Teams
| Cruz Azul | Chicago Fire | Club Tijuana | LA Galaxy |
| Club America | Houston Dynamo | Tigres UANL | Real Salt Lake |
Schedule
Quarters Finals
| 23-07-2019 | SeatGeek Stadium | Cruz Azul | 2-0 Elias Hernandez, Roberto Alvarado | Chicago Fire |
| 23-07-2019 | Dignity Health Sports Park | Club Tijuana | 2-2 Ariel Nahuelpan, Washington Camacho / Emanuel Boateng, David Romney (1-3 pen.) | LA Galaxy |
| 24-07-2019 | BBVA Compass Stadium | Club America | 1-1 Nicolas Benedetti / DaMarcus Beasley (6-5 pen.) | Houston Dynamo |
| 24-07-2019 | Rio Tinto Stadium | Tigres UANL | 1-0 Eduardo Vargas | Real Salt Lake |
Semifinal
| 21-08-2019 | Cruz Azul | 2-1 Jos Maduea, Orbelin Pineda / Emil Cuello | LA Galaxy | |
| 21-08-2019 | Club America | 2-2 Andrs Ibargen (2) / Paul Aguilar (og), Bruno Valdez (og) (3-5 pen.) | Tigres UANL |
Final
| 18-09-2019 | Sam Boyd Stadium, Las Vegas | Cruz Azul | 2-1 Víctor Yoshimar Yotún, Jonathan Javier Rodríguez / Guido Hernán Pizarro | Tigres UANL |