| Tarih | Ev Sahibi Takım | Skor | Misafir Takım |
|---|---|---|---|
| ROUND 1 | |||
| 26.02.21 07:00 | Kawasaki Frontale | 2-0 Akihiro Ienaga (2) | Yokohama F. Marinos |
| 27.02.21 07:00 | Consadole Sapporo | 5-1 Yoshiaki Komai, Takuro Kaneko (2), Anderson Lopes, Chanathip Songkrasin / Kleber | Yokohama FC |
| 27.02.21 07:00 | Oita Trinita | 1-1 Arata Watanabe / Takeru Kishimoto | Tokushima Vortis |
| 27.02.21 07:00 | Sanfrecce Hiroshima | 1-1 Junior Santos / Shuhei Akasaki | Vegalta Sendai |
| 27.02.21 07:00 | Urawa Red Diamonds | 1-1 Yuki Abe / Masato Morishige | FC Tokyo |
| 27.02.21 08:00 | Kashima Antlers | 1-3 Ryotaro Araki / Thiago Santana, Yusuke Goto, Ayase Ueda (og) | Shimizu S-pulse |
| 27.02.21 08:00 | Shonan Bellmare | 0-1 Daichi Hayashi | Sagan Tosu |
| 27.02.21 09:00 | Cerezo Osaka | 2-0 Yoshito Okubo, Tatsuhiro Sakamoto | Kashiwa Reysol |
| 27.02.21 10:00 | Vissel Kobe | 1-0 Kyogo Furuhashi | Gamba Osaka |
| 28.02.21 06:00 | Avispa Fukuoka | 1-2 Yutaka Yoshida (og) / Mateus (2) | Nagoya Grampus |
| ROUND 11 | |||
| 03.03.21 11:00 | Kawasaki Frontale | 3-2 Leandro Damiao (2), Kaoru Mitoma / Yoshito Okubo (2) | Cerezo Osaka |
| 22-04-21 11:00 | Nagoya Grampus | 2-0 Ryogo Yamasaki, Yuki Soma | Gamba Osaka |
| ROUND 2 | |||
| 06.03.21 07:00 | FC Tokyo | 3-2 Kyosuke Tagawa, Leandro, Masato Morishige / Yoshito Okubo, Riki Harakawa | Cerezo Osaka |
| 06.03.21 07:00 | Shimizu S-pulse | 2-2 Carlinhos Junior, Katsuhiro Nakayama / Yuya Yamagishi, Emil Salomonsson | Avispa Fukuoka |
| 06.03.21 07:00 | Tokushima Vortis | 1-1 Yuki Kakita / Ryuho Kikuchi | Vissel Kobe |
| 06.03.21 07:00 | Vegalta Sendai | 1-5 Rikiya Uehara / Yu Kobayashi (2), Daiya Tono, Koji Hachisuka (og), Reo Hatate | Kawasaki Frontale |
| 06.03.21 08:00 | Sagan Tosu | 2-0 Keita Yamashita (2) | Urawa Red Diamonds |
| 06.03.21 08:00 | Yokohama FC | 1-2 Kohei Tezuka / Yuto Misao, Seigo Kobayashi | Oita Trinita |
| 06.03.21 09:00 | Kashiwa Reysol | 2-1 Hiroto Goya (2) / Takuya Okamoto | Shonan Bellmare |
| 06.03.21 09:00 | Nagoya Grampus | 1-0 Yuki Soma | Consadole Sapporo |
| 07.03.21 06:00 | Yokohama F. Marinos | 3-3 Daizen Maeda (2), Ado Onaiwu / Junior Santos, Shunki Higashi, Douglas Vieira | Sanfrecce Hiroshima |
| 24.07.21 06:00 | Gamba Osaka | 0-1 Arthur | Kashima Antlers |
| ROUND 3 | |||
| 10.03.21 11:00 | Avispa Fukuoka | 1-3 Caue / Marcos Junior, Ryuta Koike, Daizen Maeda | Yokohama F. Marinos |
| 10.03.21 12:00 | Cerezo Osaka | 2-1 Ryuya Nishio, Hiroshi Kiyotake / Katsuhiro Nakayama | Shimizu S-pulse |
| 10.03.21 12:00 | FC Tokyo | 2-3 Diego Oliveira, Kensuke Nagai / Dyanfrez Douglas (2), Yuta Goke | Vissel Kobe |
| 10.03.21 12:00 | Kashima Antlers | 3-1 Ryotaro Araki (2) , Koki Machida / Takuya Okamoto | Shonan Bellmare |
| 10.03.21 12:00 | Kashiwa Reysol | 0-1 Takuma Ominami (og) | Nagoya Grampus |
| 10.03.21 12:00 | Kawasaki Frontale | 2-0 Leandro Damiao (2) | Tokushima Vortis |
| 10.03.21 12:00 | Sagan Tosu | 5-0 Keita Yamashita, Eduardo, Tomoya Koyamatsu, uta Higuchi, Noriyoshi Sakai | Vegalta Sendai |
| 10.03.21 12:00 | Sanfrecce Hiroshima | 2-1 Kosei Shibasaki, Yoshifumi Kashiwa / Anderson Lopes | Consadole Sapporo |
| 10.03.21 12:30 | Urawa Red Diamonds | 2-0 Kenyu Sugimoto, Yuki Abe | Yokohama FC |
| 27.07.21 12:30 | Gamba Osaka | 2-1 Leandro Pereira, Takashi Usami / Henrique Trevisan | Oita Trinita |
| ROUND 4 | |||
| 13.03.21 07:00 | Tokushima Vortis | 1-2 Yuki Kakita / Emil Salomonsson, Takeshi Kanamori | Avispa Fukuoka |
| 13.03.21 07:00 | Yokohama FC | 1-4 Ryo Germain / Yuta Toyokawa, Yoshito Okubo, Mutsuki Kato, Toshiyuki Takagi | Cerezo Osaka |
| 13.03.21 08:00 | Shonan Bellmare | 3-1 Ryo Takahashi, Shintaro Nago, Shuto Machino / Yoshiki Matsushita | Vegalta Sendai |
| 13.03.21 09:00 | Kashima Antlers | 1-1 Ryotaro Araki / Yuya Asano | Sanfrecce Hiroshima |
| 13.03.21 10:00 | Kawasaki Frontale | 1-0 Akihiro Ienaga | Kashiwa Reysol |
| 13.03.21 11:00 | Vissel Kobe | 0-1 Sho Inagaki | Nagoya Grampus |
| 14.03.21 06:00 | Yokohama F. Marinos | 3-0 Daizen Maeda (2), Ryuta Koike | Urawa Red Diamonds |
| 14.03.21 07:00 | Shimizu S-pulse | 0-0 | Sagan Tosu |
| 14.03.21 08:00 | Oita Trinita | 1-1 Yamato Machida / Ryoma Watanabe | FC Tokyo |
| 30.07.21 08:00 | Consadole Sapporo | 0-2 Shinya Yajima, Leandro Pereira | Gamba Osaka |
| ROUND 5 | |||
| 17.03.21 11:00 | Avispa Fukuoka | 1-0 Takeshi Kanamori | Kashima Antlers |
| 17.03.21 12:00 | Cerezo Osaka | 1-0 Tatsuhiro Sakamoto | Oita Trinita |
| 17.03.21 12:00 | FC Tokyo | 3-2 Kyosuke Tagawa, Diego Oliveira, Tsuyoshi Watanabe / Naoki Yamada, Ryo Takahashi | Shonan Bellmare |
| 17.03.21 12:00 | Sagan Tosu | 2-0 Daichi Hayashi (2) | Kashiwa Reysol |
| 17.03.21 12:00 | Sanfrecce Hiroshima | 1-0 Hayato Araki | Shimizu S-pulse |
| 17.03.21 12:00 | Vissel Kobe | 1-1 Ryuho Kikuchi / Leandro Damiao | Kawasaki Frontale |
| 17.03.21 12:00 | Yokohama F. Marinos | 1-0 Daizen Maeda | Tokushima Vortis |
| 17.03.21 12:30 | Nagoya Grampus | 3-0 Naoki Maeda, Mateus, Ryogo Yamasaki | Yokohama FC |
| 17.03.21 12:30 | Urawa Red Diamonds | 0-0 | Consadole Sapporo |
| 03.08.21 12:30 | Vegalta Sendai | 0-1 Patric | Gamba Osaka |
| ROUND 6 | |||
| 20.03.21 07:00 | Consadole Sapporo | 3-4 Anderson Lopes (3) / Hotaru Yamaguchi (2), Kyogo Furuhashi (2) | Vissel Kobe |
| 21.03.21 06:00 | FC Tokyo | 2-1 Kyosuke Tagawa, Diego Oliveira / Koji Hachisuka | Vegalta Sendai |
| 21.03.21 07:00 | Oita Trinita | 1-3 Shun Nagasawa / Toshihiro Aoyama, Hayao Kawabe, Shun Ayukawa | Sanfrecce Hiroshima |
| 21.03.21 07:00 | Sagan Tosu | 0-0 | Avispa Fukuoka |
| 21.03.21 07:00 | Tokushima Vortis | 2-1 Ryuji Sugimoto (og), Taisei Miyashiro / Yutaro Hakamata | Yokohama FC |
| 21.03.21 08:00 | Shonan Bellmare | 0-0 | Cerezo Osaka |
| 21.03.21 08:00 | Urawa Red Diamonds | 0-5 Yu Kobayashi (2), Leandro Damiao, Reo Hatate, Yasuto Wakisaka | Kawasaki Frontale |
| 21.03.21 09:00 | Kashima Antlers | 0-1 Sho Inagaki | Nagoya Grampus |
| 21.03.21 09:00 | Kashiwa Reysol | 1-2 Yuta Kamiya / Yoshinori Suzuki, Thiago Santana | Shimizu S-pulse |
| 06.08.21 09:00 | Gamba Osaka | 2-3 Leandro Pereira, Patric / Elber, Marcos Junior, Kota Mizunuma | Yokohama F. Marinos |
| ROUND 7 | |||
| 02.04.21 12:00 | Cerezo Osaka | 1-0 Hiroaki Okuno | Sagan Tosu |
| 03.04.21 06:00 | Yokohama F. Marinos | 1-1 Elber / Naoki Yamada | Shonan Bellmare |
| 03.04.21 07:00 | Avispa Fukuoka | 1-2 Tatsuki Nara / Anderson Lopes, Akito Fukumori | Consadole Sapporo |
| 03.04.21 07:00 | Nagoya Grampus | 0-0 | FC Tokyo |
| 03.04.21 07:00 | Sanfrecce Hiroshima | 0-0 | Gamba Osaka |
| 03.04.21 07:00 | Vegalta Sendai | 0-2 Kyogo Furuhashi, Ryuho Kikuchi | Vissel Kobe |
| 03.04.21 08:00 | Urawa Red Diamonds | 2-1 Takahiro Akimoto, Tomoaki Makino / Ikuma Sekigawa | Kashima Antlers |
| 03.04.21 10:00 | Yokohama FC | 1-1 Masakazu Tashiro / Takuma Ominami | Kashiwa Reysol |
| 03.04.21 12:00 | Kawasaki Frontale | 2-0 Kaoru Mitoma (2) | Oita Trinita |
| 04.04.21 07:00 | Shimizu S-pulse | 0-3 Taisei Miyashiro, Ken Iwao, Yuki Kakita | Tokushima Vortis |
| ROUND 8 | |||
| 06.04.21 12:00 | Yokohama F. Marinos | 1-0 Ado Onaiwu | Cerezo Osaka |
| 07.04.21 12:00 | FC Tokyo | 2-1 Diego Oliveira (2) / Anderson Lopes | Consadole Sapporo |
| 07.04.21 12:00 | Gamba Osaka | 0-0 | Avispa Fukuoka |
| 07.04.21 12:00 | Kashima Antlers | 2-1 Ayase Ueda, Ryohei Shirasaki / Hayato Nakama | Kashiwa Reysol |
| 07.04.21 12:00 | Kawasaki Frontale | 1-0 Daiya Tono | Sagan Tosu |
| 07.04.21 12:00 | Shimizu S-pulse | 0-2 Takuya Iwanami, Kenyu Sugimoto | Urawa Red Diamonds |
| 07.04.21 12:00 | Shonan Bellmare | 0-0 | Nagoya Grampus |
| 07.04.21 12:00 | Tokushima Vortis | 1-0 Takeru Kishimoto | Vegalta Sendai |
| 07.04.21 12:00 | Vissel Kobe | 1-0 Kyogo Furuhashi | Oita Trinita |
| 07.04.21 12:00 | Yokohama FC | 0-3 Yuya Asano (2), Kosei Shibasaki | Sanfrecce Hiroshima |
| ROUND 9 | |||
| 10.04.21 07:00 | Sanfrecce Hiroshima | 0-1 Satoshi Tanaka | Shonan Bellmare |
| 10.04.21 07:00 | Cerezo Osaka | 2-2 Motohiko Nakajima, Mutsuki Kato / Masakazu Yoshioka, Juanma Delgado | Avispa Fukuoka |
| 11.04.21 06:05 | Consadole Sapporo | 2-2 Shunta Tanaka, Anderson Lopes / Katsuya Nagato, Ayase Ueda | Kashima Antlers |
| 11.04.21 07:00 | FC Tokyo | 2-4 Adailton, Takuya Uchida / Akihiro Ienaga (2), Kaoru Mitoma, Leandro Damiao | Kawasaki Frontale |
| 11.04.21 07:00 | Vegalta Sendai | 0-0 | Yokohama F. Marinos |
| 11.04.21 08:00 | Oita Trinita | 0-3 Ryogo Yamasaki, Keisuke Saka (og), Yoichiro Kakitani | Nagoya Grampus |
| 11.04.21 08:00 | Sagan Tosu | 3-0 Keita Yamashita, Fuchi Honda, Keita Yamashita | Yokohama FC |
| 11.04.21 09:00 | Urawa Red Diamonds | 1-0 Takahiro Sekine | Tokushima Vortis |
| 11.04.21 10:00 | Kashiwa Reysol | 1-0 Hidekazu Otani | Gamba Osaka |
| 11.04.21 10:00 | Vissel Kobe | 1-1 Kyogo Furuhashi / Elsinho | Shimizu S-pulse |
| ROUND 10 | |||
| 16.04.21 12:00 | Consadole Sapporo | 1-3 Anderson Lopes / Ado Onaiwu, Daizen Maeda, Elber | Yokohama F. Marinos |
| 17.04.21 07:00 | Avispa Fukuoka | 1-0 Bruno Mendes | FC Tokyo |
| 17.04.21 07:00 | Oita Trinita | 0-1 Ataru Esaka | Kashiwa Reysol |
| 17.04.21 07:00 | Tokushima Vortis | 0-1 Koki Machida | Kashima Antlers |
| 17.04.21 07:00 | Yokohama FC | 2-2 | Vegalta Sendai |
| 17.04.21 08:00 | Shonan Bellmare | 0-0 Yutaro Hakamata, Kosuke Saito / Takuma Nishimura, Kyohei Yoshino | Vissel Kobe |
| 18.04.21 08:00 | Gamba Osaka | 0-0 | Shimizu S-pulse |
| 18.04.21 08:00 | Nagoya Grampus | 1-2 Sho Inagaki / Daichi Hayashi, Noriyoshi Sakai | Sagan Tosu |
| 18.04.21 08:00 | Kawasaki Frontale | 1-1 Akihiro Ienaga / Tsukasa Morishima | Sanfrecce Hiroshima |
| 18.04.21 08:00 | Cerezo Osaka | 1-0 Yusuke Maruhashi | Urawa Red Diamonds |
| ROUND 1 | |||
| 24.04.21 06:00 | Consadole Sapporo | 2-1 Tsuyoshi Ogashiwa, Jay Bothroyd / Chihiro Kato | Vegalta Sendai |
| 24.04.21 07:00 | FC Tokyo | 1-2 Masato Morishige / Noriyoshi Sakai, Yuta Higuchi | Sagan Tosu |
| 24.04.21 07:00 | Sanfrecce Hiroshima | 1-2 Shunki Higashi / Bruno Mendes, Hiroyuki Mae | Avispa Fukuoka |
| 24.04.21 07:00 | Yokohama F. Marinos | 5-0 Marcos Junior, Ado Onaiwu (2), Daizen Maeda, Leo Ceara | Yokohama FC |
| 24.04.21 09:00 | Kashiwa Reysol | 5-1 Hiroto Goya (2), Ataru Esaka, Keiya Shiihashi, Hayato Nakama / Taisei Miyashiro | Tokushima Vortis |
| 24.04.21 10:00 | Kashima Antlers | 1-1 Ayase Ueda / Kyogo Furuhashi | Vissel Kobe |
| 25.04.21 07:00 | Shimizu S-pulse | 1-1 Thiago Santana / Wellington | Shonan Bellmare |
| 25.04.21 09:00 | Urawa Red Diamonds | 3-2 Daigo Nishi, Tomoaki Makino, Tatsuya Tanaka / Yamato Machida (2) | Oita Trinita |
| ROUND 12 | |||
| 01.05.21 07:00 | Avispa Fukuoka | 2-0 Bruno Mendes, John Mary | Urawa Red Diamonds |
| 01.05.21 07:00 | FC Tokyo | 0-3 Ado Onaiwu (3) | Yokohama F. Marinos |
| 01.05.21 07:00 | Vegalta Sendai | 1-0 Takuma Nishimura | Kashiwa Reysol |
| 01.05.21 08:00 | Vissel Kobe | 3-0 Kyogo Furuhashi (2), Yuya Nakasaka | Sanfrecce Hiroshima |
| 01.05.21 09:00 | Sagan Tosu | 2-0 Keita Yamashita, Keiya Sento | Tokushima Vortis |
| 01.05.21 10:00 | Yokohama FC | 0-3 Ryohei Shirasaki, Shoma Doi, Koki Machida | Kashima Antlers |
| 02.05.21 07:00 | Oita Trinita | 1-0 Yamato Machida | Shimizu S-pulse |
| 02.05.21 08:00 | Shonan Bellmare | 0-0 | Consadole Sapporo |
| 02.05.21 08:00 | Cerezo Osaka | 1-1 Motohiko Nakajima / Patric | Gamba Osaka |
| 12.05.21 12:00 | Kawasaki Frontale | 3-2 Jesiel, Miki Yamane, Yuichi Maruyama (og) / Sho Inagaki, Diogo Mateus | Nagoya Grampus |
| ROUND 13 | |||
| 08.05.21 07:00 | Sagan Tosu | 0-0 | Sanfrecce Hiroshima |
| 08.05.21 07:00 | Nagoya Grampus | 1-0 Yutaka Yoshida | Cerezo Osaka |
| 08.05.21 07:00 | Gamba Osaka | 0-2 Leandro Damiao, Kaoru Mitoma | Kawasaki Frontale |
| 09.05.21 06:00 | Yokohama F. Marinos | 2-0 Thomas Vermaelen (og), Jun Amano | Vissel Kobe |
| 09.05.21 07:00 | Avispa Fukuoka | 1-0 Takaaki Shichi | Kashiwa Reysol |
| 09.05.21 07:00 | Shimizu S-pulse | 1-1 Thiago Santana / Kohei Tezuka | Yokohama FC |
| 09.05.21 08:00 | Shonan Bellmare | 2-0 Shintaro Nago, Wellington | Oita Trinita |
| 09.05.21 08:00 | Tokushima Vortis | 1-2 Taisei Miyashiro / Anderson Lopes (2) | Consadole Sapporo |
| 09.05.21 09:00 | Urawa Red Diamonds | 2-0 Kasper Junker, Yuki Abe | Vegalta Sendai |
| 09.05.21 10:00 | Kashima Antlers | 3-0 Koki Machida, Yuta Matsumura, Ayase Ueda | FC Tokyo |
| ROUND 14 | |||
| 15.05.21 07:00 | Shimizu S-pulse | 0-3 Yoichiro Kakitani, Diogo Mateus (2) | Nagoya Grampus |
| 15.05.21 07:00 | Vegalta Sendai | 0-1 Daiki Watari | Avispa Fukuoka |
| 15.05.21 08:00 | Kashima Antlers | 5-3 Shoma Doi (3), Ryotaro Araki, Ayase Ueda / Ado Onaiwu (2), Jun Amano | Yokohama F. Marinos |
| 15.05.21 09:00 | Kashiwa Reysol | 0-4 Diego Oliveira, Adailton (2), Hirotaka Mita | FC Tokyo |
| 15.05.21 09:00 | Oita Trinita | 1-1 Shun Nagasawa / Keita Yamashita | Sagan Tosu |
| 15.05.21 09:00 | Sanfrecce Hiroshima | 0-1 Takeru Kishimoto | Tokushima Vortis |
| 15.05.21 10:00 | Yokohama FC | 2-0 Yota Maejima, Takuya Matsuura | Shonan Bellmare |
| 15.05.21 12:00 | Vissel Kobe | 1-1 Thomas Vermaelen / Tatsuhiro Sakamoto | Cerezo Osaka |
| 16.05.21 08:00 | Kawasaki Frontale | 2-0 Kaoru Mitoma, Yu Kobayashi | Consadole Sapporo |
| 16.05.21 10:00 | Gamba Osaka | 0-3 Kasper Junker (2), Tatsuya Tanaka | Urawa Red Diamonds |
| ROUND 15 | |||
| 22.05.21 07:00 | Consadole Sapporo | 2-0 Anderson Lopes, Takuro Kaneko | Shimizu S-pulse |
| 22.05.21 07:00 | Sagan Tosu | 2-1 Keita Yamashita, Yuta Higuchi / Yuta Matsumura | Kashima Antlers |
| 22.05.21 07:00 | Vegalta Sendai | 2-1 Takuma Nishimura, Chihiro Kato / Shun Nagasawa | Oita Trinita |
| 22.05.21 08:00 | Kawasaki Frontale | 3-1 Akihiro Ienaga, Ao Tanaka, Kaoru Mitoma / Kleber | Yokohama FC |
| 22.05.21 09:00 | Urawa Red Diamonds | 2-0 Tatsuya Tanaka, Kasper Junker | Vissel Kobe |
| 22.05.21 10:00 | Avispa Fukuoka | 2-1 Bruno Mendes, Douglas Grolli / Shintaro Nago | Shonan Bellmare |
| 22.05.21 10:00 | Yokohama F. Marinos | 1-1 Ken Matsubara / Ippei Shinozuka | Kashiwa Reysol |
| 22.05.21 11:00 | Tokushima Vortis | 0-0 | Nagoya Grampus |
| 22.05.21 12:00 | FC Tokyo | 1-0 Diego Oliveira | Gamba Osaka |
| 23.05.21 08:00 | Cerezo Osaka | Sanfrecce Hiroshima | |
| ROUND 16 | |||
| 26.05.21 12:00 | Consadole Sapporo | 0-0 | Sagan Tosu |
| 26.05.21 12:00 | Kashima Antlers | 1-0 Ryotaro Araki | Cerezo Osaka |
| 26.05.21 12:00 | Kashiwa Reysol | 1-2 Keiya Shiihashi / Yuta Goke, Naoki Kawaguchi (og) | Vissel Kobe |
| 26.05.21 12:00 | Oita Trinita | 0-1 Daizen Maeda | Yokohama F. Marinos |
| 26.05.21 12:00 | Sanfrecce Hiroshima | 2-2 Rhayner, Hayao Kawabe / Shinzo Koroki, Kasper Junker | Urawa Red Diamonds |
| 26.05.21 12:00 | Shimizu S-pulse | 3-0 Thiago Santana, Valdo, Eiichi Katayama | FC Tokyo |
| 26.05.21 12:00 | Shonan Bellmare | 1-1 Naoki Yamada / Leandro Damiao | Kawasaki Frontale |
| 26.05.21 12:00 | Yokohama FC | 1-1 Kleber / Bruno Mendes | Avispa Fukuoka |
| 26.05.21 12:30 | Nagoya Grampus | 0-1 Quenten Martinus | Vegalta Sendai |
| 27.05.21 12:00 | Gamba Osaka | 2-1 Patric, Takashi Usami / Ken Iwao | Tokushima Vortis |
| ROUND 17 | |||
| 29.05.21 12:00 | Kashiwa Reysol | 1-2 Cristiano / Tsuyoshi Ogashiwa, Daihachi Okamura | Consadole Sapporo |
| 30.05.21 06:00 | Yokohama F. Marinos | 2-1 Elber, Leo Ceara / Thiago Santana | Shimizu S-pulse |
| 30.05.21 07:00 | FC Tokyo | 0-0 | Sanfrecce Hiroshima |
| 30.05.21 07:00 | Vissel Kobe | 1-1 Dyanfrez Douglas / Keiya Sento | Sagan Tosu |
| 30.05.21 08:00 | Oita Trinita | 2-1 Shun Nagasawa, Henrique Trevisan / Jordy Croux | Avispa Fukuoka |
| 30.05.21 08:00 | Tokushima Vortis | 1-1 Caca / Shuto Machino | Shonan Bellmare |
| 30.05.21 08:00 | Vegalta Sendai | 1-1 Quenten Martinus / Tiago | Cerezo Osaka |
| 30.05.21 10:00 | Gamba Osaka | 2-0 Leandro Pereira (2) | Yokohama FC |
| 30.05.21 11:00 | Urawa Red Diamonds | 0-0 | Nagoya Grampus |
| 30.05.21 12:00 | Kawasaki Frontale | 2-1 Leandro Damiao, Yu Kobayashi / Ayase Ueda | Kashima Antlers |
| ROUND 18 | |||
| 14-04-2021 | Cerezo Osaka | 1-2 Ryosuke Shindo / Taisei Miyashiro, Ryuya Nishio (og) | Tokushima Vortis |
| 14-04-2021 | Sagan Tosu | 0-1 Takashi Usami | Gamba Osaka |
| 19.06.21 06:00 | Avispa Fukuoka | 1-2 Yuya Yamagishi / Kyogo Furuhashi, Andres Iniesta | Vissel Kobe |
| 19.06.21 07:00 | Consadole Sapporo | 2-0 Takuro Kaneko (2) | Oita Trinita |
| 19.06.21 12:00 | Sanfrecce Hiroshima | 1-0 Keiya Shiihashi (k.k.) | Kashiwa Reysol |
| 19.06.21 11:00 | Yokohama FC | 0-1 Adailton | FC Tokyo |
| 20.06.21 10:00 | Kashima Antlers | 1-1 Juan Matheus Alano / Takuma Nishimura | Vegalta Sendai |
| 20.06.21 12:00 | Urawa Red Diamonds | 2-3 Kasper Junker (2) / Naoki Yamada, Wellington, Takuya Okamoto | Shonan Bellmare |
| 17.07.21 | Shimizu S-pulse | 0-2 Yasuto Wakizaka, Ryota Oshima | Kawasaki Frontale |
| 12.08.21 | Yokohama F. Marinos | 2-0 Kenyu Sugimoto, Marcos Junior | Nagoya Grampus |
| ROUND 19 | |||
| 14-04-2021 | Nagoya Grampus | 1-0 Yuichi Maruyama | Sanfrecce Hiroshima |
| 14-04-2021 | Kawasaki Frontale | 3-1 Daiya Tono, Kei Chinen, Miki Yamane / Emil Salomonsson | Avispa Fukuoka |
| 02-06-2021 | Shonan Bellmare | 0-0 | Gamba Osaka |
| 23.06.21 12:00 | Kashiwa Reysol | 0-2 Tomoya Ugajin, Kai Shibato | Urawa Red Diamonds |
| 23.06.21 12:00 | Oita Trinita | 0-0 | Kashima Antlers |
| 23.06.21 12:00 | Tokushima Vortis | 0-1 Kyosuke Tagawa | FC Tokyo |
| 23.06.21 12:00 | Vegalta Sendai | 2-3 Kyohei Yoshino, Yoshiki Matsushita / Yuito Suzuki, Akira Silvano, Thiago Santana | Shimizu S-pulse |
| 23.06.21 12:00 | Vissel Kobe | 5-0 Dyanfrez Douglas, Kyogo Furuhashi (3), Ryuho Kikuchi | Yokohama FC |
| 23.06.21 12:00 | Yokohama F. Marinos | 2-0 Marcos Junior, Takuya Wada | Sagan Tosu |
| 08-09-21 12:00 | Consadole Sapporo | 0-3 Riku Matsuda, Naoyuki Fujita, Yoshito Okubo | Cerezo Osaka |
| ROUND 20 | |||
| 12.05.21 11:00 | Gamba Osaka | 1-2 Kazunari Ichimi / Hayao Kawabe, Sho Sasaki | Sanfrecce Hiroshima |
| 12.05.21 11:00 | Kawasaki Frontale | 2-2 Yu Kobayashi, Kaoru Mitoma / Shogo Nakahara, Quenten Martinus | Vegalta Sendai |
| 27.06.21 11:00 | Tokushima Vortis | 0-1 Takeru Kishimoto (og) | Yokohama F. Marinos |
| 27.06.21 11:00 | Yokohama FC | 1-1 Kazuma Watanabe / Valdo | Shimizu S-pulse |
| 27.06.21 11:30 | Kashima Antlers | 4-0 Tomoya Inukai, Diego Pituca, Keigo Tsunemoto, Everaldo | Consadole Sapporo |
| 27.06.21 12:00 | FC Tokyo | 3-0 Leandro, Diego Oliveira, Ryoya Ogawa | Oita Trinita |
| 27.06.21 12:00 | Shonan Bellmare | 2-4 Shuto Machino, Wellington / Pedro Raul (2), Cristiano, Takuma Ominami | Kashiwa Reysol |
| 27.06.21 12:00 | Urawa Red Diamond | 2-0 Yoshio Koizumi, Takahiro Akimoto | Avispa Fukuoka |
| 17-07-21 | Cerezo Osaka | 1-1 Koji Toriumi / Kyogo Furuhashi | Vissel Kobe |
| 17-07-21 | Sagan Tosu | 3-1 Tomoya Koyamatsu, Noriyoshi Sakai, Yoshihiro Nakano / Eduardo (k.k.) | Nagoya Grampus |
| ROUND 21 | |||
| 12.05.21 11:00 | Nagoya Grampus | 0-2 Tomoya Inukai, Daiki Sugioka | Kashima Antlers |
| 02-06-2021 | Yokohama FC | 0-2 Yu Kobayashi (2) | Kawasaki Frontale |
| 03.07.21 12:00 | Kashiwa Reysol | 1-2 Mao Hosoya / Ado Onaiwu, Daizen Maeda | Yokohama F. Marinos |
| 03.07.21 12:00 | Vegalta Sendai | 0-0 | Urawa Red Diamonds |
| 03.07.21 12:00 | Sanfrecce Hiroshima | 1-1 Junior Santos / Noriyoshi Sakai | Sagan Tosu |
| 03.07.21 12:00 | Vissel Kobe | 3-1 Kyogo Furuhashi, Hotaru Yamaguchi, Yuya Nakasaka / Tarik Elyounoussi | Shonan Bellmare |
| 04.07.21 06:05 | Consadole Sapporo | 1-0 Shota Fukuoka (og) | Tokushima Vortis |
| 04.07.21 11:00 | Shimizu S-pulse | 1-0 Teruki Hara | Oita Trinita |
| 17.07.21 | Avispa Fukuoka | 0-1 Patric | Gamba Osaka |
| 21.07.21 | Cerezo Osaka | 3-3 Matsuki Kato, Tatsuhiro Sakamoto, Tiago Pagnussat / Leandro (2), Diego | FC Tokyo |
| ROUND 22 | |||
| 29-04.21 12:00 | Nagoya Grampus | 0-4 Reo Hatate,Leandro Damiao (2), Daiya Tono | Kawasaki Frontale |
| 10.07.21 11:00 | Yokohama F. Marinos | 2-0 Tatsuki Nara (og), Ado Onaiwu | Avispa Fukuoka |
| 10.07.21 12:00 | Oita Trinita | 1-0 Yamato Machida | Urawa |
| 10.07.21 12:00 | Vegalta Sendai | 1-1 Takumi Mase / Lucas Fernandes | Consadole Sapporo |
| 21.07.21 11:00 | Gamba Osaka | 1-2 Patric / Junya Tanaka, Douglas | Vissel Kobe |
| 11.07.21 11:00 | Sanfrecce Hiroshima | 0-1 Keijiro Ogawa | Yokohama FC |
| 11.07.21 11:00 | Tokushima Vortis | 2-2 Masaki Watai, Yudai Konishi / Caca (k.k.), Teruki Hara | Shimizu S-pulse |
| 11.07.21 12:00 | Kashiwa Reysol | 2-1 Cristiano, Raul Pedro / Tomoya Inukai | Kashima |
| 11.07.21 12:00 | Shonan Bellmare | 0-1 Kensuke Nagai | FC Tokyo |
| 24.07.21 12:00 | Sagan Tosu | 3-3 Noriyoshi Sakai, Tomoya Koyamatsu, Yuta Higuchi / Matsuki Kato (2), Tatsuhiro Sakamoto | Cerezo Osaka |
| ROUND 23 | |||
| 09.08.21 08:00 | Consadole Sapporo | 2-1 Kazuki Fukai, Tsuyoshi Ogashiwa / Takahiro Akimoto | Urawa |
| 09.08.21 11:00 | Shimizu S-pulse | 2-2 Eiichi Katayama, Kenta Nishizawa / Marcos Junior, Elber | Yokohama F. Marinos |
| 09.08.21 11:00 | Yokohama FC | 2-0 Shinnosuke Nakatani (og), Yusuke Matsuo | Nagoya Grampus |
| 09.08.21 12:00 | Avispa Fukuoka | 1-1 Hiroyuki Mae / Junior Santos | Sanfrecce Hiroshima |
| 09.08.21 12:00 | Cerezo Osaka | 0-0 | Vegalta Sendai |
| 09.08.21 12:00 | Oita Trinita | 0-2 Leandro Damiao, Daiya Tono | Kawasaki Frontale |
| 09.08.21 12:00 | Sagan Tosu | 1-0 Keiya Sento | FC Tokyo |
| 09.08.21 12:00 | Shonan Bellmare | 1-2 Yuki Ohashi / Kosei Tani (og), Tomoya Inukai | Kashima |
| 09.08.21 12:00 | Tokushima Vortis | 2-1 Taisei Miyashiro / Kazuki Nishiya, Tiago Alves | Gamba Osaka |
| 09.08.21 12:00 | Vissel Kobe | 1-2 Yutaro Oda / Cristiano, Mao Hosoya | Kashiwa Reysol |
| ROUND 24 | |||
| 13.08.21 12:00 | Shimizu S-pulse | 0-1 Hiroto Yamami | Gamba Osaka |
| 13.08.21 12:00 | Yokohama F. Marinos | 5-1 Daizen Maeda (3), Leo Ceara (2) / Kohei Isa | Oita Trinita |
| 14.08.21 07:00 | Consadole Sapporo | 3-2 Tsuyoshi Ogashiwa, Ryota Aoki (2) / Adailton (2) | FC Tokyo |
| 14.08.21 11:00 | Nagoya Grampus | 1-0 Kim Min-Tae | Shonan Bellmare |
| 14.08.21 12:00 | Kashiwa Reysol | 0-0 | Kawasaki Frontale |
| 14.08.21 12:00 | Urawa | 2-1 Takahiro Akimoto, Ataru Esaka / Keita Yamashita | Sagan Tosu |
| 14.08.21 12:00 | Vegalta Sendai | 0-0 | Yokohama FC |
| 15.08.21 11:30 | Kashima | 3-0 Ryotaro Araki (2), Koki Machida | Tokushima Vortis |
| 15.08.21 12:00 | Avispa Fukuoka | 2-1 Yuya Yamagishi, Jordy Croux / Adam Taggart | Cerezo Osaka |
| 05-09.21 12:00 | Sanfrecce Hiroshima | 1-1 Shunki Higashi / Daiju Sasaki | Vissel Kobe |
| ROUND 25 | |||
| 21.08.21 11:00 | Yokohama F. Marinos | 5-0 Marcos Junior, Leo Ceara (3), Jun Amano | Vegalta Sendai |
| 21.08.21 12:00 | Gamba Osaka | 0-0 | FC Tokyo |
| 21.08.21 12:00 | Kashiwa Reysol | 1-3 Cristiano / Yuta Higuchi, Tomoya Koyamatsu (2) | Sagan Tosu |
| 21.08.21 12:00 | Oita Trinita | 1-1 Hiroto Goya / Tsuyoshi Ogashiwa | Consadole Sapporo |
| 21.08.21 12:00 | Sanfrecce Hiroshima | 1-1 Yoshifumi Kashiwa / Leandro Damiao | Kawasaki Frontale |
| 21.08.21 12:00 | Shonan Bellmare | 1-1 Wellington / Yuito Suzuki | Shimizu S-pulse |
| 21.08.21 12:00 | Tokushima Vortis | 0-1 Takahiro Sekine | Urawa |
| 21.08.21 12:00 | Vissel Kobe | 1-0 Hotaru Yamaguchi | Kashima |
| 21.08.21 12:30 | Cerezo Osaka | 3-1 Tiago (2), Tatsuhiro Sakamoto / Kazuma Watanabe | Yokohama FC |
| 22.08.21 11:00 | Nagoya Grampus | 1-0 Jakub Swierczok | Avispa Fukuoka |
| ROUND 26 | |||
| 25.08.21 12:00 | Avispa Fukuoka | 1-0 Jordy Croux | Kawasaki Frontale |
| 25.08.21 12:00 | Consadole Sapporo | 0-2 Sho Inagaki (2) | Nagoya Grampus |
| 25.08.21 12:00 | Oita Trinita | 1-3 Yuki Kagawa / Gotoku Sakai, Andres Iniesta, Ryuho Kikuchi | Vissel Kobe |
| 25.08.21 12:00 | Sagan Tosu | 0-4 Daizen Maeda, Leo Ceara, Kota Mizunuma, Teruhito Nakagawa | Yokohama F. Marinos |
| 25.08.21 12:00 | Shimizu S-pulse | 0-4 Ayase Ueda, Arthur Caike, Ryuji Izumi, Yasushi Endo | Kashima |
| 25.08.21 12:00 | Tokushima Vortis | 0-1 Yusuke Segawa | Kashiwa Reysol |
| 25.08.21 12:00 | Urawa | 1-0 Kasper Junker | Sanfrecce Hiroshima |
| 25.08.21 12:00 | Vegalta Sendai | 1-2 Hisashi Appiah Tawiah / Joan Oumari, Diego Oliveira | FC Tokyo |
| 25.08.21 12:00 | Yokohama FC | 3-1 Arthur Silva, Felipe Vizeu, Reo Yasunaga / Yuji Ono | Gamba Osaka |
| 25.08.21 12:30 | Cerezo Osaka | 1-5 Hiroshi Kiyotake / Shota Kobayashi, Tarik Elyounoussi,Akimi Barada, Yuki Ohashi, Kazuki Oiwa | Shonan Bellmare |
| ROUND 27 | |||
| 28.08.21 07:00 | Consadole Sapporo | 0-2 Yu Kobayashi, Daiya Tono | Kawasaki Frontale |
| 28.08.21 12:00 | Gamba Osaka | 0-1 Riku Matsuda | Cerezo Osaka |
| 28.08.21 12:00 | Sanfrecce Hiroshima | 4-1 Ezequiel, Shun Takagi (og), Junior Santos (2) / Naoki Nomura | Oita Trinita |
| 28.08.21 12:00 | Vissel Kobe | 0-1 Leandro | FC Tokyo |
| 28.08.21 12:00 | Yokohama F. Marinos | 0-2 Ryotaro Araki, Ayase Ueda | Kashima |
| 29.08.21 11:00 | Nagoya Grampus | 1-1 Naoki Maeda / Thiago Santana | Shimizu S-pulse |
| 29.08.21 12:00 | Avispa Fukuoka | 3-0 Takeshi Kanamori, John Mary (2) | Tokushima Vortis |
| 29.08.21 12:00 | Kashiwa Reysol | 2-1 Yusuke Segawa, Cristiano / Kazuma Watanabe | Yokohama FC |
| 29.08.21 12:00 | Shonan Bellmare | 0-0 | Urawa |
| 29.08.21 12:00 | Vegalta Sendai | 0-1 Eduardo | Sagan Tosu |
| ROUND 28 | |||
| 10.09.21 08:00 | Nagoya Grampus | 3-0 Mateus dos Santos Castro, Mu Kanazaki, Joel Fujita (k.k.) | Tokushima Vortis |
| 11.09.21 08:00 | Yokohama FC | 0-2 Koya Yuruki, Tomoaki Okubo | Urawa |
| 11.09.21 08:00 | Cerezo Osaka | 0-2 Douglas, Ryota Aoki | Consadole Sapporo |
| 11.09.21 08:00 | Sagan Tosu | 2-1 Ryohei Shirasaki, Eduardo / Thiago Santana | Shimizu S-pulse |
| 11.09.21 08:00 | Sanfrecce Hiroshima | 1-3 Douglas Vieira / Daizen Maeda, Yuki Saneto, Leo Ceara | Yokohama F. Marinos |
| 11.09.21 08:00 | Kashima Antlers | 0-3 Juanma Delgado (2), Yuya Yamagishi | Avispa Fukuoka |
| 11.09.21 08:00 | Oita Trinita | 2-0 Yuta Koide, Kohei Isa | Shonan Bellmare |
| 12.09.21 08:00 | FC Tokyo | 0-1 Mao Hosoya | Kashiwa Reysol |
| 12.09.21 08:00 | Gamba Osaka | 2-3 Shinya Yajima, Patric / Cayman Togashi (2), Takuma Nishimura | Vegalta Sendai |
| 29.09.21 | Kawasaki Frontale | 3-1 Leandro Damiao, Thomas Vermaelen (og), Akihiro Ienaga / Yoshinori Muto | Vissel Kobe |
| ROUND 29 | |||
| 18.09.21 08:00 | Sagan Tosu | 0-0 | Oita Trinita |
| 18.09.21 08:00 | FC Tokyo | 4-0 Diego Oliveira (2), Leandro (2) | Yokohama FC |
| 18.09.21 08:00 | Kashima | 3-1 Ayase Ueda, Juan Alano, Shoma Doi / Tiago Alves | Gamba Osaka |
| 18.09.21 08:00 | Kashiwa Reysol | 0-3 Douglas Vieira (3) | Sanfrecce Hiroshima |
| 18.09.21 08:00 | Shimizu S-pulse | 2-1 Thiago Santana, Noriaki Fujimoto / Felippe Cardoso | Vegalta Sendai |
| 18.09.21 08:00 | Shonan Bellmare | 1-1 Yuki Ohashi / Juanma Delgado | Avispa Fukuoka |
| 18.09.21 08:00 | Tokushima Vortis | 1-3 Kazunari Ichimi / Yasuto Wakizaka, Kei Chinen (2) | Kawasaki Frontale |
| 18.09.21 08:00 | Urawa | 2-0 Ataru Esaka, Koya Yuruki | Cerezo Osaka |
| 18.09.21 08:00 | Vissel Kobe | 1-0 Yuya Nakasaka | Consadole Sapporo |
| 18.09.21 08:00 | Nagoya Grampus | 2-1 Shinnosuke Nakatani, Jakub Swierczok / Kenyu Sugimoto | Yokohama F. Marinos |
| ROUND 30 | |||
| 24.09.21 08:00 | Shimizu S-pulse | 0-2 Yoshinori Muto, Leo Osaki | Vissel Kobe |
| 25.09.21 08:00 | Avispa Fukuoka | 3-0 Juanma Delgado, Yuya Yamagishi, Daiki Watari | Sagan Tosu |
| 25.09.21 08:00 | Yokohama FC | 2-2 Saulo (2) / Marcos Junior, Daizen Maeda | Yokohama F. Marinos |
| 25.09.21 08:00 | FC Tokyo | 1-2 Kyosuke Tagawa / Hiroki Sakai, Ataru Esaka | Urawa |
| 25.09.21 08:00 | Vegalta Sendai | 0-1 Hidenori Ishii | Tokushima Vortis |
| 26.09.21 08:00 | Cerezo Osaka | 1-2 Riki Harakawa / Ayase Ueda (2) | Kashima |
| 26.09.21 08:00 | Consadole Sapporo | 0-2 Sho Sasaki, Douglas Vieira | Sanfrecce Hiroshima |
| 26.09.21 08:00 | Gamba Osaka | 2-1 Takashi Usami, Shunya Suganuma / Yuta Kamiya | Kashiwa Reysol |
| 26.09.21 08:00 | Kawasaki Frontale | 2-1 Reo Hatate, Kei Chinen / Satoshi Tanaka | Shonan Bellmare |
| 26.09.21 08:00 | Nagoya Grampus | 1-0 Sho Inagaki | Oita Trinita |
| ROUND 31 | |||
| 01.10.21 08:00 | Shonan Bellmare | 0-1 Daizen Maeda | Yokohama F. Marinos |
| 02.10.21 08:00 | Avispa Fukuoka | 1-2 John Mary / Thiago Santana, Carlinhos Junior | Shimizu S-pulse |
| 02.10.21 08:00 | Gamba Osaka | 1-5 Patric / Yoshiaki Komai, Lucas Fernandes, Tomoki Takamine, Takuro Kaneko, Douglas | Consadole Sapporo |
| 02.10.21 08:00 | Kashima Antlers | 1-2 Ayase Ueda / Tatsuki Seko, Ryo Germain | Yokohama FC |
| 02.10.21 08:00 | Kashiwa Reysol | 1-1 Yuta Kamiya / Cayman Togashi | Vegalta Sendai |
| 02.10.21 08:00 | Kawasaki Frontale | 1-0 Leandro Damiao | FC Tokyo |
| 02.10.21 08:00 | Vissel Kobe | 5-1 Yuya Osako, Andres Iniesta (2), Yoshinori Muto, Bojan Krkic / Yoshio Koizumi | Urawa |
| 03.10.21 08:00 | Oita Trinita | 1-0 Yamato Machida | Cerezo Osaka |
| 03.10.21 08:00 | Sanfrecce Hiroshima | 1-0 Yuya Asano | Nagoya Grampus |
| 03.10.21 08:00 | Tokushima Vortis | 3-0 Yuki Kakita (2), Mushaga Bakenga | Sagan Tosu |
| ROUND 32 | |||
| 23-09.21 08:00 | FC Tokyo | 1-1 Adailton / Jakub Swierczok | Nagoya Grampus |
| 23-09.21 08:00 | Kashima Antlers | 1-2 Juan Alano / Kazuya Yamamura, Ten Miyagi | Kawasaki Frontale |
| 23-09.21 08:00 | Sanfrecce Hiroshima | 0-1 Ryosuke Shindo | Cerezo Osaka |
| 16.10.21 08:00 | Sagan Tosu | 1-1 Noriyoshi Sakai / Shuto Machino | Shonan Bellmare |
| 16.10.21 08:00 | Shimizu S-pulse | 0-1 Hiromu Mitsumaru | Kashiwa Reysol |
| 16.10.21 08:00 | Urawa | 1-1 Ataru Esaka / Patric | Gamba Osaka |
| 16.10.21 08:00 | Vissel Kobe | 1-0 Dyanfrez Douglas | Avispa Fukuoka |
| 16.10.21 08:00 | Yokohama F. Marinos | 2-1 Kenyu Sugimoto, Daizen Maeda / Daiki Suga | Consadole Sapporo |
| 16.10.21 08:00 | Yokohama FC | 5-3 Yusuke Matsuo, Saulo (2), Yuya Takagi, Kazuma Watanabe / Ken Iwao, Yuki Kakita (2) | Tokushima Vortis |
| 17.10.21 08:00 | Oita Trinita | 2-0 Arata Watanabe (2) | Vegalta Sendai |
| ROUND 33 | |||
| 22.10.21 08:00 | Urawa | 5-1 Koya Yuruki (2), Takahiro Sekine, Kasper Junker, Ataru Esaka / Savio Matheus | Kashiwa Reysol |
| 23.10.21 08:00 | Shonan Bellmare | 2-1 Yuki Ohashi, Naoki Yamada / Yusuke Matsuo | Yokohama FC |
| 23.10.21 08:00 | FC Tokyo | 1-2 Ryoma Watanabe / Arthur Caike, Ayase Ueda | Kashima |
| 23.10.21 08:00 | Vegalta Sendai | 2-0 Kunimitsu Sekiguchi, Ryoma Kida | Sanfrecce Hiroshima |
| 23.10.21 08:00 | Gamba Osaka | 1-0 Takashi Usami | Sagan Tosu |
| 23.10.21 08:00 | Tokushima Vortis | 1-1 Taisei Miyashiro / Yamato Machida | Oita Trinita |
| 24.10.21 08:00 | Cerezo Osaka | 2-1 Takashi Inui, Mutsuki Kato / Yuki Saneto | Yokohama F. Marinos |
| 24.10.21 08:00 | Consadole Sapporo | 0-0 | Avispa Fukuoka |
| 24.10.21 08:00 | Kawasaki Frontale | 10 Leandro Damiao | Shimizu S-pulse |
| 24.10.21 08:00 | Nagoya Grampus | 2-2 Naoki Maeda, Jakub Swierczok / Yoshinori Muto, Andres Iniesta | Vissel Kobe |
| ROUND 34 | |||
| 06-11-2021 | Shimizu S-pulse | 2-2 Thiago Santana, Yuta Taki / Takuro Kaneko, Kazuki Fukai | Consadole Sapporo |
| 06-11-2021 | Vissel Kobe | 1-0 Yuya Osako | Tokushima Vortis |
| 06-11-2021 | Yokohama F. Marinos | 8-0 Daizen Maeda (3), Marcos Junior, Ryuta Koike (2), Keigo Higashi (og), Kota Mizunuma | FC Tokyo |
| 07-11-2021 | Avispa Fukuoka | 1-1 Katsuya Iwatake (og) / Felipe Vizeu | Yokohama FC |
| 07-11-2021 | Kashima | 1-0 Shoma Doi | Urawa |
| 07-11-2021 | Kashiwa Reysol | 1-0 Takuma Ominami | Cerezo Osaka |
| 07-11-2021 | Oita Trinita | 2-3 Hiroki Fujiharu (og), Hiroto Goya / Patric (3) | Gamba Osaka |
| 07-11-2021 | Sagan Tosu | 3-1 Yuto Iwasaki, Noriyoshi Sakai, Tomoya Koyamatsu / Leandro Damiao | Kawasaki Frontale |
| 07-11-2021 | Shonan Bellmare | 0-0 | Sanfrecce Hiroshima |
| 07-11-2021 | Vegalta Sendai | 1-1 Takuma Nishimura / Yoichiro Kakitani | Nagoya Grampus |
| ROUND 35 | |||
| 03.11.21 | Avispa Fukuoka | 1-0 John Mary | Oita Trinita |
| 03.11.21 | Consadole Sapporo | 1-1 Ryota Aoki / Taiyo Hiraoka | Shonan Bellmare |
| 03.11.21 | FC Tokyo | 4-0 Adailton, Ronaldo (og), Diego Oliveira, Masato Morishige | Shimizu S-pulse |
| 03.11.21 | Kawasaki Frontale | 1-1 Jesiel / Hiroki Sakai | Urawa |
| 03.11.21 | Nagoya Grampus | 2-0 Jakub Swierczok, Shinnosuke Nakatani | Kashiwa Reysol |
| 03.11.21 | Sanfrecce Hiroshima | 1-4 Ezequiel / Arthur Caike (2), Ryotaro Araki, Keigo Tsunemoto | Kashima |
| 03.11.21 | Tokushima Vortis | 0-1 Mutsuki Kato | Cerezo Osaka |
| 03.11.21 | Vissel Kobe | 4-2 Yoshinori Muto, Dyanfrez Douglas, Hotaru Yamaguchi, Lincoln / Takumi Mase, Chihiro Kato | Vegalta Sendai |
| 03.11.21 | Yokohama F. Marinos | 0-1 Shu Kurata | Gamba Osaka |
| 03.11.21 | Yokohama FC | 0-0 | Sagan Tosu |
| ROUND 36 | |||
| 20.11.21 09:00 | Cerezo Osaka | 1-4 Hiroaki Okuno / Leandro Damiao (2), Marcinho, Ten Miyagi | Kawasaki Frontale |
| 20.11.21 09:00 | FC Tokyo | 0-2 Joel Chima Fujita, Yuki Kakita | Tokushima Vortis |
| 20.11.21 09:00 | Gamba Osaka | 1-3 Patric / Jakub Swierczok (2), Yoichiro Kakitani | Nagoya Grampus |
| 20.11.21 09:00 | Kashima Antlers | 0-0 | Oita Trinita |
| 20.11.21 09:00 | Kashiwa Reysol | 0-0 | Avispa Fukuoka |
| 20.11.21 09:00 | Sagan Tosu | 1-0 Yuta Higuchi | Consadole Sapporo |
| 20.11.21 09:00 | Shimizu S-pulse | 1-0 Thiago Santana | Sanfrecce Hiroshima |
| 20.11.21 09:00 | Urawa | 2-1 Atsuki Ito, Tatsuya Tanaka / Leo Ceara | Yokohama F. Marinos |
| 20.11.21 09:00 | Vegalta Sendai | 0-2 Wellington, Takuya Okamoto | Shonan Bellmare |
| 20.11.21 09:00 | Yokohama FC | 0-2 Yuya Osako, Andres Iniesta | Vissel Kobe |
| ROUND 37 | |||
| 27.11.21 09:00 | Avispa Fukuoka | 2-2 Jordy Croux, Takeshi Kanamori / Ryoma Kida (2) | Vegalta Sendai |
| 27.11.21 09:00 | Cerezo Osaka | 2-1 Mitchell Langerak (og), Ryuya Nishio / Yoichiro Kakitani | Nagoya Grampus |
| 27.11.21 09:00 | Consadole Sapporo | 3-1 Milan Tucic (2), Tsuyoshi Ogashiwa / Cristiano | Kashiwa Reysol |
| 27.11.21 09:00 | Kashima | 1-0 Ayase Ueda | Sagan Tosu |
| 27.11.21 09:00 | Kawasaki Frontale | 4-1 Leandro Damiao (2), Reo Hatate, Shintaro Kurumaya / Takashi Usami | Gamba Osaka |
| 27.11.21 09:00 | Oita Trinita | 2-0 Yamato Machida, Hideto Takahashi (og) | Yokohama FC |
| 27.11.21 09:00 | Sanfrecce Hiroshima | 1-2 Tsukasa Shiotani / Adailton, Kazuya Konno | FC Tokyo |
| 27.11.21 09:00 | Shonan Bellmare | 0-1 Takeru Kishimoto | Tokushima Vortis |
| 27.11.21 09:00 | Urawa | 0-1 Keita Nakamura | Shimizu S-pulse |
| 27.11.21 09:00 | Vissel Kobe | 0-2 Daizen Maeda, Teruhito Nakagawa | Yokohama F. Marinos |
| ROUND 38 | |||
| 04.12.21 09:00 | FC Tokyo | 0-0 | Avispa Fukuoka |
| 04.12.21 09:00 | Gamba Osaka | 0-0 | Shonan Bellmare |
| 04.12.21 09:00 | Kashiwa Reysol | 2-3 Sachiro Toshima, Savio Matheus / Asahi Masuyama, Arata Watanabe, Hokuto Shimoda | Oita Trinita |
| 04.12.21 09:00 | Nagoya Grampus | 0-0 | Urawa |
| 04.12.21 09:00 | Sagan Tosu | 0-2 Yuya Osako, Junya Tanaka | Vissel Kobe |
| 04.12.21 09:00 | Shimizu S-pulse | 2-1 Yoshinori Suzuki, Kenta Nishizawa / Ryo Takeuchi (og) | Cerezo Osaka |
| 04.12.21 09:00 | Tokushima Vortis | 2-4 Takeru Kishimoto, Kazunari Ichimi / Tomoya Fujii, Ezequiel (2), Yuya Asano | Sanfrecce Hiroshima |
| 04.12.21 09:00 | Vegalta Sendai | 0-1 Diego Pituca | Kashima |
| 04.12.21 09:00 | Yokohama F. Marinos | 1-1 Daizen Maeda / Leandro Damiao | Kawasaki Frontale |
| 04.12.21 09:00 | Yokohama FC | 0-1 Tsuyoshi Ogashiwa | Consadole Sapporo |
