Group A
| Team | Pld. | W | D | L | Goals | Pts. | Qualification |
| AS Roma | 6 | 4 | 1 | 1 | 13-5 | 13 | Advance to knockout phase |
| BSC Young Boys | 6 | 3 | 1 | 2 | 9-7 | 10 | Advance to knockout phase |
| CFR Cluj | 6 | 1 | 2 | 3 | 4-10 | 5 | |
| CSKA Sofia | 6 | 1 | 2 | 3 | 3-7 | 5 |
| Date | Venue | Host Team | Score | Away Team |
| 22-10-2020 | Stadion Wankdorf, Bern | BSC Young Boys | 1-2 Jean-Pierre Nsame / Bruno Peres, Marash Kumbulla | AS Roma |
| 22-10-2020 | Vasil Levski National Stadium, Sofia | CSKA Sofia | 0-2 Mario Junior Rondón, Ciprian Ioan Deac | CFR Cluj |
| 29-10-2020 | Stadionul Dr. Constantin Rădulescu, Cluj-Napoca | CFR Cluj | 1-1 Mario Junior Rondón / Christian Fassnacht | BSC Young Boys |
| 29-10-2020 | Stadio Olimpico, Rome | AS Roma | 0-0 | CSKA Sofia |
| 05-11-2020 | Stadion Wankdorf, Bern | BSC Young Boys | 3-0 Felix Khonde Mambimbi (2), Miralem Sulejmani | CSKA Sofia |
| 05-11-2020 | Stadio Olimpico, Rome | AS Roma | 5-0 Henrikh Mkhitaryan, Roger Ibañez, Borja Mayoral Moya (2), Pedro Rodríguez | CFR Cluj |
| 26-11-2020 | Vasil Levski National Stadium, Sofia | CSKA Sofia | 0-1 Jean-Pierre Nsame | BSC Young Boys |
| 26-11-2020 | Stadionul Dr. Constantin Rădulescu, Cluj-Napoca | CFR Cluj | 0-2 Gabriel Debeljuh (og), Jordan Veretout | AS Roma |
| 03-12-2020 | Stadio Olimpico, Rome | AS Roma | 3-1 Borja Mayoral, Riccardo Calafiori, Edin Dzeko / Jean-Pierre Nsame | BSC Young Boys |
| 03-12-2020 | Stadionul Dr. Constantin Rădulescu, Cluj-Napoca | CFR Cluj | 0-0 | CSKA Sofia |
| 10-12-2020 | Stadion Wankdorf, Bern | BSC Young Boys | 2-1 Gianluca Gaudino, Jean-Pierre Nsame / Gabriel Debeljuh | CFR Cluj |
| 10-12-2020 | Vasil Levski National Stadium, Sofia | CSKA Sofia | 3-1 Tiago Rodrigues, Ali Sowe (2) / Tommaso Milanese | AS Roma |
Group B
| Team | Pld. | W | D | L | Goals | Pts. | Qualification |
| Arsenal | 6 | + | 0 | 0 | 20-5 | 18 | Advance to knockout phase |
| FK Molde | 6 | 3 | 1 | 2 | 9-11 | 10 | Advance to knockout phase |
| Rapid Wien | 6 | 2 | 1 | 3 | 11-13 | 6 | |
| Dundalk | 6 | 0 | 0 | 6 | 8-19 | 0 |
| Date | Venue | Host Team | Score | Away Team |
| 22-10-2020 | Tallaght Stadium, Dublin | Dundalk | 1-2 Sean Murray / Etzaz Hussain, Ohi Omoijuanfo | FK Molde |
| 22-10-2020 | Allianz Stadion, Vienna | Rapid Wien | 1-2 Taxiarchis Fountas / David Luiz, Pierre Emerick Aubameyang | Arsenal |
| 29-10-2020 | Emirates Stadium, London | Arsenal | 3-0 Edward Keddar Nketiah, Joseph George Willock, Nicolas Pépé | Dundalk |
| 29-10-2020 | Aker Stadion, Molde | FK Molde | 1-0 Anthony Ohikhuaeme Omoijuanfo | Rapid Wien |
| 05-11-2020 | Allianz Stadion, Vienna | Rapid Wien | 4-3 Dejan Ljubicic, Kelvin Arase, Maximilian Hofmann, Yusuf Demir / Patrick Hoban, David McMillan (2) | Dundalk |
| 05-11-2020 | Emirates Stadium, London | Arsenal | 4-1 Kristoffer Haugen (og), Sheriff Sinyan (og), Nicolas Pepe, Joseph Willock / Martin Ellingsen | FK Molde |
| 26-11-2020 | Tallaght Stadium, Dublin | Dundalk | 1-3 Chris Shields / Christoph Knasmullner, Ercan Kara (2) | Rapid Wien |
| 26-11-2020 | Aker Stadion, Molde | FK Molde | 0-3 Nicolas Pepe, Reiss Nelson, Folarin Balogun | Arsenal |
| 03-12-2020 | Emirates Stadium, London | Arsenal | 4-1 Alexandre Lacazette, Pablo Mari, Edward Nketiah, Emile Smith-Rowe / Koya Kitagawa | Rapid Wien |
| 03-12-2020 | Aker Stadion, Molde | FK Molde | 3-1 Magnus Eikrem, Ohi Omoijuanfo, Martin Ellingsen / Jordan Flores | Dundalk |
| 10-12-2020 | Tallaght Stadium, Dublin | Dundalk | 2-4 Jordan Flores, Sean Hoare / Edward Nketiah, Mohamed Elneny, Joseph Willock, Folarin Balogun | Arsenal |
| 10-12-2020 | Allianz Stadion, Vienna | Rapid Wien | 2-2 Marcel Ritzmaier, Melih Ibrahimoglu / Magnus Eikrem (2) | FK Molde |
Group C
| Team | Pld. | W | D | L | Goals | Pts. | Qualification |
| Bayer Leverkusen | 6 | 5 | 0 | 1 | 21-8 | 15 | Advance to knockout phase |
| Slavia Prague | 6 | 4 | 0 | 2 | 11-10 | 12 | Advance to knockout phase |
| Hapoel Be’er Sheva | 6 | 2 | 0 | 4 | 7-13 | 6 | |
| OGC Nice | 6 | 1 | 0 | 5 | 8-16 | 3 |
| Date | Venue | Host Team | Score | Away Team |
| 22-10-2020 | BayArena, Leverkusen | Bayer Leverkusen | 6-2 Nadiem Amiri, Lucas Alario, Moussa Diaby, Karim Bellarabi (2), Florian Wirtz / Amine Gouiri, Alexis Claude-Maurice | OGC Nice |
| 22-10-2020 | HaMoshava Stadium, Petah Tikva | Hapoel Be’er Sheva | 3-1 Jhonatan Agudelo, Elton Acolatse (2) / Lukas Provod | Slavia Prague |
| 29-10-2020 | Sinobo Stadium, Prague | Slavia Prague | 1-0 Peter Olayinka | Bayer Leverkusen |
| 29-10-2020 | Allianz Riviera, Nice | OGC Nice | 1-0 Amine Gouiri | Hapoel Be’er Sheva |
| 05-11-2020 | HaMoshava Stadium, Petah Tikva | Hapoel Be’er Sheva | 2-4 Elton Acolatse (2) / Or Dadya (og), Leon Bailey (2), Florian Wirtz | Bayer Leverkusen |
| 05-11-2020 | Sinobo Stadium, Prague | Slavia Prague | 3-2 Abdallah Sima, Jan Kuchta (2) / Amine Gouiri, Dan Ndoye | OGC Nice |
| 26-11-2020 | BayArena, Leverkusen | Bayer Leverkusen | 4-1 Patrik Schick, Leon Bailey, Kerem Demirbay, Lucas Alario / Itamar Shviro | Hapoel Be’er Sheva |
| 26-11-2020 | Allianz Riviera, Nice | OGC Nice | 1-3 Amine Gouiri / Ondrej Lingr, Peter Olayinka, Abdallah Sima | Slavia Prague |
| 03-12-2020 | Sinobo Stadium, Prague | Slavia Prague | 3-0 Abdallah Sima, Nicolae Stanciu, David Twito (og) | Hapoel Be’er Sheva |
| 03-12-2020 | Allianz Riviera, Nice | OGC Nice | 2-3 Dan Ndoye, Hassane Kamara / Moussa Diaby, Aleksandar Dragovic, Julian Baumgartlinger | Bayer Leverkusen |
| 10-12-2020 | BayArena, Leverkusen | Bayer Leverkusen | 4-0 Leon Bailey (2), Moussa Diaby, Karim Bellarabi | Slavia Prague |
| 10-12-2020 | HaMoshava Stadium, Petah Tikva | Hapoel Be’er Sheva | 1-0 Rotem Hatuel | OGC Nice |
Group D
| Team | Pld. | W | D | L | Goals | Pts. | Qualification |
| Rangers FC | 6 | 4 | 2 | 0 | 13-7 | 10 | Advance to knockout phase |
| SL Benfica | 6 | 3 | 3 | 0 | 18-9 | 9 | Advance to knockout phase |
| Lech Poznań | 6 | 1 | 1 | 4 | 7-14 | 4 | |
| Standard Liège | 6 | 1 | 0 | 5 | 6-14 | 3 |
| Date | Venue | Host Team | Score | Away Team |
| 22-10-2020 | Stade Maurice Dufrasne, Liège | Standard Liège | 0-2 James Tavernier, Kemar Roofe | Rangers FC |
| 22-10-2020 | Stadion Miejski, Poznań | Lech Poznań | 2-4 Mikael Ishak (2) / Pizzi, Darwin Nunez (3) | SL Benfica |
| 29-10-2020 | Estádio da Luz, Lisbon | SL Benfica | 3-0 Pizzi (2), Lech Poznań | Standard Liège |
| 29-10-2020 | Ibrox Stadium, Glasgow | Rangers FC | 1-0 Alfredo José Morelos | Lech Poznań |
| 05-11-2020 | Estádio da Luz, Lisbon | SL Benfica | 3-3 Connor Goldson (og), Rafa Silva, Darwin Nunez / Diogo Goncalves (og), Glen Kamara, Alfredo Morelos | Rangers FC |
| 05-11-2020 | Stadion Miejski, Poznań | Lech Poznań | 3-1 Michal Skoras, Mikael Ishak (2) / Maxime Lestienne | Standard Liège |
| 26-11-2020 | Ibrox Stadium, Glasgow | Rangers FC | 2-2 Scott Arfield, Kemar Roofe / James Tavernier (og), Pizzi | SL Benfica |
| 26-11-2020 | Stade Maurice Dufrasne, Liège | Standard Liège | 2-1 Abdoul Tapsoba, Konstantinos Laifis / Mikael Ishak | Lech Poznań |
| 03-12-2020 | Estádio da Luz, Lisbon | SL Benfica | 4-0 Jan Vertonghen, Darwin Nunez, Pizzi , Julian Weigl | Lech Poznań |
| 03-12-2020 | Ibrox Stadium, Glasgow | Rangers FC | 3-2 Connor Goldson, James Tavernier, Scott Arfield / Duje Cop, Maxime Lestienne | Standard Liège |
| 10-12-2020 | Stade Maurice Dufrasne, Liège | Standard Liège | 2-2 Nicolas Raskin, Abdoul Tapsoba / Everton, Pizzi | SL Benfica |
| 10-12-2020 | Stadion Miejski, Poznań | Lech Poznań | 0-2 Cedric Itten, Ianis Hagi | Rangers FC |
Group E
| Team | Pld. | W | D | L | Goals | Pts. | Qualification |
| PSV Eindhoven | 6 | 4 | 0 | 2 | 12-9 | 12 | Advance to knockout phase |
| Granada CF | 6 | 3 | 2 | 1 | 6-3 | 11 | Advance to knockout phase |
| PAOK | 6 | 1 | 3 | 2 | 8-7 | 6 | |
| AC Omonia Nicosia | 6 | 1 | 1 | 4 | 5-12 | 4 |
| Date | Venue | Host Team | Score | Away Team |
| 22-10-2020 | Philips Stadion, Eindhoven | PSV Eindhoven | 1-2 Mario Gotze / Jorge Molina, Darwin Machis | Granada CF |
| 22-10-2020 | Toumba Stadium, Thessaloniki | PAOK | 1-1 Thomas Murg / Eric Bautheac | AC Omonia Nicosia |
| 29-10-2020 | GSP Stadium, Strovolos | AC Omonia Nicosia | 1-2 Jordi Gómez / Donyell Malen (2) | PSV Eindhoven |
| 29-10-2020 | Nuevo Los Cármenes, Granada | Granada CF | 0-0 | PAOK |
| 05-11-2020 | Toumba Stadium, Thessaloniki | PAOK | 4-1 Stefan Schwab, Andrija Zivkovic (2), Christos Tzolis / Eran Zahavi | PSV Eindhoven |
| 05-11-2020 | GSP Stadium, Strovolos | AC Omonia Nicosia | 0-2 Yangel Herrera, Luis Suarez | Granada CF |
| 26-11-2020 | Philips Stadion, Eindhoven | PSV Eindhoven | 3-2 Cody Gakpo, Chukwunonso Madueke, Donyell Malen / Fernando Varela, Christos Tzolis | PAOK |
| 26-11-2020 | Nuevo Los Cármenes, Granada | Granada CF | 2-1 Luis Suarez, Alberto Soro / Ernest Asante | AC Omonia Nicosia |
| 03-12-2020 | GSP Stadium, Strovolos | AC Omonia Nicosia | 2-1 Andronikos Kakoulis, Jordi Gomez / Christos Tzolis | PAOK |
| 03-12-2020 | Nuevo Los Cármenes, Granada | Granada CF | 0-1 Donyell Malen | PSV Eindhoven |
| 10-12-2020 | Philips Stadion, Eindhoven | PSV Eindhoven | 4-0 Donyell Malen, Denzel Dumfries, Joel Piroe (2) | AC Omonia Nicosia |
| 10-12-2020 | Toumba Stadium, Thessaloniki | PAOK | 0-0 | Granada CF |
Group F
| Team | Pld. | W | D | L | Goals | Pts. | Qualification |
| SSC Napoli | 6 | 3 | 2 | 1 | 7-4 | 11 | Advance to knockout phase |
| Real Sociedad | 6 | 2 | 3 | 1 | 5-4 | 9 | Advance to knockout phase |
| AZ Alkmaar | 6 | 2 | 2 | 2 | 7-5 | 8 | |
| HNK Rijeka | 6 | 1 | 1 | 4 | 6-12 | 4 |
| Date | Venue | Host Team | Score | Away Team |
| 22-10-2020 | Stadio San Paolo, Naples | SSC Napoli | 0-1 Dani De Wit | AZ Alkmaar |
| 22-10-2020 | Stadion Rujevica, Rijeka | HNK Rijeka | 0-1 Jon Bautista | Real Sociedad |
| 29-10-2020 | Anoeta, San Sebastián | Real Sociedad | 0-1 Matteo Politano | SSC Napoli |
| 29-10-2020 | AFAS Stadion, Alkmaar | AZ Alkmaar | 4-1 Teun Koopmeiners, Albert Guðmundsson (2), Karl Jesper Karlsson / Sandro Kulenović | HNK Rijeka |
| 05-11-2020 | Stadion Rujevica, Rijeka | HNK Rijeka | 1-2 Robert Muric / Diego Demme, Filip Braut (og) | SSC Napoli |
| 05-11-2020 | Anoeta, San Sebastián | Real Sociedad | 1-0 Cristian Portu | AZ Alkmaar |
| 26-11-2020 | Stadio San Paolo, Naples | SSC Napoli | 2-0 Matteo Politano, Hirving Lozano | HNK Rijeka |
| 26-11-2020 | AFAS Stadion, Alkmaar | AZ Alkmaar | 0-0 | Real Sociedad |
| 03-12-2020 | AFAS Stadion, Alkmaar | AZ Alkmaar | 1-1 Bruno Martins Indi / Dries Mertens | SSC Napoli |
| 03-12-2020 | Anoeta, San Sebastián | Real Sociedad | 2-2 Jon Bautista, Nacho Monreal / Stjepan Loncar, Darko Velkovski | HNK Rijeka |
| 10-12-2020 | Stadion Rujevica, Rijeka | HNK Rijeka | 2-1 Luka Menalo, Ivan Tomecak / Owen Wijndal | AZ Alkmaar |
| 10-12-2020 | Stadio San Paolo, Naples | SSC Napoli | 1-1 Piotr Zielinski / Willian Jose | Real Sociedad |
Group G
| Team | Pld. | W | D | L | Goals | Pts. | Qualification |
| Leicester City | 6 | 4 | 1 | 1 | 14-5 | 13 | Advance to knockout phase |
| S.C. Braga | 6 | 4 | 1 | 1 | 14-10 | 13 | Advance to knockout phase |
| Zorya Luhansk | 6 | 2 | 0 | 4 | 6-11 | 6 | |
| AEK Athens | 6 | 1 | 0 | 5 | 7-15 | 3 |
| Date | Venue | Host Team | Score | Away Team |
| 22-10-2020 | Estádio Municipal, Braga | S.C. Braga | 3-0 Wenderson Galeno, Paulinho, Ricardo Horta | AEK Athens |
| 22-10-2020 | King Power Stadium, Leicester | Leicester City | 3-0 James Maddison, Harvey Barnes, Kelechi Iheanacho | Zorya Luhansk |
| 29-10-2020 | Slavutych-Arena, Zaporizhia | Zorya Luhansk | 1-2 Dmytro Ivanisenia / Paulinho, Nicolas Gaitan | S.C. Braga |
| 29-10-2020 | Olympic Stadium, Athens | AEK Athens | 1-2 Muamer Tankovic / Jamie Vardy, Hamza Choudhury | Leicester City |
| 05-11-2020 | King Power Stadium, Leicester | Leicester City | 4-0 Kelechi Iheanacho (2), Dennis Praet, James Maddison | S.C. Braga |
| 05-11-2020 | Slavutych-Arena, Zaporizhia | Zorya Luhansk | 1-4 Vladyslav Kochergin / Muamer Tankovic, Petros Mantalos, Marko Livaja (2) | AEK Athens |
| 26-11-2020 | Estádio Municipal, Braga | S.C. Braga | 3-3 Mohamed Al Musrati, Paulinho, Fransergio / Harvey Barnes, Luke Thomas, Jamie Vardy | Leicester City |
| 26-11-2020 | Olympic Stadium, Athens | AEK Athens | 0-3 Artem Gromov, Vladyslav Kabaev, Vladlen Yurchenko | Zorya Luhansk |
| 03-12-2020 | Olympic Stadium, Athens | AEK Athens | 2-4 Nelson Oliveira, Stavros Vasilantonopoulos / Vitor Tormena, Ricardo Esgaio, Ricardo Horta, Wenderson Galeno | S.C. Braga |
| 03-12-2020 | Slavutych-Arena, Zaporizhia | Zorya Luhansk | 1-0 Allahyar Sayyadmanesh | Leicester City |
| 10-12-2020 | Estádio Municipal, Braga | S.C. Braga | 2-0 Joel Abu Hanna (og), Ricardo Horta | Zorya Luhansk |
| 10-12-2020 | King Power Stadium, Leicester | Leicester City | 2-0 Cengiz Ünder, Harvey Barnes | AEK Athens |
Group H
| Team | Pld. | W | D | L | Goals | Pts. | Qualification |
| AC Milan | 6 | 4 | 1 | 1 | 12-7 | 13 | Advance to knockout phase |
| LOSC Lille | 6 | 3 | 2 | 1 | 14-8 | 11 | Advance to knockout phase |
| Sparta Prague | 6 | 2 | 0 | 4 | 10-12 | 6 | |
| Celtic | 6 | 1 | 1 | 4 | 10-19 | 4 |
| Date | Venue | Host Team | Score | Away Team |
| 22-10-2020 | Celtic Park, Glasgow | Celtic | 1-3 Mohamed Elyounoussi / Rade Krunic, Brahim Diaz, Jens Hauge | AC Milan |
| 22-10-2020 | Stadion Letná, Prague | Sparta Prague | 1-4 Borek Dockal / Yusuf Yazici (3), Jonathan Ikone | LOSC Lille |
| 29-10-2020 | Stade Pierre-Mauroy, Villeneuve-d’Ascq | LOSC Lille | 2-2 Zeki Çelik, Jonathan Ikone / Mohamed Elyounoussi (2) | Celtic |
| 29-10-2020 | San Siro, Milan | AC Milan | 3-0 Brahim Diaz, Rafael Leao, Diogo Dalot | Sparta Prague |
| 05-11-2020 | San Siro, Milan | AC Milan | 0-3 Yusuf Yazici (3) | LOSC Lille |
| 05-11-2020 | Celtic Park, Glasgow | Celtic | 1-4 Leigh Griffiths / Lukas Julis (3), Ladislav Krejci | Sparta Prague |
| 26-11-2020 | Stade Pierre-Mauroy, Villeneuve-d’Ascq | LOSC Lille | 1-1 Jonathan Bamba / Samu Castillejo | AC Milan |
| 26-11-2020 | Stadion Letná, Prague | Sparta Prague | 4-1 David Hancko, Lukas Julis, Lukas Julis, Srdjan Plavsic / Odsonne Edouard | Celtic |
| 03-12-2020 | San Siro, Milan | AC Milan | 4-2 Hakan Çalhanoğlu, Samu Castillejo, Jens Hauge, Brahim Diaz / Tomas Rogic, Odsonne Edouard | Celtic |
| 03-12-2020 | Stade Pierre-Mauroy, Villeneuve-d’Ascq | LOSC Lille | 2-1 Burak Yılmaz (2) / Ladislav Krejci | Sparta Prague |
| 10-12-2020 | Stadion Letná, Prague | Sparta Prague | 0-1 Jens Hauge | AC Milan |
| 10-12-2020 | Celtic Park, Glasgow | Celtic | 3-2 Christopher Jullien, Callum McGregor,David Turnbull / Tim Weah, Jonathan Ikone | LOSC Lille |
Group I
| Team | Pld. | W | D | L | Goals | Pts. | Qualification |
| Villarreal CF | 5 | 4 | 1 | 0 | 14-5 | 13 | Advance to knockout phase |
| Maccabi TelAviv | 6 | 3 | 2 | 1 | 6-7 | 11 | Advance to knockout phase |
| DG Sivasspor | 6 | 2 | 0 | 4 | 9-11 | 6 | |
| Qarabağ | 5 | 0 | 1 | 4 | 4-10 | 1 |
| Date | Venue | Host Team | Score | Away Team |
| 22-10-2020 | Estadio de la Cerámica, Villarreal | Villarreal CF | 5-3 Takefusa Kubo, Carlos Bacca, Juan Foyth, Paco Alcacer (2) / Olarenwaju Kayode, Mustapha Yatabare | DG Sivasspor |
| 22-10-2020 | Bloomfield Stadium, Tel Aviv | Maccabi Tel Aviv | 1-0 Yonatan Cohen | Qarabağ |
| 29-10-2020 | Başakşehir Fatih Terim Stadium, Istanbul (Turkey | Qarabağ | 1-3 Owusu Kwabena / Yeremi Santos, Paco Alcacer (2) | Villarreal CF |
| 29-10-2020 | New Sivas 4 Eylül Stadium, Sivas | DG Sivasspor | 1-2 Olarenwaju Kayode / Dan Biton, Dor Peretz | Maccabi Tel Aviv |
| 05-11-2020 | Estadio de la Cerámica, Villarreal | Villarreal CF | 4-0 Carlos Bacca (2), Alex Baena, Fer Nino | Maccabi Tel Aviv |
| 05-11-2020 | New Sivas 4 Eylül Stadium, Sivas | DG Sivasspor | 2-0 Caner Osmanpaşa, Olarenwaju Kayode | Qarabağ |
| 26-11-2020 | Bloomfield Stadium, Tel Aviv | Maccabi Tel Aviv | 1-1 Aleksandar Pesic / Alex Baena | Villarreal CF |
| 26-11-2020 | Tofiq Bahramov Stadium (Baku) | Qarabağ | 2-3 Abdellah Zoubir, Uros Matic / Arouna Kone (2), Olarenwaju Kayode | DG Sivasspor |
| 03-12-2020 | Tofiq Bahramov Stadium (Baku) | Qarabağ | 1-1 Jaime Romero / Yonatan Cohen | Maccabi Tel Aviv |
| 03-12-2020 | New Sivas 4 Eylül Stadium, Sivas | DG Sivasspor | 0-1 Samuel Chimerenka Chukweze | Villarreal CF |
| 10-12-2020 | Bloomfield Stadium, Tel Aviv | Maccabi Tel Aviv | 1-0 Enric Saborit | DG Sivasspor |
| Estadio de la Cerámica, Villarreal | Villarreal CF | Qarabağ |
Group J
| Team | Pld. | W | D | L | Goals | Pts. | Qualification |
| Tottenham Hotspur | 6 | 4 | 1 | 1 | 15-5 | 13 | Advance to knockout phase |
| Royal Antwerp F.C. | 6 | 4 | 0 | 2 | 8-5 | 12 | Advance to knockout phase |
| LASK Linz | 6 | 3 | 1 | 2 | 11-12 | 10 | |
| Ludogorets Razgard | 6 | 0 | 0 | 6 | 7-19 | 0 |
| Date | Venue | Host Team | Score | Away Team |
| 22-10-2020 | Tottenham Hotspur Stadium, London | Tottenham Hotspur | 3-0 Lucas, Andres Andrade (og), Son Heung-Min | LASK Linz |
| 22-10-2020 | Huvepharma Arena, Razgrad | Ludogorets Razgard | 1-2 Higinio Marin / Pieter Gerkens, Lior Refaelov | Royal Antwerp F.C. |
| 29-10-2020 | Linzer Stadion, Linz | LASK Linz | 4-3 Husein Balic, Andreas Gruber, Marko Raguz, Olivier Verdon (og) / Elvis Manu (3) | Ludogorets Razgard |
| 29-10-2020 | Bosuilstadion, Antwerp | Royal Antwerp F.C. | 1-0 Lior Refaelov | Tottenham Hotspur |
| 05-11-2020 | Huvepharma Arena, Razgrad | Ludogorets Razgard | 1-3 Claudiu Keseru / Harry Kane, Lucas, Giovani Lo Celso | Tottenham Hotspur |
| 05-11-2020 | Bosuilstadion, Antwerp | Royal Antwerp F.C. | 0-1 Johannes Eggestein | LASK Linz |
| 26-11-2020 | Tottenham Hotspur Stadium, London | Tottenham Hotspur | 4-0 Carlos Vinicius (2), Harry Winks, Lucas | Ludogorets Razgard |
| 26-11-2020 | Linzer Stadion, Linz | LASK Linz | 0-2 Lior Refaelov, Pieter Gerkens | Royal Antwerp F.C. |
| 03-12-2020 | Linzer Stadion, Linz | LASK Linz | 3-3 Mamoudou Karamoko, Peter Michorl, Johannes Eggestein / Gareth Bale, Heung-Min, Dele Alli | Tottenham Hotspur |
| 03-12-2020 | Bosuilstadion, Antwerp | Royal Antwerp F.C. | 3-1 Martin Hongla, Ritchie De Laet, Manuel Benson / Kiril Despodov | Ludogorets Razgard |
| 10-12-2020 | Tottenham Hotspur Stadium, London | Tottenham Hotspur | 2-0 Carlos Vinicius, Giovani Lo Celso | Royal Antwerp F.C. |
| 10-12-2020 | Huvepharma Arena, Razgrad | Ludogorets Razgard | 1-3 Elvis Manu / Philipp Wiesinger, Rene Renner, Mads Emil Madsen | LASK Linz |
Group K
| Team | Pld. | W | D | L | Goals | Pts. | Qualification |
| GNK Dinamo Zagrep | 6 | 4 | 2 | 0 | 9-1 | 14 | Advance to knockout phase |
| Wolfsberger AC | 6 | 3 | 1 | 2 | 7-6 | 10 | Advance to knockout phase |
| Feyenoord | 6 | 1 | 2 | 3 | 4-8 | 5 | |
| CSKA Moscow | 6 | 0 | 3 | 3 | 3-8 | 3 |
| Date | Venue | Host Team | Score | Away Team |
| 22-10-2020 | Stadion Maksimir, Zagreb | GNK Dinamo Zagrep | 0-0 | Feyenoord |
| 22-10-2020 | Wörthersee Stadion, Klagenfurt | Wolfsberger AC | 1-1 Michael Liendl / Adolfo Gaich | CSKA Moscow |
| 29-10-2020 | VEB Arena, Moscow | CSKA Moscow | 0-0 | GNK Dinamo Zagrep |
| 29-10-2020 | De Kuip, Rotterdam | Feyenoord | 1-4 Steven Berghuis / Michael Liendl (3), Dejan Joveljic | Wolfsberger AC |
| 05-11-2020 | Stadion Maksimir, Zagreb | GNK Dinamo Zagrep | 1-0 Iyayi Atiemwe | Wolfsberger AC |
| 05-11-2020 | De Kuip, Rotterdam | Feyenoord | 3-1 Ridgeciano Haps, Orkun Kokçü, Lutsharel Geertruida / Marcos Senesi (og) | CSKA Moscow |
| 26-11-2020 | Wörthersee Stadion, Klagenfurt | Wolfsberger AC | 0-3 Lovro Majer, Bruno Petkovic, Luka Ivanusec | GNK Dinamo Zagrep |
| 26-11-2020 | VEB Arena, Moscow | CSKA Moscow | 0-0 | Feyenoord |
| 03-12-2020 | VEB Arena, Moscow | CSKA Moscow | 0-1 Dario Vizinger | Wolfsberger AC |
| 03-12-2020 | De Kuip, Rotterdam | Feyenoord | 0-2 Bruno Petkovic, Lovro Majer | GNK Dinamo Zagrep |
| 10-12-2020 | Stadion Maksimir, Zagreb | GNK Dinamo Zagrep | 3-1 Josko Gvardiol, Mislav Orsic, Lirim Kastrati / Kristijan Bistrovic | CSKA Moscow |
| 10-12-2020 | Wörthersee Stadion, Klagenfurt | Wolfsberger AC | 1-0 Dejan Joveljic | Feyenoord |
Group L
| Team | Pld. | W | D | L | Goals | Pts. | Qualification |
| 1899 Hoffenheim | 6 | 5 | 1 | 0 | 17-2 | 16 | Advance to knockout phase |
| FK Crvena Zvezda | 6 | 3 | 2 | 1 | 9-4 | 11 | Advance to knockout phase |
| Slovan Liberec | 6 | 2 | 1 | 3 | 4-13 | 7 | |
| K.A.A. Gent | 6 | 0 | 0 | 6 | 4-15 | 0 |
| Date | Venue | Host Team | Score | Away Team |
| 22-10-2020 | Rhein-Neckar-Arena, Sinsheim | 1899 Hoffenheim | 2-0 Christoph Baumgartner, Munas Dabbur | FK Crvena Zvezda |
| 22-10-2020 | Stadion u Nisy, Liberec | Slovan Liberec | 1-0 Abdulla Yusuf | K.A.A. Gent |
| 29-10-2020 | Red Star Stadium, Belgrade | K.A.A. Gent | 1-4 Tim Kleindienst / Ishak Belfodil, Florian Grillitsch, Mijat Gacinovic, Munas Dabbur | 1899 Hoffenheim |
| 29-10-2020 | Ghelamco Arena, Ghent | FK Crvena Zvezda | 5-1 El Fardou Ben (2), Milan Gajic, Aleksandar Katai, Diego Falcinelli / Jan Matousek | Slovan Liberec |
| 05-11-2020 | Red Star Stadium, Belgrade | FK Crvena Zvezda | 2-1 Guelor Kanga, Aleksandar Katai / Vadis Odjidja | K.A.A. Gent |
| 05-11-2020 | Rhein-Neckar-Arena, Sinsheim | 1899 Hoffenheim | 5-0 Munas Dabbur (2), Florian Grillitsch, Sargis Adamyan (2) | Slovan Liberec |
| 26-11-2020 | Ghelamco Arena, Ghent | K.A.A. Gent | 0-2 Njegos Petrovic, Nemanja Milunovic | FK Crvena Zvezda |
| 26-11-2020 | Stadion u Nisy, Liberec | Slovan Liberec | 0-2 Christoph Baumgartner, Andrej Kramaric | 1899 Hoffenheim |
| 03-12-2020 | Ghelamco Arena, Ghent | K.A.A. Gent | 1-2 Roman Yaremchuk / Kamso Mara, Taras Kacharaba | Slovan Liberec |
| 03-12-2020 | Red Star Stadium, Belgrade | FK Crvena Zvezda | 0-0 | 1899 Hoffenheim |
| 10-12-2020 | Rhein-Neckar-Arena, Sinsheim | 1899 Hoffenheim | 4-1 Maximilian Beier (2), Robert Skov,Andrej Kramaric / Nurio Fortuna | K.A.A. Gent |
| 10-12-2020 | Stadion u Nisy, Liberec | Slovan Liberec | 0-0 | FK Crvena Zvezda |