EHF Avrupa Kupası, Avrupa Hentbol Federasyonu (EHF) tarafından düzenlenen yıllık bir erkek hentbol kulübü turnuvasıdır. 1993 yılında EHF Şehir Kupası olarak kurulan bu organizasyon, 2000 yılında EHF Challenge Cup olarak yeniden adlandırıldı ve 2020-21 sezonundan itibaren EHF Avrupa Kupası olarak devam etmektedi
1. Tur
| Tarih | 1. Takım | Toplam Skor | 2. Takım | 1. Maç | 2. Maç |
| 18-09-2021 19-09-2021 | A.E.S.H. Pylea | 53-68 | HC Dukla Praha | 28-37 | 25-31 |
| 18-09-2021 19-09-2021 | KH ISMM Koprivnice | 53-59 | Selfoss | 25-31 | 28-28 |
| 18-09-2021 19-09-2021 | KH Trepca | 47-66 | Holon Yuvalim HC | 22-29 | 25-37 |
| 12-09-2021 18-09-2021 | Beykoz Belediye SK | 62-56 | JD Techniek Hurry-Up | 32-23 | 30-33 |
| 17-09-2021 18-09-2021 | HB Dudelange | 45-52 | Raimond Sassari | 24-26 | 21-29 |
| 11-09-2021 18-09-2021 | Alingsås HK | 63-53 | K Metaloplastika Sabac | 29-23 | 34-30 |
| 12-09-2021 18-09-2021 | Motor-Politekhnika | 43-73 | Baekkelaget Handball Elite | 23-41 | 20-32 |
| 11-09-2021 18-09-2021 | Apoel HC | 38-69 | HC Robe Zubri | 27-29 | 11-40 |
| 11-09-2021 18-09-2021 | Viljandi HC | 43-45 | MRK Sloga Doboj | 20-20 | 23-25 |
| 11-09-2021 18-09-2021 | CS Minaur Baia Mare | 77-43 | HC Lokomotiv G. Oryahovitsa | 44-22 | 33-21 |
| 11-09-2021 18-09-2021 | RK Sloboda | 46-47 | Bianco Monte Drama 1986 | 29-23 | 17-24 |
| 11-09-2021 18-09-2021 | Handball Kaerjeng | 68-49 | KH Vellaznimi HC | 32-23 | 36-26 |
| 11-09-2021 18-09-2021 | Granitas-Karys | 75-40 | RK Zeleznicar 1949 | 46-18 | 29-22 |
| 12-09-2021 18-09-2021 | SG INSIGNIS Handball Westwien | 46-60 | SGAU-Saratov | 27-29 | 19-31 |
2. Tur
| Tarih | 1. Takım | Toplam Skor | 2. Takım | 1. Maç | 2. Maç |
| 23-10-2021 24-10-2021 | Handball Kaerjeng | 53-68 | CSM Focsani 2007 | 27-35 | 26-33 |
| 16-10-2021 24-10-2021 | VHC Sviesa Vilnius | 52-53 | HC Tallinn | 24-22 | 28-31 |
| 23-10-2021 24-10-2021 | Herpertz Bevo HC | 60-62 | AS SGS Ramhat Hashron | 30-32 | 30-30 |
| 16-10-2021 24-10-2021 | H71 | 42-56 | Drammen HK | 22-24 | 20-32 |
| 17-10-2021 23-10-2021 | HSC Suhr Aarau | 52-51 | Förthof UHK Krems | 25-22 | 27-29 |
| 16-10-2021 23-10-2021 | RK Partizan | 63-53 | HC Berchem | 33-22 | 30-31 |
| 17-10-2021 23-10-2021 | RK Borac m:tel | 50-54 | KH Besa Famgas | 28-25 | 22-29 |
| 17-10-2021 23-10-2021 | A.C. Diomidis Argous | 55-58 | Bianco Monte Drama 1986 | 26-30 | 29-28 |
| 22-10-2021 23-10-2021 | Raimond Sassari | 53-61 | Nærbø IL | 28-35 | 25-26 |
| 16-10-2021 23-10-2021 | Granitas-Karys | 46-52 | Pölva Serviti | 27-26 | 19-26 |
| 17-10-2021 23-10-2021 | HC Masheka | 52-56 | ZRHK TENAX Dobele | 27-22 | 25-34 |
| 16-10-2021 23-10-2021 | FH Hafnarfjordur | 55-62 | SKA Minsk | 29-37 | 26-25 |
| 16-10-2021 23-10-2021 | HC Dragunas Klaipeda | 48-51 | MSK Povazska Bystrica | 26-25 | 22-26 |
| 16-10-2021 23-10-2021 | BK-46 Handboll | 0-20 | SGAU-Saratov | 0-10 | 0-10 |
| 16-10-2021 23-10-2021 | Beykoz Belediye SK | 53-56 | SKIF Krasnodar | 29-30 | 24-26 |
| 23-10-2021 24-10-2021 | Beşiktaş JK | 76-60 | Holon Yuvalim HC | 38-32 | 38-28 |
| 16-09-2021 23-09-2021 | HC Izvidac | 50-62 | HC Dukla Praha | 26-28 | 24-34 |
| 16-09-2021 23-09-2021 | Fivers | 66-70 | Baekkelaget Handball Elite | 34-38 | 32-32 |
| 16-09-2021 23-09-2021 | Sparkasse Schwaz Handball Tirol | 50-52 | Sabbianco Anorthosis Famagusta | 24-27 | 26-25 |
| 23-09-2021 23-09-2021 | Donbas | 48-65 | Alingsås HK | 25-34 | 23-31 |
| 15-09-2021 23-09-2021 | ASD Accademia P. Conversano 2014 | 64-49 | MRK Sloga Doboj | 31-24 | 33-25 |
| 16-09-2021 23-09-2021 | Selfoss | 53-59 | RK Jeruzalem Ormoz | 31-31 | 22-28 |
| 22-09-2021 23-09-2021 | CS Minaur Baia Mare | 68-61 | Hapoel SP Ashdod HC | 35-32 | 33-29 |
| 16-09-2021 17-09-2021 | Odessa | 63-75 | Handball Esch | 31-38 | 32-37 |
| 16-09-2021 17-09-2021 | HCB Karvina | 64-51 | İzmir BŞB. GSK. | 32-26 | 32-25 |
| 16-09-2021 17-09-2021 | Parnassos Strovolou | 39-62 | Haukar | 14-25 | 25-37 |
| 15-09-2021 16-09-2021 | HC Robe Zubri | 86-42 | HC Osam Lovech | 43-20 | 43-22 |
3. Tur
| Tarih | 1. Takım | Toplam Skor | 2. Takım | 1. Maç | 2. Maç |
| 28-11-2021 05-12-2021 | HSC Suhr Aarau | 60-54 | RK Jeruzalem Ormoz | 31-27 | 29-27 |
| 28-11-2021 05-12-2021 | Drammen HK | 28-29 | HC Dukla Praha | 28-29 | |
| 27-11-2021 04-12-2021 | Bianco Monte Drama 1986 | 69-81 | HC Victor | 39-41 | 30-41 |
| 26-11-2021 27-11-2021 | AS SGS Ramhat Hashron | 57-72 | IFK Skövde HK | 28-37 | 29-35 |
| 04-12-2021 05-12-2021 | SKIF Krasnodar | 25-22 | MSK Povazska Bystrica | 25-22 | |
| 27-11-2021 04-12-2021 | Sabbianco Anorthosis Famagusta | 46-62 | HCB Karvina | 24-29 | 22-33 |
| 28-11-2021 05-12-2021 | Beşiktaş JK | 28-25 | SKA Minsk | 28-25 | |
| 27-11-2021 04-12-2021 | CSM Focsani 2007 | 54-53 | Haukar | 28-26 | 26-27 |
| 27-11-2021 04-12-2021 | ASD Accademia P. Conversano 2014 | 54-56 | Nærbø IL | 27-25 | 27-31 |
| 27-11-2021 05-12-2021 | Handball Esch | 30-30 | Baekkelaget Handball Elite | 30-30 | |
| 26-11-2021 28-11-2021 | ZRHK TENAX Dobele | 49-57 | A.C. PAOK | 25-28 | 24-29 |
| 28-11-2021 04-12-2021 | Talent tym Plzen | 63-59 | HC Robe Zubri | 35-27 | 28-32 |
| 28-11-2021 05-12-2021 | KH Besa Famgas | 30-28 | AHC Potaissa Turda | 30-28 | |
| 28-11-2021 05-12-2021 | SGAU-Saratov | 25-24 | Pölva Serviti | 25-24 | |
| 27-11-2021 04-12-2021 | RK Partizan | 53-54 | CS Minaur Baia Mare | 30-26 | 23-28 |
| 04-12-2021 05-12-2021 | Alingsås HK | 36-18 | HC Tallinn | 36-18 |
1 / 16 Turu
Çeyrek Final
Yarı Final
Final
| 2020-21 | 2022-23 |