| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|
| Coquimbo Unido | 3–1 | Aragua | 3–0
Federico Pereyra, Gonzalez, Ruben Farfan | 0–1
Fernandez |
| Vasco da Gama | 1-0 | Oriente Petrolero | 1–0
German Ezeguiel Cano | 0-0 |
| Blooming | 0-5 | Emelec | 0–3
Facundo Barcelo (2), Arroyo | 0-2
Jose Francisco Cevallos, Robert Burbano |
| Zamora | 1-3 | Plaza Colonia | 1–0
Jorge Ignacio Gonzalez | 0-3
Ramiro Quintana, Facundo Waller (2) |
| Nacional Potosí | 2–2
(3–4 Pen.) | Melgar | 0–2
Joel Melchor Sanchez, Othoniel Arce | 2–0
Pablo Nicolas Royon (2) |
| Atlético Grau | 1-3 | River Plate | 1–2
Ramirez, Juan Olivera, Jose Neris | 1-0
Juan Olivera |
| Unión Santa FE | 3-2 | Atlético Mineiro | 3–0
Walter Ariel Bou, Marcelo Cabrera, Horacio Gabriel Carabajal | 0-2
Romulo Otero, Hyoran Kaue Dalmoro |
| Bahia | 6-1 | Nacional | 3–0
Gilberto, Gregore, Elber | 3-1
Jose Elber, Gilberto Oliveira (2) / Leonardo Villagra |
| Fénix | 3-2 | El Nacional | 1–0
Jose Ignacio Pallas | 2-2
Maureen Franco, Nicolas Machado / Holger Matomoros, Felipe Mejia |
| Atlético Nacional | 4–1 | Huracán | 3–0
Munoz, Jefferson Andres Dugue, Vladimir Javier Hernandez | 1–1
Felipe Andrade / Leandro Damian |
| Sol de América | 2-0 | Goiás | 1–0
Nildo Viera | 1-0
Hernán Novick |
| Mineros | 4–5 | Sportivo Luqueño | 2–3
Richard Jose Blanco (2) / Murillo, Pitta, Diaz | 2–2
Mynor Javier Escoe, Paulo Lima (og) / Noguera, Paulo Lima |
| Vélez Sarsfield | 2–2 | Aucas | 1–0
Adrian Ricardo Centurion | 1–2
Thiago Almada / Alexander Alvarado, Jhon Jairo Espinoza |
| Millonarios | 2-1 | Always Ready | 2–0
David Macallister Silva, Zapata | 0-1
Omar Andres Bertel Vergara |
| Lanús | 3-2 | Universidad Católica | 3–0
Lautaro German Acosta, Nicolas Orsini (2) | 0-2
Walter Leodán Chalá Vázquez, Juan Manuel Tévez |
| Deportivo Cali | 5-2 | River Plate | 2–1
Vasguez, Arrieta / Perez | 3-1
Ángelo José Rodríguez, Agustín Palavecino (2) / Dionisio Perez |
| Argentinos Juniors | 1-1 | Sport Huancayo | 1–1
Gabriel Hauche / Lliuya | 0-0 |
| Fluminense | 1–1 | Unión La Calera | 1–1
Evanilson / Gonzalo Pablo Castellani | 0–0 |
| Huachipato | 2-0 | Deportivo Pasto | 1–0
Claudia Sepulveda | 1-0
Juan Ignacio Sánchez Sotelo |
| Cusco | 2-3 | Audax Italiano | 2–0
Vilchez, Jose Antonio Devecchi (og) | 0-3
Rodrigo Julián Holgado (2) |
| Independiente | 2-2 | Fortaleza | 1–0
Leandro Miguel Fernandez | 1-2
Bruno Ferreira Melo (og) / Juninho, Marlon |
| Llaneros | 0-7 | Liverpool | 0–2
Fabian Agustin Davila, Hernan Alonzo | 0-5
Lucas Ocampo, Andres Pereira, Bruno Correa (2), Emiliano Alfaro |
Sao Paulo