Week 1
| Date | Groupe | Host Team | Score | Away Team |
| 19-09-2019 | A | Qarabağ | 0-3 Javier Hernandez, Munir El Haddadi, Oliver Torres | Sevilla |
| 19-09-2019 | A | APOEL | 3-4 Andrija Pavlovic (2), Tomas De Vincenti / Danel Sinani (2), Antoine Bernier, Dominik Stolz | F91 Dudalenge |
| 19-09-2019 | B | Dynamo Kyiv | 1-0 Vitaliy Buyalskyy | Malmö FF |
| 19-09-2019 | B | F.C. Copenhagen | 1-0 Michael Santos | Lugano FC |
| 19-09-2019 | C | Getafe | 1-0 Angel Rodriguez | Trabzonspor |
| 19-09-2019 | C | FC Basel | 5-0 Kevin Bua (2), Luca Zuffi, Tonny Vilhena (og), Noah Okafor | Krasnodar |
| 19-09-2019 | D | PSV Eindhoven | 3-2 Donyell Malen, Sebastian Coates (og), Timo Baumgartl / Bruno Fernandes, Pedro Mendes | Sporting CP |
| 19-09-2019 | D | LASK Linz | 1-0 James Holland | Rosenborg |
| 19-09-2019 | E | Rennes | 1-1 Mbaye Niang / Ryan Christie | Celtic |
| 19-09-2019 | E | CFR Cluj | 2-1 Ciprian Deac, Billel Omrani / Bastos | S.S. Lazio |
| 19-09-2019 | F | Eintracht Frankfurt | 0-3 Joseph Willock, Bukayo Saka, Pierre Emerick Aubameyang | Arsenal |
| 19-09-2019 | F | Standard Liege | 2-0 Florent Hanin (og), Paul-Jose Mpoku | Vitoria de Guimaraes |
| 19-09-2019 | G | FC Porto | 2-1 Soares (2) / Jean-Pierre Nsame | Young Boys |
| 19-09-2019 | G | Rangers | 1-0 Sheyi Ojo | Feyenoord |
| 19-09-2019 | H | Ludogorets Razfrad | 5-1 Wanderson, Jody Lukoki, Claudiu Keseru (3) / Igor Diveev | CSKA Moscow |
| 19-09-2019 | H | Espanyol | 1-1 Matias Vargas / Javi Lopez (og) | Ferencvaros |
| 19-09-2019 | I | KAA Gent | 3-2 Jonathan David (2), Loic Perrin (og) / Wahbi Khazri, Thomas Kaminski (og) | Saint-Etienne |
| 19-09-2019 | I | Vfl Wolfsburg | 3-1 Maximilian Arnold, Admir Mehmedi, Josip Brekalo / Evgeniy Banada | Oleksandriya |
| 19-09-2019 | J | A.S. Roma | 4-0 Junior Caicara (og), Edin Dzeko, Nicolo Zaniolo, Justin Kluivert | Başakşehir FK |
| 19-09-2019 | J | Borussia Mönchengladbach | 0-4 Shon Weissman, Mario Leitgeb (2), Marcel Ritzmaier | Wolfsberger AC |
| 19-09-2019 | K | Slovan Bratislava | 4-2 Andraz Sporar (2), Marin Ljubicic, Moha / Adem Ljajic, Vasil Bozhikov (og) | Beşiktaş |
| 19-09-2019 | K | Wolwerhampton Wanderers | 0-1 Ricardo Horta | S.C. Braga |
| 19-09-2019 | L | Partizan | 2-2 Bibras Natcho(2) / Calvin Stengs, Myron Boadu | AZ Alkmaar |
| 19-09-2019 | L | Manchester United | 1-0 Mason Greenwood | FC Astana |
Week 2
| Date | Groupe | Host Team | Score | Away Team |
| 03-10-2019 | A | Dudalenge | 1-4 Antoine Bernier / Abdellah Zoubir, Michel, Richard, Dani Quintana | Qarabag |
| 03-10-2019 | A | Sevilla | 1-0 Javier Hernandez | APOEL |
| 03-10-2019 | B | Lugano | 0-0 | Dynamo Kyiv |
| 03-10-2019 | B | Malmö FF | 1-1 Markus Rosenberg / Lasse Nielsen (og) | FC Kobenhavn |
| 03-10-2019 | C | FK Krasnodar | 1-2 Ari / Angel Rodriguez | Getafe |
| 03-10-2019 | C | Trabzonspor | 2-2 Abdulkadir Parmak, Jose Ernesto Sosa / Silvan Widmer, Noah Okafor | FC Basel |
| 03-10-2019 | D | Rosenborg | 1-4 Samuel Adegbenro / Pablo Rosario, Birger Meling (og), Donyell Malen (2) | PSV |
| 03-10-2019 | D | Sporting CP | 2-1 Luiz Phellype, Bruno Fernandes / Marko Raguz | LASK Linz |
| 03-10-2019 | E | Celtic | 2-0 Odsonne Edouard, Mohamed Elyounoussi | CFR Cluj |
| 03-10-2019 | E | Lazio | 2-1 Sergej Milinkovic-Savic, Ciro Immobile / Jeremy Morel | Rennes |
| 03-10-2019 | F | Arsenal | 4-0 Gabriel Martinelli (2), Joseph Willock, Dani Ceballos | Standard Liege |
| 03-10-2019 | F | Guimaraes | 0-1 Obite Evan Ndicka | Enitracht Frankfurt |
| 03-10-2019 | G | Feyenord | 2-0 Jens Toornstra, Rick Karsdorp | FC Porto |
| 03-10-2019 | G | Young Boys | 2-1 Roger Assale, Christian Fassnacht / Alfredo Morelos | Rangers |
| 03-10-2019 | H | CSKA Moscow | 0-2 Wu Lei, Victor Campuzano | Espanyol |
| 03-10-2019 | H | Ferencvaros | 0-3 Jody Lukoki, Rafael Forster (2) | Ludogorets |
| 03-10-2019 | I | Oleksandria | 1-1 Artem Sitalo / Laurent Depoitre | Gent |
| 03-10-2019 | I | Saint Etienne | 1-1 Timothee Kolodziejczak / William | Wolfsburg |
| 03-10-2019 | J | Başakşehir FK | 1-1 Edin Visca / Patrick Herrmann | Borussia Monchengladbach |
| 03-10-2019 | J | Wolfsberger AC | 1-1 Michael Liendl / Leonardo Spinazzola | AS Roma |
| 03-10-2019 | K | Beşiktaş | 0-1 Willy Boly | Wolwerhampton Wolwes |
| 03-10-2019 | K | Braga | 2-2 Bruno Viana, Wenderson Galeno / Andraz Sporar, Bruno Viana (og) | Slovan Bratislava |
| 03-10-2019 | L | Astana | 1-2 Runar Mar Sigurjonsson / Umar Sadig (2) | Partizan |
| 03-10-2019 | L | AZ Alkmaar | 0-0 | Manchester United |
Week 3
| Date | Groupe | Host Team | Score | Away Team |
| 24-10-2019 | A | Qarabag | 2-2 Dani Quintana, Ailton / Maksim Medvedev (og), Linus Hallenius | APOEL |
| 24-10-2019 | A | Sevilla | 3-0 Franco Vazquez (2), Munir El Haddadi | Dudalenge |
| 24-10-2019 | B | Dynamo Kyiv | 1-1 Artem Shabanov / Pieros Sotiriou | FC Kobenhavn |
| 24-10-2019 | B | Malmö FF | 2-1 Jo Inge Berget, Guillermo Molins / Alexander Gerndt | Lugano |
| 24-10-2019 | C | Trabzonspor | 0-2 Marcus Berg, Tonny Vilhena | FK Krasnodar |
| 24-10-2019 | C | Getafe | 0-1 Fabian Frei | FC Basel |
| 24-10-2019 | D | Sporting CP | 1-0 Yannick Bolasie | Rosenborg |
| 24-10-2019 | D | PSV | 0-0 | LASK Linz |
| 24-10-2019 | E | Celtic | 2-1 Ryan Christie, Christopher Jullien / Manuel Lazzari | Lazio |
| 24-10-2019 | E | Rennes | 0-1 Ciprian Deac | CFR Cluj |
| 24-10-2019 | F | Arsenal | 3-2 Gabriel Martinelli, Nicolas Pepe / Bruno Duarte, Marcus Edwards | Guimaraes |
| 24-10-2019 | F | Enitracht Frankfurt | 2-1 David Angel Abraham, Martin Hinteregger / Selim Amallah | Standard Liege |
| 24-10-2019 | G | Young Boys | 2-0 Roger Assale, Jean-Pierre Nsame | Feyenord |
| 24-10-2019 | G | FC Porto | 1-1 Luis Diaz / Alfredo Morelos | Rangers |
| 24-10-2019 | H | CSKA Moscow | 0-1 Roland Varga | Ferencvaros |
| 24-10-2019 | H | Ludogorets | 0-1 Victor Campuzano | Espanyol |
| 24-10-2019 | I | Saint Etienne | 1-1 Gabriel Silva / Gabriel Silva (og | Oleksandria |
| 24-10-2019 | I | Gent | 2-2 Roman Yaremchuk (2) / Wout Weghorst, Joao Victor | Wolfsburg |
| 24-10-2019 | J | Başakşehir FK | 1-0 İrfan Can Kahveci | Wolfsberger AC |
| 24-10-2019 | J | AS Roma | 1-1 Nicolo Zaniolo / Lars Stindl | Borussia Monchengladbach |
| 24-10-2019 | K | Beşiktaş | 1-2 Mehmet Umut Nayir / Ricardo Horta, Wilson Eduardo | AC Braga |
| 24-10-2019 | K | Slovan Bratislava | 1-2 Andraz Sporar / Romain Saiss, Raul Jimene | Wolwerhampton Wolwes |
| 24-10-2019 | L | AZ Alkmaar | 6-0 Teun Koopmeiners (2), Myron Boadu, Calvin Stengs, Yukinari Sugawara, Oussama Idrissi | Astana |
| 24-10-2019 | L | Partizan | 0-1 Anthony Martia | Manchester United |
Week 4
| Date | Groupe | Host Team | Score | Away Team |
| 07-10-2019 | A | APOEL | 2-1 Lucas Souza, Nicolas Ioannou/ Maksim Medvedev | Qarabag |
| 07-10-2019 | A | Dudalenge | 2-5 Danel Sinani (2) / Munas Dabbur (2), Munir El Haddadi (3) | Sevilla |
| 07-10-2019 | B | FC Kobenhavn | 1-1 Jens Stage / Benjamin Verbic | Dynamo Kyiv |
| 07-10-2019 | B | Lugano | 0-0 | Malmö FF |
| 07-10-2019 | C | FK Krasnodar | 3-1 Serkan Asan (og), Manuel Fernandes, Ivan Ignatyev / Anthony Nwakaeme | Trabzonspor |
| 07-10-2019 | C | FC Basel | 2-1 Arthur, Fabian Frei / Jaime Mata | Getafe |
| 07-10-2019 | D | Rosenborg | 0-2 Sebastian Coates, Bruno Fernandes | Sporting CP |
| 07-10-2019 | D | LASK Linz | 4-1 Reinhold Ranftl, Dominik Frieser, Joao Klauss (2) / Daniel Schwaab | PSV |
| 07-10-2019 | E | Lazio | 1-2 Ciro Immobile / James Forrest, Olivier Ntcham | Celtic |
| 07-10-2019 | E | CFR Cluj | 1-0 Mario Rondon | Rennes |
| 07-10-2019 | F | Guimaraes | 1-1 Bruno Duarte / Shkodran Mustafi | Arsenal |
| 07-10-2019 | F | Standard Liege | 2-1 Zinho Vanheusden, Maxime Lestienne / Filip Kostic | Enitracht Frankfurt |
| 07-10-2019 | G | Feyenord | 1-1 Steven Berghuis / Marvin Spielmann | Young Boys |
| 07-10-2019 | G | Rangers | 2-0 Alfredo Morelos, Steven Davis | FC Porto |
| 07-10-2019 | H | Ferencvaros | 0-0 | CSKA Moscow |
| 07-10-2019 | H | Espanyol | 6-0 Oscar Melendo, Lluis Lopez, Matias Vargas, Victor Campuzano, Adria Pedrosa, Facundo Ferreyra | Ludogorets |
| 07-10-2019 | I | Oleksandria | 2-2 Denys Bezborodko, Maksym Zaderaka / Wahbi Khazri, Mahdi Camara | Saint Etienne |
| 07-10-2019 | I | Wolfsburg | 1-3 Joao Victor / Roman Yaremchuk, Laurent Depoitre, Michael Ngadeu | Gent |
| 07-10-2019 | J | Wolfsberger AC | 0-3 Edin Visca, Enzo Crivelli (2) | Başakşehir FK |
| 07-10-2019 | J | Borussia Monchengladbach | 2-1 Federico Fazio (og), Marcus Thuram / Federico Fazio | AS Roma |
| 07-10-2019 | K | AC Braga | 3-1 Paulinho (2), Wilson Eduardo / Tyler Boyd | Beşiktaş |
| 07-10-2019 | K | Wolwerhampton Wolwes | 1-0 Raul Jimenez | Slovan Bratislava |
| 07-10-2019 | L | Astana | 0-5 Myron Boadu (2), Fredrik Midtsjo, Oussama Idrissi, Pantelis Hatzidiakos | AZ Alkmaar |
| 07-10-2019 | L | Manchester United | 3-0 Mason Greenwood, Anthony Martial, Marcus Rashfor | Partizan |
Week 5
| Date | Groupe | Host Team | Score | Away Team |
| 27-11-2019 | A | Sevilla | 2-0 Bryan Salvatierra, Munas Dabbur | Qarabag |
| 27-11-2019 | A | Dudalenge | 0-2 Uros Matic, Georgos Merkis | APOEL |
| 27-11-2019 | B | Malmö FF | 4-3 Rasmus Bengtsson, Markus Rosenberg (2), Erdal Rakip / Vitaliy Mykolenko, Viktor Tsygankov, Benjamin Verbic | Dynamo Kyiv |
| 27-11-2019 | B | Lugano | 0-1 Nikolaj Thomsen | FC Kobenhavn |
| 27-11-2019 | C | Trabzonspor | 0-1 Jaime Mata | Getafe |
| 27-11-2019 | C | FK Krasnodar | 1-0 Ari | FC Basel |
| 27-11-2019 | D | Rosenborg | 1-2 Bjorn Johnsen / Thomas Goiginger, Dominik Frieser | LASK Linz |
| 27-11-2019 | D | Sporting CP | 4-0 Luiz Phellype, Bruno Fernandes (2), Jeremy Mathieu | PSV |
| 27-11-2019 | E | Lazio | 1-0 Joaquin Correa | CFR Cluj |
| 27-11-2019 | E | Celtic | 3-1 Lewis Morgan, Ryan Christie, Michael Johnston / Adrien Hunou | Rennes |
| 27-11-2019 | F | Guimaraes | 1-1 Andre Pereira / Maxime Lestienne | Standard Liege |
| 27-11-2019 | F | Arsenal | 1-2 Pierre Emerick Aubameyang / Daichi Kamada (2) | Enitracht Frankfurt |
| 27-11-2019 | G | Feyenord | 2-2 Jens Toornstra, Luis Sinisterra / Alfredo Morelos (2) | Rangers |
| 27-11-2019 | G | Young Boys | 1-2 Christian Fassnacht / Vincent Aboubakar (2) | FC Porto |
| 27-11-2019 | H | Ferencvaros | 2-2 David Siger, Michal Skvarka / Oscar Melendo, Sergi Darder | Espanyol |
| 27-11-2019 | H | CSKA Moscow | 1-1 Fedor Chalov / Claudiu Keseru | Ludogorets |
| 27-11-2019 | I | Oleksandria | 0-1 Wout Weghorst | Wolfsburg |
| 27-11-2019 | I | Saint Etienne | 0-0 | Gent |
| 27-11-2019 | J | Wolfsberger AC | 0-1 Lars Stindl | Borussia Monchengladbach |
| 27-11-2019 | J | Başakşehir FK | 0-3 Jordan Veretout, Justin Kluivert, Edin Dzeko | AS Roma |
| 27-11-2019 | K | AC Braga | 3-3 Andre Horta, Paulinho, Fransergio / Raul Jimenez, Matthew Doherty, Adama Traore | Wolwerhampton Wolwes |
| 27-11-2019 | K | Beşiktaş | 2-1 Enzo Roco, Adem Ljajic / Erik Daniel | Slovan Bratislava |
| 27-11-2019 | L | Astana | 2-1 Dmitry Shomko, DiShon Bernard (og) / Jesse Lingard | Manchester United |
| 27-11-2019 | L | AZ Alkmaar | 2-2 Ferdy Druijf (2) / Takuma Asano, Seydouba Soumah | Partizan |
Week 6
| Date | Groupe | Host Team | Score | Away Team |
| 12-12-2019 | A | APOEL | 1-0 Vujadin Savic | Sevilla |
| 12-12-2019 | A | Qarabag | 1-1 Magaye Gueye / Sabir Bougrine | Dudalenge |
| 12-12-2019 | B | Dynamo Kyiv | 1-1 Viktor Tsygankov / Marco Aratore | Lugano |
| 12-12-2019 | B | FC Kobenhavn | 0-1 Sotirios Papagiannopoulos (og) | Malmö FF |
| 12-12-2019 | C | Getafe | 3-0 Leandro Cabrera, Jorge Molin, Kenedy | FK Krasnodar |
| 12-12-2019 | C | FC Basel | 2-0 Silvan Widmer, Valentin Stocker | Trabzonspor |
| 12-12-2019 | D | LASK Linz | 3-0 Gernot Trauner, Joao Klauss, Marko Raguz | Sporting CP |
| 12-12-2019 | D | PSV | 1-1 Mohammed Ihattaren / Pal Andre Helland | Rosenborg |
| 12-12-2019 | E | CFR Cluj | 2-0 Andrei Andonie Burca, Damian Djokovic | Celtic |
| 12-12-2019 | E | Rennes | 2-0 Joris Gnagnon (2) | Lazio |
| 12-12-2019 | F | Standard Liege | 2-2 Samuel Bastien, Selim Amallah / Alexandre Lacazette, Bukayo Saka | Arsenal |
| 12-12-2019 | F | Enitracht Frankfurt | 2-3 Danny da Costa, Daichi Kamada / Rochinha, Al Musrati, Marcus Edwards | Guimaraes |
| 12-12-2019 | G | Rangers | 1-1 Alfredo Morelos / Borna Barisic (og) | Young Boys |
| 12-12-2019 | G | FC Porto | 3-2 Luis Diaz, Tyrell Malacia (og) , Soares / Eric Botteghin, Sam Larsson | Feyenord |
| 12-12-2019 | H | Espanyol | 0-1 Nikola Vlasic | CSKA Moscow |
| 12-12-2019 | H | Ludogorets | 1-1 Jody Lukoki / Nikolai Signevich | Ferencvaros |
| 12-12-2019 | I | Wolfsburg | 1-0 Paulo Otavio | Saint Etienne |
| 12-12-2019 | I | Gent | 2-1 Laurent Depoitre (2) / Denis Miroshnichenko | Oleksandria |
| 12-12-2019 | J | Borussia Monchengladbach | 1-2 Marcus Thuram / Irfan Can Kahveci, Enzo Crivelli | Başakşehir FK |
| 12-12-2019 | J | AS Roma | 2-2 Diego Perotti, Edin Dzeko / Alessandro Florenzi (og) Shon Weissman | Wolfsberger AC |
| 12-12-2019 | K | Wolwerhampton Wolwes | 4-0 Diogo Jota(3), Leander Dendoncker | Beşiktaş |
| 12-12-2019 | K | Slovan Bratislava | 2-4 Andraz Sporar, Moha / Rui Fonte, Francisco Trincao, Vasil Bozhikov (og), Paulinho | AC Braga |
| 12-12-2019 | L | Manchester United | 4-0 Ashley Young, Mason Greenwood (2), Juan Mata | AZ Alkmaar |
| 12-12-2019 | L | Partizan | 4-1 Seydouba Soumah, Takuma Asano, Umar Sadiq (2) / Dorin Rotariu | Astana |