2), Jose Alvarez | Cerro Largo |
| 16-08-2021 | Club Nacional | 1-0 Guzman Corujo | Liverpool FC |
| 16-08-2021 | Montevideo Wanderers FC | 0-2 Emilio Zeballos, Nicolas Dibble | Plaza Colonia |
| 16-08-2021 | Boston River | 0-2 Francisco Martirena, Fernando Alfaro | CA Fenix |
| 16-08-2021 | CS Cerrito | 0-0 | Deportivo Maldonado |
| APERTURA - ROUND 15 | |||
| 20-08-2021 | CA Progreso | 1-4 Gustavo Alles / Marcelo Allende, Juan Cejas (2), Axel Perez | Montevideo City Torque |
| 20-08-2021 | CA Fenix | 2-1 Ignacio Pereira, Angel Rodriguez / Rodrigo Rivero | Montevideo Wanderers FC |
| 21-08-2021 | Liverpool FC | 3-0 Federico Martinez (2), Hernan Figueredo | CS Cerrito |
| 21-08-2021 | Deportivo Maldonado | 0-2 Facundo Labandeira, Nicolas Freitas | Boston River |
| 21-08-2021 | CA River Plate | 2-0 Douglas Arezo, Luciano Boggio | Club Nacional |
| 22.08.2021 | Plaza Colonia | 2-0 Diogo (2) | Rentistas |
| 22.08.2021 | SUD America | 1-1 Tomas Andrade / Pablo Ceppelini | CA Penarol |
| 22.08.2021 | Cerro Largo | 3-1 Santiago Paiva, Leandro Onetto, Leandro Otormin / Gabriel Albin Aguilar | Villa Espanola |
