| Tarih | Ev Sahibi Takım | Sonuç | Misafir takım |
|---|---|---|---|
| CLAUSURA - 1. HAFTA | |||
| 16.01.2021 | Danubio | 0-3 Angel Cayetano, Enzo Borges (2) | Cerro Largo |
| 16.01.2021 | CA Cerro | 1-1 Maicol Cabrera / Jonathan Urretaviscaya | CA Penarol |
| 17.01.2021 | Centro Atletico Fenix | 1-1 Luciano Nequecaur / Douglas Arezo | CA River Plate |
| 17.01.2021 | Progreso | 0-0 | Montevideo City Torque |
| 18.01.2021 | Defensor Sporting | 1-1 Vicente Poggi / Diego Hernandez | Montevideo Wanderers FC |
| 18.01.2021 | Plaza Colonia | 0-0 | Liverpool Montevideo |
| 18.01.2021 | Club Nacional | 1-1 Armando Mendez / Nicolas Colazo | Rentistas |
| 19.01.2021 | Boston River | 5-0 Facundo Rodriguez, Agustin Nadruz, Adolfo Baran, Matias Rigoleto, Diego Romero Lanz | Deportivo Maldonado |
| CLAUSURA - 2. HAFTA | |||
| 20.01.2021 | Montevideo City Torque | 3-0 Leandro Otormin, Matias Coccaro, Jose Ignacio Alvarez | Centro Atletico Fenix |
| 22.01.2021 | Deportivo Maldonado | 2-4 Maximiliano Cantera, Eduardo Darias / Federico Pereira (2), Ignacio Ramirez, Agustin Ocampo | Liverpool Montevideo |
| 20.01.2021 | CA River Plate | 1-2 Nicolas Gonzalez / Maicol Cabrera, Jose Tancredi | CA Cerro |
| 21.01.2021 | Montevideo Wanderers FC | 2-0 Maximiliano Perez, Diego Hernandez | Danubio |
| 21.01.2021 | Cerro Largo | 0-0 | Club Nacional |
| 21.01.2021 | Plaza Colonia | 0-1 Haibrany Ruiz Diaz (k.k.) | Progreso |
| 22.01.2021 | Rentistas | 0-1 Jose Alberti | Boston River |
| 28-01-2021 | CA Penarol | 1-2 Facundo Daniel Torres / Mathias Cardacio, Cristian Chavez | Defensor Sporting |
| CLAUSURA - 3. HAFTA | |||
| 29.01.2021 | Centro Atletico Fenix | 3-3 Leonardo Henriques Coelho, Maureen Franco (2) / Juan Cruz Mascia (2), Leandro Suhr | Plaza Colonia |
| 30.01.2021 | Boston River | 2-1 Ruben Bentancourt (2) / Hugo Dorrego | Cerro Largo |
| 30.01.2021 | Progreso | 0-4 Ignacio Ramirez, Alan Medina, Gonzalo Bueno (2) | Liverpool Montevideo |
| 31.01.2021 | Deportivo Maldonado | 3-1 Maximiliano Cantera, Facundo Batista (2) / Maximiliano Lemos | Rentistas |
| 31.01.2021 | Danubio | 0-1 Matias Britos | CA Penarol |
| 31.01.2021 | Club Nacional | 2-1 Emiliano Martinez, Felipe Ignacio Carballo Ares / Maximiliano Perez | Montevideo Wanderers FC |
| 01.02.2021 | CA Cerro | 1-3 Felipe Klein / Gustavo Del Prete, Maicol Cabrera (k.k.), Matias Coccaro | Montevideo City Torque |
| 01.02.2021 | Defensor Sporting | 0-2 Marcos Montiel, Thiago Borbas | CA River Plate |
| CLAUSURA - 4. HAFTA | |||
| 02.02.2021 | Progreso | 0-1 Agustin Canobbio | Centro Atletico Fenix |
| 02.02.2021 | Cerro Largo | 1-2 Carlos Nunez / Maximiliano Cantera, Eduardo Darias | Deportivo Maldonado |
| 03.02.2021 | Liverpool Montevideo | 2-2 Ignacio Ramirez (2) / Gonzalo Vega, Franco Perez | Rentistas |
| 03.02.2021 | CA Penarol | 0-0 | Club Nacional |
| 04.02.2021 | Montevideo Wanderers FC | 2-2 Sebastian Gorga (og), Darwin Torres / Matias Rigoleto, Ruben Bentancourt | Boston River |
| 04.02.2021 | CA River Plate | 0-4 Martin Nicolas Comachi, Javier Mendez, Santiago Paiva, Matias Deorta | Danubio |
| 04.02.2021 | Plaza Colonia | 2-1 Nicolas Ecequiel Dibble, Federico Perez / Jose Tancredi | CA Cerro |
| 05.02.2021 | Montevideo City Torque | 0-0 | Defensor Sporting |
| CLAUSURA - 5. HAFTA | |||
| 06-02-2021 | Centro Atletico Fenix | 0-2 Hernan Figueredo, Ignacio Ramirez | Liverpool Montevideo |
| 06-02-2021 | Rentistas | 2-1 Carlos Villalba, Gonzalo Vega / Hugo Dorrego | Cerro Largo |
| 06-02-2021 | Deportivo Maldonado | 1-1 Facundo Batista / Hernan Rivero | Montevideo Wanderers FC |
| 07-02-2021 | Boston River | 1-2 Ruben Bentancourt / Fabian Estoyanoff, Agustin Alvarez Martinez | CA Penarol |
| 07-02-2021 | Danubio | 0-4 Matias Santos, Sebastian Guerrero, Matias Coccaro (2) | Montevideo City Torque |
| 07-02-2021 | CA Cerro | 2-0 Mario Garcia, Richard Martin Gonzalez | Progreso |
| 08-02-2021 | Defensor Sporting | 3-2 Alvaro Navarro, Vicente Poggi, Matias Ocampo / Nicolas Dibble, Juan Cruz Mascia | Plaza Colonia |
| 08-02-2021 | Club Nacional | 3-0 Guzman Rodriguez (og), Gonzalo Bergessio, Gabriel Neves | CA River Plate |
| CLAUSURA - 6. HAFTA | |||
| 10-02-2021 | Liverpool Montevideo | 3-2 Agustin Ocampo, Ignacio Ramirez, Camilo Candido / Angel Cayetano | Cerro Largo |
| 10-02-2021 | Plaza Colonia | 3-0 Nicolas Dibble, Mario Risso, Ezequias Emanuel Redin | Danubio |
| 11-02-2021 | Montevideo Wanderers FC | 3-2 Hernan Rivero, Kevin Rolon, Diego Riolfo / Gonzalo Vega, 85' Ederson Rodriguez | Rentistas |
| 11-02-2021 | Montevideo City Torque | 1-2 Sebastian Guerrero Martinez / Felipe Carballo, Gonzalo Bergessio | Club Nacional |
| 11-02-2021 | Centro Atletico Fenix | 3-3 Bryan Olivera, Maureen Franco (2) / Richard Martin Gonzalez, Jose Luis Tancredi, Franco Lopez | CA Cerro |
| 11-02-2021 | Progreso | 3-3 Alex Silva (2), Fabricio Fernandez / Facundo Mallo, Diego Coelho (2) | Defensor Sporting |
| 11-02-2021 | CA River Plate | 3-1 Marcos Montiel, Gonzalo Viera, Thiago Borbas / Alejandro Martinuccio | Boston River |
| 12-02-2021 | CA Penarol | 1-1 Agustin Alvarez Martinez / Maximiliano Cantera | Deportivo Maldonado |
| CLAUSURA - 7. HAFTA | |||
| 14-02-2021 | Cerro Largo | 1-3 Gabriel Baez Corradi / Leonardo Pais, Hernan Rivero, Diego Riolfo | Montevideo Wanderers FC |
| 14-02-2021 | Club Nacional | 1-1 Gonzalo Bergessio / Juan Cruz Mascia | Plaza Colonia |
| 14-02-2021 | CA Cerro | 1-1 Jose Luis Tancredi / Franco Romero | Liverpool Montevideo |
| 14-02-2021 | Rentistas | 0-1 Facundo Torres | CA Penarol |
| 15-02-2021 | Boston River | 0-3 Franco Pizzichillo, Gustavo Del Prete, Lucas Rodriguez | Montevideo City Torque |
| 15-02-2021 | Deportivo Maldonado | 1-2 Ignacio Nicolini / Marcos Montiel, Matias Arezo | CA River Plate |
| 15-02-2021 | Danubio | 0-1 Fabricio Fernandez | Progreso |
| 16-02-2021 | Defensor Sporting | 2-2 Mathias Cardacio (2) / Maureen Franco, Facundo Mallo (og) | Centro Atletico Fenix |
| CLAUSURA - 8. HAFTA | |||
| 17-02-2021 | CA River Plate | 1-1 Jose Neris / Renato Cesar | Rentistas |
| 17-02-2021 | Liverpool Montevideo | 2-1 Christian Almeida, Ignacio Ramirez / Hernan Rivero | Montevideo Wanderers FC |
| 18-02-2021 | Cerro Largo | 1-1 Enzo Borges / Agustin Alvarez Martinez | CA Penarol |
| 18-02-2021 | CA Cerro | 0-0 | Defensor Sporting |
| 18-02-2021 | Centro Atletico Fenix | 1-1 Javier Mendez (og) / Santiago Paiva | Danubio |
| 18-02-2021 | Progreso | 0-1 Gonzalo Bergessio | Club Nacional |
| 19-02-2021 | Montevideo City Torque | 1-1 Dario Pereira / Cesar Pereyra | Deportivo Maldonado |
| 19-02-2021 | Plaza Colonia | 3-0 Haibrany Nick Ruiz Diaz Minervino, Imanol Enriquez, Diogo | Boston River |
| CLAUSURA - 9. HAFTA | |||
| 20-02-2021 | CA River Plate | 2-0 Sebastian Piriz, Matias Arezo | Cerro Largo |
| 21-02-2021 | Defensor Sporting | 0-3 Ignacio Ramirez, Franco Romero, Gonzalo Bueno | Liverpool Montevideo |
| 21-02-2021 | Montevideo Wanderers FC | 0-1 Facundo Torres | CA Penarol |
| 21-02-2021 | Rentistas | 1-2 Gonzalo Vega / Matias Coccaro, Yonatthan Rak | Montevideo City Torque |
| 22-02-2021 | Club Nacional | 2-2 Emiliano Martinez, Brian Ocampo / Maureen Franco, Luciano Nequecaur | Centro Atletico Fenix |
| 22-02-2021 | Danubio | 2-1 Leandro Rodriguez, Matias Jones / Mario Garcia | CA Cerro |
| 23-02-2021 | Deportivo Maldonado | 1-1 Hernan Toledo / Juan Cruz Mascia | Plaza Colonia |
| 24-02-2021 | Boston River | 2-3 Ruben Bentancourt (2)/ Esteban Gonzalez, Federico Platero, Fabricio Fernandez | Progreso |
| CLAUSURA - 10. HAFTA | |||
| 26-02-2021 | Liverpool Montevideo | 1-1 Ignacio Ramirez / Facundo Torres | CA Penarol |
| 27-02-2021 | CA River Plate | 1-1 Matias Arezo / Hernan Rivero | Montevideo Wanderers FC |
| 28-02-2021 | CA Cerro | 0-1 Gonzalo Bergessio | Club Nacional |
| 28-02-2021 | Centro Atletico Fenix | 2-1 Agustin Canobbio (2) / Jose Alberti | Boston River |
| 01-03-2021 | Montevideo City Torque | 0-0 | Cerro Largo |
| 01-03-2021 | Defensor Sporting | 1-1 Facundo Milan / Santiago Mederos | Danubio |
| 01-03-2021 | Plaza Colonia | 5-0 Nicolas Dibble (3), Ramiro Quintana, Facundo Piriz | Rentistas |
| 02-03-2021 | Progreso | 1-1 Ricardo Nahuel Roldan / Maximiliano Cantera | Deportivo Maldonado |
| CLAUSURA - 11. HAFTA | |||
| 05-03-2021 | Montevideo Wanderers FC | 2-8 Mauro Mendez, Nicolas Quagliata / Dario Pereira, Marcelo Allende, Jose Alvarez (2), Matias Santos, Andrew Teuten, Yonatthan Rak, Matias Coccaro | Montevideo City Torque |
| 06-03-2021 | Boston River | 2-0 Ruben Bentancourt, Matias Rigoleto | CA Cerro |
| 07-03-2021 | CA Penarol | 2-0 Matias Britos, Agustin Alvarez Martinez | CA River Plate |
| 07-03-2021 | Danubio | 0-1 Ignacio Ramirez | Liverpool Montevideo |
| 08-03-2021 | Cerro Largo | 3-1 Hamilton Pereira, Hugo Dorrego, Martin Ferreira / Nicolas Dibble | Plaza Colonia |
| 08-03-2021 | Club Nacional | 2-1 Felipe Carballo (2) / Facundo Milan | Defensor Sporting |
| 08-03-2021 | Rentistas | 1-3 Gonzalo Vega / Fabricio Fernandez, Martin Marta, Joel Lew | Progreso |
| 09-03-2021 | Deportivo Maldonado | 0-2 Kaique, Luciano Nequecaur | Centro Atletico Fenix |
| CLAUSURA - 12. HAFTA | |||
| 12-03-2021 | Plaza Colonia | 3-0 Federico Perez, Mario Risso, Facundo Kidd | Montevideo Wanderers FC |
| 13-03-2021 | Defensor Sporting | 1-2 Tabare Viudez / Ruben Bentancourt, Leandro Lozano | Boston River |
| 13-03-2021 | Danubio | 2-1 Nicolas Siri, Javier Mendez / Thiago Vecino | Club Nacional |
| 14-03-2021 | CA Cerro | 2-3 Maicol Cabrera, Franco Lopez / Facundo Batista (3) | Deportivo Maldonado |
| 14-03-2021 | Liverpool Montevideo | 3-2 Agustin Davila, Christian Almeida, Franco Romero / Nicolas Rodriguez (2) | CA River Plate |
| 15-03-2021 | Cerro Largo | 1-0 Martin Marta (og) | Progreso |
| 15-03-2021 | Montevideo City Torque | 1-2 Dario Pereira / David Terans, Agustin Alvarez Martinez | CA Penarol |
| 15-03-2021 | Centro Atletico Fenix | 3-0 Maureen Franco (2), Kaique | Rentistas |
| CLAUSURA - 13. HAFTA | |||
| 18-03-2021 | Deportivo Maldonado | 2-1 Eduardo Darias, Lucas Nunez / Rodrigo Rojo | Defensor Sporting |
| 19-03-2021 | Rentistas | 0-1 Alejandro Della Nave | CA Cerro |
| 20-03-2021 | Boston River | 1-5 Enzo Larrosa / Nicolas Siri (3), Jose Luis Rodriguez, Leandro Rodriguez | Danubio |
| 20-03-2021 | CA River Plate | 1-1 Gonzalo Viera / Yonatthan Rak | Montevideo City Torque |
| 21-03-2021 | CA Penarol | 1-3 David Terans / Facundo Piriz, Haibrany Nick Ruiz Diaz Minervino, Diogo | Plaza Colonia |
| 21-03-2021 | Centro Atletico Fenix | 1-0 Andres Schetino | Cerro Largo |
| 22-03-2021 | Montevideo Wanderers FC | 1-3 Maximiliano Perez / Fabricio Fernandez, Rodrigo Viega, Esteban Gonzalez | Progreso |
| 22-03-2021 | Club Nacional | 0-4 Jean Rosso, Alan Medina, Ignacio Ramirez, Gaston Perez | Liverpool Montevideo |
| CLAUSURA - 14. HAFTA | |||
| 23-03-2021 | Danubio | 2-2 Jose Luis Rodriguez, Santiago Mederos / Cesar Pereyra, Facundo Batista | Deportivo Maldonado |
| 24-03-2021 | Liverpool Montevideo | 4-1 Camilo Candido, Ignacio Ramirez (2), Agustin Ocampo / Matias Coccaro | Montevideo City Torque |
| 25-03-2021 | CA Cerro | 0-1 Guillermo May | Cerro Largo |
| 25-03-2021 | Club Nacional | 1-2 Felipe Carballo / Nicolas Freitas, Enzo Larrosa | Boston River |
| 25-03-2021 | Centro Atletico Fenix | 3-3 Maureen Franco (2), Agustin Alfaro / Angel Rodriguez (k.k.), Nicolas Quagliata, Leonardo Pais | Montevideo Wanderers FC |
| 25-03-2021 | Plaza Colonia | 1-0 Ramiro Quintana | CA River Plate |
| 25-03-2021 | Progreso | 0-2 Gary Kagelmacher, Agustin Alvarez | CA Penarol |
| 26-03-2021 | Defensor Sporting | 0-0 | Rentistas |
| CLAUSURA - 15. HAFTA | |||
| 28-03-2021 | Rentistas | 1-0 Franco Perez | Danubio |
| 29-03-2021 | Boston River | 1-0 Ruben Bentancourt | Liverpool Montevideo |
| 29-03-2021 | Cerro Largo | 0-0 | Defensor Sporting |
| 29-03-2021 | Deportivo Maldonado | 1-2 Facundo Batista / Gonzalo Bergessio (2) | Club Nacional |
| 29-03-2021 | Montevideo Wanderers FC | 1-1 Mauro Mendez / Jose Luis Tancredi | CA Cerro |
| 29-03-2021 | CA River Plate | 3-2 Nicolas Rodriguez, Nicolas Gonzalez, Matias Alonso / Fabricio Fernandez, Martin Marta | Progreso |
| 30-03-2021 | Montevideo City Torque | 2-0 Gabriel Chocobar , Franco Pizzichillo | Plaza Colonia |
| 30-03-2021 | CA Penarol | 3-1 Agustin Alvarez Martinez, David Terans (2) / Maureen Franco | Centro Atletico Fenix |
