| ROUND 1 | |||
|---|---|---|---|
| 19.07.21 23:00 | Central Cordoba de Santiago (13) | 1-1 Milton Gimenez / Giuliano Galoppo | Banfield (12) |
| 20.07.21 01:15 | Godoy Cruz (10) | 2-1 Bruno Sosa, Ezequiel Bullaude / Bruno Sosa '74 Guillermo Ortiz '80 Ezequiel Bullaude | Rosario Central (19) |
| 18.07.21 18:30 | Huracan (14) | 2-1 Enrique Triverio, Santiago Hezze / Lucas Barrios | Defensa Y Justicia (26) |
| 18.07.21 20:45 | Arsenal Sarandi (16) | 1-1 Mateo Carabajal / Nicolas Fernandez | San Lorenzo (3) |
| 18.07.21 23:00 | River Plate (6) | 1-2 Matias Suarez / Rodrigo Aliendro, Yeiler Goez | Colon Santa Fe (5) |
| 19.07.21 01:15 | Independiente (1) | 0-0 | Argentinos Jrs (15) |
| 17.07.21 02:15 | Sarmiento Junin (21) | 0-3 Juan Apaolaza, Manuel Castro, Juan Apaolaza | Estudiantes L.P. (17) |
| 17.07.21 18:30 | Aldosivi (20) | 0-2 Sebastian Sosa, Franco Leys | Patronato (8) |
| 17.07.21 20:45 | Lanus (4) | 4-2 Jose Lopez, Jose Sand (2), Victor Malcorra / Leonardo Heredia, Ramiro Carrera | Atletico Tucuman (9) |
| 17.07.21 20:45 | Newells Old Boys (7) | 3-2 Gabriel Compagnucci, Juan Garro, Jonathan Cristaldo / Michael Santos, Carlos Auzqui | Talleres Cordoba (18) |
| 17.07.21 23:00 | Gimnasia L.P. (11) | 2-2 Matias Perez Garcia, Guillermo Fratta / Brian Mansilla, Matias Tissera | Platense (23) |
| 18.07.21 01:15 | Velez Sarsfield (22) | 0-0 | Racing Club (2) |
| 17.07.21 00:00 | Union Santa Fe (25) | 1-1 Fernando Marquez / Agustin Obando | Boca Juniors (24) |
| ROUND 2 | |||
| 26.07.21 23:00 | Talleres Cordoba (18) | 2-0 Carlos Auzqui, Diego Valoyes | Arsenal Sarandi (16) |
| 27.07.21 01:15 | Argentinos Jrs (15) | 1-0 Lucas Villalba | Newells Old Boys (7) |
| 25.07.21 18:30 | Defensa Y Justicia (26) | 1-2 Miguel Merentiel / Sebastian Lomonaco, Martin Ojeda | Godoy Cruz (10) |
| 25.07.21 18:30 | Patronato (8) | 2-0 Sebastian Sosa, Brian Nievas | Sarmiento Junin (21) |
| 25.07.21 20:45 | Rosario Central (19) | 1-0 Emiliano Vecchio | Velez Sarsfield (22) |
| 25.07.21 23:00 | River Plate (6) | 4-0 Braian Romero, Matias Suarez, Nicolas De La Cruz, Paulo Diaz | Union Santa Fe (25) |
| 26.07.21 01:15 | Estudiantes L.P. (17) | 0-1 Juan Insaurralde | Independiente (1) |
| 24.07.21 02:15 | Platense (23) | 0-1 Brian Guzman | Aldosivi (20) |
| 24.07.21 18:30 | Colon Santa Fe (5) | 1-4 Facundo Farias / Angel Gonzalez, Jose Sand (3) | Lanus (4) |
| 24.07.21 20:45 | San Lorenzo (3) | 1-0 Alexis Sabella | Central Cordoba de Santiago (13) |
| 24.07.21 23:00 | Racing Club (2) | 0-0 | Gimnasia L.P. (11) |
| 25.07.21 01:15 | Banfield (12) | 0-0 | Boca Juniors (24) |
| 24.07.21 00:00 | Atletico Tucuman (9) | 1-0 Ramiro Carrera | Huracan (14) |
| ROUND 3 | |||
| 30.07.21 02:00 | Newells Old Boys (7) | 4-2 Ignacio Scocco, Nicolas Castro (2), Justo Giani / Manuel Castro (2) | Estudiantes L.P. (17) |
| 29.07.21 02:00 | Lanus (4) | 0-3 Bruno Zuculini, Nicolas De La Cruz (2) | River Plate (6) |
| 29.07.21 19:15 | Central Cordoba de Santiago (13) | 2-1 Juan Cruz Komar (k.k.), Milton Gimenez / Enzo Hernan Diaz | Talleres Cordoba (18) |
| 29.07.21 21:30 | Arsenal Sarandi (16) | 1-0 Bruno Christian Sepulveda | Argentinos Jrs (15) |
| 29.07.21 23:45 | Gimnasia L.P. (11) | 1-0 Leonardo Morales | Rosario Central (19) |
| 28.07.21 02:00 | Boca Juniors (24) | 0-2 Gino Peruzzi, Nestor Ortigoza | San Lorenzo (3) |
| 28.07.21 19:15 | Godoy Cruz (10) | 1-2 Matias Ramirez / Ramiro Carrera, Guillermo Acosta | Atletico Tucuman (9) |
| 28.07.21 19:15 | Union Santa Fe (25) | 0-1 Juan Manuel Cruz | Banfield (12) |
| 28.07.21 21:30 | Sarmiento Junin (21) | 1-0 Luciano Gondou | Platense (23) |
| 28.07.21 21:30 | Velez Sarsfield (22) | 0-0 | Defensa Y Justicia (26) |
| 28.07.21 23:45 | Independiente (1) | 2-0 Andres Roa, Silvio Romero | Patronato (8) |
| 27.07.21 21:30 | Huracan (14) | 1-1 Jhonatan Candia / Wilson Morelo | Colon Santa Fe (5) |
| 27.07.21 23:45 | Aldosivi (20) | 0-2 Marcelo Correa, Ignacio Piatti | Racing Club (2) |
| ROUND 4 | |||
| 31.07.21 18:30 | Colon Santa Fe (5) | 1-0 Cristian Ferreira | Godoy Cruz (10) |
| 31.07.21 20:45 | Lanus (4) | 1-1 Jose Sand / Martin Ezequiel Canete | Union Santa Fe (25) |
| 31.07.21 23:00 | Racing Club (2) | 1-0 Benjamin Garre | Sarmiento Junin (21) |
| 01.08.21 01:15 | Platense (23) | 1-1 Augusto Schott / Andres Roa | Independiente (1) |
| 01.08.21 18:30 | Defensa Y Justicia (26) | 3-2 Francisco Pizzini, Walter Bou, Rodrigo Contreras / Guillermo Fratta, Garcia Matias Perez | Gimnasia L.P. (11) |
| 01.08.21 20:45 | Talleres Cordoba (18) | 0-0 | Boca Juniors (24) |
| 01.08.21 23:00 | River Plate (6) | 1-1 Braian Romero / Nicolas Silva | Huracan (14) |
| 02.08.21 01:15 | San Lorenzo (3) | 1-1 Nicolas Fernandez / Ramiro Enrique | Banfield (12) |
| 02.08.21 21:45 | Argentinos Jrs (15) | 1-1 Mateo Agustin Coronel / Alejandro Martinez | Central Cordoba de Santiago (13) |
| 02.08.21 21:45 | Patronato (8) | 0-0 | Newells Old Boys (7) |
| 03.08.21 00:00 | Estudiantes L.P. (17) | 4-0 Leandro Nicolas Diaz, Manuel Castro, Fabian Noguera, Leonardo Godoy | Arsenal Sarandi (16) |
| 03.08.21 00:00 | Rosario Central (19) | 1-2 Gaston Avila / Gaston Andres Lodico (2) | Aldosivi (20) |
| 03.08.21 02:15 | Atletico Tucuman (9) | 0-0 | Velez Sarsfield (22) |
| ROUND 5 | |||
| 07.08.21 00:00 | Sarmiento Junin (21) | 1-0 Gabriel Graciani | Rosario Central (19) |
| 07.08.21 02:15 | Newells Old Boys (7) | 1-0 Ignacio Scocco | Platense (23) |
| 07.08.21 18:30 | Banfield (12) | 0-1 Angelo Martino | Talleres Cordoba (18) |
| 07.08.21 20:45 | Union Santa Fe (25) | 4-0 Federico Gattoni (k.k.), Fernando Marquez, Lucas Esquivel, Cristian Insaurralde | San Lorenzo (3) |
| 07.08.21 23:00 | Huracan (14) | 0-1 Jose Sand | Lanus (4) |
| 08.08.21 01:15 | Godoy Cruz (10) | 2-1 Martin Ojeda (2) / Julian Alvarez | River Plate (6) |
| 08.08.21 18:30 | Gimnasia L.P. (11) | 1-0 Brahian Aleman | Atletico Tucuman (9) |
| 08.08.21 20:45 | Velez Sarsfield (22) | 0-1 Facundo Farias | Colon Santa Fe (5) |
| 08.08.21 23:00 | Boca Juniors (24) | 1-1 Sebastian Martinez (k.k.) / Matias Romero | Argentinos Jrs (15) |
| 09.08.21 01:15 | Independiente (1) | 1-0 Silvio Romero | Racing Club (2) |
| 09.08.21 23:00 | Aldosivi (20) | 1-0 Gaston Lodico | Defensa Y Justicia (26) |
| 09.08.21 23:00 | Arsenal Sarandi (16) | 2-2 Alan Ruiz, Leonel Picco / Oliver Paz Benitez, Junior Arias | Patronato (8) |
| 10.08.21 01:15 | Central Cordoba de Santiago (13) | 1-2 Milton Gimenez / Juan Apaolaza, Gustavo Del Prete | Estudiantes L.P. (17) |
| ROUND 6 | |||
| 14.08.21 00:00 | Colon Santa Fe (5) | 1-0 Eric Meza | Gimnasia L.P. (11) |
| 14.08.21 02:15 | Huracan (14) | 0-0 | Union Santa Fe (25) |
| 14.08.21 18:30 | Atletico Tucuman (9) | 2-2 Augusto Lotti, Joaquin Pereyra / Martin Cauteruccio (2) | Aldosivi (20) |
| 14.08.21 20:45 | Argentinos Jrs (15) | 2-0 Nicolas Reniero, Gabriel Carabajal | Banfield (12) |
| 14.08.21 23:00 | River Plate (6) | 2-0 Enzo Fernandez, Braian Romero | Velez Sarsfield (22) |
| 15.08.21 01:15 | Rosario Central (19) | 1-2 Ignacio Russo / Silvio Romero (2) | Independiente (1) |
| 15.08.21 18:30 | Patronato (8) | 1-0 Leandro Marin | Central Cordoba de Santiago (13) |
| 15.08.21 20:45 | Platense (23) | 2-1 Mauro Bogado, Lucas Acevedo / Brian Farioli | Arsenal Sarandi (16) |
| 15.08.21 23:00 | Estudiantes L.P. (17) | 1-0 Fabian Noguera | Boca Juniors (24) |
| 16.08.21 01:15 | Racing Club (2) | 2-0 Tomas Chancalay, Fabricio Dominguez | Newells Old Boys (7) |
| 16.08.21 23:00 | Talleres Cordoba (18) | 2-0 Enzo Diaz, Hector Fertoli | San Lorenzo (3) |
| 17.08.21 01:15 | Defensa Y Justicia (26) | 4-2 Rodrigo Contreras, Francisco Pizzini, Carlos Rotondi, Lucas Barrios / Jonathan Torres (2) | Sarmiento Junin (21) |
| 17.08.21 01:15 | Lanus (4) | 3-1 Ignacio Malcorra, Jose Manuel Lopez, Jose Sand / Ezequiel Bullaude | Godoy Cruz (10) |
| ROUND 7 | |||
| 20.08.21 22:00 | Aldosivi (20) | 3-0 Martin Cauteruccio (2), Federico Gino | Colon Santa Fe (5) |
| 20.08.21 22:00 | Sarmiento Junin (21) | 3-0 Lautaro Montoya, Patricio Cucchi, Luciano Gondou | Atletico Tucuman (9) |
| 20.08.21 22:00 | Independiente (1) | 0-0 | Defensa Y Justicia (26) |
| 20.08.21 22:00 | Banfield (12) | 1-1 Jesus Datolo / Manuel Castro | Estudiantes L.P. (17) |
| 21.08.21 22:00 | Arsenal Sarandi (16) | 0-3 Tomas Chancalay (2), Dario Cvitanich | Racing Club (2) |
| 21.08.21 22:00 | Boca Juniors (24) | 1-0 Luis Vazquez | Patronato (8) |
| 21.08.21 22:00 | Central Cordoba de Santiago (13) | 2-2 Alejandro Martinez, Milton Gimenez / Augusto Schott, Gonzalo Bettini (og) | Platense (23) |
| 21.08.21 22:00 | Velez Sarsfield (22) | 5-1 Agustin Bouzat, Thiago Almada, Santiago Caseres, Francisco Ortega, Ricardo Centurion / Tomas Belmonte | Lanus (4) |
| 21.08.21 22:00 | Godoy Cruz (10) | 1-1 Martin Ojeda / Elias Lopez (og) | Huracan (14) |
| 22.08.21 22:00 | Newells Old Boys (7) | 1-1 Nicolas Castro / Damian Martinez | Rosario Central (19) |
| 22.08.21 22:00 | San Lorenzo (3) | 0-1 Nicolas Reniero | Argentinos Jrs (15) |
| 22.08.21 22:00 | Union Santa Fe (25) | 1-2 Juan Manuel Garcia / Mateo Retegui, Julian Malatini | Talleres Cordoba (18) |
| 22.08.21 22:00 | Gimnasia L.P. (11) | 1-1 Luis Miguel Rodriguez / Matias Suarez | River Plate (6) |
| ROUND 8 | |||
| 24.08.21 22:00 | Patronato | 1-1 Nicolas Delgadillo / Luciano Pons | Banfield |
| 24.08.21 22:00 | Colon Santa Fe | 1-1 Cristian Ferreira / Guido Mainero | Sarmiento Junin |
| 24.08.21 22:00 | Atletico Tucuman (9) | 2-0 Franco Mussis, Renzo Ivan Tesuri | Independiente (1) |
| 24.08.21 22:00 | Racing Club | 0-0 | Central Cordoba de Santiago |
| 25.08.21 22:00 | Defensa Y Justicia | 2-0 Gabriel Hachen, Francisco Pizzini | Newells Old Boys |
| 25.08.21 22:00 | Argentinos Jrs (15) | 1-2 Jonathan Gomez / Enzo Diaz, Michael Santos | Talleres Cordoba (18) |
| 25.08.21 22:00 | Estudiantes L.P. | 2-0 Nicolas Pasquini (2) | San Lorenzo |
| 25.08.21 22:00 | Godoy Cruz | 1-2 Sebastian Lomonaco / Emanuel Britez, Nicolas Cordero | Union Santa Fe |
| 25.08.21 22:00 | Huracan | 1-1 Jhonatan Candia / Luca Orellano | Velez Sarsfield |
| 25.08.21 22:00 | Lanus | 2-0 Jose Manuel Lopez, Angel Gonzalez | Gimnasia L.P. |
| 25.08.21 22:00 | Platense | 1-3 Nicolas Bertolo / Norberto Briasco, Diego Gonzalez, Cristian Pavon | Boca Juniors |
| 26.08.21 22:00 | River Plate | 2-0 Julian Alvarez, Enzo Perez | Aldosivi |
| 25.08.21 22:00 | Rosario Central | 4-0 Lucas Gamba (3), Marco Ruben | Arsenal Sarandi |
| ROUND 9 | |||
| 28.08.21 22:00 | Independiente | 3-0 Alan Sonora (2), Andres Roa | Colon Santa Fe |
| 28.08.21 22:00 | Gimnasia L.P. | 0-0 | Huracan |
| 28.08.21 22:00 | Banfield | 2-4 Jesus Datolo, Juan Manuel Cruz / Matias Tissera, Brian Mansilla, Facundo Curuchet (2) | Platense |
| 29.08.21 22:00 | Aldosivi | 2-3 Martin Cauteruccio (2) / ose Manuel Lopez, Jose Sand (2) | Lanus |
| 29.08.21 22:00 | Velez Sarsfield | 3-0 Federico Mancuello, Nestor Breitenbruch (og), Agustin Bouzat | Godoy Cruz |
| 29.08.21 22:00 | Arsenal Sarandi | 0-0 | Defensa Y Justicia |
| 29.08.21 22:00 | Boca Juniors | 0-0 | Racing Club |
| 29.08.21 22:00 | Central Cordoba de Santiago | 2-4 Milton Gimenez, Sebastian Ribas / Gaston Avila, Marco Ruben (2), Facundo Almada | Rosario Central |
| 29.08.21 22:00 | Newells Old Boys | 1-2 Ignacio Scocco / Franco Mussis, Augusto Lotti | Atletico Tucuman |
| 29.08.21 22:00 | San Lorenzo | 3-0 Nicolas Fernandez, Cristian Zapata, Franco Di Santo | Patronato |
| 29.08.21 22:00 | Sarmiento Junin | 1-2 Gabriel Alanis / Jorge Carrascal, Enzo Perez | River Plate |
| 29.08.21 22:00 | Talleres Cordoba | 2-0 Mariano Andujar (og), Carlos Auzqui | Estudiantes L.P. |
| 29.08.21 22:00 | Union Santa Fe | 1-0 Nicolas Cordero | Argentinos Jrs |
| ROUND 10 | |||
| 03.09.21 22:00 | Huracan | 2-0 Franco Cristaldo, Claudio Yacob | Aldosivi |
| 03.09.21 22:00 | Defensa Y Justicia | 1-1 Gabriel Hachen / Pablo Arganaraz | Central Cordoba de Santiago |
| 04.09.21 22:00 | Atletico Tucuman | 0-0 | Arsenal Sarandi |
| 04.09.21 22:00 | Colon Santa Fe | 1-1 Facundo Farias / Facundo Mansilla | Newells Old Boys |
| 04.09.21 22:00 | Lanus | 1-1 Jose Sand / Gabriel Alanis | Sarmiento Junin |
| 04.09.21 22:00 | Rosario Central | 1-2 Gaston Avila / Luis Vazquez, Fernando Torrent (og) | Boca Juniors |
| 04.09.21 22:00 | Platense | 1-1 Brian Mansilla / Franco Di Santo | San Lorenzo |
| 05.09.21 22:00 | River Plate | 1-1 Braian Romero / Fabricio Bustos | Independiente |
| 05.09.21 22:00 | Patronato | 0-0 | Talleres Cordoba |
| 05.09.21 22:00 | Racing Club | 0-0 | Banfield |
| 05.09.21 22:00 | Godoy Cruz | 4-0 Damian Perez, Ezequiel Bullaude, Martin Ojeda (2) | Gimnasia L.P. |
| 06.09.21 22:00 | Estudiantes L.P. | 1-1 Matias Pellegrini / Gabriel Florentin | Argentinos Jrs |
| 06.09.21 22:00 | Velez Sarsfield | 4-0 Luca Orellano, Juan Lucero, Lucas Janson, Ricardo Centurion | Union Santa Fe |
| ROUND 11 | |||
| 13.09.21 22:00 | Gimnasia L.P. | 0-0 | Velez Sarsfield |
| 13.09.21 22:00 | Independiente | 0-1 Jose Manuel Lopez | Lanus |
| 13.09.21 22:00 | Sarmiento Junin | 0-0 | Huracan |
| 13.09.21 22:00 | San Lorenzo | 1-1 Alexis Sabella / Nery Dominguez | Racing Club |
| 13.09.21 22:00 | Aldosivi | 1-4 Martin Cauteruccio / Martin Ojeda, Sebastian Lomonaco, Ezequiel Bullaude, Elias Lopez | Godoy Cruz |
| 14.09.21 22:00 | Arsenal Sarandi | 0-0 | Colon Santa Fe |
| 14.09.21 22:00 | Talleres Cordoba | 2-1 Hector Fertoli, Carlos Auzqui / Augusto Schott | Platense |
| 14.09.21 22:00 | Central Cordoba de Santiago | 2-0 Lucas Melano (2) | Atletico Tucuman |
| 14.09.21 22:00 | Boca Juniors | 0-0 | Defensa Y Justicia |
| 16.09.21 22:00 | Banfield | 1-2 Juan Manuel Cruz / Marco Ruben (2) | Rosario Central |
| 16.09.21 22:00 | Argentinos Jrs | 1-1 Nicolas Reniero / Arias Junior | Patronato |
| 16.09.21 22:00 | Newells Old Boys | 1-4 Ignacio Scocco / Diego Nicolas De La Cruz, Julian Alvarez (2), Jorge Andres Carrascal | River Plate |
| 16.09.21 22:00 | Union Santa Fe | 0-2 Gustavo Del Prete, Manuel Castro | Estudiantes L.P. |
| ROUND 12 | |||
| 18.09.21 22:00 | Atletico Tucuman | 1-2 Lisandro Lopez (og) / Lisandro Lopez, Rodrigo Montes | Boca Juniors |
| 18.09.21 22:00 | Racing Club | 1-2 Lisandro Lopez / Michael Santos, Enzo Diaz | Talleres Cordoba |
| 18.09.21 22:00 | Godoy Cruz | 1-1 Cristian Colman / Jonathan Torres | Sarmiento Junin |
| 18.09.21 22:00 | Velez Sarsfield | 3-2 Thiago Almada (2), Juan Lucero / Francisco Cerro, Martin Cauteruccio | Aldosivi |
| 19.09.21 22:00 | Colon Santa Fe | 1-0 Rodrigo Aliendro | Central Cordoba de Santiago |
| 19.09.21 22:00 | Huracan | 0-1 Alan Sonora | Independiente |
| 19.09.21 22:00 | Platense | 0-0 | Argentinos Jrs |
| 19.09.21 22:00 | River Plate | 1-0 Emiliano Mendez (og) | Arsenal Sarandi |
| 19.09.21 22:00 | Patronato | 1-2 Sebastian Sosa / Juan Apaolaza, Gustavo Del Prete | Estudiantes L.P. |
| 20.09.21 22:00 | Defensa Y Justicia | 0-0 | Banfield |
| 20.09.21 22:00 | Gimnasia L.P. | 1-0 German Guiffrey | Union Santa Fe |
| 20.09.21 22:00 | Lanus | 1-2 Jose Manuel Lopez / Nicolas Castro (2) | Newells Old Boys |
| 20.09.21 22:00 | Rosario Central | 1-0 Luca Dupuy | San Lorenzo |
| ROUND 13 | |||
| 25.09.21 22:00 | Aldosivi | 1-3 Francisco Grahl / Luis Miguel Rodriguez, Nicolas Contin (2) | Gimnasia L.P. |
| 25.09.21 22:00 | Arsenal Sarandi | 1-0 Bruno Sepulveda | Lanus |
| 25.09.21 22:00 | Talleres Cordoba | 4-1 Diego Valoyes, Nahuel Tenaglia, Mateo Retegui (2) / Alan Marinelli | Rosario Central |
| 25.09.21 22:00 | Sarmiento Junin | 0-1 Juan Lucero | Velez Sarsfield |
| 25.09.21 22:00 | Banfield | 2-0 Juan Manuel Cruz (2) | Atletico Tucuman |
| 25.09.21 22:00 | Central Cordoba de Santiago | 1-3 Leonardo Sequeira / Jorge Carrascal, Julian Alvarez, Braian Romero | River Plate |
| 25.09.21 22:00 | Estudiantes L.P. | 1-1 Gustavo Del Prete / Matias Tissera | Platense |
| 26.09.21 22:00 | Union Santa Fe | 2-0 Mauro Luna Diale (2) | Patronato |
| 26.09.21 22:00 | Independiente | 1-4 Rodrigo Marquez / Martin Ojeda, Thomas Ortega (og), Tomas Badaloni, Ezequiel Bullaude | Godoy Cruz |
| 26.09.21 22:00 | San Lorenzo | 2-1 Nicolas Ezequiel Fernandez Mercau, Siro Cabral / Francisco Pizzini | Defensa Y Justicia |
| 26.09.21 22:00 | Boca Juniors | 1-0 Nicolas Orsini | Colon Santa Fe |
| 27.09.21 22:00 | Newells Old Boys | 0-1 Matias Coccaro | Huracan |
| 27.09.21 22:00 | Argentinos Jrs | 2-0 Javier Cabrera, Kevin Mac Allister | Racing Club |
| ROUND 14 | |||
| 01.10.21 22:00 | Aldosivi | 1-2 Emanuel Britez (og) / Gaston Gonzalez (2) | Union Santa Fe |
| 01.10.21 22:00 | Lanus | 2-1 Jose Manuel Lopez, Ignacio Malcorra / Leonardo Sequeira | Central Cordoba de Santiago |
| 02.10.21 22:00 | Atletico Tucuman | 0-0 | San Lorenzo |
| 02.10.21 22:00 | Platense | 0-0 | Patronato |
| 02.10.21 22:00 | Huracan | 1-0 Matias Coccaro | Arsenal Sarandi |
| 02.10.21 22:00 | Velez Sarsfield | 3-3 Juan Lucero, Thiago Almada, Matias De Los Santos / Silvio Romero (2), Ayrton Enrique Costa | Independiente |
| 02.10.21 22:00 | Godoy Cruz | 2-2 Martin Ojeda (2) / Leonel Gonzalez (og), Jonathan Cristaldo | Newells Old Boys |
| 03.10.21 22:00 | Gimnasia L.P. | 0-1 Jonathan Torres | Sarmiento Junin |
| 03.10.21 22:00 | Racing Club | 1-1 Anibal Moreno / Leonardo Godoy | Estudiantes L.P. |
| 03.10.21 22:00 | River Plate | 2-1 Julian Alvarez (2)/ Carlos Zambrano | Boca Juniors |
| 03.10.21 22:00 | Rosario Central | 0-1 Gabriel Carabajal | Argentinos Jrs |
| 04.10.21 22:00 | Colon Santa Fe | 0-0 | Banfield |
| 04.10.21 22:00 | Defensa Y Justicia | 3-0 Miguel Merentiel (2), Hugo Silva | Talleres Cordoba |
| ROUND 15 | |||
| 08.10.21 22:00 | Union Santa Fe | 1-2 Juan Garcia / Matias Tissera, Kevin Lomonaco | Platense |
| 08.10.21 22:00 | Central Cordoba de Santiago | 1-2 Sebastian Ribas / Fabian Henriquez, Cesar Ibanez | Huracan |
| 09.10.21 22:00 | Argentinos Jrs | 0-2 Nicolas Tripichio, Walter Bou | Defensa Y Justicia |
| 09.10.21 22:00 | Estudiantes L.P. | 2-2 Manuel Castro, Jaime Ayovi / Gino Infantino (2) | Rosario Central |
| 09.10.21 22:00 | Newells Old Boys | 1-2 Juan Fernando Garro / Juan Lucero, Cristian Tarragona | Velez Sarsfield |
| 09.10.21 22:00 | Patronato | 1-2 Fabio Vazquez / Lisandro Lopez, Enzo Copetti | Racing Club |
| 09.10.21 22:00 | Sarmiento Junin | 3-0 Luciano Gondou, Braian Salvareschi, Jair Arismendi | Aldosivi |
| 10.10.21 22:00 | Banfield | 0-1 Gustavo Canto (og) | River Plate |
| 10.10.21 22:00 | Boca Juniors | 4-2 Marcelo Weigandt, Agustin Almendra, Cristian Pavon, Luis Vazquez / Ignacio Malcorra, Diego Braghieri | Lanus |
| 11.10.21 22:00 | Independiente | 1-1 Silvio Romero / Johan Carbonero | Gimnasia L.P. |
| 11.10.21 22:00 | Arsenal Sarandi | 0-0 | Godoy Cruz |
| 11.10.21 22:00 | San Lorenzo | 1-2 Agustin Martegani / Paolo Goltz, Eric Meza | Colon Santa Fe |
| 11.10.21 22:00 | Talleres Cordoba | 2-0 Nahuel Tenaglia, Michael Santos | Atletico Tucuman |
| ROUND 16 | |||
| 15.10.21 22:00 | Godoy Cruz | 0-0 | Central Cordoba de Santiago |
| 15.10.21 22:00 | Rosario Central | 3-2 Marco Ruben, Luciano Ferreyra, Emiliano Vecchio / Sebastian Sosa (2) | Patronato |
| 16.10.21 22:00 | Defensa Y Justicia | 2-1 Miguel Merentiel, Walter Bou / Gustavo Del Prete | Estudiantes L.P. |
| 16.10.21 22:00 | Velez Sarsfield | 0-0 | Arsenal Sarandi |
| 16.10.21 22:00 | Sarmiento Junin | 3-4 Jonathan Torres, Gabriel Alanis, Luciano Gondou / Gaston Gonzalez (2), Franco Calderon, Mauro Luna | Union Santa Fe |
| 16.10.21 22:00 | Gimnasia L.P. | 1-0 Johan Carbonero | Newells Old Boys |
| 16.10.21 22:00 | Huracan | 0-3 Agustin Almendra, Luis Vazquez, Marcos Rojo | Boca Juniors |
| 16.10.21 22:00 | Lanus | 1-1 Jose Manuel Lopez / Juan Manuel Cruz | Banfield |
| 16.10.21 22:00 | Racing Club | 0-1 Hernan Lamberti | Platense |
| 17.10.21 22:00 | River Plate | 3-1 Julian Alvarez (3) / Nicolas Ezequiel Fernandez Mercau | San Lorenzo |
| 17.10.21 22:00 | Aldosivi | 1-0 Martin Cauteruccio | Independiente |
| 17.10.21 22:00 | Colon Santa Fe | 1-0 Alexis Castro | Talleres Cordoba |
| 17.10.21 22:00 | Atletico Tucuman | 4-3 Ramiro Ruiz Rodriguez, Ramiro Carrera, Augusto Lotti, Marcelo Ortiz / Nicolas Reniero, Mateo Coronel, Kevin Mac Allister | Argentinos Jrs |
| ROUND 17 | |||
| 19.10.21 22:00 | Platense | 1-1 Matias Tissera / Lucas Gamba | Rosario Central |
| 19.10.21 22:00 | Union Santa Fe | 1-1 Franco Calderon / Enzo Copetti | Racing Club |
| 20.10.21 22:00 | Arsenal Sarandi | 0-1 Johan Carbonero | Gimnasia L.P. |
| 20.10.21 22:00 | Banfield | 1-4 Juan Manuel Cruz / Enrique Triverio, Jonas Acevedo, Matias Coccaro (2) | Huracan |
| 20.10.21 22:00 | Boca Juniors | 2-1 Frank Fabra, Luis Vazquez / Tomas Badaloni | Godoy Cruz |
| 20.10.21 22:00 | Central Cordoba de Santiago | 1-2 Alejandro Martinez, Federico Mancuello / Juan Lucero | Velez Sarsfield |
| 20.10.21 22:00 | Estudiantes L.P. | 1-1 Leandro Diaz / Agustin Rogel (og) | Atletico Tucuman |
| 20.10.21 22:00 | Patronato | 3-3 Matias Ibanez, Junior Arias, Ezequiel Unsain (og) / Francisco Pizzini, Nicolas Tripichio, Carlos Rotondi | Defensa Y Justicia |
| 20.10.21 22:00 | San Lorenzo | 1-3 Marcelo Herrera / Lautaro Acosta, Pedro De La Vega, Angel Gonzalez | Lanus |
| 21.10.21 22:00 | Independiente | 1-1 Lucas Romero / Luciano Gondou | Sarmiento Junin |
| 21.10.21 22:00 | Newells Old Boys | 0-0 | Aldosivi |
| 21.10.21 22:00 | Argentinos Jrs | 3-1 Gabriel Carabajal, Nicolas Reniero, Mateo Coronel / Rodrigo Aliendro | Colon Santa Fe |
| 21.10.21 22:00 | Talleres Cordoba | 0-2 Robert Rojas, Braian Romero | River Plate |
| ROUND 18 | |||
| 23.10.21 22:00 | Gimnasia L.P. | 2-2 Maximiliano Coronel, Luis Miguel Rodriguez / Milton Gimenez (2) | Central Cordoba de Santiago |
| 23.10.21 22:00 | Defensa Y Justicia | 2-1 Miguel Merentiel, Raul Loaiza / Matias Tissera | Platense |
| 23.10.21 22:00 | Rosario Central | 2-1 Gino Infantino, Marco Ruben / Enzo Copetti | Racing Club |
| 24.10.21 22:00 | Colon Santa Fe | 2-1 Eric Meza, Federico Lertora / Leonardo Burian (og) | Estudiantes L.P. |
| 24.10.21 22:00 | Velez Sarsfield | 2-0 Federico Mancuello, Cristian Tarragona | Boca Juniors |
| 24.10.21 22:00 | Godoy Cruz | 2-1 Gonzalo Abrego, Ezequiel Bullaude / Giuliano Galoppo | Banfield |
| 24.10.21 22:00 | Huracan | 2-1 Franco Cristaldo, Jhonatan Candia / Franco Di Santo | San Lorenzo |
| 25.10.21 22:00 | Independiente | 1-0 Brian Martinez | Union Santa Fe |
| 25.10.21 22:00 | Atletico Tucuman | 2-2 Ramiro Carrera (2) / Sebastian Sosa (2) | Patronato |
| 25.10.21 22:00 | Aldosivi | 2-1 Leandro Maciel, Gaston Andres Lodico / Bruno Seplveda | Arsenal Sarandi |
| 25.10.21 22:00 | Lanus | 3-3 Jose Manuel Lopez (2), Jose Sand / Michael Santos (2), Carlos Auzqui | Talleres Cordoba |
| 25.10.21 22:00 | River Plate | 3-0 Bruno Zuculini, Julian Alvarez, Braian Romero | Argentinos Jrs |
| 25.10.21 22:00 | Sarmiento Junin | 2-1 Jonathan Torres, Luciano Gondou / Maximiliano Comba | Newells Old Boys |
| ROUND 19 | |||
| 29.10.21 23:00 | Argentinos Jrs | 0-1 Lautaro Acosta | Lanus |
| 29.10.21 23:00 | Racing Club | 1-2 Enzo Copetti / Walter Bou,Franco Paredes | Defensa Y Justicia |
| 30.10.21 23:00 | Arsenal Sarandi | 1-0 Alejo Antilef | Sarmiento Junin |
| 30.10.21 23:00 | Talleres Cordoba | 1-0 Diego Valoyes | Huracan |
| 30.10.21 23:00 | Banfield | 2-1 Ramiro Enrique, Jesus Datolo / Juan Lucero | Velez Sarsfield |
| 30.10.21 23:00 | Platense | 4-1 Matias Tissera, Horacio Tijanovich, Hernan Lamberti, Tomas Sandoval / Leonardo Heredia | Atletico Tucuman |
| 30.10.21 23:00 | Boca Juniors | 0-1 Luis Miguel Rodriguez | Gimnasia L.P. |
| 31.10.21 23:00 | Central Cordoba de Santiago | 0-0 | Aldosivi |
| 31.10.21 23:00 | Estudiantes L.P. | 1-1 Leandro Diaz / Robert Rojas | River Plate |
| 31.10.21 23:00 | Newells Old Boys | 1-0 Roman Alberto Bravo | Independiente |
| 31.10.21 23:00 | Patronato | 2-0 Gabriel Gudino, Junior Arias | Colon Santa Fe |
| 31.10.21 23:00 | Union Santa Fe | 3-1 Mauro Luna Diale, Imanol Machuca, Juan Garcia / Marco Ruben | Rosario Central |
| 31.10.21 23:00 | San Lorenzo | 1-0 Franco Di Santo | Godoy Cruz |
| ROUND 20 | |||
| 05.11.21 23:00 | Lanus | 1-1 Ignacio Malcorra / Leandro Diaz | Estudiantes L.P. |
| 05.11.21 23:00 | Defensa Y Justicia | 3-0 Francisco Pizzini, Miguel Merentiel, Walter Bou | Rosario Central |
| 06.11.21 23:00 | Atletico Tucuman | 0-2 Javier Correa, Matias Rojas | Racing Club |
| 06.11.21 23:00 | Independiente | 3-0 Alan Sonora, Silvio Romero, Alan Velasco | Arsenal Sarandi |
| 06.11.21 23:00 | Godoy Cruz | 0-2 Rafael Perez, Juan Komar | Talleres Cordoba |
| 06.11.21 23:00 | Colon Santa Fe | 3-0 Eric Meza, Cristian Bernardi, Rodrigo Aliendro | Platense |
| 07.11.21 23:00 | Gimnasia L.P. | 0-1 Ramiro Enrique | Banfield |
| 07.11.21 23:00 | River Plate | 5-0 Agustin Palavecino, Julian Alvarez (4) | Patronato |
| 07.11.21 23:00 | Velez Sarsfield | 2-1 Lucas Janson (2) / Francisco Ortega (og) | San Lorenzo |
| 07.11.21 23:00 | Sarmiento Junin | 1-3 Jonathan Torres / Agustin Tomas Gallo, Claudio Riano, Milton Gimenez | Central Cordoba de Santiago |
| 08.11.21 23:00 | Newells Old Boys | 1-0 Pablo Perez | Union Santa Fe |
| 08.11.21 23:00 | Huracan | 1-1 Enrique Triverio / Gabriel Florentin | Argentinos Jrs |
| 08.11.21 23:00 | Aldosivi | 0-3 Agustin Almendra, Edwin Cardona, Sebastian Villa | Boca Juniors |
| ROUND 21 | |||
| 18.11.21 23:00 | Union Santa Fe | 2-3 Emanuel Britez, Claudio Corvalan / Miguel Merentiel, Walter Bou (2) | Defensa Y Justicia |
| 18.11.21 23:00 | Banfield | 0-2 Martin Cauteruccio, Alexis Maldonado (og) | Aldosivi |
| 18.11.21 23:00 | Patronato | 3-2 Junior Arias, Hector Canteros, Sebastian Sosa / Jose Sand, Ignacio Malcorra | Lanus |
| 19.11.21 23:00 | Estudiantes L.P. | 4-1 Gustavo Del Prete (2), Leandro Nicolas Diaz (2) / Franco Sebastian Cristaldo | Huracan |
| 20.11.21 23:00 | Rosario Central | 3-1 Lucas Gamba, Emiliano Vecchio (2) / Oscar Benitez | Atletico Tucuman |
| 20.11.21 23:00 | San Lorenzo | 0-1 Eric Ramirez | Gimnasia L.P. |
| 20.11.21 23:00 | Talleres Cordoba | 1-1 Michael Santos / Juan-Martin Lucero | Velez Sarsfield |
| 20.11.21 23:00 | Argentinos Jrs | 0-0 | Godoy Cruz |
| 20.11.21 23:00 | Central Cordoba de Santiago | 1-0 Cristian Orlando Vega | Independiente |
| 20.11.21 23:00 | Boca Juniors | 2-0 Luis Vazquez, Frank Fabra | Sarmiento Junin |
| 21.11.21 23:00 | Racing Club | 1-2 Leonardo Burian (og) / Cristian Ferreira, Lucas Beltran | Colon Santa Fe |
| 21.11.21 23:00 | Arsenal Sarandi | 3-1 Alejo Antilef, Bruno Sepulveda, Brian Farioli / Ignacio Scocco | Newells Old Boys |
| 21.11.21 23:00 | Platense | 0-1 Julian Alvarez | River Plate |
| ROUND 22 | |||
| 23.11.21 23:00 | Aldosivi | 2-0 Gabriel Hauche (2) | San Lorenzo |
| 23.11.21 23:00 | Huracan | 1-0 Jose Moya | Patronato |
| 23.11.21 23:00 | Gimnasia L.P. | 5-2 Johan Carbonero, Erik Ramirez, Luis Miguel Rodriguez, Lucas Licht, Brahian Aleman / Francisco Gerometta (og), Juan Komar | Talleres Cordoba |
| 23.11.21 23:00 | Godoy Cruz | 1-3 Martin Ojeda / Gustavo Del Prete, Leandro Diaz (2) | Estudiantes L.P. |
| 23.11.21 23:00 | Velez Sarsfield | 2-0 Lautaro Giannetti, Lucas Pratto | Argentinos Jrs |
| 24.11.21 23:00 | Atletico Tucuman | 0-4 Miguel Merentiel, Gabriel Hachen, Walter Bou, Francisco Pizzini | Defensa Y Justicia |
| 24.11.21 23:00 | Newells Old Boys | 1-0 Maxi Rodriguez | Central Cordoba de Santiago |
| 24.11.21 23:00 | Independiente | 1-0 Carlos Benavidez | Boca Juniors |
| 24.11.21 23:00 | Sarmiento Junin | 0-0 | Banfield |
| 25.11.21 23:00 | Colon Santa Fe | 1-4 Gonzalo Piovi / Marco Ruben (3), Emiliano Vecchio | Rosario Central |
| 25.11.21 23:00 | Lanus | 3-3 Guillermo Burdisso, Jose Manuel Lopez, Jose Sand / Horacio Tijanovich, Matias Tissera (2) | Platense |
| 25.11.21 23:00 | River Plate | 4-0 Agustin Palavecino, Julian Alvarez, Braian Romero (2) | Racing Club |
| 25.11.21 23:00 | Arsenal Sarandi | 0-1 Emanuel Britez | Union Santa Fe |
| ROUND 23 | |||
| 27.11.21 23:00 | Talleres Cordoba | 2-0 Diego Valoyes, Nahuel Tenaglia | Aldosivi |
| 27.11.21 23:00 | Patronato | 0-3 Ian Escobar, Tomas Badaloni, Martin Ojeda | Godoy Cruz |
| 27.11.21 23:00 | Estudiantes L.P. | 1-0 Leandro Nicolas Diaz | Velez Sarsfield |
| 28.11.21 23:00 | Rosario Central | 2-2 Marco Ruben (2) / Agustin Palavecino (2) | River Plate |
| 28.11.21 23:00 | Defensa Y Justicia | 1-1 Miguel Merentiel / Alexis Castro | Colon Santa Fe |
| 28.11.21 23:00 | Argentinos Jrs | 3-0 Gabriel Avalos, Gabriel Carabajal, Jonathan Sandoval | Gimnasia L.P. |
| 29.11.21 23:00 | Central Cordoba de Santiago | 5-0 Milton Gimnez (2), Sebastian Ribas (2), Lucas Melano | Arsenal Sarandi |
| 29.11.21 23:00 | Platense | 4-2 Matias Tissera (3), Brian Mansilla / Rodrigo Cabral, Jose Moya | Huracan |
| 29.11.21 23:00 | Racing Club | 3-1 Lisandro Lopez, Leonardo Sigali, Carlos Alcaraz / Jose Sand | Lanus |
| 29.11.21 23:00 | Union Santa Fe | 3-0 Juan Manuel Garcia (3) | Atletico Tucuman |
| 30.11.21 23:00 | San Lorenzo | 1-0 Nicolas Fernandez | Sarmiento Junin |
| 30.11.21 23:00 | Banfield | 4-1 Alexis Maldonado, Luciano Lollo, Giuliano Galoppo, Joel Sonora / Alexis Maldonado (og) | Independiente |
| 30.11.21 23:00 | Boca Juniors | 0-0 | Newells Old Boys |
| ROUND 24 | |||
| 03.12.21 23:00 | Central Cordoba de Santiago | 2-0 Nahuel Banegas, Leonardo Sequeira | Union Santa Fe |
| 03.12.21 23:00 | Velez Sarsfield | 0-0 | Patronato |
| 03.12.21 23:00 | Colon Santa Fe | 3-0 Gonzalo Piovi, Cristian Bernardi, Alexis Castro | Atletico Tucuman |
| 04.12.21 23:00 | Godoy Cruz | 2-2 Tomas Badaloni, Matias Ramirez / Matias Tissera, Ivan Gomez | Platense |
| 04.12.21 23:00 | Arsenal Sarandi | 1-1 Bruno Sepulveda / Juan Ramirez | Boca Juniors |
| 04.12.21 23:00 | Huracan | 1-0 Matias Coccaro | Racing Club |
| 04.12.21 23:00 | Lanus | 2-2 Jose Manuel Lopez, Jose Sand / Marco Ruben (2) | Rosario Central |
| 04.12.21 23:00 | Sarmiento Junin | 1-2 Jonathan Torres / Diego Garcia, Jose Romero | Talleres Cordoba |
| 05.12.21 23:00 | Independiente | 1-1 Silvio Romero / Nestor Ortigoza | San Lorenzo |
| 05.12.21 23:00 | River Plate | 2-3 Enzo Fernandez, Braian Romero / Walter Bou, Miguel Merentiel, Franco Paredes | Defensa Y Justicia |
| 05.12.21 23:00 | Gimnasia L.P. | 4-4 Brahian Aleman, Luis Miguel Rodriguez (3) / Gustavo Del Prete, Nicolas Pasquini, Fabian Noguera, Leandro Diaz | Estudiantes L.P. |
| 06.12.21 23:00 | Aldosivi | 3-2 Gabriel Hauche, Jonathan Zacaria, Malcom Braida / Gabriel Avalos (2) | Argentinos Jrs |
| 06.12.21 23:00 | Newells Old Boys | 0-0 | Banfield |
| ROUND 25 | |||
| 10.12.21 23:00 | Platense | 3-2 Matias Tissera, Facundo Curuchet, Ignacio Schor / Juan Lucero, Enzo Martinez | Velez Sarsfield |
| 10.12.21 23:00 | Estudiantes L.P. | 2-3 Fabian Noguera, Ezequiel Naya / Malcom Braida, Gabriel Hauche (2) | Aldosivi |
| 11.12.21 23:00 | Argentinos Jrs | 2-0 Mateo Coronel, Gabriel Avalos | Sarmiento Junin |
| 11.12.21 23:00 | Atletico Tucuman | 1-1 Yonathan Cabral / Julian Alvarez | River Plate |
| 11.12.21 23:00 | Boca Juniors | 8-1 Cristian Pavon (2), Eduardo Salvio, Exequiel Zeballos, Diego Gonzalez, Eros Nazareno Mancuso, Luis Vazquez, Sebastian Villa / Milton Gimenez | Central Cordoba de Santiago |
| 11.12.21 23:00 | Patronato | 0-0 | Gimnasia L.P. |
| 11.12.21 23:00 | Racing Club | 2-1 Javier Correa (2) / Ezequiel Bullaude | Godoy Cruz |
| 11.12.21 23:00 | Union Santa Fe | 3-0 Imanol Machuca, Juan Manuel Garcia, Gaston Gonzalez | Colon Santa Fe |
| 11.12.21 23:00 | Rosario Central | 1-4 Luca Dupuy / Matias Cccaro (2), Jhonatan Candia, Walter Perez | Huracan |
| 12.12.21 23:00 | San Lorenzo | 3-2 Nestor Ortigoza, Franco Di Santo (2) / Francisco Gonzalez, Julian Fernandez | Newells Old Boys |
| 12.12.21 23:00 | Talleres Cordoba | 1-2 Mateo Retegui / Silvio Romero, Carlos Benavidez | Independiente |
| 12.12.21 23:00 | Defensa Y Justicia | 2-1 Carlos Rotondi, Walter Bou / Angel Gonzalez | Lanus |
| 13.12.21 23:00 | Banfield | 0-0 | Arsenal Sarandi |
