Aryna Sabalenka finalde Ashleigh Barty'yi 6-0, 3-6, 6-4 yenerek 2021 Madrid Açık'ta tek bayanlar tenis şampiyonluğunu kazandı. Kiki Bertens, turnuvanın en son 2019'da düzenlendiği andan itibaren savunan şampiyondu, ancak ikinci turda Veronika Kudermetova'ya yenildi. Paula Badosa, turnuvanın yarı final aşamasına ulaşan tarihteki ilk İspanyol kadın oyuncu oldu.
 |
|
| Şampiyon | Aryna Sabalenka (Belarus |
|---|---|
| Finalist | Ashleigh Barty (Avustralya) |
| Final Skor | 6–0, 3–6, 6–4 |
1. Tur
| Tarih | 1. Oyuncu | Skor/Setler | 2. Oyuncu |
| 29-04-2021 | Ashleigh Barty | 2-0 (6-2, 6-1) | Shelby Rogers |
| 29-04-2021 | Hsieh Su-wei | 0-2 (2-6, 4-6) | Tamara Zidanšek |
| 29-04-2021 | Kateryna Ihorivna Kozlova | 0-2 (4-6, 2-6) | Laura Natalie Siegemund |
| 29-04-2021 | Alison Riske | 0-2 (1-6, 1-6) | Iga Świątek |
| 29-04-2021 | Petra Kvitová | 2-0 (6-2, 6-3) | Marie Bouzková |
| 29-04-2021 | Angelique Kerber | 2-0 (7-6, 6-1) | Markéta Vondroušová |
| 29-04-2021 | Veronika Eduardovna Kudermetova | 2-0 (6-1, 6-4) | Elena Sergeyevna Vesnina |
| 29-04-2021 | Victoria Jiménez Kasintseva | 0-2 (4-6, 0-6) | Kiki Bertens |
| 29-04-2021 | Elina Mykhailivna Svitolina | 1-2 (6-2, 4-6, 6-7) | Jil Belén Teichmann |
| 29-04-2021 | Paula Badosa Gibert | 2-0 (6-1, 7-5) | Barbora Krejčíková |
| 29-04-2021 | Ana Bogdan | 0-2 (0-6, 3-6) | Anastasija Sevastova |
| 29-04-2021 | Yulia Antonovna Putintseva | 2-0 (6-4, 6-2) | Johanna Konta |
| 29-04-2021 | Danka Kovinić | 0-2 (4-6, 1-6) | Sloane Stephens |
| 29-04-2021 | Yaroslava Vyacheslavovna Shvedova | 0-2 (2-6, 3-6) | Ons Jabeur |
| 29-04-2021 | Petra Martić | 0-2 (3-6, 2-6) | Bernarda Pera |
| 29-04-2021 | Kristina “Kiki” Mladenovic | 0-2 (4-6, 2-6) | Belinda Bencic |
| 29-04-2021 | Aryna Siarhiejeŭna Sabalenka | 2-0 (6-1, 6-2) | Vera Igorevna Zvonareva |
| 29-04-2021 | Irina-Camelia Begu | 1-2 (6-4, 4-6, 6-7) | Daria Sergeyevna Kasatkina |
| 30-04-2021 | Jessica Pegula | 2-0 (7-6, 6-3) | Sorana Mihaela Cîrstea |
| 30-04-2021 | Ekaterina Evgenyevna Alexandrova | (5-7, 6-3) | Victória Fyódorovna Azárenka |
| 30-04-2021 | Elise Mertens | 2-0 (6-3, 6-3) | Zhang Shuai |
| 30-04-2021 | Ajla Tomljanović | 0-2 (4-6, 0-6) | Elena Andreyevna Rybakina |
| 30-04-2021 | Magda Linette | 1-2 (2-6, 6-3, 1-6) | Zheng Saisai |
| 30-04-2021 | Sara Sorribes Tormo | 0-2 (0-6, 5-7) | Simona Halep |
| 30-04-2021 | Karolína Plíšková | 2-1 (5-7, 6-3, 6-2) | Cori “Coco” Gauff |
| 30-04-2021 | Anastasia Sergeyevna Pavlyuchenkova | 2-0 (7-5, 6-2) | Madison Keys |
| 30-04-2021 | Polona Hercog | 0-2 (3-6, 1-6) | Jeļena Ostapenko |
| 30-04-2021 | Venus Williams | 0-2 (2-6, 4-6) | Jennifer Elizabeth Brady |
| 30-04-2021 | Maria Sakkari | 2-1 (0-6, 6-1, 6-4) | Amanda Anisimova |
| 30-04-2021 | Nina Stojanović | 0-2 (4-6, 5-7) | Anett Kontaveit |
| 30-04-2021 | Wang Qiang | 0-2 (1-6, 3-6) | Karolína Muchová |
| 30-04-2021 | Misaki Doi | 0-2 (5-7, 2-6) | Naomi Osaka |
2. Tur
| Tarih | 1. Oyuncu | Skor/Setler | 2. Oyuncu |
| 01-05-2021 | Ashleigh Barty (Avustralya) | 2-1 (6-4, 1-6, 6-3) | Tamara Zidanšek |
| 01-05-2021 | Laura Natalie Siegemund | 0-2 (3-6, 3-6) | Iga Świątek (Polonya) |
| 01-05-2021 | Petra Kvitová (Çek Cumhuriyeti) | 2-0 (6-4, 7-5) | Angelique Kerber |
| 01-05-2021 | Veronika Eduardovna Kudermetova (Rusya) | 2-0 (6-4, 6-3) | Kiki Bertens |
| 01-05-2021 | Jil Belén Teichmann | 1-2 (7-5, 1-6, 2-6) | Paula Badosa Gibert (İspanya) |
| 01-05-2021 | Anastasija Sevastova (Letonya) | 2-0 (6-3, 6-3) | Yulia Antonovna Putintseva |
| 01-05-2021 | Sloane Stephens | 1-2 (6-4, 1-6, 3-6) | Ons Jabeur (Tunus) |
| 01-05-2021 | Bernarda Pera | 1-2 (6-3, 1-6, 6-7) | Belinda Bencic (İsviçre) |
| 02-05-2021 | Aryna Siarhiejeŭna Sabalenka (Belarus) | 2-0 (6-3, 6-3) | Daria Sergeyevna Kasatkina |
| 02-05-2021 | Jessica Pegula (ABD) | w/o | Victória Fyódorovna Azárenka |
| 02-05-2021 | Elise Mertens (Belçika) | 2-0 (7-6, 7-5) | Elena Andreyevna Rybakina (Kazakistan) |
| 02-05-2021 | Zheng Saisai | 0-2 (0-6, 4-6) | Simona Halep (Romanya) |
| 02-05-2021 | Karolína Plíšková | 0-2 (0-6, 5-7) | Anastasia Pavlyuchenkova (Rusya) |
| 02-05-2021 | Jeļena Ostapenko | 0-2 (2-6, 1-6) | Jennifer Elizabeth Brady (ABD) |
| 02-05-2021 | Maria Sakkari (Yunanistan) | 2-0 (6-3, 6-1) | Anett Kontaveit |
| 02-05-2021 | Karolína Muchová (Çek Cumhuriyeti) | 2-1 (6-4, 3-6, 6-1) | Naomi Osaka |
3. Tur
| Tarih | 1. Oyuncu | Skor/Setler | 2. Oyuncu |
| 03-05-2021 | Ashleigh Barty (Avustralya) | 2-0 (7-5, 6-4) | Iga Świątek (Polonya) |
| 03-05-2021 | Petra Kvitová (Çek Cumhuriyeti) | 2-1 (6-3, 4-6, 6-4) | Veronika Eduardovna Kudermetova (Rusya) |
| 03-05-2021 | Anastasija Sevastova (Letonya) | 1-2 (7-6, 6-7, 0-6) | Paula Badosa Gibert (İspanya) |
| 03-05-2021 | Ons Jabeur (Tunus) | 0-2 (6-7, 3-4) | Belinda Bencic (İsviçre) |
| 04-05-2021 | Aryna Siarhiejeŭna Sabalenka (Belarus) | 2-0 (6-1, 6-2) | Jessica Pegula (ABD) |
| 04-05-2021 | Elise Mertens (Belçika) | 2-1 (4-6, 7-5, 7-5) | Simona Halep (Romanya) |
| 04-05-2021 | Anastasia Pavlyuchenkova (Rusya) | 2-1 (7-5, 6-7, 6-3) | Jennifer Elizabeth Brady (ABD) |
| 04-05-2021 | Maria Sakkari (Yunanistan) | 1-2 (0-6, 7-6, 5-7) | Karolína Muchová (Çek Cumhuriyeti) |
Çeyrek Final
| Tarih | 1. Oyuncu | Skor/Setler | 2. Oyuncu |
| 05-05-2021 | Ashleigh Barty (Avustralya) | 2-1 (6-1, 3-6, 6-3) | Petra Kvitová (Çek Cumhuriyeti) |
| 05-05-2021 | Paula Badosa Gibert (İspanya) | 2-0 (6-4, 7-5) | Belinda Bencic (İsviçre) |
| 05-05-2021 | Aryna Siarhiejeŭna Sabalenka (Belarus) | 2-0 (6-1, 4-0) | Elise Mertens (Belçika) |
| 05-05-2021 | Anastasia Pavlyuchenkova (Rusya) | 2-0 (7-6, 7-6) | Karolína Muchová (Çek Cumhuriyeti) |
Yarı Final
| Tarih | 1. Oyuncu | Skor/Setler | 2. Oyuncu |
| 06-05-2021 | Ashleigh Barty (Avustralya) | 2-0 (6-4, 6-3) | Paula Badosa Gibert (İspanya) |
| 06-05-2021 | Aryna Siarhiejeŭna Sabalenka (Belarus) | 2-0 (6-2, 6-3) | Anastasia Pavlyuchenkova (Rusya) |
Final
| Tarih | 1. Oyuncu | Skor/Setler | 2. Oyuncu |
| 08-05-2021 | Aryna Siarhiejeŭna Sabalenka (Belarus) | 2-1 (6–0, 3–6, 6–4) | Ashleigh Barty (Avustralya) |
| 2019 | 2022 |