| 1. HAFTA | |||
|---|---|---|---|
| 13.08.21 17:00 | Genclerbirligi | 2-4 Kerim Avcı, Sandro Lima / Umut Bulut (2), Taşkın İlter, Cenk Ahmet Kılıç | Eyupspor |
| 14.08.21 17:00 | Istanbulspor AS | 3-4 Ibrahim Yilmaz (3) / Dever Orgill (3), Andre Sousa | Manisa Buyuksehir |
| 14.08.21 17:00 | Balikesirspor | 1-0 Anıl Taşdemir | Boluspor |
| 14.08.21 17:00 | Denizlispor | 0-2 Burak Suleyman, Levent Aycicek | Bandirmaspor |
| 15.08.21 17:00 | Bursaspor | 1-1 Burak Altıparmak / Samed Kaya | Adanaspor AS |
| 15.08.21 17:00 | Keciorengucu | 1-1 Issa Djibrilla / Husamettin Yener | Altinordu |
| 15.08.21 17:00 | Menemen Belediye | 2-0 Ahmet Sagat, Mahamadou Ba | Erzurum BB |
| 15.08.21 17:00 | Tuzlaspor | 1-1 Safa Kınalı / Kwabena Owusu | Ankaragucu |
| 16.08.21 17:00 | Kocaelispor | 0-3 Yonathan Del Valle, Ercan Coşkun, Oğuz Gürbulak | Umraniyespor |
| 2. HAFTA | |||
| 20.08.21 17:00 | Samsunspor | 3-1 Yasin Öztekin (3) / Oğuz Han Aynaoğlu | Balikesirspor |
| 21.08.21 17:00 | Adanaspor AS | 0-0 | Genclerbirligi |
| 21.08.21 17:00 | Altinordu | 1-3 Ahmet İlhan Özek / Jurgen Bardhi, Ismail Konuk, Tayfun Aydoğan | Tuzlaspor |
| 21.08.21 17:00 | Eyupspor | 2-1 Taşkın İlter, Mustafa Dingil (k.k.) / Emeka Eze | Keciorengucu |
| 22.08.21 17:00 | Ankaragucu | 0-0 | Kocaelispor |
| 22.08.21 17:00 | Bandirmaspor | 1-0 Chukwuma Akabueze | Menemen Belediye |
| 22.08.21 17:00 | Manisa Buyuksehir | 1-0 Nizamettin Çalışkan | Denizlispor |
| 22.08.21 17:00 | Umraniyespor | 2-0 Yacine Bammou, Idrissa Camara | Istanbulspor AS |
| 23.08.21 17:00 | Erzurum BB | 2-1 Aykut Akgün (k.k.), Arvydas Novikovas / Reagy Ofosu | Bursaspor |
| 3. HAFTA | |||
| 27.08.21 17:00 | Tuzlaspor (18) | 3-1 Ahmet Yazar, İsmail Konuk, Samet Asatekin / Kabongo Kasongo | Boluspor (6) |
| 28.08.21 17:00 | Bursaspor (7) | 0-2 Timur Temeltaş, Pa Dibba | Eyupspor (10) |
| 28.08.21 17:00 | Keciorengucu (13) | 2-0 Emeka Eze, Vusal Isgandarli | Adanaspor AS (1) |
| 28.08.21 17:00 | Kocaelispor (14) | 1-0 Benhur Keser | Samsunspor (17) |
| 28.08.21 17:00 | Menemen Belediye (16) | 0-4 Alim Öztürk (2), Serkan Goksu, Idrissa Camara | Umraniyespor (19) |
| 29.08.21 17:00 | Denizlispor (8) | 0-3 Özer Özdemir (k.k.), Ali Kaan Guneren (2) | Ankaragucu (3) |
| 29.08.21 17:00 | Erzurum BB (9) | 1-0 Mustafa Akbaş | Bandirmaspor (5) |
| 29.08.21 17:00 | Genclerbirligi (11) | 0-3 Nino Kouter, Nizamettin Calışkan, Guevin Tormin | Manisa Buyuksehir (15) |
| 29.08.21 17:00 | Istanbulspor AS (12) | 3-0 Aldin Cajic, Melih Kabasakal, Berkay Görmez | Altinordu (2) |
| 4. HAFTA | |||
| 11.09.21 17:00 | Adanaspor AS (1) | 6-2 Ognjen Ozegovic (3), Evren Korkmaz, Samed Kaya, Ahmethan Köse / Mohamed Mahdi Sabba, Ahmet Sağat | Menemen Belediye (16) |
| 11.09.21 17:00 | Manisa Buyuksehir (15) | 0-1 Mustafa Yumlu | Erzurum BB (9) |
| 11.09.21 17:00 | Umraniyespor (19) | 2-0 Yonathan Del Valle, Tomislav Glumac | Bandirmaspor (5) |
| 11.09.21 17:00 | Eyupspor (10) | 0-2 Ömer Şişmanoğlu, Muğdat Çelik | Denizlispor (8) |
| 12.09.21 17:00 | Altinordu (2) | 2-1 Ali Dere, Husamettin Yener / Tim Matavz | Bursaspor (7) |
| 12.09.21 17:00 | Ankaragucu (3) | 2-0 Sinan Osmanoglu, Eren Derdiyok | Genclerbirligi (11) |
| 12.09.21 17:00 | Boluspor (6) | 2-0 Bertu Ozyurek, Kabongo Kasongo | Kocaelispor (14) |
| 12.09.21 17:00 | Samsunspor (17) | 2-0 Hasan Kılıç, Tomane | Keciorengucu (13) |
| 13.09.21 17:00 | Balikesirspor (4) | 0-1 Tayfun Aydoğan | Tuzlaspor (18) |
| 5. HAFTA | |||
| 14.09.21 17:00 | Bandirmaspor (5) | 1-1 Doğan Can Davas / Bogdan Stancu, Mete Kaan Demir | Eyupspor (10) |
| 14.09.21 17:0017:00 | Erzurum BB (9) | 0-2 Onur Ayık, Yonathan Del Valle | Umraniyespor (19) |
| 15.09.21 17:00 | Bursaspor (7) | 4-1 Emirhan Aydoğan, Massimo Bruno, Batuhan Köri Kerem Şen / Luka Capan (og) | Samsunspor (17) |
| 15.09.21 17:00 | Denizlispor (8) | 2-0 Ömer Şişmanoğlu (2) | Adanaspor AS (1) |
| 15.09.21 17:00 | Genclerbirligi (11) | 3-2 Barış Alıcı, Blessing Eleke, Sandro Lima / Ali Dere, Ahmet Ilhan Ozek | Altinordu (2) |
| 15.09.21 17:00 | Menemen Belediye (16) | 2-0 Ahmet Sagat, Rasheed Ibrahim Akanbi | Manisa Buyuksehir (15) |
| 16.09.21 17:00 | Keciorengucu (13) | 0-3 Kabongo Kasongo (2), Bertu Özyürek | Boluspor (6) |
| 16.09.21 17:00 | Kocaelispor (14) | 3-1 Dino Ndlovu (3) / Cumali Bişi | Balikesirspor (4) |
| 16.09.21 17:00 | Istanbulspor AS (12) | 0-1 Eren Derdiyok | Ankaragucu (3) |
| 6. HAFTA | |||
| 18.09.21 17:00 | Eyupspor | 0-1 Arvydas Novikovas | Erzurum BB |
| 18.09.21 17:00 | Manisa Buyuksehir | 1-3 Sertaç Çam / Chukwuma E. Akabueze, Doğan Can Davas, Guy Michel Landel | Bandirmaspor |
| 19.09.21 17:00 | Altinordu (2) | 2-1 Recep Aydın, Ahmet Dereli / Brice Dja Djedje | Denizlispor (8) |
| 19.09.21 17:00 | Samsunspor | 2-2 Moryke Fofana, Tomane / Barış Alıcı, Arda Kızıdağ | Genclerbirligi |
| 19.09.21 17:00 | Tuzlaspor | 0-0 | Bursaspor |
| 19.09.21 17:00 | Adanaspor AS (1) | 0-0 | Umraniyespor (19) |
| 20.09.21 17:00 | Ankaragucu (3) | 2-2 Eren Derdiyok, Yusuf Abdioglu / Ahmet Sagat, Rasheed Ibrahim Akanbi | Menemen Belediye (16) |
| 20.09.21 17:00 | Balikesirspor (4) | 2-1 Batuhan İşçiler, Oğuzhan Aynaoğlu / Ali Yavuz Kol | Keciorengucu (13) |
| 20.09.21 17:00 | Boluspor (6) | 1-1 Odah Marshal / Kağan Miray Bağış | Istanbulspor AS (12) |
| 7. HAFTA | |||
| 24.09.21 17:00 | Kocaelispor | 1-0 Benhur Keser | Tuzlaspor |
| 25.09.21 17:00 | Genclerbirligi | 1-0 Barış Alıcı | Boluspor |
| 25.09.21 17:00 | Erzurum BB | 3-1 Yohan Roche (og), Gokhan Alsan, Arvydas Novikovas / Samed Kaya | Adanaspor AS |
| 25.09.21 17:00 | Umraniyespor | 1-0 Alim Ozturk | Manisa Buyuksehir |
| 26.09.21 17:00 | Bandirmaspor | 2-1 Guy-Michel Landel, Dogan Can Davas / Ahmet Dereli | Altinordu |
| 26.09.21 17:00 | Bursaspor | 0-4 Eren Derdiyok (3), Yusuf Abdioglu | Ankaragucu |
| 26.09.21 17:00 | Istanbulspor AS | 1-0 Ibrahim Yılmaz | Balikesirspor |
| 26.09.21 17:00 | Menemen Belediye | 1-1 Mohamed Sabbah / Pa Dibba | Eyupspor |
| 27.09.21 17:00 | Denizlispor | 2-3 Kevin Mayi, Ömer Şişmanoğlu / Yasin Öztekin, Hasan Kılıç, Melih Okutan | Samsunspor |
| 8. HAFTA | |||
| 01.10.21 17:00 | Altinordu | 1-0 Enis Destan | Menemen Belediye |
| 02.10.21 17:00 | Tuzlaspor | 1-0 Sedat Sahinturk | Keciorengucu |
| 02.10.21 17:00 | Adanaspor AS | 1-5 Gökay Güney (og) / Lokman Gör, Philippe Keny (2), Dogan Can Davas, Remi Mulumba | Bandirmaspor |
| 02.10.21 17:00 | Kocaelispor | 2-1 Dino Ndlovu (2) / Ibrahim Yilmaz | Istanbulspor AS |
| 02.10.21 17:00 | Balikesirspor | 0-2 Blessing Eleke (2) | Genclerbirligi |
| 03.10.21 17:00 | Ankaragucu | 2-1 Eren Derdiyok, Kwabena Owusu / Arvydas Novikovas | Erzurum BB |
| 03.10.21 17:00 | Boluspor | 0-0 | Denizlispor |
| 03.10.21 17:00 | Eyupspor | 3-2 Umut Bulut, Bogdan Stancu, Enes Keskin / Erhan Kara, Andre Sousa | Manisa Buyuksehir |
| 03.10.21 17:00 | Samsunspor | 1-1 Hasan Kılıç / Yonathan Del Valle | Umraniyespor |
| 9. HAFTA | |||
| 16.10.21 17:00 | Bandirmaspor | 1-2 Guido Kocer / Erdem Ozgenc, Yusuf Abdioglu | Ankaragucu |
| 16.10.21 17:00 | Menemen Belediye | 3-2 Omer Sahbas, Mazlum Demir, Ahmet Sagat / Tomane, Ismael Diomande | Samsunspor |
| 16.10.21 17:00 | Umraniyespor | 2-2 Idrissa Camara, Stefano Napoleoni / Umut Bulut (2) | Eyupspor |
| 16.10.21 17:00 | Denizlispor | 2-1 Hakan Cinemre, Kevin Mayi / Halil Colak | Balikesirspor |
| 17.10.21 17:00 | Bursaspor | 3-1 Nicolas Zalazar, Ismail Yuksek, Massimo Bruno / Kabongo Kasongo | Boluspor |
| 17.10.21 17:00 | Erzurum BB | 6-2 Martin Hasek, Herolind Shala, Eren Tozlu (3), Arvydas Novikovas / Sami Satılmış, Ahmet Ilhan Ozek | Altinordu |
| 17.10.21 17:00 | Keciorengucu | 0-1 Dino Ndlovu | Kocaelispor |
| 17.10.21 17:00 | Manisa Buyuksehir | 0-3 Ognjen Ozegovic (2), Celil Yuksel | Adanaspor AS |
| 18.10.21 17:00 | Istanbulspor AS | 1-0 İbrahim Yılmaz | Tuzlaspor |
| 10. HAFTA | |||
| 22.10.21 17:00 | Ankaragucu | 2-1 Gboly Ariyibi, Mehmet Murat Ucar / Guevin Tormin | Manisa Buyuksehir |
| 22.10.21 17:00 | Eyupspor | 1-0 Bogdan Stancu | Adanaspor AS |
| 24.10.21 17:00 | Boluspor | 1-0 Berk Yıldız | Menemen Belediye |
| 24.10.21 17:00 | Keciorengucu | 3-2 Ibrahim Olawoyin Olasunkanmi (2), Vusal Isgandarli / Emir Gultekin, Ali Yaşar | Istanbulspor AS |
| 24.10.21 17:00 | Samsunspor | 0-0 | Erzurum BB |
| 24.10.21 17:00 | Tuzlaspor | 0-3 Philippe Keny, Guido Kocer, Guy-Michel Landel | Bandirmaspor |
| 24.10.21 17:00 | Altinordu | 0-2 Onur Ayık (2) | Umraniyespor |
| 24.10.21 17:00 | Balikesirspor | 0-2 Namik Alaskarov, Batuhan Kör | Bursaspor |
| 24.10.21 17:00 | Kocaelispor | 1-2 Dino Ndlovu / Gokhan Gul, Dmytro Hrechyshkin | Genclerbirligi |
| 11. HAFTA | |||
| 30.10.21 18:00 | Manisa FK | 2-2 Okan Eken (2) / Emin Bayram, Kabongo Kasongo | Boluspor |
| 30.10.21 18:00 | Eyupspor | 2-0 Umut Bulut, Muhammed Akarslan | Ankaragucu |
| 30.10.21 18:00 | Bandirmaspor | 2-0 hukwuma Akabueze, Philippe Keny | Samsunspor |
| 31.10.21 18:00 | Denizlispor | 1-1 Oğuz Yımaz / Dino Ndlovu | Kocaelispor |
| 31.10.21 18:00 | Erzurum BB | 2-1 Aly Malle, Eren Tozlu / İbrahim Halil Colak | Balikesirspor |
| 31.10.21 18:00 | Genclerbirligi | 0-2 Jetmir Topalli, Okan Erdoğan | Istanbulspor AS |
| 31.10.21 18:00 | Umraniyespor | 2-1 Idrissa Camara, Stefano Napoleoni / Sedat Şahintürk | Tuzlaspor |
| 01.11.21 18:00 | Bursaspor | 2-0 Kerem Şen, İsmail Yüksek | Keciorengucu |
| 01.11.21 18:00 | Adanaspor AS | 1-0 Uğurcan Yazgılı | Altinordu |
| 12. HAFTA | |||
| 05.11.21 18:00 | Tuzlaspor | 3-0 Jurgen Bardhi, Rahmi Anil Basaran, Ahmet Yazar | Denizlispor |
| 06.11.21 18:00 | Altinordu | 1-2 Ahmet Ilhan Özek / Pa Dibba, Yalçın Kılınç | Eyupspor |
| 06.11.21 18:00 | Ankaragucu | 3-0 Kwabena Owusu, Eren Derdiyok, Aatif Chahechouhe | Umraniyespor |
| 06.11.21 18:00 | Istanbulspor AS | 3-2 Valon Ethemi, Jetmir Topalli, İbrahim Yılmaz / Rasheed Ibrahim Akanbi, Mazlum Demir | Menemen Belediye |
| 06.11.21 18:00 | Samsunspor | 1-0 Moryke Fofana | Manisa Buyuksehir |
| 06.11.21 18:00 | Boluspor | 0-0 | Bandirmaspor |
| 07.11.21 18:00 | Keciorengucu | 2-0 Vusal Isgandarli, Emeka Eze | Genclerbirligi |
| 07.11.21 18:00 | Balikesirspor | 1-2 Roman Bezjak / Celil Yuksel, Samed Kaya | Adanaspor AS |
| 07.11.21 18:00 | Kocaelispor | 2-1 Dino Ndlovu, Benhur Keser / Namik Alaskarov | Bursaspor |
| 13. HAFTA | |||
| 20.11.21 18:00 | Bursaspor | 2-4 Batuhan Kor, Massimo Bruno / Muammer Sarikaya (2), Jetmir Topalli, İbrahim Yılmaz | Istanbulspor AS |
| 20.11.21 18:00 | Menemen Belediye | 2-1 Ahmet Sagat, Emre Ozer / Abraham Nwankwo | Balikesirspor |
| 20.11.21 18:00 | Erzurum BB | 3-2 Arvydas Novikovas, Eren Tozlu, Martin Hasek / Dejvi Bregu (2) | Boluspor |
| 20.11.21 18:00 | Genclerbirligi | 0-1 Jurgen Bardhi | Tuzlaspor |
| 21.11.21 18:00 | Adanaspor AS | 1-0 Sinan Osmanoğlu (k.k.) | Ankaragucu |
| 21.11.21 18:00 | Bandirmaspor | 1-0 Mehmet Özcan | Kocaelispor |
| 21.11.21 18:00 | Denizlispor | 2-1 Okan Derici, Hakan Cinemre / Hamza Gur | Keciorengucu |
| 21.11.21 18:00 | Manisa Buyuksehir | 1-0 Demba Diallo | Altinordu |
| 22.11.21 18:00 | Eyupspor | 2-2 Timur Temeltas, Pa Dibba / Tomane, Cihan Kahraman | Samsunspor |
| 14. HAFTA | |||
| 26.11.21 18:00 | Balikesirspor | 0-0 | Manisa Buyuksehir |
| 26.11.21 18:00 | Genclerbirligi | 2-0 Blessing Eleke, Dmytro Hrechyshkin | Bursaspor |
| 27.11.21 18:00 | Samsunspor | 1-0 Tomane | Adanaspor AS |
| 27.11.21 18:00 | Kocaelispor | 1-2 Benhur Keser / Mohamed Sabbah, Toni Gomes | Menemen Belediye |
| 27.11.21 18:00 | Boluspor | 3-1 Dejvi Bregu, Kabongo Kasongo (2) / Umut Bulut | Eyupspor |
| 27.11.21 18:00 | Istanbulspor AS | 1-1 Melih Kabasakal / Omer Sismanoglu | Denizlispor |
| 28.11.21 18:00 | Keciorengucu | 3-2 Emeka Eze (3) / Idrissa Camara, Yonathan Del Valle | Umraniyespor |
| 28.11.21 18:00 | Altinordu | 2-1 Ahmet Ilhan Ozek (2) / Ali Kaan Güneren | Ankaragucu |
| 22-12-21 | Tuzlaspor | 1-1 Ahmet Yazar / Orhan Ovacıklı | Erzurum BB |
| 15. HAFTA | |||
| 04.12.21 18:00 | Bandirmaspor | 1-2 Arb Manaj / Arda Kızıldağ, Sandro Lima | Genclerbirligi |
| 04.12.21 18:00 | Erzurum BB | 3-1 Aly Malle, Eren Tozlu, Martin Hasek / Valon Ethemi | Istanbulspor AS |
| 04.12.21 18:00 | Adanaspor AS | 1-1 Celil Yuksel / Veaceslav Posmac | Tuzlaspor |
| 05.12.21 18:00 | Altinordu | 0-2 Vukan Savicevic, Moryke Fofana | Samsunspor |
| 05.12.21 18:00 | Umraniyespor | 1-2 Yacine Bammou / Abdurrahman Canlı, Dejvi Bregu | Boluspor |
| 05.12.21 18:00 | Denizlispor | 1-3 Brahim Darri / Massimo Bruno, Namik Alaskarov, Tim Matavz | Bursaspor |
| 05.12.21 18:00 | Manisa Buyuksehir | 2-1 Okan Eken, Marvin Gakpa / Yigitali Bayrak | Kocaelispor |
| 06.12.21 18:00 | Menemen Belediye | 2-2 Ahmet Sagat, Mazlum Demir / Ibrahim Olawoyin Olasunkanmi, Issa Djibrilla | Keciorengucu |
| 06.12.21 18:00 | Ankaragucu | 2-0 Ghayas Zahid, Mehmet Murat Ucar | Balikesirspor |
| 16. HAFTA | |||
| 10.12.21 18:00 | Genclerbirligi | 1-0 Metehan Mert | Denizlispor |
| 10.12.21 18:00 | Kocaelispor | 2-0 Abdoulaye Cisse, Mouhamed Diop | Erzurum BB |
| 11.12.21 18:00 | Balikesirspor | 1-2 Halil Colak / Onur Ayık, Oğuz Gürbulak | Umraniyespor |
| 11.12.21 18:00 | Boluspor | 0-0 | Adanaspor AS |
| 11.12.21 18:00 | Bursaspor | 1-1 Namik Alaskarov / Serge Tabekou | Manisa Buyuksehir |
| 11.12.21 18:00 | Istanbulspor AS | 2-1 Eslem Öztürk, İbrahim Yılmaz / Umut Bulut | Eyupspor |
| 11.12.21 18:00 | Keciorengucu | 3-2 Issa Djibrilla, Fatih Selimhan Solmaz, Emeka Eze / Philippe Keny, Guido Kocer | Bandirmaspor |
| 11.12.21 18:00 | Tuzlaspor | 1-1 Selcuk Alibaz / Rasheed Ibrahim Akanbi | Menemen Belediye |
| 12.12.21 18:00 | Samsunspor | 2-0 Yasin Öztekin, Berk Taşkın | Ankaragucu |
| 17. HAFTA | |||
| 14.12.21 18:00 | Erzurum BB | 2-0 Emircan Altıntaş, Aaron Olanare | Genclerbirligi |
| 14.12.21 18:00 | Manisa Buyuksehir | 1-1 Marvin Gakpa / Ibrahim Olawoyin Olasunkanmi | Keciorengucu |
| 14.12.21 18:00 | Altinordu | 3-2 Ahmet Dereli, Kursad Surmeli, Burak Ince / Mouhamed Diop, Michael Pereira | Kocaelispor |
| 15.12.21 18:00 | Bandirmaspor | 3-0 Levent Aycicek, Burak Suleyman, Kerim Avcı | Balikesirspor |
| 15.12.21 18:00 | Eyupspor | 2-0 Umut Bulut, Pa Dibba | Tuzlaspor |
| 15.12.21 18:00 | Menemen Belediye | 0-0 | Denizlispor |
| 15.12.21 18:00 | Samsunspor | 1-1 Yasin Oztekin / Dejvi Bregu | Boluspor |
| 16.12.21 18:00 | Adanaspor AS | 1-0 Isaac Donkor | Istanbulspor AS |
| 16.12.21 18:00 | Umraniyespor | 4-1 Kartal Yılmaz, Serkan Goksu, Burak Altiparmak (og), Yacine Bammou / İsmail Yuksek | Bursaspor |
| 18. HAFTA | |||
| 18.12.21 18:00 | Balikesirspor | 3-4 Anıl Taşdemir (2), Doğa İşeri / Ahmet Dereli (4) | Altinordu |
| 18.12.21 18:00 | Boluspor | 0-2 Sinan Osmanoglu, Ghayas Zahid | Ankaragucu |
| 18.12.21 18:00 | Keciorengucu | 3-3 Hamza Gur, Emeka Eze, Vusal Isgandarli / Emircan Altintas, Aykut Demir, Suleyman Koc | Erzurum BB |
| 19.12.21 18:00 | Bursaspor | 0-1 Matej Pucko | Bandirmaspor |
| 19.12.21 18:00 | Genclerbirligi | 5-0 Metehan Mert, Sandro Lima (3), Aaron Tshibola | Menemen Belediye |
| 19.12.21 18:00 | Kocaelispor | 1-1 Mouhamed Diop / Timur Temeltaş | Eyupspor |
| 19.12.21 18:00 | Tuzlaspor | 0-1 Serge Tabekou | Manisa Buyuksehir |
| 20.12.21 18:00 | Istanbulspor AS | 2-1 Valon Ethemi, Melih Kabasakal / Moryke Fofana | Samsunspor |
| 20.12.21 18:00 | Denizlispor | 0-1 Antonio Mrsic | Umraniyespor |
| 19. HAFTA | |||
| 24.12.21 18:00 | Adanaspor AS | 2-0 Yohan Roche, Firatcan Uzum | Kocaelispor |
| 24.12.21 18:00 | Altinordu | 2-1 Ahmet Dereli, Sami Satılmış / Berk Yıldız | Boluspor |
| 25.12.21 18:00 | Erzurum BB | 3-1 Aaron Olanare (2), Oltan Karakullukcu / Brahim Darri | Denizlispor |
| 25.12.21 18:00 | Bandirmaspor | 0-0 | Istanbulspor AS |
| 25.12.21 18:00 | Menemen Belediye | 0-0 | Bursaspor |
| 26.12.21 18:00 | Ankaragucu | 2-1 Sinan Osmanoglu, Eren Derdiyok / Emeka Eze | Keciorengucu |
| 26.12.21 18:00 | Eyupspor | 1-1 Umut Bulut / Erdem Gokce | Balikesirspor |
| 26.12.21 18:00 | Samsunspor | 2-2 Yasin Oztekin (2) / Safa Kinali, Ahmet Yazar | Tuzlaspor |
| 26.12.21 18:00 | Umraniyespor | 3-1 Antonio Mrsic, Yusuf Gultekin, Muammer Denizhan Taskan / Sandro Lima | Genclerbirligi |
| 20. HAFTA | |||
| 09.01.22 18:00 | Adanaspor AS | 3-1 Thomas Bruns, Samuel Tetteh, Celil Yuksel / Massimo Bruno | Bursaspor |
| 09.01.22 18:00 | Ankaragucu | 1-0 Alperen Babacan | Tuzlaspor |
| 09.01.22 18:00 | Umraniyespor | 1-0 Stefano Napoleoni | Kocaelispor |
| 09.01.22 18:00 | Bandirmaspor | 3-4 Hakan Cinemre (og), Dogan Can Davas, Kerim Avcı / Oğuz Yılmaz, Ilhan Depe, Ozer Ozdemir, Omer Sismanoglu | Denizlispor |
| 09.01.22 18:00 | Eyupspor | 1-0 Umut Bulut | Genclerbirligi |
| 09.01.22 18:00 | Erzurum BB | 1-1 Emircan Altıntaş / Ahmet Sagat | Menemen Belediye |
| 09.01.22 18:00 | Manisa Buyuksehir | 1-2 Anıl Koç / Aldin Cajic, İbrahim Yılmaz | Istanbulspor AS |
| 09.01.22 18:00 | Boluspor | 1-0 Berk Yıldız | Balikesirspor |
| 10.01.22 18:00 | Altinordu | 2-3 Recep Aydın, Feyttullah Gurluk / Ibrahim Olawoyin Olasunkanmi, brahim Mirza Aral, Ali Yavuz Kol | Keciorengucu |
| 21. HAFTA | |||
| 14.01.22 18:00 | Menemen Belediye | 1-1 Ahmet Sağat / Doğan Can Davas | Bandirmaspor |
| 15.01.22 18:00 | Denizlispor | 0-1 Marvin Gakpa | Manisa Buyuksehir |
| 15.01.22 18:00 | Kocaelispor | 1-2 Michael Pereira / Sahverdi Cetin, Mehmet Murat Ucar | Ankaragucu |
| 15.01.22 18:00 | Istanbulspor AS | 1-0 İbrahim Yılmaz | Umraniyespor |
| 16.01.22 18:00 | Balikesirspor | 0-2 Yasin Oztekin, Moryke Fofana | Samsunspor |
| 16.01.22 18:00 | Bursaspor | 0-0 | Erzurum BB |
| 16.01.22 18:00 | Keciorengucu | 0-0 | Eyupspor |
| 16.01.22 18:00 | Tuzlaspor | 2-1 Tayfun Aydogan, Onat Kutay Kurt / Sami Satılmış | Altinordu |
| 17.01.22 18:00 | Genclerbirligi | 0-3 Samuel Tetteh (2), Thomas Jan Paul Bruns | Adanaspor AS |
| 22. HAFTA | |||
| 21.01.22 18:00 | Samsunspor | 3-0 Tomane, Diogo Coelho Georges Mandjeck (og), Hasan Kılıç | Kocaelispor |
| 22.01.22 18:00 | Altinordu | 0-5 Jetmir Topalli, Ibrahim Yilmaz, Berkay Gormez, Emir Gultekin, Aldin Cajic | Istanbulspor AS |
| 22.01.22 18:00 | Ankaragucu | 2-1 Ali Kaan Guneren, Yusuf Abdioglu / Oguz Yilmaz | Denizlispor |
| 22.01.22 18:00 | Umraniyespor | 2-1 Idrissa Camara, Onur Ayık / Ahmet Sagat | Menemen Belediye |
| 22.01.22 18:00 | Manisa Buyuksehir | 3-1 Erhan Çelenk, Marvin Gakpa, Okan Eken / Gökhan Gül | Genclerbirligi |
| 23.01.22 18:00 | Adanaspor AS | 0-1 Anthony Uzodimma | Keciorengucu |
| 23.01.22 18:00 | Bandirmaspor | 2-1 Kerim Avcı, Matej Pucko / Aaron Olanare | Erzurum BB |
| 02.03.22 18:00 | Boluspor | 0-1 Okwuchukwu Ezeh | Tuzlaspor |
| 10.03.22 18:00 | Eyupspor | 3-0 Pa Dibba, Umut Bulut, Timur Temeltaş | Bursaspor |
| 23. HAFTA | |||
| 05.02.22 18:00 | Bursaspor | 1-0 Hasan Ayaroglu | Altinordu |
| 05.02.22 18:00 | Keciorengucu | 1-1 Adamu Alhassan / Yasin Oztekin | Samsunspor |
| 05.02.22 18:00 | Tuzlaspor | 0-2 Sedat Dursun, Foxi Kethevoama | Balikesirspor |
| 05.02.22 18:00 | Denizlispor | 2-2 Kevin Mayi, Bekir Turac Boke / Pa Dibba, Umut Bulut | Eyupspor |
| 06.02.22 18:00 | Erzurum BB | 1-0 Loick Landre (og) | Manisa Buyuksehir |
| 06.02.22 18:00 | Genclerbirligi | 0-3 Sinan Osmanoglu, Kwabena Owusu, Mehmet Murat Ucar | Ankaragucu |
| 06.02.22 18:00 | Menemen Belediye | 2-1 Ahmet Sagat, Batuhan Kirdaroglu / Samuel Tetteh | Adanaspor AS |
| 06.02.22 18:00 | Bandirmaspor | 2-0 Philippe Keny, Kerim Avcı | Umraniyespor |
| 07.02.22 18:00 | Kocaelispor | 1-2 Rasheed Ibrahim Akanbi / Emin Bayram, Tugay Kacar | Boluspor |
| 24. HAFTA | |||
| 11.02.22 18:00 | Altinordu | 1-2 Recep Aydın / Sandro Lima, Blessing Eleke | Genclerbirligi |
| 11.02.22 18:00 | Samsunspor | 1-1 Tomane / Joao Pedro | Bursaspor |
| 12.02.22 18:00 | Adanaspor AS | 0-0 | Denizlispor |
| 12.02.22 18:00 | Ankaragucu | 0-1 Valon Ethemi | Istanbulspor AS |
| 12.02.22 18:00 | Balikesirspor | 1-2 Foxi Kethevoama / Benhur Keser, Babacar Gueye | Kocaelispor |
| 12.02.22 18:00 | Boluspor | 0-0 | Keciorengucu |
| 13.02.22 18:00 | Eyupspor | 2-0 Umut Bulut, Ogulcan Caglayan | Bandirmaspor |
| 13.02.22 18:00 | Manisa Buyuksehir | 1-1 Ognjen Ozegovic / Ahmet Sagat | Menemen Belediye |
| 13.02.22 18:00 | Umraniyespor | 3-3 Mustafa Yumlu (og), Onur Ayık, Yacine Bammou / Yacine Bammou (k.k.), Eren Tozlu, Mustafa Yumlu | Erzurum BB |
| 25. HAFTA | |||
| 15.02.22 18:00 | Genclerbirligi | 2-2 Baris Alıcı, Metehan Mert / Moryke Fofana, Melih Okutan | Samsunspor |
| 15.02.22 18:00 | Bursaspor | 0-1 Okwuchukwu Ezeh | Tuzlaspor |
| 16.02.22 18:00 | Menemen Belediye | 1-1 Abdullah Aydin / Ishak Cakmak | Ankaragucu |
| 16.02.22 18:00 | Denizlispor | 1-0 Kubilay Aktas (og) | Altinordu |
| 16.02.22 18:00 | Istanbulspor AS | 1-2 İbrahim Yılmaz / Gökhan Karadeniz, Kabongo Kasongo | Boluspor |
| 16.02.22 18:00 | Keciorengucu | 3-1 Hamza Gur, Ali Yavuz Kol, Birol Parlak (og) / Peter Ambrose | Balikesirspor |
| 17.02.22 18:00 | Bandirmaspor | 0-0 | Manisa Buyuksehir |
| 17.02.22 18:00 | Erzurum BB | 1-1 Oltan Karakullukçu / Cenk Ahmet Kılıç | Eyupspor |
| 17.02.22 18:00 | Umraniyespor | 2-1 Antonio Mrsic, Alim Ozturk / Samuel Tetteh | Adanaspor AS |
| 26. HAFTA | |||
| 19.02.22 18:00 | Boluspor | 3-1 Kabongo Kasongo, Gökhan Karadeniz, Berk Yıldız / Barış Alıcı | Genclerbirligi |
| 19.02.22 18:00 | Tuzlaspor | 0-0 | Kocaelispor |
| 20.02.22 18:00 | Samsunspor | 5-0 Tomane, Yasin Oztekin (3), Moryke Fofana | Denizlispor |
| 20.02.22 18:00 | Ankaragucu | 2-1 Erdem Ozgenç, Kwabena Owusu / Mehmet Erdem Ugurlu | Bursaspor |
| 20.02.22 18:00 | Balikesirspor | 1-3 Halil Colak / Muammer Sarikaya, Jetmir Topalli, Ibrahim Yilmaz | Istanbulspor AS |
| 21.02.22 18:00 | Eyupspor | 1-1 Yalçın Kılınç / Mahamadou Ba | Menemen Belediye |
| 21.02.22 18:00 | Manisa Buyuksehir | 2-1 Marvin Gakpa, Taha Sahin / Yacine Bammou | Umraniyespor |
| 21.02.22 18:00 | Altinordu | 0-2 Philippe Keny, Milutin Osmajic | Bandirmaspor |
| 21.02.22 18:00 | Adanaspor AS | 1-1 Amadou Ciss / Arvydas Novikovas | Erzurum BB |
| 27. HAFTA | |||
| 25.02.22 18:00 | Denizlispor | 2-0 Özer Özdemir, Ömer Şişmanoğlu | Boluspor |
| 26.02.22 18:00 | Manisa Buyuksehir | 2-1 Erhan Celenk, Demba Diallo / Timur Temeltaş | Eyupspor |
| 26.02.22 18:00 | Keciorengucu | 1-0 Hamza Gur | Tuzlaspor |
| 26.02.22 18:00 | Genclerbirligi | 2-0 Blessing Eleke (2) | Balikesirspor |
| 27.02.22 18:00 | Bandirmaspor | 1-0 Doğan Can Davas | Adanaspor AS |
| 27.02.22 18:00 | Erzurum BB | 0-1 Yusuf Abdioglu | Ankaragucu |
| 27.02.22 18:00 | Istanbulspor AS | 1-1 Melih Kabasakal / Babacar Gueye | Kocaelispor |
| 27.02.22 18:00 | Umraniyespor | 3-1 Onur Ayık, Yacine Bammou (2) / Hasan Kılıç | Samsunspor |
| 28.02.22 18:00 | Menemen Belediye | 0-1 Ahmet İlhan Özek | Altinordu |
| 28. HAFTA | |||
| 04.03.22 18:00 | Kocaelispor | 1-0 Rasheed Ibrahim Akanbi | Keciorengucu |
| 05.03.22 18:00 | Ankaragucu | 1-0 Ghayas Zahid | Bandirmaspor |
| 05.03.22 18:00 | Samsunspor | 2-4 Tomane, Seyfettin Yaşar (og) / Abdoulaye Cisse, Ahmet Sagat (2), Emre Batuhan Adiguzel | Menemen Belediye |
| 05.03.22 18:00 | Altinordu | 1-0 Ahmet İlhan Özek | Erzurum BB |
| 06.03.22 18:00 | Adanaspor AS | 2-0 Eren Karadağ, Youssef Ait Bennasser | Manisa Buyuksehir |
| 06.03.22 18:00 | Boluspor | 1-1 Kabongo Kasongo / Nicolas Zalazar | Bursaspor |
| 06.03.22 18:00 | Eyupspor | 0-1 Onur Ayık | Umraniyespor |
| 06.03.22 18:00 | Tuzlaspor | 0-2 Valon Ethemi, İbrahim Yılmaz | Istanbulspor AS |
| 07.03.22 18:00 | Balikesirspor | 0-1 Hakan Cinemre | Denizlispor |
| 29. HAFTA | |||
| 18.03.22 18:00 | Istanbulspor AS | 1-1 Jetmir Topalli / Emeka Eze | Keciorengucu |
| 19.03.22 18:00 | Umraniyespor | 0-1 Volkan Fındıklı | Altinordu |
| 19.03.22 18:00 | Menemen Belediye | 3-2 Muhammed Erturk, Oguzhan Capar, Abdoulaye Cisse / Kabongo Kasongo, Kemal Ruzgar | Boluspor |
| 19.03.22 18:00 | Erzurum BB | 1-2 Suleyman Koc / Osman Celik, Hasan Kilic | Samsunspor |
| 20.03.22 18:00 | Bandirmaspor | 3-1 Levent Aycicek, Caner Cavlan, Milutin Osmajic / Jurgen Bardhi | Tuzlaspor |
| 20.03.22 18:00 | Bursaspor | 2-1 Onur Atasayar, Joao Pedro / Sedat Dursun | Balikesirspor |
| 20.03.22 18:00 | Genclerbirligi | 1-1 Omurcan Artan / Babacar Gueye | Kocaelispor |
| 20.03.22 18:00 | Manisa Buyuksehir | 1-1 Hakan Barış / Gboly Ariyibi | Ankaragucu |
| 21.03.22 18:00 | Adanaspor AS | 1-1 Yohan Roche / Pa Dibba | Eyupspor |
| 30. HAFTA | |||
| 01-04.22 18:00 | Tuzlaspor | 1-1 Ahmet Yazar / Yonathan Del Valle | Umraniyespor |
| 02.04.22 18:00 | Boluspor | 1-2 Bekim Balaj / Erhan Çelenk, Marvin Gakpa | Manisa Buyuksehir |
| 02.04.22 18:00 | Keciorengucu | 2-1 Anthony Uzodimma (2) / Mehmet Erdem Ugurlu | Bursaspor |
| 02.04.22 18:00 | Samsunspor | 0-1 Milutin Osmajic | Bandirmaspor |
| 02.04.22 18:00 | Istanbulspor AS | 0-0 | Genclerbirligi |
| 03.04.22 18:00 | Ankaragucu | 2-3 Sinan Osmanoğlu, Kwabena Owusu / Gerson Rodrigues, Ogulcan Caglayan (2) | Eyupspor |
| 03.04.22 18:00 | Balikesirspor | 1-5 Batuhan İşçiler / Aaron Olanare (3), Mucahit Albayrak, Eren Tozlu | Erzurum BB |
| 03.04.22 18:00 | Altinordu | 2-0 Ahmet Ilhan Ozek, Kursad Surmeli | Adanaspor AS |
| 03.04.22 18:00 | Kocaelispor | 1-5 Michael Pereira / Mustafa Çeçenoglu (2), Kevin Mayi (2), Ömer Şişmanoğlu | Denizlispor |
| 31. HAFTA | |||
| 09.04.22 18:00 | Adanaspor AS | 3-1 Firatcan Üzüm, Amadou Ciss (2) / Halil Colak | Balikesirspor |
| 09.04.22 18:00 | Umraniyespor | 2-2 Yacine Bammou, Antonio Mrsic / Aatif Chahechouhe, Yasin Güreler | Ankaragucu |
| 09.04.22 18:00 | Genclerbirligi | 2-0 Baris Alıcı, Sandro Lima | Keciorengucu |
| 09.04.22 18:00 | Bandirmaspor | 3-0 Guy-Michel Landel, Levent Aycicek, Beykan Simsek | Boluspor |
| 10.04.22 18:00 | Bursaspor | 2-1 Hasan Ayaroğlu, Joao Pedro / Michael Pereira | Kocaelispor |
| 10.04.22 18:00 | Denizlispor | 2-4 Bekir Boke, Hakan Cinemre / Kadeem Harris, Lamine Diack, Ahmet Yazar, Okwuchukwu Ezeh | Tuzlaspor |
| 10.04.22 18:00 | Manisa Buyuksehir | 2-0 Okan Eken, Erhan Celenk | Samsunspor |
| 10.04.22 18:00 | Menemen Belediye | 1-3 Toni Gomes / Jetmir Topalli (2), Muammer Sarıkaya | Istanbulspor AS |
| 11.04.22 18:00 | Eyupspor | 2-2 Timur Temeltaş, Olivier Thill / Ahmet İlhan Özek, Strahil Popov (og) | Altinordu |
| 32. HAFTA | |||
| 15.04.22 18:00 | Tuzlaspor | 4-0 Ahmet Yazar, Okwuchukwu Ezeh (2), Lamine Diack | Genclerbirligi |
| 15.04.22 18:00 | Keciorengucu | 0-1 Ilhan Depe | Denizlispor |
| 15.04.22 18:00 | Istanbulspor AS | 3-1 Ferhat Yazgan, Valon Ethemi, Jetmir Topalli / Namik Alaskarov | Bursaspor |
| 16.04.22 18:00 | Altinordu | 1-0 Şeref Özcan | Manisa Buyuksehir |
| 16.04.22 18:00 | Balikesirspor | 1-1 Anıl Taşdemir / Ahmet Sagat | Menemen Belediye |
| 16.04.22 18:00 | Boluspor | 0-2 Martin Hasek, 74' Eren Tozlu | Erzurum BB |
| 16.04.22 18:00 | Kocaelispor | 2-1 Dimitrios Kolovos, Benhur Keser / Philippe Keny | Bandirmaspor |
| 17.04.22 18:00 | Ankaragucu | 2-0 Cem Ekinci, Ghayas Zahid | Adanaspor AS |
| 17.04.22 18:00 | Samsunspor | 2-2 Hasan Kılıç, Vukan Savicevic / Jonathan Buatu, Alaaddin Okumuş (k.k.) | Eyupspor |
| 33. HAFTA | |||
| 19.04.22 18:00 | Umraniyespor | 2-1 Antonio Mrsic, Yacine Bammou / Ibrahim Olawoyin Olasunkanmi | Keciorengucu |
| 19.04.22 18:00 | Denizlispor | 4-3 Ömer Şişmanoğlu (2), İlhan Depe, Tiago Lopes / Eduard Rroca (3) | Istanbulspor AS |
| 19.04.22 18:00 | Bursaspor | 0-0 | Genclerbirligi |
| 20.04.22 18:00 | Ankaragucu | 2-3 Geraldo, Gboly Ariyibi / Seref Ozcan (2), Husamettin Yener | Altinordu |
| 20.04.22 18:00 | Erzurum BB | 1-1 Aaron Olanare / Okwuchukwu Ezeh | Tuzlaspor |
| 20.04.22 18:00 | Manisa Buyuksehir | 3-0 Marvin Gakpa, Serge Tabekou, Okan Eken | Balikesirspor |
| 20.04.22 18:00 | Menemen Belediye | 1-1 Toni Gomes / Babacar Gueye | Kocaelispor |
| 21.04.22 18:00 | Adanaspor AS | 1-0 Thomas Bruns | Samsunspor |
| 21.04.22 18:00 | Eyupspor | 0-2 Gökhan Karadeniz, Berk Yıldız | Boluspor |
| 34. HAFTA | |||
| 23.04.22 18:00 | Bursaspor | 1-0 Namik Alaskarov | Denizlispor |
| 23.04.22 18:00 | Genclerbirligi | 2-0 Metehan Mert, Sandro Lima | Bandirmaspor |
| 24.04.22 18:00 | Balikesirspor | 0-2 Kwabena Owusu, Yasin Gureler | Ankaragucu |
| 24.04.22 18:00 | Boluspor | 0-2 Antonio Mrsic (2) | Umraniyespor |
| 24.04.22 18:00 | Istanbulspor AS | 1-2 Eduard Rroca / Mucahit Albayrak, Gokhan Alsan | Erzurum BB |
| 24.04.22 18:00 | Keciorengucu | 1-0 Emeka Eze | Menemen Belediye |
| 24.04.22 18:00 | Kocaelispor | 2-1 Mehmet Taş, Berkay Dabanlı / Loick Landre | Manisa Buyuksehir |
| 25.04.22 18:00 | Samsunspor | 2-1 Moryke Fofana, Junior Tallo / Feyttullah Gurluk | Altinordu |
| 25.04.22 18:00 | Tuzlaspor | 4-1 Cekdar Orhan, Kadeem Harris (2), Okwuchukwu Ezeh / Youssef Ait Bennasser | Adanaspor AS |
| 35. HAFTA | |||
| 24.04.22 18:00 | Adanaspor AS | 1-2 Yohan Roche / Berk Yıldız, Gokhan Karadeniz | Boluspor |
| 24.04.22 18:00 | Ankaragucu | 0-0 | Samsunspor |
| 24.04.22 18:00 | Bandirmaspor | 0-2 Emeka Eze (2) | Keciorengucu |
| 24.04.22 18:00 | Denizlispor | 2-1 Brice Dja Djedje, Ömer Şişmanoğlu / Barış Alıcı | Genclerbirligi |
| 24.04.22 18:00 | Erzurum BB | 1-0 Martin Hasek | Kocaelispor |
| 24.04.22 18:00 | Eyupspor | 1-2 Pa Dibba / Inainfe Michael Ologo, Mehmet Yeşil | Istanbulspor AS |
| 24.04.22 18:00 | Manisa Buyuksehir | 1-3 Loick Landre / Joao Pedro (2), Thievy Bifouma | Bursaspor |
| 24.04.22 18:00 | Menemen Belediye | 1-1 Ahmet Sagat / Okwuchukwu Ezeh | Tuzlaspor |
| 24.04.22 18:00 | Umraniyespor | 4-1 Yacine Bammou, Yonathan Del Valle, Yusuf Gültekin (2) / Berk Tosun | Balikesirspor |
| 36. HAFTA | |||
| 08.05.22 18:00 | Balikesirspor | 1-5 Anil Tasdemir / Milutin Osmajic (3), Kerim Avcı, Philippe Keny | Bandirmaspor |
| 08.05.22 18:00 | Boluspor | 2-1 Bekim Balaj (2) / Polat Yaldır | Samsunspor |
| 08.05.22 18:00 | Bursaspor | 3-2 Luka Capan, Cenk Şahin, Uğur Kaan Yıldız / Ajdin Hasic, Idrissa Camara | Umraniyespor |
| 08.05.22 18:00 | Denizlispor | 2-1 Ömer Şişmanoğlu, Tiago Lopes / Ahmet Sagat | Menemen Belediye |
| 08.05.22 18:00 | Genclerbirligi | 2-1 Sintayehu Sallalich, Baris Alıcı / Mucahit Albayrak | Erzurum BB |
| 08.05.22 18:00 | Istanbulspor AS | 1-1 Ibrahim Yilmaz / Amadou Ciss | Adanaspor AS |
| 08.05.22 18:00 | Keciorengucu | 2-1 Ibrahim Olawoyin Olasunkanmi, Emeka Eze / Marvin Gakpa | Manisa Buyuksehir |
| 08.05.22 18:00 | Kocaelispor | 2-2 Mehmet Tas, v / Ahmet Ilhan Ozek, Recep Aydin | Altinordu |
| 08.05.22 18:00 | Tuzlaspor | 3-2 Onat Kutay Kurt, Ahmet Yazar, Gökhan Akkan / Ahmed Ildiz, Pa Dibba | Eyupspor |
| 37. HAFTA | |||
| 14.05.22 18:00 | Altinordu | 2-1 Husamettin Yener, Ahmet Dereli / Muhammed Dogan | Balikesirspor |
| 14.05.22 18:00 | Ankaragucu | 1-2 Ghayas Zahid / Odise Roshi, Jakob Novak | Boluspor |
| 14.05.22 18:00 | Bandirmaspor | 4-2 Kerim Avcı, Philippe Keny, Milutin Osmajic, Lokman Gör / Burak Altıparmak, Massimo Bruno | Bursaspor |
| 14.05.22 18:00 | Erzurum BB | 2-2 Aaron Olanare, Arvydas Novikovas / Emeka Eze, Issa Djibrilla | Keciorengucu |
| 14.05.22 18:00 | Eyupspor | 2-1 Gerson Rodrigues (2) / İlyas Yavuz | Kocaelispor |
| 14.05.22 18:00 | Manisa Buyuksehir | 4-1 Okan Eken, Marvin Gakpa, Hakan Barış, Ognjen Ozegovic / Sedat Sahinturk | Tuzlaspor |
| 14.05.22 18:00 | Menemen Belediye | 1-3 Gokhan Gul (og) / Sandro Lima, Kazenga LuaLua, Aaron Tshibola | Genclerbirligi |
| 14.05.22 18:00 | Samsunspor | 0-0 | Istanbulspor AS |
| 14.05.22 18:00 | Umraniyespor | 0-0 | Denizlispor |
| 38. HAFTA | |||
| 20.05.22 18:00 | Tuzlaspor | 2-4 Ahmet Yazar (2) / Moryke Fofana (2), Tomane, Polat Yaldır | Samsunspor |
| 20.05.22 18:00 | Boluspor | 2-1 Bekim Balaj, Erdem Can Polat / Seref Ozcan | Altinordu |
| 20.05.22 18:00 | Balikesirspor | 0-3 Mete Kaan Demir, Caner Huseyin Bag, Jesse Sekidika | Eyupspor |
| 20.05.22 18:00 | Denizlispor | 4-0 Oguz Yilmaz, Gokhan Suzen, Omer Sismanoglu, Okan Derici | Erzurum BB |
| 20.05.22 18:00 | Istanbulspor AS | 0-0 | Bandirmaspor |
| 21.05.22 18:00 | Kocaelispor | 4-1 Rasheed Ibrahim Akanbi, Yigitali Bayrak, Yusuf Efe Yaman (2) / Amadou Ciss | Adanaspor AS |
| 21.05.22 18:00 | Genclerbirligi | 2-4 Sandro Lima (2) / Yonathan Del Valle (2), Antonio Mrsic, Onur Ayık | Umraniyespor |
| 21.05.22 18:00 | Bursaspor | 1-0 Berat Altındiş | Menemen Belediye |
| 21.05.22 18:00 | Keciorengucu | 1-2 Emeka Eze / Eren Derdiyok, Ali Kaan Guneren | Ankaragucu |
