| ROUND 1 | |||
|---|---|---|---|
| 21.08.21 18:30 | Inter (9) | 4-0 Milan Skriniar, Hakan Çalhanoğlu, Arturo Vidal, Edin Dzeko | Genoa (7) |
| 21.08.21 18:30 | Verona (8) | 2-3 Mattia Zaccagni (2) / Giacomo Raspadori, Filip Djuricic, Hamed Junior Traor | Sassuolo (16) |
| 21.08.21 20:45 | Empoli (5) | 1-3 Filippo Bandinelli / Sergej Milinkovic-Savic, Manuel Lazzari, Ciro Immobile | Lazio (11) |
| 21.08.21 20:45 | Torino (18) | 1-2 Andrea Belotti / Luis Muriel, Roberto Piccoli | Atalanta (2) |
| 22.08.21 18:30 | Bologna (3) | 3-2 Lorenzo De Silvestri (2), Marko Arnautovic / Federico Bonazzoli, Mamadou Coulibaly | Salernitana (14) |
| 22.08.21 18:30 | Udinese (19) | 2-2 Roberto Pereyra, Gerard Deulofeu / Paulo Dybala, Juan Cuadrado | Juventus (10) |
| 22.08.21 20:45 | AS Roma (12) | 3-1 Henrikh Mkhitaryan, Jordan Veretout (2) / Nikola Milenkovic | Fiorentina (6) |
| 22.08.21 20:45 | Napoli (13) | 2-0 Lorenzo Insigne, Eljif Elmas | Venezia (20) |
| 23.08.21 18:30 | Cagliari (4) | 2-2 Joao Pedro (2) / Emmanuel Gyasi, Simone Bastoni | Spezia (17) |
| 23.08.21 20:45 | Sampdoria (15) | 0-1 Brahim Diaz | AC Milan (1) |
| ROUND 2 | |||
| 27.08.21 18:30 | Udinese (19) | 3-0 Ignacio Pussetto, Gerard Deulofeu, Nahuel Molina | Venezia (20) |
| 27.08.21 20:45 | Verona (8) | 1-3 Ivan Ilic / Lautaro Martinez, Joaquin Correa (2) | Inter (9) |
| 28.08.21 18:30 | Atalanta (2) | 0-0 | Bologna (3) |
| 28.08.21 18:30 | Lazio (11) | 6-1 Ciro Immobile (3), Felipe Anderson, Elseid Hysaj, Luis Alberto / Daniele Verde | Spezia (17) |
| 28.08.21 20:45 | Fiorentina (6) | 2-1 Nicolas Gonzalez, Dusan Vlahovic / Simone Verdi | Torino (18) |
| 28.08.21 20:45 | Juventus (10) | 0-1 Leonardo Mancuso | Empoli (5) |
| 29.08.21 18:30 | Genoa (7) | 1-2 Andrea Cambiaso / Fabian Ruiz, Andrea Petagna | Napoli (13) |
| 29.08.21 18:30 | Sassuolo (16) | 0-0 | Sampdoria (15) |
| 29.08.21 20:45 | AC Milan (1) | 4-1 Sandro Tonali, Rafael Leao, Olivier Giroud (2) / Alessandro Deiola | Cagliari (4) |
| 29.08.21 20:45 | Salernitana (14) | 0-4 Lorenzo Pellegrini (2), Jordan Veretout, Tammy Abraham | AS Roma (12) |
| ROUND 3 | |||
| 12.09.21 19:30 | Empoli (5) | 1-2 Nedim Bajrami / Thomas Henry, David Okereke | Venezia (20) |
| 12.09.21 19:30 | Atalanta (2) | 1-2 Duvan Zapata / Dusan Vlahovic (2) | Fiorentina (6) |
| 12.09.21 19:30 | Napoli (13) | 2-1 Matteo Politano, Kalidou Koulibaly / Alvaro Morata | Juventus (10) |
| 12.09.21 19:30 | AC Milan (1) | 2-0 Rafael Leao, Zlatan Ibrahimovic | Lazio (11) |
| 12.09.21 19:30 | AS Roma (12) | 2-1 Bryan Cristante, Stephan El Shaarawy / Filip Djuricic | Sassuolo (16) |
| 12.09.21 19:30 | Cagliari (4) | 2-3 Joao Pedro, Luca Ceppitelli / Mattia Destro, Mohamed Fares (2) | Genoa (7) |
| 12.09.21 19:30 | Sampdoria (15) | 2-2 Maya Yoshida, Tommaso Augello / Federico Dimarco, Lautaro Martinez | Inter (9) |
| 12.09.21 19:30 | Spezia (17) | 0-1 Lazar Samardzic | Udinese (19) |
| 12.09.21 19:30 | Torino (18) | 4-0 Antonio Sanabria, Kasper Bremer, Tommaso Pobega, Sasa Lukic | Salernitana (14) |
| 13.09.21 19:30 | Bologna (3) | 1-0 Mattias Svanberg | Verona (8) |
| ROUND 4 | |||
| 17.09.21 19:30 | Sassuolo (16) | 0-1 Marko Pjaca | Torino (18) |
| 18.09.21 19:30 | Salernitana (14) | 0-1 Duvan Zapata | Atalanta (2) |
| 18.09.21 19:30 | Inter (9) | 6-1 Lautaro Martinez, Milan Skriniar, Nicolo Barella, Matias Vecino, Edin Dzeko (2) / Arthur Theate | Bologna (3) |
| 18.09.21 19:30 | Genoa (7) | 1-2 Domenico Criscito / Riccardo Saponara, Giacomo Bonaventura | Fiorentina (6) |
| 19.09.21 19:30 | Juventus (10) | 1-1 Alvaro Morata / Ante Rebic | AC Milan (1) |
| 19.09.21 19:30 | Lazio (11) | 2-2 Ciro Immobile, Danilo Cataldi / Joao Pedro, Keita Balde | Cagliari (4) |
| 19.09.21 19:30 | Empoli (5) | 0-3 Francesco Caputo (2), Antonio Candreva | Sampdoria (15) |
| 19.09.21 19:30 | Venezia (20) | 1-2 Pietro Ceccaroni / Simone Bastoni, Mehdi Bourabia | Spezia (17) |
| 19.09.21 19:30 | Verona (8) | 3-2 Antonin Barak, Gianluca Caprari, Davide Faraoni / Ivan Ilic (og), Lorenzo Pellegrini | AS Roma (12) |
| 20.09.21 19:30 | Udinese (19) | 0-4 Victor Osimhen, Amir Rrahmani, Kalidou Koulibaly, Hirving Lozano | Napoli (13) |
| ROUND 5 | |||
| 21.09.21 19:30 | Fiorentina (6) | 1-3 Riccardo Sottil / Matteo Darmian, Edin Dzeko, Ivan Perisic | Inter (9) |
| 21.09.21 19:30 | Bologna (3) | 2-2 Aaron Hickey, Marko Arnautovic / Mattia Destro, Domenico Criscito | Genoa (7) |
| 21.09.21 19:30 | Atalanta (2) | 2-1 Robin Gosens, Davide Zappacosta / Domenico Berardi | Sassuolo (16) |
| 22.09.21 19:30 | AC Milan (1) | 2-0 Brahim Diaz, Theo Hernandez | Venezia (20) |
| 22.09.21 19:30 | Cagliari (4) | 0-2 Federico Di Francesco, Leo Stulac | Empoli (5) |
| 22.09.21 19:30 | Spezia (17) | 2-3 Emmanuel Gyasi, Janis Antiste / Moise Kean, Federico Chiesa, Matthijs de Ligt | Juventus (10) |
| 22.09.21 19:30 | Salernitana (14) | 2-2 Cedric Gondo, Mamadou Coulibaly / Nikola Kalinic (2) | Verona (8) |
| 23.09.21 19:30 | Sampdoria (15) | 0-4 Victor Osimhen (2), Fabian Ruiz, Piotr Zielinski | Napoli (13) |
| 23.09.21 19:30 | Torino (18) | 1-1 Marko Pjaca / Ciro Immobile | Lazio (11) |
| 23.09.21 19:30 | AS Roma (12) | 1-0 Tammy Abraham | Udinese (19) |
| ROUND 6 | |||
| 25.09.21 19:30 | Genoa | 3-3 Domenico Criscito, Mattia Destro (2) / Giovanni Simeone, Antonin Barak, Nikola Kalinic | Verona |
| 25.09.21 19:30 | Spezia | 1-2 Daniele Verde / Daniel Maldini, Brahim Diaz | AC Milan |
| 25.09.21 19:30 | Inter | 2-2 Lautaro Martinez, Edin Dzeko / Ruslan Malinovskiy, Rafael Toloi | Atalanta |
| 26.09.21 19:30 | Juventus | 3-2 Paulo Dybala, Leonardo Bonucci, Manuel Locatelli / Maya Yoshida, Antonio Candreva | Sampdoria |
| 26.09.21 19:30 | Empoli | 4-2 Kevin Bonifazi (og), Andrea Pinamonti, Nedim Bajrami, Samuele Ricci / Musa Barrow, Marko Arnautovic | Bologna |
| 26.09.21 19:30 | Lazio | 3-2 Sergej Milinkovic-Savic, Pedro, Felipe Anderson / Roger Ibanez, Jordan Veretout | AS Roma |
| 26.09.21 19:30 | Napoli | 2-0 Victor Osimhen, Lorenzo Insigne | Cagliari |
| 26.09.21 19:30 | Sassuolo | 1-0 Domenico Berardi | Salernitana |
| 26.09.21 19:30 | Udinese | 0-1 Dusan Vlahovic | Fiorentina |
| 27.09.21 19:30 | Venezia | 1-1 Mattia Aramu / Josip Brekalo | Torino |
| ROUND 7 | |||
| 01.10.21 19:30 | Cagliari | 1-1 Keita Balde / Gianluca Busio | Venezia |
| 02.10.21 19:30 | Salernitana | 1-0 Milan Djuric | Genoa |
| 02.10.21 19:30 | Torino | 0-1 Manuel Locatelli | Juventus |
| 02.10.21 19:30 | Sassuolo | 1-2 Domenico Berardi / Edin Dzeko, Lautaro Martinez | Inter |
| 03.10.21 19:30 | AS Roma | 2-0 Lorenzo Pellegrini, Henrikh Mkhitaryan | Empoli |
| 03.10.21 19:30 | Atalanta | 2-3 Duvan Zapata, Mario Pasalic / Davide Calabria, Sandro Tonali, Rafael Leao | AC Milan |
| 03.10.21 19:30 | Bologna | 3-0 Musa Barrow, Arthur Theate, Aaron Hickey | Lazio |
| 03.10.21 19:30 | Fiorentina | 1-2 Lucas Martinez / Hirving Lozano, Amir Rrahmani | Napoli |
| 03.10.21 19:30 | Sampdoria | 3-3 Jens Stryger Larsen (og), Fabio Quagliarella, Antonio Candreva / Beto, Roberto Pereyra, Fernando Forestieri | Udinese |
| 03.10.21 19:30 | Verona | 4-0 Giovanni Simeone, Davide Faraoni, Gianluca Caprari, Daniel Bessa | Spezia |
| ROUND 8 | |||
| 16.10.21 19:30 | AC Milan | 3-2 Olivier Giroud, Franck Kessie, Koray Gunter (og) / Gianluca Caprari, Antonin Barak | Verona |
| 16.10.21 19:30 | Spezia | 2-1 David Strelec, Viktor Kovalenko / Simy | Salernitana |
| 16.10.21 19:30 | Lazio | 3-1 Ciro Immobile, Felipe Anderson, Sergej Milinkovic-Savic / Ivan Perisic | Inter |
| 17.10.21 19:30 | Cagliari | 3-1 Joao Pedro (2), Martin Caceres / Morten Thorsby | Sampdoria |
| 17.10.21 19:30 | Empoli | 1-4 Federico Di Francesco / Mattia Viti (og), Josip Ilicic (2), Duvan Zapata | Atalanta |
| 17.10.21 19:30 | Genoa | 2-2 Mattia Destro, Johan Vasquez / Gianluca Scamacca (2) | Sassuolo |
| 17.10.21 19:30 | Napoli | 1-0 Victor Osimhen | Torino |
| 17.10.21 19:30 | Udinese | 1-1 Beto / Musa Barrow | Bologna |
| 17.10.21 19:30 | Juventus | 1-0 Moise Kean | AS Roma |
| 18.10.21 19:30 | Venezia | 1-0 Mattia Aramu | Fiorentina |
| ROUND 9 | |||
| 22.10.21 19:30 | Torino | 3-2 Antonio Sanabria, Tommaso Pobega, Josip Brekalo / Mattia Destro, Felipe Caicedo | Genoa |
| 22.10.21 19:30 | Sampdoria | 2-1 Emmanuel Gyasi (og), Antonio Candreva / Daniele Verde | Spezia |
| 23.10.21 19:30 | Salernitana | 2-4 Luca Ranieri, Ardian Ismajli (og) / Andrea Pinamonti (2), Patrick Cutrone, Stefan Strandberg (og) | Empoli |
| 23.10.21 19:30 | Sassuolo | 3-1 Domenico Berardi, Thomas Henry (og), Davide Frattesi / David Okereke | Venezia |
| 23.10.21 19:30 | Bologna | 2-4 Zlatan Ibrahimovic (og), Musa Barrow / Rafael Leao, Davide Calabria, Ismael Bennacer, Zlatan Ibrahimovic | AC Milan |
| 24.10.21 19:30 | AS Roma | 0-0 | Napoli |
| 24.10.21 19:30 | Atalanta | 1-1 Ruslan Malinovskiy / Beto | Udinese |
| 24.10.21 19:30 | Fiorentina | 3-0 Cristiano Biraghi, Nicolas Gonzalez, Dusan Vlahovic | Cagliari |
| 24.10.21 19:30 | Inter | 1-1 Edin Dzeko / Paulo Dybala | Juventus |
| 24.10.21 19:30 | Verona | 4-1 Giovanni Simeone (4) / Ciro Immobile | Lazio |
| ROUND 10 | |||
| 26.10.21 19:30 | AC Milan | 1-0 Olivier Giroud | Torino |
| 26.10.21 19:30 | Spezia | 1-1 Salvatore Sirigu (og) / Domenico Criscito | Genoa |
| 26.10.21 19:30 | Venezia | 1-2 Mattia Aramu / Federico Bonazzoli, Andrea Schiavone | Salernitana |
| 27.10.21 19:30 | Cagliari | 1-2 Leonardo Pavoletti / Roger Ibanez, Lorenzo Pellegrini | AS Roma |
| 27.10.21 19:30 | Empoli | 0-2 Danilo D'Ambrosio, Federico Dimarco | Inter |
| 27.10.21 19:30 | Juventus | 1-2 Weston McKennie / Davide Frattesi, Maxime Lopez | Sassuolo |
| 27.10.21 19:30 | Lazio | 1-0 Pedro | Fiorentina |
| 27.10.21 19:30 | Sampdoria | 1-3 Francesco Caputo / Kristoffer Askildsen (og), Duvan Zapata, Josip Ilicic | Atalanta |
| 27.10.21 19:30 | Udinese | 1-1 Isaac Success / Antonin Barak | Verona |
| 28.10.21 19:30 | Napoli | 3-0 Fabian Ruiz, Lorenzo Insigne (2) | Bologna |
| ROUND 11 | |||
| 30.10.21 20:30 | Torino | 3-0 Dennis Praet, Wilfried Stephane Singo, Andrea Belotti | Sampdoria |
| 30.10.21 20:30 | Verona | 2-1 Giovanni Simeone (2) / Weston McKennie | Juventus |
| 30.10.21 20:30 | Atalanta | 2-2 Duvan Zapata, Marten de Roon / Pedro, Ciro Immobile | Lazio |
| 31.10.21 20:30 | Sassuolo | 1-2 Lorenzo Tonelli (og) / Andrea Pinamonti, Szymon Zurkowski | Empoli |
| 31.10.21 20:30 | Fiorentina | 3-0 Dusan Vlahovic (2), Jose Callejon | Spezia |
| 31.10.21 20:30 | Genoa | 0-0 | Venezia |
| 31.10.21 20:30 | Inter | 2-0 Joaquin Correa (2) | Udinese |
| 31.10.21 20:30 | Salernitana | 0-1 Piotr Zielinski | Napoli |
| 31.10.21 20:30 | AS Roma | 1-2 Stephan El Shaarawy / Zlatan Ibrahimovic, Franck Kessie | AC Milan |
| 01.11.21 20:30 | Bologna | 2-0 Lorenzo De Silvestri, Marko Arnautovic | Cagliari |
| ROUND 12 | |||
| 05.11.21 20:30 | Empoli | 2-2 Federico Di Francesco, Szymon Zurkowski / Domenico Criscito, Flavio Bianchi | Genoa |
| 07.11.21 20:30 | AC Milan | 1-1 Stefan de Vrij (og) / Hakan Calhanoglu | Inter |
| 06.11.21 20:30 | Cagliari | 1-2 Joao Pedro / Mario Pasalic, Duvan Zapata | Atalanta |
| 06.11.21 20:30 | Spezia | 1-0 Jacopo Sala | Torino |
| 06.11.21 20:30 | Juventus | 1-0 Juan Cuadrado | Fiorentina |
| 07.11.21 20:30 | Lazio | 3-0 Ciro Immobile, Pedro, Luis Alberto | Salernitana |
| 07.11.21 20:30 | Napoli | 1-1 Giovanni Di Lorenzo / Giovanni Simeone | Verona |
| 07.11.21 20:30 | Sampdoria | 1-2 Morten Thorsby / Mattias Svanberg, Marko Arnautovic | Bologna |
| 07.11.21 20:30 | Udinese | 3-2 Gerard Deulofeu, Davide Frattesi (og), Beto / Domenico Berardi, Davide Frattesi | Sassuolo |
| 07.11.21 20:30 | Venezia | 3-2 Mattia Caldara, Mattia Aramu, David Okereke / Eldor Shomurodov, Tammy Abraham | AS Roma |
| ROUND 13 | |||
| 20.11.21 20:30 | Lazio | 0-2 Leonardo Bonucci (2) | Juventus |
| 20.11.21 20:30 | Fiorentina | 4-3 Alfred Duncan, Riccardo Saponara, Dusan Vlahovic (2) / Zlatan Ibrahimovic (2), Lorenzo Venuti (og) | AC Milan |
| 20.11.21 20:30 | Atalanta | 5-2 Mario Pasalic (2), Duvan Zapata, Luis Muriel, Ruslan Malinovskiy / Mbala Nzola (2) | Spezia |
| 21.11.21 20:30 | Genoa | 0-2 Felix Afena-Gyan (2) | AS Roma |
| 21.11.21 20:30 | Inter | 3-2 Hakan Calhanoglu, Ivan Perisic, Lautaro Martinez / Piotr Zielinski, Dries Mertens | Napoli |
| 21.11.21 20:30 | Salernitana | 0-2 Francesco Di Tacchio (og), Antonio Candreva | Sampdoria |
| 21.11.21 20:30 | Sassuolo | 2-2 Gianluca Scamacca, Domenico Berardi / Keita Balde, Joao Pedro | Cagliari |
| 21.11.21 20:30 | Bologna | 0-1 David Okereke | Venezia |
| 22.11.21 20:30 | Torino | 2-1 Josip Brekalo, Kasper Bremer / Fernando Forestieri | Udinese |
| 22.11.21 20:30 | Verona | 2-1 Antonin Barak, Adrien Tameze / Simone Romagnoli | Empoli |
| ROUND 14 | |||
| 26.11.21 20:30 | Cagliari | 1-1 Leonardo Pavoletti / Federico Bonazzoli | Salernitana |
| 27.11.21 20:30 | Empoli | 2-1 Filippo Bandinelli, Andrea Pinamonti / Dusan Vlahovic | Fiorentina |
| 27.11.21 20:30 | Sampdoria | 3-1 Antonio Candreva, Albin Ekdal, Nicola Murru / Adrien Tameze | Verona |
| 27.11.21 20:30 | Venezia | 0-2 Hakan Calhanoglu, Lautaro Martinez | Inter |
| 27.11.21 20:30 | Juventus | 0-1 Duvan Zapata | Atalanta |
| 28.11.21 20:30 | Napoli | 4-0 Piotr Zielinski, Dries Mertens (2), Fabian Ruiz | Lazio |
| 28.11.21 20:30 | AC Milan | 1-3 Alessio Romagnoli / Gianluca Scamacca, Simon Kjaer (og), Domenico Berardi | Sassuolo |
| 28.11.21 20:30 | AS Roma | 1-0 Tammy Abraham | Torino |
| 28.11.21 20:30 | Spezia | 0-1 Marko Arnautovic | Bologna |
| 28.11.21 20:30 | Udinese | 0-0 | Genoa |
| ROUND 15 | |||
| 30.11.21 20:30 | Atalanta | 4-0 Mario Pasalic (3), Teun Koopmeiners | Venezia |
| 30.11.21 20:30 | Verona | 0-0 | Cagliari |
| 30.11.21 20:30 | Salernitana | 0-2 Paulo Dybala, Alvaro Morata | Juventus |
| 30.11.21 20:30 | Fiorentina | 3-1 Jose Callejon, Dusan Vlahovic, Riccardo Sottil / Manolo Gabbiadini | Sampdoria |
| 01.12.21 20:30 | Bologna | 1-0 Mattias Svanberg | AS Roma |
| 01.12.21 20:30 | Genoa | 0-3 Zlatan Ibrahimovic, Junior Messias (2) | AC Milan |
| 01.12.21 20:30 | Inter | 2-0 Roberto Gagliardini, Lautaro Martinez | Spezia |
| 01.12.21 20:30 | Sassuolo | 2-2 Gianluca Scamacca, Gianmarco Ferrari / Fabian Ruiz, Dries Mertens | Napoli |
| 02.12.21 20:30 | Lazio | 4-4 Ciro Immobile, Pedro, Sergej Milinkovic-Savic, Francesco Acerbi / Beto (2), Nahuel Molina, Tolgay Arslan | Udinese |
| 02.12.21 20:30 | Torino | 2-2 Tommaso Pobega, Marko Pjaca / Simone Romagnoli, Andrea La Mantia | Empoli |
| ROUND 16 | |||
| 04.12.21 20:30 | AC Milan | 2-0 Franck Kessie, Alexis Saelemaekers | Salernitana |
| 04.12.21 20:30 | AS Roma | 0-3 Hakan Calhanoglu, Edin Dzeko, Denzel Dumfries | Inter |
| 04.12.21 20:30 | Napoli | 2-3 Piotr Zielinski, Dries Mertens / Ruslan Malinovskiy, Merih Demiral, Remo Freuler | Atalanta |
| 05.12.21 20:30 | Bologna | 2-3 Musa Barrow, Aaron Hickey / Youssef Maleh, Cristiano Biraghi, Dusan Vlahovic | Fiorentina |
| 05.12.21 20:30 | Juventus | 2-0 Juan Cuadrado, Paulo Dybala | Genoa |
| 05.12.21 20:30 | Sampdoria | 1-3 Manolo Gabbiadini / Sergej Milinkovic-Savic, Ciro Immobile (2) | Lazio |
| 05.12.21 20:30 | Venezia | 3-4 Pietro Ceccaroni, Domen Crnigoj, Thomas Henry / Thomas Henry (og), Gianluca Caprari, Giovanni Simeone (2) | Verona |
| 05.12.21 20:30 | Spezia | 2-2 Rey Manaj, Emmanuel Gyasi / Giacomo Raspadori (2) | Sassuolo |
| 06.12.21 20:30 | Cagliari | 1-1 Joao Pedro / Andrea Carboni (og) | Torino |
| 06.12.21 20:30 | Empoli | 3-1 Petar Stojanovic, Nedim Bajrami, Andrea Pinamonti / Gerard Deulofeu | Udinese |
| ROUND 17 | |||
| 10.12.21 20:30 | Genoa | 1-3 Mattia Destro / Manolo Gabbiadini (2), Francesco Caputo | Sampdoria |
| 11.12.21 20:30 | Udinese | 1-1 Beto / Zlatan Ibrahimovic | AC Milan |
| 11.12.21 20:30 | Venezia | 1-1 Mattia Aramu / Alvaro Morata | Juventus |
| 11.12.21 20:30 | Fiorentina | 4-0 Giacomo Bonaventura, Dusan Vlahovic (2), Youssef Maleh | Salernitana |
| 12.12.21 20:30 | Inter | 4-0 Lautaro Martinez (2), Hakan Çalhanoğlu, Alexis Sanchez | Cagliari |
| 12.12.21 20:30 | Napoli | 0-1 Patrick Cutrone | Empoli |
| 12.12.21 20:30 | Sassuolo | 2-1 Domenico Berardi, Giacomo Raspadori / Mattia Zaccagni | Lazio |
| 12.12.21 20:30 | Torino | 2-1 Antonio Sanabria, Lukasz Skorupski (og) / Riccardo Orsolini | Bologna |
| 12.12.21 20:30 | Verona | 1-2 Giovanni Simeone / Aleksey Miranchuk, Teun Koopmeiners | Atalanta |
| 13.12.21 20:30 | AS Roma | 2-0 Chris Smalling, Roger Ibanez | Spezia |
| ROUND 18 | |||
| 17.12.21 20:30 | Lazio | 3-1 Pedro, Francesco Acerbi, Mattia Zaccagni / Filippo Melegoni | Genoa |
| 17.12.21 20:30 | Salernitana | 0-5 Ivan Perisic, Denzel Dumfries, Alexis Sanchez, Lautaro Martinez, Roberto Gagliardini | Inter |
| 18.12.21 20:30 | Atalanta | 1-4 Luis Muriel / Chris Smalling, Tammy Abraham (2), Nicolo Zaniolo | AS Roma |
| 18.12.21 20:30 | Bologna | 0-2 Alvaro Morata, Juan Cuadrado | Juventus |
| 18.12.21 20:30 | Cagliari | 0-4 Jean-Victor Makengo, Gerard Deulofeu (2), Nahuel Molina | Udinese |
| 19.12.21 20:30 | Fiorentina | 2-2 Dusan Vlahovic, Lucas Torreira / Gianluca Scamacca, Davide Frattesi | Sassuolo |
| 19.12.21 20:30 | AC Milan | 0-1 Eljif Elmas | Napoli |
| 19.12.21 20:30 | Sampdoria | 1-1 Manolo Gabbiadini / Thomas Henry | Venezia |
| 19.12.21 20:30 | Spezia | 1-1 Riccardo Marchizza (og) / Dimitrios Nikolaou (og) | Empoli |
| 19.12.21 20:30 | Torino | 1-0 Tommaso Pobega | Verona |
| ROUND 19 | |||
| 21.12.21 20:30 | Genoa | 0-0 | Atalanta |
| 21.12.21 20:30 | Juventus | 2-0 Moise Kean, Federico Bernardeschi | Cagliari |
| 22.12.21 20:30 | AS Roma | 1-1 Eldor Shomurodov / Manolo Gabbiadini | Sampdoria |
| 22.12.21 20:30 | Empoli | 2-4 Nedim Bajrami, Andrea Pinamonti / Franck Kessie (2), Alessandro Florenzi, Theo Hernandez | AC Milan |
| 22.12.21 20:30 | Inter | 1-0 Denzel Dumfries | Torino |
| 22.12.21 20:30 | Napoli | 0-1 Juan Jesus (og) | Spezia |
| 22.12.21 20:30 | Sassuolo | 0-3 Riccardo Orsolini, Aaron Hickey, Federico Santander | Bologna |
| 22.12.21 20:30 | Venezia | 1-3 Francesco Forte / Pedro, Francesco Acerbi, Luis Alberto | Lazio |
| 22.12.21 20:30 | Verona | 1-1 Kevin Lasagna / Gaetano Castrovilli | Fiorentina |
| 20.04.22 20:30 | Udinese | 0-1 Simone Verdi | Salernitana |
| ROUND 20 | |||
| 06.01.22 20:30 | AC Milan | 3-1 Olivier Giroud, Junior Messias, Rafael Leao / Tammy Abraham | AS Roma |
| 06.01.22 20:30 | Juventus | 1-1 Federico Chiesa / Dries Mertens | Napoli |
| 06.01.22 20:30 | Lazio | 3-3 Ciro Immobile, Sergej Milinkovic-Savic (2) / Nedim Bajrami, Szymon Zurkowski, Federico Di Francesco | Empoli |
| 06.01.22 20:30 | Sampdoria | 1-2 Manolo Gabbiadini / Alessandro Deiola, Leonardo Pavoletti | Cagliari |
| 06.01.22 20:30 | Sassuolo | 1-1 Domenico Berardi / Mattia Destro | Genoa |
| 06.01.22 20:30 | Spezia | 1-2 Martin Erlic / Gianluca Caprari (2) | Verona |
| 27-04-2022 | Fiorentina | 0-4 Pablo Mari, Gerard Deulofeu, Iyenoma Udogie, Walace | Udinese |
| 27-04-2022 | Bologna | 2-1 Marko Arnautovic, Nicola Sansone / Ivan Perisic | Inter |
| 27-04-2022 | Atalanta | 4-4 Luis Muriel (2), Marten de Roon, Mario Pasalic / Antonio Sanabria, Sasa Lukic (2), Remo Freuler (og) | Torino |
| 05-05-2022 | Salernitana | 2-1 Federico Bonazzoli, Simone Verdi / Thomas Henry | Venezia |
| ROUND 21 | |||
| 09.01.22 20:30 | AS Roma | 3-4 Tammy Abraham, Henrikh Mkhitaryan, Lorenzo Pellegrini / Paulo Dybala, Manuel Locatelli, Dejan Kulusevski, Mattia De Sciglio | Juventus |
| 09.01.22 20:30 | Empoli | 1-5 Liam Henderson / Giacomo Raspadori (2), Gianluca Scamacca (2), Domenico Berardi | Sassuolo |
| 09.01.22 20:30 | Genoa | 0-1 Simone Bastoni | Spezia |
| 09.01.22 20:30 | Inter | 2-1 Alessandro Bastoni, Milan Skriniar / Ciro Immobile | Lazio |
| 09.01.22 20:30 | Napoli | 1-0 Andrea Petagna | Sampdoria |
| 09.01.22 20:30 | Udinese | 2-6 Berat Djimsiti (og), Beto / Mario Pasalic, Luis Muriel (2), Ruslan Malinovskiy, Joakim Maehle, Matteo Pessina | Atalanta |
| 09.01.22 20:30 | Venezia | 0-3 Zlatan Ibrahimovic, Theo Hernandez (2) | AC Milan |
| 09.01.22 20:30 | Verona | 1-2 Darko Lazovic / Milan Djuric, Grigoris Kastanos | Salernitana |
| 10.01.22 20:30 | Torino | 4-0 Wilfried Stephane Singo, Josip Brekalo (2), Antonio Sanabria | Fiorentina |
| 11.01.22 22:30 | Cagliari | 2-1 Leonardo Pavoletti, Gaston Pereiro / Riccardo Orsolini | Bologna |
| ROUND 22 | |||
| 15.01.22 20:30 | Salernitana | 0-3 Ciro Immobile (2), Manuel Lazzari | Lazio |
| 15.01.22 20:30 | Sampdoria | 1-2 Francesco Caputo / Wilfried Stephane Singo, Dennis Praet | Torino |
| 15.01.22 20:30 | Juventus | 2-0 Paulo Dybala, Weston McKennie | Udinese |
| 16.01.22 20:30 | AS Roma | 1-0 Sergio Oliveira | Cagliari |
| 16.01.22 20:30 | Sassuolo | 2-4 Gianluca Scamacca, Gregoire Defrel / Antonin Barak (3), Gianluca Caprari | Verona |
| 16.01.22 20:30 | Venezia | 1-1 David Okereke / Szymon Zurkowski | Empoli |
| 16.01.22 20:30 | Atalanta | 0-0 | Inter |
| 17.01.22 20:30 | Bologna | 0-2 Hirving Lozano (2) | Napoli |
| 17.01.22 20:30 | Fiorentina | 6-0 Alvaro Odriozola, Giacomo Bonaventura, Cristiano Biraghi (2), Dusan Vlahovic, Lucas Torreira | Genoa |
| 17.01.22 20:30 | AC Milan | 1-2 Rafael Leao / Kevin Agudelo, Emmanuel Gyasi | Spezia |
| ROUND 23 | |||
| 21.01.22 20:30 | Verona | 2-1 Gianluca Caprari, Nikola Kalinic / Riccardo Orsolini | Bologna |
| 22.01.22 20:30 | Genoa | 0-0 | Udinese |
| 22.01.22 20:30 20:30 | Inter | 2-1 Nicolo Barella, Edin Dzeko / Thomas Henry | Venezia |
| 22.01.22 20:30 | Lazio | 0-0 | Atalanta |
| 23.01.22 20:30 | Empoli | 2-4 Andrea Pinamonti, Nedim Bajrami / Tammy Abraham (2), Sergio Oliveira, Nicolo Zaniolo | AS Roma |
| 23.01.22 20:30 | Cagliari | 1-1 Joao Pedro / Riccardo Sottil | Fiorentina |
| 23.01.22 20:30 | Napoli | 4-1 Juan Jesus, Dries Mertens, Amir Rrahmani, Lorenzo Insigne / Federico Bonazzoli | Salernitana |
| 23.01.22 20:30 | Spezia | 1-0 Daniele Verde | Sampdoria |
| 23.01.22 20:30 | Torino | 1-1 Antonio Sanabria / Giacomo Raspadori | Sassuolo |
| 23.01.22 20:30 | AC Milan | 0-0 | Juventus |
| ROUND 24 | |||
| 05.02.22 20:30 | AS Roma | 0-0 | Genoa |
| 05.02.22 20:30 | Inter | 1-2 Ivan Perisic / Olivier Giroud (2) | AC Milan |
| 05.02.22 20:30 | Fiorentina | 0-3 Sergej Milinkovic-Savic, Ciro Immobile, Cristiano Biraghi (og) | Lazio |
| 06.02.22 20:30 | Atalanta | 1-2 Jose Luis Palomino / Gaston Pereiro (2) | Cagliari |
| 06.02.22 20:30 | Bologna | 0-0 | Empoli |
| 06.02.22 20:30 | Juventus | 2-0 Dusan Vlahovic, Denis Zakaria | Verona |
| 06.02.22 20:30 | Sampdoria | 4-0 Francesco Caputo, Stefano Sensi, Andrea Conti, Antonio Candreva | Sassuolo |
| 06.02.22 20:30 | Udinese | 2-0 Nahuel Molina, Ignacio Pussetto | Torino |
| 06.02.22 20:30 | Venezia | 0-2 Victor Osimhen, Andrea Petagna | Napoli |
| 07.02.22 20:30 | Salernitana | 2-2 Simone Verdi (2) / Rey Manaj, Daniele Verde | Spezia |
| ROUND 25 | |||
| 12.02.22 20:30 | Lazio | 3-0 Ciro Immobile, Mattia Zaccagni (2) | Bologna |
| 12.02.22 20:30 | Napoli | 1-1 Lorenzo Insigne / Edin Dzeko | Inter |
| 12.02.22 20:30 | Torino | 1-2 Josip Brekalo / Ridgeciano Haps, Domen Crnigoj | Venezia |
| 13.02.22 20:30 | AC Milan | 1-0 Rafael Leao | Sampdoria |
| 13.02.22 20:30 | Verona | 4-0 Fabio Depaoli, Antonin Barak, Gianluca Caprari, Adrien Tameze | Udinese |
| 13.02.22 20:30 | Empoli | 1-1 Andrea Pinamonti / Leonardo Pavolett | Cagliari |
| 13.02.22 20:30 | Genoa | 1-1 Mattia Destro / Federico Bonazzoli | Salernitana |
| 13.02.22 20:30 | Sassuolo | 2-2 Hamed Junior Traore, Chris Smalling (k.k.) / Tammy Abraham, Bryan Cristante | AS Roma |
| 13.02.22 20:30 | Atalanta | 1-1 Ruslan Malinovsky / Danilo | Juventus |
| 14.02.22 20:30 | Spezia | 1-2 Kevin Agudelo / Krzysztof Piatek, Sofyan Amrabat | Fiorentina |
| ROUND 26 | |||
| 19.02.22 20:30 | Juventus | 1-1 Matthijs de Ligt / Andrea Belotti | Torino |
| 20.02.22 20:30 | AS Roma | 2-2 Cristian Volpato, Edoardo Bove / Antonin Barak, Adrien Tameze | Verona |
| 20.02.22 20:30 | Sampdoria | 2-0 Fabio Quagliarella (2) | Empoli |
| 20.02.22 20:30 | Salernitana | 2-2 Federico Bonazzoli, Milan Djuric / Junior Messias, Ante Rebic | AC Milan |
| 21.02.22 20:30 | Fiorentina | 1-0 Krzysztof Piatek | Atalanta |
| 21.02.22 20:30 | Inter | 0-2 Giacomo Raspadori, Gianluca Scamacca | Sassuolo |
| 21.02.22 20:30 | Udinese | 1-1 Gerard Deulofeu / Felipe Anderson | Lazio |
| 21.02.22 20:30 | Venezia | 1-1 Thomas Henry / Caleb Ekuban | Genoa |
| 22.02.22 20:30 | Bologna | 2-1 Marko Arnautovic (2( / Rey Manaj | Spezia |
| 22.02.22 20:30 | Cagliari | 1-1 Gaston Pereiro / Victor Osimhen | Napoli |
| ROUND 27 | |||
| 25.02.22 20:30 | AC Milan | 1-1 Rafael Leao / Iyenoma Udogie | Udinese |
| 25.02.22 20:30 | Genoa | 0-0 | Inter |
| 26.02.22 20:30 | Sassuolo | 2-1 Hamed Traore, Gregoire Defrel / Arthur Cabral | Fiorentina |
| 26.02.22 20:30 | Salernitana | 1-1 Nadir Zortea / Marko Arnautovic | Bologna |
| 26.02.22 20:30 | Empoli | 2-3 Szymon Zurkowski, Andrea La Mantia / Moise Kean, Dusan Vlahovic (2) | Juventus |
| 27.02.22 20:30 | Torino | 1-2 Andrea Belotti / Raoul Bellanova, Alessandro Deiola | Cagliari |
| 27.02.22 20:30 | Verona | 3-1 Giovanni Simeone (3) / David Okereke | Venezia |
| 27.02.22 20:30 | Spezia | 0-1 Tammy Abraham | AS Roma |
| 27.02.22 20:30 | Lazio | 1-2 Pedro / Lorenzo Insigne, Fabian Ruiz | Napoli |
| 28.02.22 20:30 | Atalanta | 4-0 Mario Pasalic, Teun Koopmeiners (2), Aleksey Miranchuk | Sampdoria |
| ROUND 28 | |||
| 04.03.22 20:30 | Inter | 5-0 Lautaro Martinez (3), Edin Dzeko (2) | Salernitana |
| 05.03.22 20:30 | AS Roma | 1-0 Tammy Abraham | Atalanta |
| 05.03.22 20:30 | Udinese | 2-1 Gerard Deulofeu, Iyenoma Udogie / Francesco Caputo | Sampdoria |
| 05.03.22 20:30 | Cagliari | 0-3 Ciro Immobile, Luis Alberto, Felipe Anderson | Lazio |
| 06.03.22 20:30 | Bologna | 0-0 | Torino |
| 06.03.22 20:30 | Fiorentina | 1-1 Krzysztof Piatek / Gianluca Caprari | Verona |
| 06.03.22 20:30 | Genoa | 0-0 | Empoli |
| 06.03.22 20:30 | Juventus | 1-0 Alvaro Morata | Spezia |
| 06.03.22 20:30 | Venezia | 1-4 Thomas Henry / Giacomo Raspadori, Domenico Berardi (2), Gianluca Scamacca | Sassuolo |
| 06.03.22 20:30 | Napoli | 0-1 Olivier Giroud | AC Milan |
| ROUND 29 | |||
| 12.03.22 20:30 | AC Milan | 1-0 Pierre Kalulu | Empoli |
| 12.03.22 20:30 | Salernitana | 2-2 Federico Bonazzoli, Milan Djuric / Gianluca Scamacca, Hamed Traore | Sassuolo |
| 12.03.22 20:30 | Sampdoria | 1-3 Abdelhamid Sabiri / Maya Yoshida (og), Alvaro Morata (2) | Juventus |
| 12.03.22 20:30 | Spezia | 2-0 Martin Erlic, Rey Manaj | Cagliari |
| 13.03.22 20:30 | Atalanta | 0-0 | Genoa |
| 13.03.22 20:30 | Fiorentina | 1-0 Lucas Torreira | Bologna |
| 13.03.22 20:30 | Torino | 1-1 Kasper Bremer / Alexis Sanchez | Inter |
| 13.03.22 20:30 | Udinese | 1-1 Nahuel Molina / Lorenzo Pellegrini | AS Roma |
| 13.03.22 20:30 | Verona | 1-2 Davide Faraoni / Victor Osimhen (2) | Napoli |
| 14.03.22 20:30 | Lazio | 1-0 Ciro Immobile | Venezia |
| ROUND 30 | |||
| 18.03.22 20:30 | Sassuolo | 4-1 Domenico Berardi (2), Kaan Ayhan, Gianluca Scamacca / Daniele Verde | Spezia |
| 18.03.22 20:30 | Genoa | 1-0 Manolo Portanova | Torino |
| 19.03.22 20:30 | Napoli | 2-1 Victor Osimhen (2) / Gerard Deulofeu | Udinese |
| 19.03.22 20:30 | Inter | 1-1 Denzel Dumfries / Lucas Torreira | Fiorentina |
| 19.03.22 20:30 | Cagliari | 0-1 Ismael Bennacer | AC Milan |
| 20.03.22 20:30 | AS Roma | 3-0 Tammy Abraham (2), Lorenzo Pellegrini | Lazio |
| 20.03.22 20:30 | Bologna | 0-1 Moustapha Cisse | Atalanta |
| 20.03.22 20:30 | Empoli | 1-1 Federico Di Francesco / Matteo Cancellieri | Verona |
| 20.03.22 20:30 | Juventus | 2-0 Paulo Dybala, Dusan Vlahovic | Salernitana |
| 20.03.22 20:30 | Venezia | 0-2 Francesco Caputo (2) | Sampdoria |
| ROUND 31 | |||
| 02.04.22 20:30 | Spezia | 1-0 Emmanuel Gyasi | Venezia |
| 02.04.22 20:30 | Lazio | 2-1 Manuel Lazzari, Sergej Milinkovic-Savic / Hamed Traore | Sassuolo |
| 02.04.22 20:30 | Salernitana | 0-1 Andrea Belotti | Torino |
| 03.04.22 20:30 | Atalanta | 1-3 Marten de Roon / Lorenzo Insigne, Matteo Politano, Eljif Elmas | Napoli |
| 03.04.22 20:30 | Fiorentina | 1-0 Nicolas Gonzalez | Empoli |
| 03.04.22 20:30 | Juventus | 0-1 Hakan Calhanoglu | Inter |
| 03.04.22 20:30 | Sampdoria | 0-1 Henrikh Mkhitaryan | AS Roma |
| 03.04.22 20:30 | Udinese | 5-1 Rodrigo Becao, Beto (3), Nahuel Molina / Joao Pedro Galvao | Cagliari |
| 04.04.22 20:30 | Verona | 1-0 Giovanni Simeone | Genoa |
| 04.04.22 20:30 | AC Milan | 0-0 | Bologna |
| ROUND 32 | |||
| 09.04.22 20:30 | Cagliari | 1-2 Joao Pedro / Matthijs de Ligt, Dusan Vlahovic | Juventus |
| 09.04.22 20:30 | Inter | 2-0 Nicolo Barella, Edin Dzeko | Verona |
| 09.04.22 20:30 | Empoli | 0-0 | Spezia |
| 10.04.22 20:30 | Genoa | 1-4 Patric Gabarron (og) / Adam Marusic, Ciro Immobile (3) | Lazio |
| 10.04.22 20:30 | AS Roma | 2-1 Carles Perez, Chris Smalling / Ivan Radovanovic | Salernitana |
| 10.04.22 20:30 | Napoli | 2-3 Dries Mertens, Victor Osimhen / Nicolas Gonzalez, Jonathan Ikone, Arthur Cabral | Fiorentina |
| 10.04.22 20:30 | Sassuolo | 2-1 Hamed Traore (2) / Luis Muriel | Atalanta |
| 10.04.22 20:30 | Torino | 0-0 | AC Milan |
| 10.04.22 20:30 | Venezia | 1-2 Thomas Henry / Rodrigo Becao, Gerard Deulofeu | Udinese |
| 11.04.22 20:30 | Bologna | 2-0 Marko Arnautovic (2) | Sampdoria |
| ROUND 33 | |||
| 15.04.22 20:30 | Spezia | 1-3 Giulio Maggiore / Marcelo Brozovic, Lautaro Martinez, Alexis Sanchez | Inter |
| 15.04.22 20:30 | AC Milan | 2-0 Rafael Leao, Junior Messias | Genoa |
| 16.04.22 20:30 | Cagliari | 1-0 Alessandro Deiola | Sassuolo |
| 16.04.22 20:30 | Fiorentina | 1-0 Lucas Torreira | Venezia |
| 16.04.22 20:30 | Juventus | 1-1 Dusan Vlahovic / Marko Arnautovic | Bologna |
| 16.04.22 20:30 | Lazio | 1-1 Ciro Immobile / Pietro Pellegri | Torino |
| 16.04.22 20:30 | Sampdoria | 1-2 Francesco Caputo / Federico Fazio, Ederson | Salernitana |
| 16.04.22 20:30 | Udinese | 4-1 Ardian Ismajli (og), Gerard Deulofeu, Ignacio Pussetto, Lazar Samardzic / Andrea Pinamonti | Empoli |
| 18.04.22 20:30 | Napoli | 1-1 Lorenzo Insigne / Stephan El Shaarawy | AS Roma |
| 18.04.22 20:30 | Atalanta | 1-2 Giorgio Scalvini / Federico Ceccherini, Teun Koopmeiners (og) | Verona |
| ROUND 34 | |||
| 23.04.22 20:30 | Inter | 3-1 Denzel Dumfries, Marcelo Brozovic, Lautaro Martinez / Henrikh Mkhitaryan | AS Roma |
| 23.04.22 20:30 | Venezia | 1-3 Domen Crnigoj / Mario Pasalic, Duvan Zapata, Luis Muriel | Atalanta |
| 23.04.22 20:30 | Torino | 2-1 Sasa Lukic (2) / Rey Manaj | Spezia |
| 23.04.22 20:30 | Verona | 1-1 Gianluca Caprari / Francesco Caputo | Sampdoria |
| 24.04.22 20:30 | Bologna | 2-2 Aaron Hickey, Nicola Sansone / Iyenoma Udogie, Isaac Success | Udinese |
| 24.04.22 20:30 | Empoli | 3-2 Liam Henderson, Andrea Pinamonti (2) / Dries Mertens, Lorenzo Insigne | Napoli |
| 24.04.22 20:30 | Genoa | 1-0 Milan Badelj | Cagliari |
| 24.04.22 20:30 | Lazio | 1-2 Ciro Immobile / Olivier Giroud, Sandro Tonali | AC Milan |
| 24.04.22 20:30 | Salernitana | 2-1 Milan Djuric, Federico Bonazzoli / Riccardo Saponara | Fiorentina |
| 25.04.22 20:30 | Sassuolo | 1-2 Giacomo Raspadori / Paulo Dybala, Moise Kean | Juventus |
| ROUND 35 | |||
| 30.04..22 20:30 | Napoli | 6-1 Kalidou Koulibaly, Victor Osimhen, Hirving Lozano, Dries Mertens (2), Amir Rrahmani / Maxime Lopez | Sassuolo |
| 30.04..22 20:30 | Cagliari | 1-2 Joao Pedro / Antonin Barak, Gianluca Caprari | Verona |
| 30.04..22 20:30 | Spezia | 3-4 Kelvin Amian, Kevin Agudelo, Petko Hristov / Ciro Immobile, Ivan Provedel (og), Sergej Milinkovic-Savic, Francesco Acerbi | Lazio |
| 30.04..22 20:30 | Sampdoria | 1-0 Abdelhamid Sabiri | Genoa |
| 01.05.22 20:30 | AC Milan | 1-0 Rafael Leao | Fiorentina |
| 01.05.22 20:30 | AS Roma | 0-0 | Bologna |
| 01.05.22 20:30 | Empoli | 1-3 Szymon Zurkowski / Andrea Belotti (3) | Torino |
| 01.05.22 20:30 | Juventus | 2-1 Leonardo Bonucci (2) / Mattia Aramu | Venezia |
| 01.05.22 20:30 | Udinese | 1-2 Ignacio Pussetto / Ivan Perisic, Lautaro Martinez | Inter |
| 02.05.22 20:30 | Atalanta | 1-1 Mario Pasalic / Ederson | Salernitana |
| ROUND 36 | |||
| 06.05.22 20:30 | Inter | 4-2 Simone Romagnoli (og), Lautaro Martinez, Alexis Sanchez / Andrea Pinamonti, Kristjan Asllani | Empoli |
| 06.05.22 20:30 | Genoa | 2-1 Albert Gudmundsson, Domenico Criscito / Paulo Dybala | Juventus |
| 07.05.22 20:30 | Lazio | 2-0 Patric Gabarron, Luis Alberto | Sampdoria |
| 07.05.22 20:30 | Sassuolo | 1-1 Gianluca Scamacca / Bram Nuytinck | Udinese |
| 07.05.22 20:30 | Torino | 0-1 Fabian Ruiz | Napoli |
| 08.05.22 20:30 | Salernitana | 1-1 Simone Verdi / Giorgio Altare | Cagliari |
| 08.05.22 20:30 | Spezia | 1-3 Daniele Verde / Luis Muriel, Berat Djimsiti, Mario Pasalic | Atalanta |
| 08.05.22 20:30 | Venezia | 4-3 Thomas Henry, Sofian Kiyine, Mattia Aramu, Dennis Johnsen / Riccardo Orsolini, Marko Arnautovic, Jerdy Schouten | Bologna |
| 08.05.22 20:30 | Verona | 1-3 Davide Faraoni / Sandro Tonali (2), Alessandro Florenzi | AC Milan |
| 09.05.22 20:30 | Fiorentina | 2-0 Nicolas Gonzalez, Giacomo Bonaventura | AS Roma |
| ROUND 37 | |||
| 14.05.22 20:30 | Udinese | 2-3 Nahuel Molina, Pablo Mari / Daniele Verde, Emmanuel Gyasi, Giulio Maggiore | Spezia |
| 14.05.22 20:30 | Empoli | 1-1 Patrick Cutrone / Federico Bonazzoli | Salernitana |
| 14.05.22 20:30 | Verona | 0-1 Josip Brekalo | Torino |
| 14.05.22 20:30 | AS Roma | 1-1 Eldor Shomurodov / David Okereke | Venezia |
| 15.05.22 20:30 | AC Milan | 2-0 Rafael Leao, Theo Hernandez | Atalanta |
| 15.05.22 20:30 | Bologna | 1-3 Riccardo Orsolini / Gianluca Scamacca (2), Domenico Berardi | Sassuolo |
| 15.05.22 20:30 | Cagliari | 1-3 Babis Lykogiannis / Matteo Darmian, Lautaro Martinez (2) | Inter |
| 15.05.22 20:30 | Napoli | 3-0 Victor Osimhen, Lorenzo Insigne, Stanislav Lobotka | Genoa |
| 16.05.22 20:30 | Sampdoria | 4-1 Alex Ferrari, Fabio Quagliarella, Morten Thorsby, Abdelhamid Sabiri / Nicolas Gonzalez | Fiorentina |
| 16.05.22 20:30 | Juventus | 2-2 Dusan Vlahovic, Alvaro Morata / Alex Sandro (og), Sergej Milinkovic-Savic | Lazio |
| ROUND 38 | |||
| 220.05.22 20:30 | Torino | 0-3 Tammy Abraham (2), Lorenzo Pellegrini | AS Roma |
| 21.05.22 20:30 | Atalanta | 0-1 Leo Stulac | Empoli |
| 21.05.22 20:30 | Fiorentina | 2-0 Alfred Duncan, Nicolas Gonzalez | Juventus |
| 21.05.22 20:30 | Genoa | 0-1 Musa Barrow | Bologna |
| 21.05.22 20:30 | Lazio | 3-3 Jovane Cabral, Felipe Anderson, Pedro Rodriguez / Giovanni Simeone, Kevin Lasagna, Martin Hongla | Verona |
| 22.05.22 20:30 | Inter | 3-0 Ivan Perisic, Joaquin Correa (2) | Sampdoria |
| 22.05.22 20:30 | Sassuolo | 0-3 Olivier Giroud (2), Franck Kessie | AC Milan |
| 22.05.22 20:30 | Spezia | 0-3 Matteo Politano, Piotr Zielinski, Diego Demme | Napoli |
| 22.05.22 20:30 | Salernitana | 0-4 Gerard Deulofeu, Ilija Nestorovski, Iyenoma Udogie, Roberto Pereyra | Udinese |
| 22.05.22 20:30 | Venezia | 0-0 | Cagliari |
