| 1. HAFTA | |||
|---|---|---|---|
| 13.08.21 19:00 | Besiktas | 3-0 Georges-Kevin Nkoudou, Atiba Hutchinson, Cyle Larin | Rizespor |
| 14.08.21 19:00 | Altay | 3-0 Daouda Karamoko Bamba (2), Thaciano | Kayserispor |
| 14.08.21 19:00 | Fatih Karagumruk AS | 3-2 Papy Djilobodji (og), Aleksandar Pesic, Ahmed Musa / Angelo Sagal, Papy Djilobodji | Gaziantep FK |
| 14.08.21 19:00 | Hatayspor | 1-1 Saba Lobzhanidze / Valentin Eysseric | Kasimpasa |
| 15.08.21 19:00 | Antalyaspor | 1-1 Fredy / Dino Arslanagic | Goztepe |
| 15.08.21 19:00 | Adana Demirspor | 0-1 Mesut Ozil | Fenerbahce |
| 15.08.21 19:00 | Istanbul Basaksehir | 0-1 Cristian Borja | Alanyaspor |
| 16.08.21 19:00 | Giresunspor | 0-2 Mbaye Diagne, Alexandru Cicaldau | Galatasaray |
| 16.08.21 19:00 | Sivasspor | 0-1 Sokol Cikalleshi | Konyaspor |
| 16.08.21 19:00 | Yeni Malatyaspor | 1-5 Adem Büyük / Anastasios Bakasetas, Anthony Nwakaeme, Gervinho, Marek Hamsik, Djanini Tvaris | Trabzonspor |
| 2. HAFTA | |||
| 20.08.21 19:00 | Kayserispor | 1-1 Gökhan Sazdağı / David Akintola | Adana Demirspor |
| 21.08.21 19:00 | Alanyaspor | 1-4 Famara Diedhiou / Khaly Thiam, Martin Rodriguez, Cesar Pinares, Ahmed Yasser Rayan | Altay |
| 21.08.21 19:00 | Gaziantep FK | 0-0 | Besiktas |
| 21.08.21 19:00 | Rizespor | 0-0 | Fatih Karagumruk AS |
| 21.08.21 19:00 | Kasimpasa | 2-0 Nicolai Jorgensen, Umut Bozok | Giresunspor |
| 22.08.21 19:00 | Fenerbahce | 2-0 Miha Zajc, Enner Valencia | Antalyaspor |
| 22.08.21 19:00 | Goztepe | 0-1 Benjamin Tetteh | Yeni Malatyaspor |
| 22.08.21 19:00 | Konyaspor | 2-1 Endri Cekici, Sokol Cikalleshi / Youssouf Ndayishimiye | Istanbul Basaksehir |
| 23.08.21 19:00 | Galatasaray | 2-1 Sofiane Feghouli, Christian Luyindama / Saba Lobzhanidze | Hatayspor |
| 23.08.21 19:00 | Trabzonspor | 2-1 Anastasios Bakasetas, Anthony Nwakaeme / Isaac Cofie | Sivasspor |
| 3. HAFTA | |||
| 27.08.21 19:00 | Antalyaspor (4) | 3-2 Haji Wright (3) / Damjan Djokovic (2) | Rizespor (17) |
| 27.08.21 19:00 | Adana Demirspor (1) | 1-1 Britt Assombalonga / Abdulkerim Bardakci | Konyaspor (16) |
| 28.08.21 19:00 | Yeni Malatyaspor (20) | 2-0 Adem büyük,Benjamin Tetteh | Gaziantep FK (9) |
| 28.08.21 19:00 | Besiktas (5) | 1-0 Alex Teixeira | Fatih Karagumruk AS (6) |
| 28.08.21 19:00 | Istanbul Basaksehir (13) | 0-1 Mame Thiam | Kayserispor (15) |
| 28.08.21 19:00 | Hatayspor (12) | 5-0 Adama Traore, Saba Lobzhanidze, Ruben Ribeiro, Ayoub El Kaabi, Mohammed Kamara | Alanyaspor (2) |
| 29.08.21 19:00 | Giresunspor (10) | 0-1 Anthony Nwakaeme | Trabzonspor (19) |
| 29.08.21 19:00 | Kasimpasa (14) | 2-2 Nicolai Jorgensen, Umut Bozok / Alexandru Cicaldau, Muhammed Kerem Aktürkoğlu | Galatasaray (8) |
| 29.08.21 19:00 | Altay (3) | 0-2 Ferdi Kadioğlu, Enner Valencia | Fenerbahce (7) |
| 29.08.21 19:00 | Sivasspor (18) | 2-2 Dimitrios Goutas (2) / Halil Akbunar, Beykan Şimşek | Goztepe (11) |
| 4. HAFTA | |||
| 11.09.21 19:00 | Fatih Karagumruk AS (6) | 4-0 Aleksandar Pesic (2), Andrea Bertolacci, Yann Karamoh | Adana Demirspor (1) |
| 11.09.21 19:00 | Konyaspor (16) | 3-1 Soner Dikmen, Abdulkerim Bardakçı, Amar Rahmanovic / Ahmed Yasser Rayan | Altay (3) |
| 11.09.21 19:00 | Besiktas (5) | 3-0 Michy Batshuayi (2), Georges-Kevin Nkoudou | Yeni Malatyaspor (20) |
| 11.09.21 19:00 | Kayserispor (15) | 2-0 Bernard Mensah, Miguel Cardoso | Kasimpasa (14) |
| 12.09.21 19:00 | Fenerbahce (7) | 1-1 Bright Osayi-Samuel / Pedro Henrique | Sivasspor (18) |
| 12.09.21 19:00 | Goztepe (11) | 2-1 Cherif Ndiaye, David Tijanic / Deniz Türüç | Istanbul Basaksehir (13) |
| 12.09.21 19:00 | Rizespor (17) | 0-2 Mame Diouf, Ayoub El Kaabi | Hatayspor (12) |
| 12.09.21 19:00 | Trabzonspor (19) | 2-2 Andreas Cornelius, Anthony Nwakaeme / Emre Kılınç (2) | Galatasaray (8) |
| 13.09.21 19:00 | Gaziantep FK (9) | 2-0 Muhammet Demir, Hamza Mendyl | Antalyaspor (4) |
| 13.09.21 19:00 | Alanyaspor (2) | 1-0 Chidozie Collins Awaziem | Giresunspor (10) |
| 5. HAFTA | |||
| 17.09.21 19:00 | Altay (3) | 2-1 Leandro Kappel, Marco Paixao / Soner Aydoğdu | Goztepe (11) |
| 17.09.21 19:00 | Yeni Malatyaspor (20) | 3-4 Benjamin Tetteh, Mustafa Eskihellac, Mounir Chouiar / Andrea Bertolacci (2), Aleksandar Pesic (2) | Fatih Karagumruk AS (6) |
| 18.09.21 19:00 | Adana Demirspor (1) | 3-1 Mario Balotelli, Matias Vargas, Birkir Bjarnason / Fernando Boldrin | Rizespor (17) |
| 18.09.21 19:00 | Antalyaspor (4) | 2-3 Haji Wright, Veysel Sarı / Ridvan Yılmaz, Michy Batshuayi, Rachid Ghezzal | Besiktas (5) |
| 18.09.21 19:00 | Sivasspor (18) | 1-1 Mustapha Yatabare / Joao Figueiredo | Gaziantep FK (9) |
| 18.09.21 19:00 | Kasimpasa (14) | 0-1 Anastasios Bakasetas | Trabzonspor (19) |
| 19.09.21 19:00 | Galatasaray (8) | 0-1 Daniel Candeias | Alanyaspor (2) |
| 19.09.21 19:00 | Giresunspor (10) | 0-0 | Konyaspor (16) |
| 19.09.21 19:00 | Hatayspor (12) | 2-1 Mame Diouf, Ayoub El Kaabi / Bernard Mensah | Kayserispor (15) |
| 19.09.21 19:00 | Istanbul Basaksehir (13) | 2-0 Stefano Okaka, Fredrik Gulbrandsen | Fenerbahce (7) |
| 6. HAFTA | |||
| 21.09.21 19:00 | Besiktas | 3-3 Francisco Montero, Jozef De Souza, Ridvan Yılmaz / Matias Vargas, Mario Balotelli, Britt Assombalonga | Adana Demirspor |
| 21.09.21 19:00 | Yeni Malatyaspor | 0-1 Dimitrios Goutas | Sivasspor |
| 21.09.21 19:00 | Rizespor | 1-2 Yannick Bolasie / Eric Bjorkander 69' Khaly Thiam, Daouda Karamoko Bamba | Altay |
| 21.09.21 19:00 | Fatih Karagumruk AS | 0-0 | Antalyaspor |
| 22.09.21 19:00 | Gaziantep FK | 1-0 Muhammet Demir | Istanbul Basaksehir |
| 22.09.21 19:00 | Goztepe | 0-2 Mame Diouf (2) | Hatayspor |
| 22.09.21 19:00 | Kayserispor | 3-0 Mame Thiam (2), Emrah Bassan | Galatasaray |
| 23.09.21 19:00 | Konyaspor | 2-2 Endri Cekici (2) / Andreas Cornelius, Amir Hadziahmetovic (og) | Trabzonspor |
| 23.09.21 19:00 | Alanyaspor | 2-0 Efecan Karaca, Davidson | Kasimpasa |
| 23.09.21 19:00 | Fenerbahce | 2-1 Ferdi Kadioglu, Mesut Ozil / Souleymane Doukara | Giresunspor |
| 7. HAFTA | |||
| 24.09.21 19:00 | Altay | 2-1 Leandro Kappel, Daouda Karamoko Bamba / Güven Yalçın | Besiktas |
| 25.09.21 19:00 | Adana Demirspor | 4-0 Yunus Akgün, Steven Caulker (og), Mario Balotelli, Britt Assombalonga | Gaziantep FK |
| 25.09.21 19:00 | Sivasspor | 4-0 Olarenwaju Kayode, Dimitrios Goutas, Jorge Felix, Max Gradel | Fatih Karagumruk AS |
| 25.09.21 19:00 | Antalyaspor | 1-0 Güray Vural | Yeni Malatyaspor |
| 26.09.21 19:00 | Galatasaray | 2-1 Halil Dervisoglu, Olimpiu Morutan / Cherif Ndiaye | Goztepe |
| 26.09.21 19:00 | Giresunspor | 1-1 Fousseni Diabate / Joseph Attamah | Kayserispor |
| 26.09.21 19:00 | Hatayspor | 1-2 Dylan Saint-Louis / Diego Rossi, Filip Novak | Fenerbahce |
| 26.09.21 19:00 | Istanbul Basaksehir | 3-0 Stefano Okaka (3) | Rizespor |
| 27.09.21 19:00 | Kasimpasa | 2-2 Michal Travnik, Umut Bozok / Koka, Serdar Gurler | Konyaspor |
| 27.09.21 19:00 | Trabzonspor | 1-1 Andreas Cornelius / Famara Diedhiou | Alanyaspor |
| 8. HAFTA | |||
| 01.10.21 19:00 | Antalyaspor | 1-2 Bünyamin Balcı / Mario Balotelli, Matias Vargas | Adana Demirspor |
| 01.10.21 19:00 | Fatih Karagumruk AS | 3-1 Andrea Bertolacci (2), Jure Balkovec / Danijel Aleksic | Istanbul Basaksehir |
| 02.10.21 19:00 | Konyaspor | 1-2 Chidozie Awaziem (og) / Fatih Aksoy | Alanyaspor |
| 02.10.21 19:00 | Goztepe | 0-1 Fousseni Diabate (p | Giresunspor |
| 02.10.21 19:00 | Kayserispor | 1-2 Emrah Bassan / Anastasios Bakasetas (2) | Trabzonspor |
| 02.10.21 19:00 | Besiktas | 2-1 Güven Yalcin (2) / Rıdvan Yılmaz (k.k.) | Sivasspor |
| 03.10.21 19:00 | Fenerbahce | 2-1 Mergim Berisha, Luiz Gustavo / Michal Travnik | Kasimpasa |
| 03.10.21 19:00 | Gaziantep FK | 4-1 Alexander Merkel, Alexandru Maxim (2), Nouha Dicko / Erhan Celenk | Altay |
| 03.10.21 19:00 | Rizespor | 2-3 Joel Pohjanpalo (2) / Mostafa Mohamed (2), Olimpiu Morutan | Galatasaray |
| 03.10.21 19:00 | Yeni Malatyaspor | 0-2 Ayoub El Kaabi, Mohammed Kamara | Hatayspor |
| 9. HAFTA | |||
| 15.10.21 19:00 | Istanbul Basaksehir | 3-2 Stefano Okaka (2), Fredrik Gulbrandsen / Alex Teixeira, Michy Batshuayi | Besiktas |
| 16.10.21 19:00 | Adana Demirspor | 0-2 Benjamin Tetteh, Simon Deli (og) | Yeni Malatyaspor |
| 16.10.21 19:00 | Sivasspor | 2-2 Caner Osmanpaşa, Olarenwaju Kayode / Fredy, Dogukan Sinik | Antalyaspor |
| 16.10.21 19:00 | Giresunspor | 2-0 Selim Ay (og), Joe Champness | Rizespor |
| 17.10.21 19:00 | Altay | 0-1 Yann Karamoh | Fatih Karagumruk AS |
| 17.10.21 19:00 | Galatasaray | 1-0 Mostafa Mohamed | Konyaspor |
| 17.10.21 19:00 | Kasimpasa | 1-2 Yusuf Erdogan / Adis Jahovic, David Tijanic | Goztepe |
| 17.10.21 19:00 | Trabzonspor | 3-1 Anastasios Bakasetas (2), Yusuf Sarı / Diego Rossi | Fenerbahce |
| 18.10.21 19:00 | Hatayspor | 2-1 Mame Diouf, Mohammed Kamara / Angelo Sagal | Gaziantep FK |
| 18.10.21 19:00 | Alanyaspor | 6-3 Efecan Karaca, Majid Hosseini (og), Davidson (2), Umut Gunes, Famara Diedhiou / Onur Bulut, Mario Gavranovic, Mustafa Pektemek | Kayserispor |
| 10. HAFTA | |||
| 22.10.21 19:00 | Yeni Malatyaspor | 2-1 Benjamin Tetteh, Adem Büyük / Daouda Karamoko Bamba | Altay |
| 23.10.21 19:00 | Gaziantep FK | 1-1 Alexis Perez (og) / Serginho | Giresunspor |
| 23.10.21 19:00 | Konyaspor | 2-0 Serdar Gürler, Amir Hadziahmetovic | Kayserispor |
| 23.10.21 19:00 | Rizespor | 2-1 Cemali Sertel, Selim Ay / Umut Bozok | Kasimpasa |
| 23.10.21 19:00 | Goztepe | 0-1 Gervinho | Trabzonspor |
| 24.10.21 19:00 | Antalyaspor | 1-2 Houssam Ghacha / Berkay Ozcan (2) | Istanbul Basaksehir |
| 24.10.21 19:00 | Fatih Karagumruk AS | 1-1 Aleksandar Pesic / Ayoub El Kaabi | Hatayspor |
| 24.10.21 19:00 | Fenerbahce | 1-2 Serdar Dursun / Emre Akbaba, Efkan Bekiroglu | Alanyaspor |
| 24.10.21 19:00 | Sivasspor | 1-1 Max Gradel / Mario Balotelli | Adana Demirspor |
| 25.10.21 19:00 | Besiktas | 2-1 Cyle Larin (2) / Alexandru Cicaldau | Galatasaray |
| 11. HAFTA | |||
| 29.10.21 20:00 | Trabzonspor | 2-1 Djanini Tvaris, Anthony Nwakaeme / Damjan Djokovic | Rizespor |
| 30.10.21 20:00 | Konyaspor | 2-1 Soner Dikmen, Abdulkerim Bardakçı / Irfan Kahveci | Fenerbahce |
| 30.10.21 20:00 | Kasimpasa | 2-0 Loret Sadiku, Umut Bozok | Yeni Malatyaspor |
| 30.10.21 20:00 | Hatayspor | 1-0 Saba Lobzhanidze | Besiktas |
| 30.10.21 20:00 | Altay | 1-1 Daouda Karamoko Bamba / Mustapha Yatabare | Sivasspor |
| 31.10.21 20:00 | Galatasaray | 2-0 Olimpiu Morutan, Muhammed Kerem Aktürkoğlu | Gaziantep FK |
| 31.10.21 20:00 | Alanyaspor | 2-2 Davidson, Nemanja Milunovic / David Tijanic, Lourency | Goztepe |
| 31.10.21 20:00 | Kayserispor | 2-1 Mario Gavranovic, Mame Thiam / Andrea Bertolacci | Fatih Karagumruk AS |
| 01.11.21 20:00 | Istanbul Basaksehir | 2-1 Nacer Chadli, Edin Visca / Britt Assombalonga | Adana Demirspor |
| 01.11.21 20:00 | Giresunspor | 1-2 Fousseni Diabate / Fredy (2) | Antalyaspor |
| 12. HAFTA | |||
| 05.11.21 20:00 | Gaziantep FK | 2-0 Joao Figueiredo, Steven Caulker | Kasimpasa |
| 05.11.21 20:00 | Rizespor | 2-0 Selim Ay, Damjan Djokovic | Alanyaspor |
| 06.11.21 20:00 | Sivasspor | 0-0 | Giresunspor |
| 06.11.21 20:00 | Antalyaspor | 1-0 Paul Mukairu | Altay |
| 06.11.21 20:00 | Besiktas | 1-2 Cyle Larin / Abdülkadir Ömür, Andreas Cornelius | Trabzonspor |
| 06.11.21 20:00 | Yeni Malatyaspor | 1-3 Kubilay Kanatsızkuş / Tolga Ciğerci, Edin Visca, Stefano Okaka | Istanbul Basaksehir |
| 07.11.21 20:00 | Fenerbahce | 2-2 Miha Zajc, Mesut Ozil / Dimitrios Kolovetsios, Mario Gavranovic | Kayserispor |
| 07.11.21 20:00 | Goztepe | 0-2 Sokol Cikalleshi (2) | Konyaspor |
| 07.11.21 20:00 | Adana Demirspor | 1-0 Yunus Akgün | Hatayspor |
| 07.11.21 20:00 | Fatih Karagumruk AS | 1-1 Andrea Bertolacci / Mostafa Mohamed | Galatasaray |
| 13. HAFTA | |||
| 20.11.21 20:00 | Alanyaspor | 2-0 Khouma Babacar, Famara Diedhiou | Besiktas |
| 20.11.21 20:00 | Istanbul Basaksehir | 2-1 Fredrik Gulbrandsen, Mahmut Tekdemir / Pedro Henrique | Sivasspor |
| 20.11.21 20:00 | Hatayspor | 3-1 Ayoub El Kaabi, Ruben Ribeiro, Mame Diouf / Paul Mukairu | Antalyaspor |
| 20.11.21 20:00 | Giresunspor | 1-0 Fousseni Diabate | Yeni Malatyaspor |
| 21.11.21 20:00 | Altay | 1-3 hmed Yasser Rayan / Yunus Akgün, Britt Assombalonga, David Akintola | Adana Demirspor |
| 21.11.21 20:00 | Galatasaray | 1-2 Muhammed Kerem Akturkoglu / Mesut Ozil, Miguel Crespo | Fenerbahce |
| 21.11.21 20:00 | Kasimpasa | 1-3 Yusuf Erdogan / Tomas Brecka (og), Yann Karamoh, Aleksandar Pesic | Fatih Karagumruk AS |
| 21.11.21 20:00 | Konyaspor | 3-0 Zymer Bytyqi, Paul-Jose Mpoku, Konrad Michalak | Rizespor |
| 22.11.21 20:00 | Kayserispor | 1-1 Ilhan Parlak / Dino Arslanagic | Goztepe |
| 22.11.21 20:00 | Trabzonspor | 3-0 Abdulkadir Ömür, Djanini Tvaris, Andreas Cornelius | Gaziantep FK |
| 14. HAFTA | |||
| 26.11.21 20:00 | Adana Demirspor | 0-0 | Kasimpasa |
| 26.11.21 20:00 | Istanbul Basaksehir | 0-0 | Altay |
| 27.11.21 20:00 | Antalyaspor | 3-0 Bünyamin Balcı, Paul Mukairu, Sherel Floranus | Alanyaspor |
| 27.11.21 20:00 | Rizespor | 1-0 Selim Ay | Kayserispor |
| 27.11.21 20:00 | Besiktas | 0-4 Fousseni Diabate, Ibrahima Balde, Serginho, Joe Champness | Giresunspor |
| 28.11.21 20:00 | Fatih Karagumruk AS | 0-2 Djanini Tvaris, Abdulkadir Ömür | Trabzonspor |
| 28.11.21 20:00 | Gaziantep FK | 3-2 Steven Caulker, Muhammet Demir, oao Figueiredo / Guilherme, Sokol Cikalleshi | Konyaspor |
| 28.11.21 20:00 | Sivasspor | 4-0 Pedro Henrique, Mustapha Yatabare (3) | Hatayspor |
| 28.11.21 20:00 | Yeni Malatyaspor | 0-0 | Galatasaray |
| 28.11.21 20:00 | Goztepe | 1-1 Adis Jahovic / Serdar Dursun | Fenerbahce |
| 15. HAFTA | |||
| 03.12.21 20:00 | Kasimpasa | 1-1 Umut Bozok / Can Bozdoğan | Besiktas |
| 04.12.21 20:00 | Alanyaspor | 0-1 Keren Kesgin | Sivasspor |
| 04.12.21 20:00 | Trabzonspor | 2-0 Anthony Nwakaeme, Marek Hamsik | Adana Demirspor |
| 04.12.21 20:00 | Galatasaray | 2-2 Halil Dervisoglu, Mbaye Diagne / Cesar Pinares, Daouda Karamoko Bamba | Altay |
| 05.12.21 20:00 | Fenerbahce | 4-0 Mergim Berisha, Serdar Dursun (3) | Rizespor |
| 05.12.21 20:00 | Giresunspor | 3-1 Ibrahima Balde, Souleymane Doukara (2) / Aleksandar Pesic | Fatih Karagumruk AS |
| 05.12.21 20:00 | Hatayspor | 0-3 Danijel Aleksic (2), Stefano Okaka | Istanbul Basaksehir |
| 05.12.21 20:00 | Kayserispor | 2-0 Mame Thiam (2) | Antalyaspor |
| 06.12.21 20:00 | Konyaspor | 0-0 | Yeni Malatyaspor |
| 06.12.21 20:00 | Goztepe | 2-1 Adis Jahovic (2) / Recep Niyaz | Gaziantep FK |
| 16. HAFTA | |||
| 10.12.21 20:00 | Altay | 1-2 Cesar Pinares / Mame Diouf, Dylan Saint-Louis | Hatayspor |
| 11.12.21 20:00 | Antalyaspor | 2-1 Fredy, Dorukhan Tokoz (og) / Andreas Cornelius | Trabzonspor |
| 12.12.21 20:00 | Fatih Karagumruk AS | 1-4 Aleksandar Pesic / Amar Rahmanovic, Serdar Gurler (2), Guilherme | Konyaspor |
| 12.12.21 20:00 | Rizespor | 3-1 Joel Pohjanpalo (2), Erik Sabo / Atınc Nukan | Goztepe |
| 12.12.21 20:00 | Istanbul Basaksehir | 2-1 Edin Visca, Mahmut Tekdemir / Haris Hajradinovic | Kasimpasa |
| 12.12.21 20:00 | Adana Demirspor | 1-0 Benjamin Stambouli | Giresunspor |
| 12.12.21 20:00 | Yeni Malatyaspor | 2-6 Rayane Aabid, Benjamin Tetteh / Famara Diedhiou (2), Davidson, Emre Akbaba, Joao Novais, Khouma Babacar | Alanyaspor |
| 12.12.21 20:00 | Besiktas | 4-2 Cyle Larin, Michy Batshuayi (2), Güven Yalçın / Mame Thiam (2) | Kayserispor |
| 13.12.21 20:00 | Gaziantep FK | 3-2 Joao Figueiredo (2), Alexandru Maxim / Mesut Ozil, Miha Zajc | Fenerbahce |
| 13.12.21 20:00 | Sivasspor | 1-0 Faycal Fajr | Galatasaray |
| 17. HAFTA | |||
| 17.12.21 20:00 | Giresunspor | 3-1 Shapi Suleymanov, Ibrahima Balde, Fousseni Diabate / Andre Poko | Altay |
| 18.12.21 20:00 | Trabzonspor | 2-0 Djanini Tvaris, Andreas Cornelius | Hatayspor |
| 18.12.21 20:00 | Konyaspor | 1-0 Endri Cekici | Antalyaspor |
| 18.12.21 20:00 | Galatasaray | 1-1 Mostafa Mohamed / Stefano Okaka | Istanbul Basaksehir |
| 18.12.21 20:00 | Alanyaspor | 1-3 Famara Diedhiou / Matias Vargas, Mario Balotelli, Birkir Bjarnason | Adana Demirspor |
| 18.12.21 20:00 | Kasimpasa | 1-3 Samba Camara (og) / Faycal Fajr, Mustapha Yatabare (2) | Sivasspor |
| 19.12.21 20:00 | Fenerbahce | 2-2 Mesut Özil, Mergim Berisha / Josef (2) | Besiktas |
| 19.12.21 20:00 | Goztepe | 0-1 Caner Erkin | Fatih Karagumruk AS |
| 19.12.21 20:00 | Kayserispor | 0-0 | Gaziantep FK |
| 19.12.21 20:00 | Rizespor | 1-0 Deniz Hummet | Yeni Malatyaspor |
| 18. HAFTA | |||
| 21.12.21 20:00 | Adana Demirspor | 2-0 Yunus Akgün (2) | Galatasaray |
| 21.12.21 20:00 | Altay | 1-2 Cebrail Karayel / Andreas Cornelius (2) | Trabzonspor |
| 21.12.21 20:00 | Istanbul Basaksehir | 3-1 Deniz Turuc, Junior Caicara, Edin Visca / Mamadou Diarra | Giresunspor |
| 21.12.21 20:00 | Antalyaspor | 1-1 Naldo / Umut Bozok | Kasimpasa |
| 22.12.21 20:00 | Fatih Karagumruk AS | 1-1 Aleksandar Pesic / Mesut Ozil | Fenerbahce |
| 22.12.21 20:00 | Gaziantep FK | 2-1 Furkan Soyalp, Famara Diedhiou (og) / Joao Novais | Alanyaspor |
| 22.12.21 20:00 | Hatayspor | 1-3 Ayoub El Kaabi / Paul-Jose Mpoku (2), Koka | Konyaspor |
| 22.12.21 20:00 | Sivasspor | 1-1 Olarenwaju Kayode / Joel Pohjanpalo | Rizespor |
| 23.12.21 20:00 | Yeni Malatyaspor | 2-2 Mounir Chouiar, Adem Büyük / Mario Gavranovic, Mustafa Pektemek | Kayserispor |
| 23.12.21 20:00 | Besiktas | 2-1 Cyle Larin, Rachid Ghezzal / Cherif Ndiaye | Goztepe |
| 19. HAFTA | |||
| 25.12.21 20:00 | Kasimpasa | 2-0 Ryan Donk, Umut Bozok | Altay |
| 25.12.21 20:00 | Galatasaray | 2-0 Sofiane Feghouli, Muhammed Kerem Aktürkoğlu | Antalyaspor |
| 25.12.21 20:00 | Giresunspor | 0-1 Ayoub El Kaabi | Hatayspor |
| 25.12.21 20:00 | Trabzonspor | 0-0 | Istanbul Basaksehir |
| 26.12.21 20:00 | Goztepe | 1-1 Joher Khadim Rassoul (og) / Mario Balotelli | Adana Demirspor |
| 26.12.21 20:00 | Rizespor | 0-1 Alexandru Maxim | Gaziantep FK |
| 26.12.21 20:00 | Alanyaspor | 1-1 Efkan Bekiroglu / Aleksandar Pesic | Fatih Karagumruk AS |
| 26.12.21 20:00 | Fenerbahce | 2-0 Filip Novak, Dimitris Pelkas | Yeni Malatyaspor |
| 27.12.21 20:00 | Konyaspor | 1-0 Koka | Besiktas |
| 27.12.21 20:00 | Kayserispor | 3-0 Mario Gavranovic (2), Mame Thiam | Sivasspor |
| 20. HAFTA | |||
| 01.01.22 20:00 | Trabzonspor | 1-0 Andreas Cornelius | Yeni Malatyaspor |
| 08.01.22 20:00 | Alanyaspor | 1-1 Khouma Babacar / Junior Caicara | Istanbul Basaksehir |
| 08.01.22 20:00 | Kasimpasa | 3-1 Valentin Eysseric, Umut Bozok, Michal Travnik / Onur Ergün | Hatayspor |
| 08.01.22 20:00 | Galatasaray | 0-1 Magomed-Shapi Suleymanov | Giresunspor |
| 08.01.22 20:00 | Gaziantep FK | 3-1 Furkan Soyalp, Muhammet Demir, Joao Figueiredo / Emre Mor | Fatih Karagumruk AS |
| 09.01.22 20:00 | Goztepe | 4-0 Atınç Nukan, Cherif Ndiaye (3) | Antalyaspor |
| 09.01.22 20:00 | Kayserispor | 1-0 Mustafa Pektemek | Altay |
| 09.01.22 20:00 | Konyaspor | 0-1 Leke James | Sivasspor |
| 09.01.22 20:00 | Rizespor | 2-2 Joel Pohjanpalo (2) / Michy Batshuayi, Emirhan İlkhan | Besiktas |
| 10.01.22 20:00 | Fenerbahce | 1-2 Enner Valencia / Gokhan İnler, Younes Belhanda | Adana Demirspor |
| 21. HAFTA | |||
| 14.01.22 20:00 | Besiktas | 1-0 Michy Batshuayi | Gaziantep FK |
| 14.01.22 20:00 | Yeni Malatyaspor | 1-2 Mustafa Eskihellac / Berkan Emir, Lourency | Goztepe |
| 15.01.22 20:00 | Sivasspor | 1-1 Leke James / Abdulkadir Ömür | Trabzonspor |
| 15.01.22 20:00 | Antalyaspor | 1-1 Dogukan Sinik / Jose Sosa | Fenerbahce |
| 15.01.22 20:00 | Adana Demirspor | 1-1 Britt Assombalonga / Carlos Mane | Kayserispor |
| 15.01.22 20:00 | Fatih Karagumruk AS | 2-0 Aleksandar Pesic, Salih Dursun | Rizespor |
| 16.01.22 20:00 | Altay | 0-2 Emre Akbaba, Oguz Aydın | Alanyaspor |
| 16.01.22 20:00 | Giresunspor | 0-2 Mortadha Ben Ouanes, Florent Hadergjonaj | Kasimpasa |
| 16.01.22 20:00 | Hatayspor | 4-2 Mame Diouf, Mohammed Kamara, Saba Lobzhanidze (2) / Emre Kılınç, Muhammed Kerem Aktürkoğlu | Galatasaray |
| 22.02.22 20:00 | Istanbul Basaksehir | 2-1 Fredrik Gulbrandsen, Musa Çağıran (k.k.) / Zymer Bytyqi | Konyaspor |
| 22. HAFTA | |||
| 18.01.22 20:00 | Fatih Karagumruk AS | 0-1 Michy Batshuayi | Besiktas |
| 18.01.22 20:00 | Konyaspor | 1-0 Amar Rahmanovic | Adana Demirspor |
| 19.01.22 20:00 | Fenerbahce | 2-1 İrfan Can Kahveci, Serdar Dursun / Ahmed Yasser Rayan | Altay |
| 19.01.22 20:00 | Trabzonspor | 1-1 Andreas Cornelius / Umut Nayir | Giresunspor |
| 19.01.22 20:00 | Goztepe | 2-1 David Tijanic, Atınç Nukan / Pedro Henrique | Sivasspor |
| 19.01.22 20:00 | Kayserispor | 1-0 Ugur Demirok | Istanbul Basaksehir |
| 20.01.22 20:00 | Galatasaray | 1-3 Halil Dervişoğlu / Ryan Donk, Umut Bozok, Kevin Varga | Kasimpasa |
| 20.01.22 20:00 | Alanyaspor | 6-0 Emre Akbaba (3), Wilson Eduardo, Oğuz Aydın (2) | Hatayspor |
| 20.01.22 20:00 | Rizespor | 2-1 Joel Pohjanpalo, Gökhan Gönül / Haji Amir Wright | Antalyaspor |
| 23.01.22 20:00 | Gaziantep FK | 0-0 | Yeni Malatyaspor |
| 23. HAFTA | |||
| 22.01.22 20:00 | Istanbul Basaksehir | 1-2 Danijel Aleksic / Cherif Ndiaye, Halil Akbunar | Goztepe |
| 22.01.22 20:00 | Sivasspor | 1-1 Pedro Henrique / Miha Zajc | Fenerbahce |
| 22.01.22 20:00 | Yeni Malatyaspor | 1-1 Adem Büyük / Alex Teixeira | Besiktas |
| 22.01.22 20:00 | Adana Demirspor | 5-0 Britt Assombalonga (2), Yunus Akgün (2), Mario Balotelli | Fatih Karagumruk AS |
| 23.01.22 20:00 | Altay | 0-1 Koka | Konyaspor |
| 23.01.22 20:00 | Antalyaspor | 0-0 | Gaziantep FK |
| 23.01.22 20:00 | Galatasaray | 1-2 Alexandru Cicaldau / Anastasios Bakasetas, Edin Visca | Trabzonspor |
| 23.01.22 20:00 | Giresunspor | 1-3 Umut Nayir / Davidson, Emre Akbaba (2) | Alanyaspor |
| 23.01.22 20:00 | Hatayspor | 0-0 | Rizespor |
| 23.01.22 20:00 | Kasimpasa | 3-1 Yasir Subaşı (k.k.), Umut Bozok, Ahmet Engin / Mario Gavranovic | Kayserispor |
| 24. HAFTA | |||
| 04.02.22 20:00 | Kayserispor | 4-3 İbrahim Akdağ, Carlos Mane, Emrah Bassan, Ugur Demirok / Dylan Saint-Louis, Simon Falette, Mame Diouf | Hatayspor |
| 06.02.22 20:00 | Konyaspor | 1-0 Zymer Bytyqi | Giresunspor |
| 05.02.22 20:00 | Trabzonspor | 1-0 Edin Visca | Kasimpasa |
| 05.02.22 20:00 | Fatih Karagumruk AS | 1-0 Salih Dursun | Yeni Malatyaspor |
| 05.02.22 20:00 | Fenerbahce | 0-1 Berkay Özcan | Istanbul Basaksehir |
| 05.02.22 20:00 | Gaziantep FK | 5-1 Papy Djilobodji (2), Muhammet Demir, Alexandru Maxim, Furkan Soyalp / Dimitrios Goutas | Sivasspor |
| 06.02.22 20:00 | Goztepe | 0-2 Deniz Kadah, Thaciano | Altay |
| 06.02.22 20:00 | Rizespor | 1-3 Yusuf Sarı / Birkir Bjarnason, Mario Balotelli (2) | Adana Demirspor |
| 06.02.22 20:00 | Alanyaspor | 1-0 Wilson Eduardo / Muhammed Kerem Aktürkoğlu | Galatasaray |
| 06.02.22 20:00 | Besiktas | 0-0 | Antalyaspor |
| 25. HAFTA | |||
| 11.02.22 20:00 | Altay | 0-0 | Rizespor |
| 12.02.22 20:00 | Galatasaray | 1-1 Mostafa Mohamed / Miguel Cardoso | Kayserispor |
| 12.02.22 20:00 | Giresunspor | 1-2 Chiquinho / Enner Valencia, Dimitris Pelkas | Fenerbahce |
| 12.02.22 20:00 | Istanbul Basaksehir | 2-0 Pizzi, Serdar Gürler | Gaziantep FK |
| 13.02.22 20:00 | Kasimpasa | 2-2 Mamadou Fall, Jackson Muleka / Wilson Eduardo, Efkan Bekiroglu | Alanyaspor |
| 13.02.22 20:00 | Antalyaspor | 3-0 Fernando, Fedor Kudryashov, Admir Mehmedi | Fatih Karagumruk AS |
| 13.02.22 20:00 | Sivasspor | 2-1 Olarenwaju Kayode, Faycal Fajr / Kenan Özer | Yeni Malatyaspor |
| 13.02.22 20:00 | Trabzonspor | 2-1 Edin Visca (2) / Sokol Cikalleshi | Konyaspor |
| 14.02.22 20:00 | Adana Demirspor | 1-1 Samet Akaydın / Alex Teixeira | Besiktas |
| 14.02.22 20:00 | Hatayspor | 2-1 Mame Diouf, Ayoub El Kaabi / Halil Akbunar | Goztepe |
| 26. HAFTA | |||
| 19.02.22 20:00 | Konyaspor | 4-4 Amilton, Amar Rahmanovic, Soner Dikmen, Sokol Cikalleshi / Mortadha Ben Ouanes, Haris Hajradinovic, Umut Bozok, Awer Mabil | Kasimpasa |
| 19.02.22 20:00 | Rizespor | 0-2 Trezeguet (2) | Istanbul Basaksehir |
| 20.02.22 20:00 | Besiktas | 1-0 Domagoj Vida | Altay |
| 20.02.22 20:00 | Yeni Malatyaspor | 1-2 Rahman Buğra Çağıran / Luiz Adriano, Fernando | Antalyaspor |
| 20.02.22 20:00 | Kayserispor | 2-1 Mario Gavranovic, Mert Çetin / Magomed-Shapi Suleymanov | Giresunspor |
| 21.02.22 20:00 | Fatih Karagumruk AS | 1-2 Fabio Borini | Sivasspor |
| 21.02.22 20:00 | Fenerbahce | 2-0 Serdar Dursun (2) | Hatayspor |
| 21.02.22 20:00 | Gaziantep FK | 0-3 Britt Assombalonga (2), Birkir Bjarnason | Adana Demirspor |
| 21.02.22 20:00 | Alanyaspor | 0-4 Anthony Nwakaeme (2), Andreas Cornelius, Dorukhan Tokoz | Trabzonspor |
| 22.02.22 20:00 | Goztepe | 2-3 Cherif Ndiaye (2) / Victor Nelsson, Bafetimbi Gomis (2) | Galatasaray |
| 27. HAFTA | |||
| 25.02.22 20:00 | Trabzonspor | 3-2 Edin Visca, Djanini Tvaris, Anthony Nwakaeme / Mario Gavranovic, Mame Thiam | Kayserispor |
| 25.02.22 20:00 | Adana Demirspor | 0-0 | Antalyaspor |
| 26.02.22 20:00 | Istanbul Basaksehir | 1-2 Trezeguet / Fabio Borini, Ahmed Musa | Fatih Karagumruk AS |
| 26.02.22 20:00 | Sivasspor | 2-3 Mustapha Yatabare, Faycal Fajr / Rachid Ghezzal, Michy Batshuayi (2) | Besiktas |
| 27.02.22 20:00 | Alanyaspor | 5-1 Daniel Candeias, Umut Güneş, Famara Diedhiou, Joao Novais, Oğuz Aydın / Abdülkerim Bardakcı | Konyaspor |
| 27.02.22 20:00 | Altay | 3-2 Thaciano, Doğan Endoğan (k.k.), Andre Poko / Alexandru Maxim (2) | Gaziantep FK |
| 27.02.22 20:00 | Galatasaray | 4-2 Patrick van Aanholt (2), Ryan Babel, Bafetimbi Gomis / Gedson Fernandes, Tyler Boyd | Rizespor |
| 27.02.22 20:00 | Giresunspor | 3-1 Umut Nayir, Alexis Perez, Muhammed Gümüşkaya / Francesco Di Santo | Goztepe |
| 27.02.22 20:00 | Hatayspor | 5-2 Ayoub El Kaabi (3), Yassine Benzia, Dylan Saint-Louis / Nouha Dicko (2) | Yeni Malatyaspor |
| 28.02.22 20:00 | Kasimpasa | 1-2 Jackson Muleka / Miha Zajc, Attila Szalai | Fenerbahce |
| 28. HAFTA | |||
| 04.03.22 20:00 | Yeni Malatyaspor | 1-0 Mounir Chouiar | Adana Demirspor |
| 05.03.22 20:00 | Konyaspor | 2-0 Koka, Amar Rahmanovic | Galatasaray |
| 05.03.22 20:00 | Goztepe | 2-3 Francesco Di Santo, Cherif Ndiaye / Jackson Muleka (2), Umut Bozok | Kasimpasa |
| 05.03.22 20:00 | Rizespor | 1-2 Joel Pohjanpalo / Chiquinho, Hamidou Traore | Giresunspor |
| 06.03.22 20:00 | Fatih Karagumruk AS | 0-0 | Altay |
| 06.03.22 20:00 | Antalyaspor | 1-0 Fernando | Sivasspor |
| 06.03.22 20:00 | Fenerbahce | 1-1 Miha Zajc / Anthony Nwakaeme | Trabzonspor |
| 07.03.22 20:00 | Besiktas | 2-2 Güven Yalçın, Kenan Karaman / Trezeguet, Stefano Okaka | Istanbul Basaksehir |
| 07.03.22 20:00 | Gaziantep FK | 2-2 Alexandru Maxim (2) / Steven Caulker (og), Ayoub El Kaabi | Hatayspor |
| 07.03.22 20:00 | Kayserispor | 1-2 Andrea Bertolacci / Oğuz Aydın, Eren Yardımcı | Alanyaspor |
| 29. HAFTA | |||
| 12.03.22 20:00 | Trabzonspor | 4-2 Anthony Nwakaeme, Abdulkadir Ömür (2), Djanini Tvaris / Halil Akbunar, Soner Aydoğdu | Goztepe |
| 12.03.22 20:00 | Kasimpasa | 3-1 Awer Mabil, Umut Bozok, Mamadou Fall / Selim Ay | Rizespor |
| 12.03.22 20:00 | Hatayspor | 3-0 Saba Lobzhanidze, Ayoub El Kaabi (2) | Fatih Karagumruk AS |
| 12.03.22 20:00 | Altay | 1-0 Marco Paixao | Yeni Malatyaspor |
| 13.03.22 20:00 | Adana Demirspor | 2-3 Benjamin Stambouli, Mario Balotelli / Pedro Henrique (3) | Sivasspor |
| 13.03.22 20:00 | Alanyaspor | 2-5 Tayfur Bingol (2) / Diego Rossi, Mesut Ozil, Arda Guler, Dimitris Pelkas, Mergim Berisha | Fenerbahce |
| 13.03.22 20:00 | Kayserispor | 2-3 Abdulkadir Parmak, Mario Gavranovic / Guilherme, Sokol Cikalleshi (2) | Konyaspor |
| 14.03.22 20:00 | Istanbul Basaksehir | 0-1 Haji Wright | Antalyaspor |
| 14.03.22 20:00 | Galatasaray | 2-1 Muhammed Kerem Aktürkoğlu (2) / Rıdvan Yılmaz | Besiktas |
| 14.03.22 20:00 | Giresunspor | 2-1 Serginho, Chiquinho / Alexandru Maxim | Gaziantep FK |
| 30. HAFTA | |||
| 18.03.22 20:00 | Fatih Karagumruk AS | 3-0 Emre Mor (3) | Kayserispor |
| 18.03.22 20:00 | Rizespor | 3-2 Joel Pohjanpalo (3) / Abdulkadir Ömür, Djanini Tvaris | Trabzonspor |
| 19.03.22 20:00 | Adana Demirspor | 2-1 Tayyib Sanuc, Birkir Bjarnason / Danijel Aleksic | Istanbul Basaksehir |
| 19.03.22 20:00 | Yeni Malatyaspor | 0-2 Jackson Muleka, Ahmet Engin | Kasimpasa |
| 19.03.22 20:00 | Goztepe | 0-2 Famara Diedhiou, Tayfur Bingöl | Alanyaspor |
| 19.03.22 20:00 | Besiktas | 1-1 Michy Batshuayi / Saba Lobzhanidze | Hatayspor |
| 20.03.22 20:00 | Antalyaspor | 4-1 Veysel Sarı, Doğukan Sinik, Fernando, Naldo / Myhammet Gümüşkaya | Giresunspor |
| 20.03.22 20:00 | Fenerbahce | 2-1 Min-Jae Kim, Dimitris Pelkas / Zymer Bytyqi | Konyaspor |
| 20.03.22 20:00 | Gaziantep FK | 3-1 Papy Djilobodji, Alexandru Maxim, Joao Figueiredo / Bafetimbi Gomis | Galatasaray |
| 20.03.22 20:00 | Sivasspor | 2-1 Olarenwaju Kayode, Mustapha Yatabare / Martin Rodriguez | Altay |
| 31. HAFTA | |||
| 02.04.22 20:00 | Altay | 1-2 Ahmed Yasser Rayan / Luiz Adriano, Haji Wright | Antalyaspor |
| 02.04.22 20:00 | Galatasaray | 2-0 Bafetimbi Gomis, Ryan Babel | Fatih Karagumruk AS |
| 02.04.22 20:00 | Kayserispor | 0-4 Miha Zajc, Diego Rossi, İrfan Kahveci, Arda Guler | Fenerbahce |
| 02.04.22 20:00 | Giresunspor | 2-2 Mehmet Umut Nayir (2) / Olarenwaju Kayode, Max Gradel | Sivasspor |
| 03.04.22 20:00 | Alanyaspor | 2-1 Emre Akbaba, Efecan Karaca / Papiss Demba Cisse | Rizespor |
| 03.04.22 20:00 | Kasimpasa | 2-1 Jackson Muleka, Florent Hadergjonaj / Papy Djilobodji | Gaziantep FK |
| 03.04.22 20:00 | Konyaspor | 3-0 Sokol Cikalleshi, Ogulcan Ulgun, Zymer Bytyqi | Goztepe |
| 03.04.22 20:00 | Trabzonspor | 1-1 Andreas Cornelius / Valentin Rosier | Besiktas |
| 04.04.22 20:00 | Hatayspor | 0-0 | Adana Demirspor |
| 04.04.22 20:00 | Istanbul Basaksehir | 1-0 Danijel Aleksic | Yeni Malatyaspor |
| 32. HAFTA | |||
| 09.04.22 20:00 | Gaziantep FK | 0-0 | Trabzonspor |
| 09.04.22 20:00 | Besiktas | 4-1 Michy Batshuayi (2), Josef De Souza, Güven Yalçın / Efecan Karaca | Alanyaspor |
| 09.04.22 20:00 | Fatih Karagumruk AS | 3-2 Adnan Uğur, Aleksandar Pesic, Kristijan Bistrovic / Tarkan Serbest, Jackson Muleka | Kasimpasa |
| 09.04.22 20:00 | Goztepe | 1-2 Francesco Di Santo / Emrah Bassan, Olivier Kemen | Kayserispor |
| 09.04.22 20:00 | Rizespor | 2-1 Yannick Bolasie, Joel Pohjanpalo / Zymer Bytyqi | Konyaspor |
| 10.04.22 20:00 | Adana Demirspor | 3-1 Younes Belhanda, Samet Akaydın, Mario Balotelli / Mohammad Naderi | Altay |
| 10.04.22 20:00 | Fenerbahce | 2-0 Miha Zajc, Serdar Dursun | Galatasaray |
| 10.04.22 20:00 | Sivasspor | 0-2 Dimitrios Goutas (og), Deniz Turuc | Istanbul Basaksehir |
| 10.04.22 20:00 | Yeni Malatyaspor | 0-1 Hamidou Traore | Giresunspor |
| 11.04.22 20:00 | Antalyaspor | 4-1 Haji Wright (2), Naldo, Luiz Adriano / Mame Diouf | Hatayspor |
| 33. HAFTA | |||
| 15.04.22 20:00 | Trabzonspor | 1-1 Vitor Hugo / Lucas Biglia | Fatih Karagumruk AS |
| 15.04.22 20:00 | Kayserispor | 1-1 Emrah Bassan / Joel Pohjanpalo | Rizespor |
| 16.04.22 20:00 | Alanyaspor | 1-3 Famara Diedhiou / Haji Wright, Gokdeniz Bayrakdar (2) | Antalyaspor |
| 16.04.22 20:00 | Altay | 1-1 Ceyhun Gulselam / Trezeguet | Istanbul Basaksehir |
| 16.04.22 20:00 | Hatayspor | 1-1 Yassine Benzia / Ziya Erdal | Sivasspor |
| 16.04.22 20:00 | Fenerbahce | 2-0 Serdar Aziz, Arda Guler | Goztepe |
| 17.04.22 20:00 | Giresunspor | 0-0 | Besiktas |
| 17.04.22 20:00 | Kasimpasa | 4-0 Dogucan Haspolat, Jackson Muleka (2), Umut Bozok | Adana Demirspor |
| 17.04.22 20:00 | Konyaspor | 4-1 Endri Cekici, Koka, Amir Hadziahmetovic, Konrad Michalak / Muhammet Demir | Gaziantep FK |
| 18.04.22 20:00 | Galatasaray | 2-0 Ryan Babel, Halil Dervişoğlu | Yeni Malatyaspor |
| 34. HAFTA | |||
| 22.04.22 20:00 | Rizespor | 0-6 Diego Rossi, Serdar Dursun (3), Enner Valencia, Nazim Sangare | Fenerbahce |
| 23.04.22 20:00 | Adana Demirspor | 1-3 Matias Vargas / Bruno Peres, Andreas Cornelius, Djanini Tvaris | Trabzonspor |
| 23.04.22 20:00 | Fatih Karagumruk AS | 2-1 Aleksandar Pesic, Jimmy Durmaz / Chiquinho | Giresunspor |
| 23.04.22 20:00 | Gaziantep FK | 1-1 Joao Figueiredo / Adis Jahovic | Goztepe |
| 24.04.22 20:00 | Altay | 0-1 Kerem Aktürkoğlu | Galatasaray |
| 24.04.22 20:00 | Yeni Malatyaspor | 2-3 Benjamin Tetteh, Nouha Dicko / Nejc Skubic, Abdulkerim Bardakci, Koka | Konyaspor |
| 24.04.22 20:00 | Antalyaspor | 1-1 Haji Wright / Joseph Attamah | Kayserispor |
| 24.04.22 20:00 | Istanbul Basaksehir | 3-0 Deniz Türüç (2), Mahmut Tekdemir | Hatayspor |
| 25.04.22 20:00 | Sivasspor | 1-0 Faycal Fajr | Alanyaspor |
| 25.04.22 20:00 | Besiktas | 0-3 Jackson Muleka (2), Mortadha Ben Ouanes | Kasimpasa |
| 35. HAFTA | |||
| 29.04.22 20:00 | Fenerbahce | 3-2 Diego Rossi, Serdar Dursun, Miha Zajc / Angelo Sagal, Alexandru Maxim | Gaziantep FK |
| 29.04.22 20:00 | Giresunspor | 2-0 Umut Nayir, Serginho | Adana Demirspor |
| 30.04.22 20:00 | Trabzonspor | 2-2 Andreas Cornelius, Dorukhan Tokoz / Alassane Ndao, Haji Wright | Antalyaspor |
| 30.04.22 20:00 | Kasimpasa | 2-3 Mamadou Fall, Jackson Muleka / Trezeguet, Deniz Türüç, Fredrik Gulbrandsen | Istanbul Basaksehir |
| 30.04.22 20:00 | Konyaspor | 1-2 Zymer Bytyqi / Samed Onur, Yann Karamoh | Fatih Karagumruk AS |
| 30.04.22 20:00 | Hatayspor | 0-1 Leandro Kappel | Altay |
| 01.05.22 20:00 | Galatasaray | 2-3 Bafetimbi Gomis (2) / Mustapha Yatabare, Fredrik Ulvestad, Ahmet Oguz | Sivasspor |
| 01.05.22 20:00 | Goztepe | 1-7 Makana Baku / Kahraman Demirtas (og), Papiss Demba Cisse, Gedson (2), Yusuf Sarı, Joel Pohjanpalo, Ronaldo Mendes | Rizespor |
| 01.05.22 20:00 | Alanyaspor | 2-1 Daniel Candeias, Oguz Aydın / Nouha Dicko | Yeni Malatyaspor |
| 01.05.22 20:00 | Kayserispor | 2-3 Mame Thiam, Miguel Cardoso / Serdar Saatcı, Georges-Kevin Nkoudou (2) | Besiktas |
| 36. HAFTA | |||
| 06.05.22 20:00 | Hatayspor | 1-1 Mame Diouf / Djanini Tvaris | Trabzonspor |
| 06.05.22 20:00 | Gaziantep FK | 1-1 Alexandru Maxim / İlhan Parlak | Kayserispor |
| 07.05.22 20:00 | Adana Demirspor | 1-2 Younes Belhanda / Tayyib Sanuc (og), Emre Akbaba | Alanyaspor |
| 07.05.22 20:00 | Fatih Karagumruk AS | 3-1 Fabio Borini, Emre Mor, Burak Bekaroglu / Makana Baku | Goztepe |
| 07.05.22 20:00 | Istanbul Basaksehir | 0-0 | Galatasaray |
| 07.05.22 20:00 | Sivasspor | 1-3 Jorge Felix / Evren Eren Elmalı, Valentin Eysseric, Umut Bozok | Kasimpasa |
| 08.05.22 20:00 | Altay | 1-1 Leandro Kappel / Umut Nayir | Giresunspor |
| 08.05.22 20:00 | Besiktas | 1-1 Rachid Ghezzal / Filip Novak | Fenerbahce |
| 08.05.22 20:00 | Yeni Malatyaspor | 1-3 Buğra Çağıran / Aminu Umar, Yusuf Sarı, Joel Pohjanpalo | Rizespor |
| 09.05.22 20:00 | Antalyaspor | 3-2 Luiz Adriano, Alassane Ndao, Haji Wright / Guilherme, Endri Cekici | Konyaspor |
| 37. HAFTA | |||
| 14.05.22 20:00 | Kayserispor | 3-0 Gökhan Sazdağı (2), Hayrullah Erkip | Yeni Malatyaspor |
| 15.05.22 20:00 | Alanyaspor | 3-0 Famara Diedhiou, Wilson Eduardo, Daniel Candeias | Gaziantep FK |
| 15.05.22 20:00 | Fenerbahce | 0-0 | Fatih Karagumruk AS |
| 15.05.22 20:00 | Giresunspor | 1-1 Alexis Perez / Stefano Okaka | Istanbul Basaksehir |
| 15.05.22 20:00 | Goztepe | 0-2 Cyle Larin, Josef | Besiktas |
| 15.05.22 20:00 | Kasimpasa | 2-4 Umut Bozok (2) / Fredy, Naldo, Haji Wright, Florent Hadergjonaj (og) | Antalyaspor |
| 15.05.22 20:00 | Konyaspor | 3-1 Zymer Bytyqi, Konrad Michalak, Koka / Ayoub El Kaabi | Hatayspor |
| 15.05.22 20:00 | Trabzonspor | 2-1 Ibrahim Ozturk (og), Anthony Nwakaeme / Martin Rodriguez | Altay |
| 16.05.22 20:00 | Rizespor | 1-2 Tyler Boyd / Erdogan Yesilyurt, Fredrik Ulvestad | Sivasspor |
| 16.05.22 20:00 | Galatasaray | 3-2 Bafetimbi Gomis (2), Muhammed Kerem Akturkoglu / Mario Balotelli, Yunus Akgün | Adana Demirspor |
| 38. HAFTA | |||
| 20.05.22 20:00 | Gaziantep FK | 2-0 Luka Stankovski, Alexandru Maxim | Rizespor |
| 20.05.22 20:00 | Antalyaspor | 1-1 Alassane Ndao / Mostafa Mohamed | Galatasaray |
| 21.05.22 20:00 | Altay | 2-4 İbrahim Öztürk, Leandro Kappel / Valentin Eysseric (2), Umut Bozok (2) | Kasimpasa |
| 21.05.22 20:00 | Besiktas | 1-1 Kenan Karaman / Amar Rahmanovic | Konyaspor |
| 21.05.22 20:00 | Yeni Malatyaspor | 0-5 Serdar Dursun, Serdar Aziz, Irfan Can Kahveci, Enner Valencia (2) | Fenerbahce |
| 21.05.22 20:00 | Sivasspor | 2-1 Jorge Felix, Kerem Atakan Kesgin / Miguel Cardoso | Kayserispor |
| 22.05.22 20:00 | Fatih Karagumruk AS | 0-1 Efecan Karaca | Alanyaspor |
| 22.05.22 20:00 | Hatayspor | 4-1 Ayoub El Kaabi (2), Bertug Ozgur Yildirim, Kahraba / Hayrullah Bilazer | Giresunspor |
| 22.05.22 20:00 | Adana Demirspor | 7-0 Atakan Cankaya (og), Mario Balotelli (5), Erhun Oztumer | Goztepe |
| 22.05.22 20:00 | Istanbul Basaksehir | 3-1 Stefano Okaka, Alexandru Epureanu, Serdar Gurler / Anthony Nwakaeme | Trabzonspor |
